We offer standard microarrays for all mature miRNAs from every species represented in the latest version of the miRBase database (Release 22.1, October 2018).
Our comprehensive service includes sample labeling, array hybridization, image data processing, and in-depth bioinformatic analysis. Within 2–3 weeks of receiving your total RNA samples, we deliver both raw data and fully analyzed results.
Featuring μParaflo® Biochip technology
A high-performance microfluidic custom microarray platform
includes 100% of miRBase Version 22.1 content
Flexible design – supports custom content for all species
Optimized RNA hybridization probes, high specificity and sensitivity
An experienced service provider (since 2005) expertise in handling diverse research and clinical sample types, including FFPE, urine, and blood/plasma samples
Cost-effective, one-stop solution – from sample processing to data analysis
Overview of the Service
Microfluidics microarray platform
The µParaflo® technology integrates high throughput parallel synthesis, microfluidics, and digital photolithography to create custom arrays of DNA, RNA, or peptides. Our advanced microarray platform delivers more reliable results than traditional spotted arrays can provide.
Optimized RNA hybridization probes
LC Sciences’ Optimized RNA Hybridization Probes are designed with normalized Tms to ensure uniform hybridization affinity to their microRNA targets under high-stringency hybridization conditions, enhancing both the sensitivity and specificity of the probes.
The most current content
LC Sciences offers the only microRNA microarray currently available with version 22 probe content. Not 90% or 95% coverage, but 100% of experimentally verified microRNA sequences are represented on every array.
Complete content flexibility
All of LC Sciences’ microarrays are made to order and synthesized to each customer’s particular specifications. Validate predictions, add custom controls, or create fully custom tiling arrays for discovery of novel small RNAs. The choice is up to you!
No limitation on use of data
Unlike proprietary probe content, we make no claims on your data. You have full access and control over the results generated from your experiments.
The standard for array data quality
The µParaflo® technology enables on-chip synthesis ensuring high probe quality and tight process control. The data obtained from these microarrays is highly reliable and reproducible, as validated by qPCR and Northern blot.
In depth data analysis
LC Sciences’ in-depth data analysis includes t-tests, ANOVA, and heat maps to provide the information you need. Complex multi-array experiments are no problem for our experienced technical team. We can easily compare samples from different chips or even new experimental data to data from previous experiments.
The most customer publications
LC Sciences’ customers have published over 1,000 papers to date, confirming that microRNAs play an important role in a wide array of biological functions.
Sample Requirements
Our Comprehensive Service
At LC Sciences, we offer a genome-wide microRNA expression profiling service using a microarray detection system developed specifically for microRNA detection. Send us your total RNA sample, and we’ll perform all the necessary steps, from sample QC to data analysis. We can perform microarray analysis on a single sample to create an expression profile, or hybridize two samples on the same microarray for dual-sample analysis. This is especially useful when comparing two samples, such as wild-type vs. mutant, or samples treated in different ways.
Our comprehensive “Total RNA to Data” service includes: sample QC, sample preparation and labeling, microRNA detection (hybridization to a µParaflo® microfluidics chip), array scanning and data extraction, and full data analysis.
Within 2–3 weeks, you will receive: original and processed scan images, the array layout and list of sequences, raw and processed data, a list of differentially expressed transcripts (dual-sample arrays only), and a summary report of the results.
DNA Sequencing
LC Sciences provides a variety of fast, comprehensive DNA sequencing solutions, including exome, whole-genome, whole-genome bisulfite, and reduced representation bisulfite sequencing.
Learn MoreMicrobial Sequencing
LC Sciences provides a fast, comprehensive microbial Sequencing solution including: 16S/18S/ITS Amplicon Sequencing, 5R 16S Amplicon Metagenomic Sequencing, Shotgun Metagenomic Sequencing.
Learn MoreRNA Sequencing
LC Sciences offers a range of rapid and comprehensive RNA sequencing solutions, including poly-A RNA, micro RNA, total RNA, circRNA, m6A RNA, and more.
Learn MoreEpigenomics
LC Sciences provides specialized epigenomics services, including Whole Genome Bisulfite Sequencing (comprehensive single-base resolution DNA methylation analysis), Reduced Representation Bisulfite Sequencing (targeted CpG-rich region study with lower cost), ATAC-seq (chromatin accessibility and regulatory element investigation), and CUT&Tag (high-resolution chromatin profiling for small/single-cell samples).
Learn MoreSingle Cell Sequencing
Learn MoreProteomics & Metabolomics
LC Sciences is focused on providing scientific researchers with more minute and precise protein expression-related services, including olink proteomics.
Learn MorePre-made Library Sequencing
Learn MoreAdditional Services
Our portfolio of additional services includes Bioinformatic Services, Oligomix, MicroRNA Profiling Microarray, DNA/RNA Aptamer Microarray, Epitope Mapping, and Kinase Profiling. These services are designed to support various aspects of molecular research and biomolecular analysis, providing comprehensive solutions tailored to your specific scientific needs.
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