Decoding life sciences

Echoing life narratives

Astral DIA Proteomics

LC Sciences provides microRNA (miRNA) expression profiling services using microarrays based on our in-house-developed μParaflo® technology platform.

Astral, short for Asymmetric Track Lossless analyzer "Asymmetric", "Track" and "Lossless". The Orbitrap Astral mass spectrometer integrates a quadrupole, an Orbitrap, and a novel Asymmetric Track Lossless (Astral) mass analyzer. It delivers unprecedented processing speed, deeper proteome coverage, higher sensitivity, and superior quantitative accuracy, making it an landmark innovation in the Orbitrap series of mass spectrometers.

Applications

  • Routine proteomics research

  • High-depth proteomics analysis

  • Blood-based proteomics studies

  • Biomarker screening and validation

Advantages

  • Higher throughput

    Capable of analyzing 300 samples per day, with more than 8,000 proteins identified per sample.

    Large-scale translational research

    The Orbitrap Astral Zoom mass spectrometer identifies a greater total number of proteomes, and detecting nearly 10 times more proteomes per minute compared to conventional systems.

  • Higher sensitivity

    Through the enhanced low-input mode and TMT HR mode of the Astral mass analyzer, the Orbitrap Astral Zoom mass spectrometer can dramatically increases throughput to thousands of single cells per day through MS1- and MS2-based multi-channel acquisition strategies.

Sample Requirements


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Note: Sample amounts are provided for reference only.  For detailed information, please contact us with your customized requests.



Our Comprehensive Service


At LC Sciences, we offer a genome-wide microRNA expression profiling service using a microarray detection system developed specifically for microRNA detection. Send us your total RNA sample, and we’ll perform all the necessary steps, from sample QC to data analysis. We can perform microarray analysis on a single sample to create an expression profile, or hybridize two samples on the same microarray for dual-sample analysis.  This is especially useful when comparing two samples, such as wild-type vs. mutant, or samples treated in different ways.

Our comprehensive “Total RNA to Data” service includes: sample QC, sample preparation and labeling, microRNA detection (hybridization to a µParaflo® microfluidics chip), array scanning and data extraction, and full data analysis.


Within 2–3 weeks, you will receive: original and processed scan images, the array layout and list of sequences, raw and processed data, a list of differentially expressed transcripts (dual-sample arrays only), and a summary report of the results.


Bioinformatics Analysis Pipeline

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DNA Sequencing
LC Sciences provides a variety of fast, comprehensive DNA sequencing solutions, including exome, whole-genome, whole-genome bisulfite, and reduced representation bisulfite sequencing.
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Microbial Sequencing
LC Sciences provides a fast, comprehensive microbial Sequencing solution including: 16S/18S/ITS Amplicon Sequencing, 5R 16S Amplicon Metagenomic Sequencing, Shotgun Metagenomic Sequencing.
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RNA Sequencing
LC Sciences offers a range of rapid and comprehensive RNA sequencing solutions, including poly-A RNA, micro RNA, total RNA, circRNA, m6A RNA, and more.
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Epigenomics
LC Sciences provides specialized epigenomics services, including Whole Genome Bisulfite Sequencing (comprehensive single-base resolution DNA methylation analysis), Reduced Representation Bisulfite Sequencing (targeted CpG-rich region study with lower cost), ATAC-seq (chromatin accessibility and regulatory element investigation), and CUT&Tag (high-resolution chromatin profiling for small/single-cell samples).
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Single Cell Sequencing
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Proteomics & Metabolomics
LC Sciences is focused on providing scientific researchers with more minute and precise protein expression-related services, including olink proteomics.
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Pre-made Library Sequencing
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Additional Services
Our portfolio of additional services includes Bioinformatic Services, Oligomix, MicroRNA Profiling Microarray, DNA/RNA Aptamer Microarray, Epitope Mapping, and Kinase Profiling. These services are designed to support various aspects of molecular research and biomolecular analysis, providing comprehensive solutions tailored to your specific scientific needs.
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