| Customer Name | ####### | Customer Institutaion | ####### | Customer Email | ####### | Project ID | ####### |
|---|---|
| Salesperson | Kyle Navel | knavel@lcsciences.com |
Your reliable partner in genomics, transcriptomics and proteomics
The central dogma of gene expression is that DNA is transcribed into messenger RNAs, which in turn serves as the template for protein synthesis. The discovery of extensive transcription of large RNA transcripts that do not code for proteins, termed long noncoding RNAs (lncRNAs) provide an important new perspective on the centrality of RNA in gene regulation. An emerging theme from multiple model systems is that lncRNAs form extensive networks of ribonucleoprotein (RNP) complexes with numerous chromatin regulators, and target these enzymatic activities to appropriate locations in the genome. Consistent with this notion, long noncoding RNAs can function as modular scaffolds to specify higher order organization in RNP complexes and in chromatin states. The importance of these modes of regulation is underscored by the newly recognized roles of long RNAs for proper gene control across all kingdoms of life.
Fig.1 Schematic diagram illustrating various classes of ncRNAs. Laurent et al. Trends Genet. 2015 May ; 31(5): 239–251
As shown in Fig.1, three hypothetical loci are shown. Protein coding exons are shown as green (locus 1) or yellow boxes (locus 3). Locus 2 signifies a pseudogene of locus 1. Regulatory regions of locus 1 are shown in purple (promoter) and magenta (enhancer). Repeats are denoted by brown boxes. Lines with arrows represent ncRNAs. CAR: chromatin-associated RNA. ceRNA: Competing endogenous. RNA ciRNA: chromatin-interlinking RNA (grey) or circular intronic RNA (green). ecircRNA: exonic circular RNA. eRNA: enhancer-associated RNA. lincRNA: long intervening non-coding RNA. ncRNA-a: activating non-coding RNAs. PALR: promoter-associated long RNA. PIN: partially intronic RNA. TIN: totally intronic RNA. TSSa-RNA: transcription start site-associated RNA. T-UCR: Transcribed Ultraconserved Regions. uaRNA: 3′UTR-derived RNAs. vlincRNA: very long intergenic non-coding RNA. The role depicted here for CARs and ciRNAs in stabilizing a chromatin loop is hypothetical.
Total RNA was extracted using Trizol reagent (Invitrogen, CA, USA) following the manufacturer's procedure. The total RNA quantity and purity were analysis of Bioanalyzer 2100 and RNA 6000 Nano LabChip Kit (Agilent, CA, USA) with RIN number >7.0. Approximately 10 ug of total RNA representing a specific adipose type was used to deplete ribosomal RNA according to the manuscript of the Epicentre Ribo-Zero Gold Kit (Illumina, San Diego, USA). Following purification, the poly(A)- or poly(A)+ RNA fractions is fragmented into small pieces using divalent cations under elevated temperature. Then the cleaved RNA fragments were reverse-transcribed to create the final cDNA library in accordance with the protocol for the mRNA-Seq sample preparation kit (Illumina, San Diego, USA), the average insert size for the paired-end libraries was 300 bp (±50 bp). And then we performed the paired-end sequencing on an Illumina Hiseq 4000 at LC Sciences following the vendor's recommended protocol.
Transcripts Assembly:
Firstly, Cutadapt [1] and perl scripts in house were used to remove the reads that contained adaptor contamination, low quality bases and undetermined bases. Then sequence quality was verified using FastQC (http://www.bioinformatics.babraham.ac.uk/projects/fastqc/). We used Bowtie2 [2] and Tophat2 [3] to map reads to the genome of (____). The mapped reads of each sample were assembled using StringTie [4]. Then, all transcriptomes from (____) Samples were merged to reconstruct a comprehensive transcriptome using perl scripts and gffcompare [4]. After the final transcriptome was generated, StringTie [4] and Ballgown [5] was used to estimate the expression levels of all transcripts.
Different expression analysis of transcripts:
StringTie [4] was used to perform expression level for mRNAs and lncRNAs by calculating FPKM. The differentially expressed mRNAs and lncRNAs were selected with log2 (fold change) >1 or log2 (fold change) <-1 and with statistical significance (p value < 0.05) by R package Ballgown [5].
Bioinformatics pipeline for lncRNA (RiboZero)
Reference:
1. Martin M (2011) Cutadapt removes adapter sequences from high-throughput sequencing reads. Embnet Journal 17.
2. Langmead B, Salzberg SL (2012) Fast gapped-read alignment with Bowtie 2. Nature Methods 9: 357-359.
3. Kim D, et al. (2013) TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biology 14: R36.
4. Pertea M, et al. (2015) StringTie enables improved reconstruction of a transcriptome from RNA-seq reads. Nature Biotechnology 33: 290-295.
5. Frazee AC, et al. (2015) Ballgown bridges the gap between transcriptome assembly and expression analysis. Nature Biotechnology 33: 243.
6. Kong L, et al. (2007) CPC: assess the protein-coding potential of transcripts using sequence features and support vector machine. Nucleic Acids Research 35: 345-349.
7. Sun L, et al. (2013) Utilizing sequence intrinsic composition to classify protein-coding and long non-coding transcripts. Nucleic Acids Research 41: e166-e166.
8. Krzywinski M, et al. (2009) Circos: an information aesthetic for comparative genomics.Genome Research 19: 1639-1645.
Species name: Human
Latin name: Homo sapiens
Specimens: tissue/whole blood
| Sample | COND1 |
| EM01_M | M |
| EM02_M | M |
| EM03_M | M |
| KTY01_K | K |
| KTY02_K | K |
| KTY03_K | K |
| Dababase | Web links | Version/date |
|---|---|---|
| Genome | ftp://ftp.ensembl.org/pub/release-90/fasta/homo_sapiens/dna/ | GRCh38/Ensemble v90 | lncRNA | ftp://ftp.sanger.ac.uk/pub/gencode/Gencode_human/release_27/gencode.v27.lncRNA_transcripts.fa.gz | gencode v27 | Gene Orthology (GO) | http://www.geneontology.org/ | 2016.12 | KEGG | http://www.genome.jp/kegg/pathway.html | 2017.06 |
| Analysis item | Software | Version/date | Quality control | FastQC | 0.10.1 | Adapter remove | Cutadapt | 1.10 | Mapping | Tophat | 2.0 | Transcripts assembly | StringTie | 1.3 | Differential expression analysis | R package: Ballgown | 2016.09.29 | GO and KEGG enrichment analysis | Perl scripts in house | NA | Coding potential | CPC (Coding Potential Calculator) | 0.9 | Coding potential | CNCI (Coding-Non-Coding Index) | 2.0 |
|---|---|---|
| Sample | Raw Data | Valid Data | Valid Ratio(reads) | Q20% | Q30% | GC content% | ||
| Read | Base | Read | Base | |||||
| EM01_M | 91097877 | 13.66G | 88481920 | 13.27G | 97.13 | 99.56 | 93.67 | 51 |
| EM02_M | 88733750.50 | 13.31G | 68940088 | 10.34G | 77.69 | 99.57 | 93.75 | 51 |
| EM03_M | 90038586 | 13.51G | 69954810 | 10.49G | 77.69 | 99.56 | 93.75 | 51 |
| KTY01_K | 87751966.50 | 13.16G | 85881284 | 12.88G | 97.87 | 99.59 | 93.78 | 50 |
| KTY02_K | 85468310 | 12.82G | 83676668 | 12.55G | 97.90 | 99.63 | 94.55 | 50 |
| KTY03_K | 93711271.50 | 14.06G | 73363120 | 11.00G | 78.29 | 99.58 | 93.87 | 50 |
document location: summary/1_rawdata/ReadsQC.xlsx
| Sample | Valid reads | Mapped reads | Unique Mapped reads | Multi Mapped reads | PE Mapped reads | Mapped left reads | Mapped right reads | Reads map to sense strand | Reads map to antisense strand | Non-splice reads | Splice reads |
| EM01_M | 68984860 | 61403066(89.01%) | 59284876(85.94%) | 2118190(3.07%) | 28591268(41.45%) | 31853168(46.17%) | 29549898(42.84%) | 29588508(42.89%) | 29696368(43.05%) | 37477965(54.33%) | 21806911(31.61%) |
| EM02_M | 53747668 | 47921784(89.16%) | 46290322(86.13%) | 1631462(3.04%) | 22337066(41.56%) | 24837216(46.21%) | 23084568(42.95%) | 23104056(42.99%) | 23186266(43.14%) | 29256773(54.43%) | 17033549(31.69%) |
| EM03_M | 54537348 | 48627522(89.16%) | 46971952(86.13%) | 1655570(3.04%) | 22667090(41.56%) | 25201550(46.21%) | 23425972(42.95%) | 23444442(42.99%) | 23527510(43.14%) | 29686513(54.43%) | 17285439(31.69%) |
| KTY01_K | 67917550 | 60691201(89.36%) | 59015058(86.89%) | 1676143(2.47%) | 28186846(41.50%) | 31625635(46.56%) | 29065566(42.80%) | 29497002(43.43%) | 29518056(43.46%) | 38092998(56.09%) | 20922060(30.81%) |
| KTY02_K | 67275414 | 60947071(90.59%) | 59310831(88.16%) | 1636240(2.43%) | 28648791(42.58%) | 31402890(46.68%) | 29544181(43.92%) | 29647889(44.07%) | 29662942(44.09%) | 37119682(55.18%) | 22191149(32.99%) |
| KTY03_K | 57987788 | 52278895(90.16%) | 50842143(87.68%) | 1436752(2.48%) | 24453727(42.17%) | 27069515(46.68%) | 25209380(43.47%) | 25413011(43.82%) | 25429132(43.85%) | 32811360(56.58%) | 18030783(31.09%) |
document location: summary/1_rawdata/2_mapped_stat.xlsx
document location: summary/2_reference_mapping/3_mapped_region_stat.png
document location: summary/2_reference_mapping/4_DensityDistribution/*_chromosome.jpeg
Those transcripts assembled by StringTie which are not annotated in genome annotation database are belong to novel transcripts with class code (i, j, o, u ,x).
Class code typies and definitions:
| class code | Description |
|---|---|
| j | Potentially novel isoform (fragment): at least one splice junction is shared with a reference transcript |
| i | A transfrag falling entirely within a reference intron |
| o | Generic exonic overlap with a reference transcript |
| u | Unknown, intergenic transcript |
| x | Exonic overlap with reference on the opposite strand |
document location:
summary/4_1_lncRNA_assembly/novel_merged.fa
summary/4_1_lncRNA_assembly/novel_merged.gtf
Tips: The Gene transfer format (GTF) is a file format used to hold information about gene structure. It is a tab-delimited text format based on the general feature format (GFF), but contains some additional conventions specific to gene information. A significant feature of the GTF that can be validated: given a sequence and a GTF file, one can check that the format is correct. This significantly reduces problems with the interchange of data between groups.
Statistics of gene expression:
| Sample | Exp gene | Min. | 1st Qu. | Median | Mean | 3rd Qu. | Max. | Sd. | Sum. |
| EM01_M | 29996 | 0.00 | 0.10 | 0.52 | 5.97 | 2.13 | 26373.26 | 167.30 | 179153.22 |
| EM02_M | 29736 | 0.00 | 0.12 | 0.62 | 6.15 | 2.20 | 26355.62 | 168.65 | 182841.25 |
| EM03_M | 29748 | 0.00 | 0.12 | 0.62 | 6.15 | 2.20 | 26357.08 | 168.76 | 182971.87 |
| KTY01_K | 31055 | 0.00 | 0.11 | 0.71 | 5.36 | 2.78 | 8211.80 | 69.30 | 166435.86 |
| KTY02_K | 31694 | 0.00 | 0.10 | 0.63 | 5.53 | 2.54 | 11062.14 | 86.33 | 175266.20 |
| KTY03_K | 30888 | 0.00 | 0.12 | 0.80 | 5.44 | 2.84 | 8207.74 | 69.57 | 167879.83 |
Statistics of transcript expression:
| Sample | Exp transcript | Min. | 1st Qu. | Median | Mean | 3rd Qu. | Max. | Sd. | Sum. |
| EM01_M | 110737 | 0.00 | 0.08 | 0.23 | 2.97 | 0.79 | 21508.72 | 88.24 | 328707.53 |
| EM02_M | 105969 | 0.00 | 0.09 | 0.26 | 3.15 | 0.88 | 21454.01 | 90.76 | 334070.66 |
| EM03_M | 106264 | 0.00 | 0.09 | 0.26 | 3.14 | 0.87 | 21447.32 | 90.69 | 334067.24 |
| KTY01_K | 114526 | 0.00 | 0.08 | 0.27 | 2.84 | 1.01 | 6142.83 | 42.65 | 324720.31 |
| KTY02_K | 115596 | 0.00 | 0.08 | 0.25 | 2.93 | 0.92 | 6768.08 | 50.16 | 338956.20 |
| KTY03_K | 111819 | 0.00 | 0.09 | 0.29 | 2.91 | 1.08 | 6173.10 | 43.13 | 325887.89 |
document location:
summary/3_1_transcript_expression/1_gene_expression_statistics.xlsx
summary/3_1_transcript_expression/*_gene_expression_boxplot.png
summary/3_1_transcript_expression/1_gene_expression_statistics.xlsx
summary/3_1_transcript_expression/*_transcript_expression_boxplot.png
FI of gene expression:
| Sample | 0-0.1 FI | 0.1-0.3 FI | 0.3-3.57 FI | 3.57-15 FI | 15-60 FI | >60 FI |
| EM01_M | 7571(25.24%) | 5027(16.76%) | 12504(41.69%) | 3815(12.72%) | 823(2.74%) | 256(0.85%) |
| EM02_M | 6572(22.10%) | 5003(16.82%) | 13189(44.35%) | 3878(13.04%) | 832(2.80%) | 262(0.88%) |
| EM03_M | 6635(22.30%) | 4982(16.75%) | 13163(44.25%) | 3879(13.04%) | 828(2.78%) | 261(0.88%) |
| KTY01_K | 7499(24.15%) | 4646(14.96%) | 12319(39.67%) | 5057(16.28%) | 1229(3.96%) | 305(0.98%) |
| KTY02_K | 8113(25.60%) | 4717(14.88%) | 12474(39.36%) | 4895(15.44%) | 1188(3.75%) | 307(0.97%) |
| KTY03_K | 6903(22.35%) | 4647(15.04%) | 12699(41.11%) | 5112(16.55%) | 1221(3.95%) | 306(0.99%) |
FI of transcripts expression:
| Sample | 0-0.1 FI | 0.1-0.3 FI | 0.3-3.57 FI | 3.57-15 FI | 15-60 FI | >60 FI |
| EM01_M | 33696(30.43%) | 28453(25.69%) | 40165(36.27%) | 6445(5.82%) | 1460(1.32%) | 518(0.47%) |
| EM02_M | 29157(27.51%) | 27365(25.82%) | 40984(38.68%) | 6459(6.10%) | 1483(1.40%) | 521(0.49%) |
| EM03_M | 29420(27.69%) | 27392(25.78%) | 41005(38.59%) | 6445(6.07%) | 1482(1.39%) | 520(0.49%) |
| KTY01_K | 32337(28.24%) | 27288(23.83%) | 43920(38.35%) | 8250(7.20%) | 2125(1.86%) | 606(0.53%) |
| KTY02_K | 34571(29.91%) | 28024(24.24%) | 42426(36.70%) | 7874(6.81%) | 2073(1.79%) | 628(0.54%) |
| KTY03_K | 29868(26.71%) | 26792(23.96%) | 44124(39.46%) | 8297(7.42%) | 2126(1.90%) | 612(0.55%) |
document location:
summary/3_1_transcript_expression/2_gene_expression_interval.xlsx
summary/3_1_transcript_expression/2_transcript_expression_interval.xlsx
document location:
summary/3_1_transcript_expression/*_gene_expression_density.png
summary/3_1_transcript_expression/*_transcript_expression_density.png
Gene expression profiling:
| gene_id | gene_name | transcript_id | GO | KEGG | KO_ENTRY | EC | Description | FPKM.EM01_M | FPKM.EM02_M | FPKM.EM03_M | FPKM.KTY01_K | FPKM.KTY02_K | FPKM.KTY03_K |
| ENSG00000000005 | TNMD | ENST00000373031 | GO:0001886(endothelial cell morphogenesis);GO:0001937(negative regulation of endothelial cell proliferation);GO:0005515(protein binding);GO:0005635(nuclear envelope);GO:0005737(cytoplasm);GO:0016021(integral component of membrane);GO:0016525(negative regulation of angiogenesis);GO:0035990(tendon cell differentiation);GO:0071773(cellular response to BMP stimulus) | NA | NA | NA | tenomodulin [Source:HGNC Symbol;Acc:HGNC:17757] | 0.05 | 0.07 | 0.07 | 0 | 0 | 0 |
| ENSG00000002079 | MYH16 | ENST00000439784 | NA | NA | NA | NA | NA | 0.00 | 0.00 | 0.00 | 0.01 | 0.01 | 0.01 |
| ENSG00000002587 | HS3ST1 | ENST00000002596;ENST00000514690 | GO:0005796(Golgi lumen);GO:0005975(carbohydrate metabolic process);GO:0006024(glycosaminoglycan biosynthetic process);GO:0008146(sulfotransferase activity);GO:0008467([heparan sulfate]-glucosamine 3-sulfotransferase 1 activity);GO:0016021(integral component of membrane);GO:0030203(glycosaminoglycan metabolic process);GO:0044281(small molecule metabolic process) | NA | NA | NA | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 [Source:HGNC Symbol;Acc:HGNC:5194] | 0.16 | 0.16 | 0.16 | 0.10 | 0.10 | 0.10 |
| ENSG00000002726 | AOC1 | ENST00000493429;ENST00000467291;ENST00000622116;ENST00000360937;ENST00000619575 | GO:0004872(receptor activity);GO:0005261(cation channel activity);GO:0005272(sodium channel activity);GO:0005507(copper ion binding);GO:0005509(calcium ion binding);GO:0005615(extracellular space);GO:0005777(peroxisome);GO:0005886(plasma membrane);GO:0005923(bicellular tight junction);GO:0008131(primary amine oxidase activity);GO:0008144(drug binding);GO:0008201(heparin binding);GO:0008270(zinc ion binding);GO:0009308(amine metabolic process);GO:0032403(protein complex binding);GO:0035725(sodium ion transmembrane transport);GO:0035874(cellular response to copper ion starvation);GO:0042493(response to drug);GO:0042803(protein homodimerization activity);GO:0046677(response to antibiotic);GO:0048038(quinone binding);GO:0052597(diamine oxidase activity);GO:0052598(histamine oxidase activity);GO:0052599(methylputrescine oxidase activity);GO:0052600(propane-1,3-diamine oxidase activity);GO:0055114(oxidation-reduction process);GO:0070062(extracellular exosome);GO:0071280(cellular response to copper ion);GO:0071420(cellular response to histamine);GO:0071504(cellular response to heparin);GO:0097185(cellular response to azide) | 00330(Arginine and proline metabolism);00340(Histidine metabolism);00380(Tryptophan metabolism) | NA | NA | amine oxidase, copper containing 1 [Source:HGNC Symbol;Acc:HGNC:80] | 0.11 | 0.08 | 0.08 | 0.23 | 0.30 | 0.25 |
| ENSG00000002745 | WNT16 | ENST00000222462 | GO:0003408(optic cup formation involved in camera-type eye development);GO:0005102(receptor binding);GO:0005109(frizzled binding);GO:0005576(extracellular region);GO:0005578(proteinaceous extracellular matrix);GO:0005615(extracellular space);GO:0005737(cytoplasm);GO:0007275(multicellular organismal development);GO:0010628(positive regulation of gene expression);GO:0014068(positive regulation of phosphatidylinositol 3-kinase signaling);GO:0016055(Wnt signaling pathway);GO:0030182(neuron differentiation);GO:0030216(keratinocyte differentiation);GO:0043616(keratinocyte proliferation);GO:0045165(cell fate commitment);GO:0046330(positive regulation of JNK cascade);GO:0046849(bone remodeling);GO:0060317(cardiac epithelial to mesenchymal transition);GO:0060548(negative regulation of cell death);GO:0090399(replicative senescence);GO:0090403(oxidative stress-induced premature senescence) | 04310(Wnt signaling pathway);04340(Hedgehog signaling pathway);04916(Melanogenesis);05200(Pathways in cancer);05217(Basal cell carcinoma) | NA | NA | wingless-type MMTV integration site family, member 16 [Source:HGNC Symbol;Acc:HGNC:16267] | 0.08 | 0.07 | 0.07 | 0.03 | 0.04 | 0.03 |
| ENSG00000002746 | HECW1 | ENST00000395891;ENST00000493057;ENST00000471043;ENST00000461842 | GO:0004842(ubiquitin-protein transferase activity);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0016874(ligase activity);GO:0042787(protein ubiquitination involved in ubiquitin-dependent protein catabolic process);GO:0061630(ubiquitin protein ligase activity);GO:0090090(negative regulation of canonical Wnt signaling pathway) | NA | NA | NA | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:22195] | 0.03 | 0.04 | 0.04 | 0.13 | 0.15 | 0.12 |
| ENSG00000003137 | CYP26B1 | ENST00000001146;ENST00000461519 | GO:0001709(cell fate determination);GO:0001768(establishment of T cell polarity);GO:0001972(retinoic acid binding);GO:0004497(monooxygenase activity);GO:0005506(iron ion binding);GO:0005737(cytoplasm);GO:0005789(endoplasmic reticulum membrane);GO:0006766(vitamin metabolic process);GO:0006805(xenobiotic metabolic process);GO:0006954(inflammatory response);GO:0007140(male meiosis);GO:0007283(spermatogenesis);GO:0008401(retinoic acid 4-hydroxylase activity);GO:0009954(proximal/distal pattern formation);GO:0010628(positive regulation of gene expression);GO:0016705(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen);GO:0020037(heme binding);GO:0030326(embryonic limb morphogenesis);GO:0034653(retinoic acid catabolic process);GO:0042573(retinoic acid metabolic process);GO:0043587(tongue morphogenesis);GO:0044281(small molecule metabolic process);GO:0045580(regulation of T cell differentiation);GO:0048384(retinoic acid receptor signaling pathway);GO:0048385(regulation of retinoic acid receptor signaling pathway);GO:0048387(negative regulation of retinoic acid receptor signaling pathway);GO:0055114(oxidation-reduction process);GO:0060349(bone morphogenesis);GO:0061436(establishment of skin barrier);GO:0070268(cornification);GO:0071300(cellular response to retinoic acid);GO:2001037(positive regulation of tongue muscle cell differentiation) | 00830(Retinol metabolism) | NA | NA | cytochrome P450, family 26, subfamily B, polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:20581] | 0.21 | 0.18 | 0.18 | 0.02 | 0.16 | 0.02 |
| ENSG00000004660 | CAMKK1 | ENST00000348335;ENST00000158166;ENST00000573483 | GO:0004672(protein kinase activity);GO:0004674(protein serine/threonine kinase activity);GO:0004683(calmodulin-dependent protein kinase activity);GO:0005515(protein binding);GO:0005516(calmodulin binding);GO:0005524(ATP binding);GO:0005634(nucleus);GO:0005829(cytosol);GO:0006468(protein phosphorylation);GO:0007268(synaptic transmission);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0032147(activation of protein kinase activity);GO:0045860(positive regulation of protein kinase activity) | 04920(Adipocytokine signaling pathway) | NA | NA | calcium/calmodulin-dependent protein kinase kinase 1, alpha [Source:HGNC Symbol;Acc:HGNC:1469] | 0.29 | 0.34 | 0.33 | 0.10 | 0.09 | 0.10 |
| ENSG00000004777 | ARHGAP33 | ENST00000314737;ENST00000221905;ENST00000601474;ENST00000591438;ENST00000586918;ENST00000587447;ENST00000593034 | GO:0005096(GTPase activator activity);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0007165(signal transduction);GO:0007264(small GTPase mediated signal transduction);GO:0015031(protein transport);GO:0035091(phosphatidylinositol binding);GO:0043547(positive regulation of GTPase activity);GO:0051056(regulation of small GTPase mediated signal transduction) | NA | NA | NA | Rho GTPase activating protein 33 [Source:HGNC Symbol;Acc:HGNC:23085] | 0.25 | 0.24 | 0.23 | 0.19 | 0.21 | 0.22 |
| ENSG00000004809 | SLC22A16 | ENST00000460159;ENST00000330550 | GO:0005275(amine transmembrane transporter activity);GO:0005886(plasma membrane);GO:0007275(multicellular organismal development);GO:0007283(spermatogenesis);GO:0007338(single fertilization);GO:0015101(organic cation transmembrane transporter activity);GO:0015226(carnitine transmembrane transporter activity);GO:0015695(organic cation transport);GO:0015837(amine transport);GO:0015879(carnitine transport);GO:0016021(integral component of membrane);GO:0022857(transmembrane transporter activity);GO:0030154(cell differentiation);GO:0030317(sperm motility);GO:0046717(acid secretion);GO:0055085(transmembrane transport);GO:1902603(carnitine transmembrane transport) | NA | NA | NA | solute carrier family 22 (organic cation/carnitine transporter), member 16 [Source:HGNC Symbol;Acc:HGNC:20302] | 0.02 | 0.02 | 0.02 | 0 | 0.01 | 0 |
| ENSG00000004846 | ABCB5 | ENST00000404938;ENST00000443026 | GO:0002481(antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent);GO:0002485(antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent);GO:0002489(antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent);GO:0002591(positive regulation of antigen processing and presentation of peptide antigen via MHC class I);GO:0005524(ATP binding);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006810(transport);GO:0008152(metabolic process);GO:0015562(efflux transmembrane transporter activity);GO:0016021(integral component of membrane);GO:0016887(ATPase activity);GO:0030154(cell differentiation);GO:0042391(regulation of membrane potential);GO:0042626(ATPase activity, coupled to transmembrane movement of substances);GO:0048058(compound eye corneal lens development);GO:0055085(transmembrane transport) | 02010(ABC transporters) | NA | NA | ATP-binding cassette, sub-family B (MDR/TAP), member 5 [Source:HGNC Symbol;Acc:HGNC:46] | 0.01 | 0.01 | 0.01 | 0.02 | 0.02 | 0.02 |
| ENSG00000004848 | ARX | ENST00000379044 | GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000980(RNA polymerase II distal enhancer sequence-specific DNA binding);GO:0001206(RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription);GO:0001764(neuron migration);GO:0003677(DNA binding);GO:0003682(chromatin binding);GO:0005634(nucleus);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007411(axon guidance);GO:0021759(globus pallidus development);GO:0021772(olfactory bulb development);GO:0021800(cerebral cortex tangential migration);GO:0021831(embryonic olfactory bulb interneuron precursor migration);GO:0021846(cell proliferation in forebrain);GO:0021853(cerebral cortex GABAergic interneuron migration);GO:0030900(forebrain development);GO:0042127(regulation of cell proliferation);GO:0043565(sequence-specific DNA binding);GO:0044241(lipid digestion);GO:0046622(positive regulation of organ growth);GO:0072148(epithelial cell fate commitment) | NA | NA | NA | aristaless related homeobox [Source:HGNC Symbol;Acc:HGNC:18060] | 0 | 0 | 0 | 0.02 | 0.01 | 0.02 |
| ENSG00000004939 | SLC4A1 | ENST00000262418;ENST00000498270 | GO:0003779(actin binding);GO:0005215(transporter activity);GO:0005452(inorganic anion exchanger activity);GO:0005515(protein binding);GO:0005623(cell);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006810(transport);GO:0006811(ion transport);GO:0006820(anion transport);GO:0006821(chloride transport);GO:0006873(cellular ion homeostasis);GO:0008022(protein C-terminus binding);GO:0008509(anion transmembrane transporter activity);GO:0015106(bicarbonate transmembrane transporter activity);GO:0015108(chloride transmembrane transporter activity);GO:0015301(anion:anion antiporter activity);GO:0015701(bicarbonate transport);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0016323(basolateral plasma membrane);GO:0030018(Z disc);GO:0030506(ankyrin binding);GO:0030863(cortical cytoskeleton);GO:0042803(protein homodimerization activity);GO:0043495(protein anchor);GO:0044281(small molecule metabolic process);GO:0051453(regulation of intracellular pH);GO:0055085(transmembrane transport);GO:0070062(extracellular exosome);GO:0072562(blood microparticle);GO:1902476(chloride transmembrane transport) | 04966(Collecting duct acid secretion) | NA | NA | solute carrier family 4 (anion exchanger), member 1 (Diego blood group) [Source:HGNC Symbol;Acc:HGNC:11027] | 0.12 | 0.11 | 0.11 | 0.01 | 0.03 | 0.01 |
| ENSG00000004948 | CALCR | ENST00000359558 | GO:0001669(acrosomal vesicle);GO:0004872(receptor activity);GO:0004888(transmembrane signaling receptor activity);GO:0004930(G-protein coupled receptor activity);GO:0004948(calcitonin receptor activity);GO:0005515(protein binding);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005929(cilium);GO:0007166(cell surface receptor signaling pathway);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007188(adenylate cyclase-modulating G-protein coupled receptor signaling pathway);GO:0007189(adenylate cyclase-activating G-protein coupled receptor signaling pathway);GO:0007204(positive regulation of cytosolic calcium ion concentration);GO:0008565(protein transporter activity);GO:0015031(protein transport);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0030279(negative regulation of ossification);GO:0030316(osteoclast differentiation);GO:0030424(axon);GO:0030819(positive regulation of cAMP biosynthetic process);GO:0031623(receptor internalization);GO:0032841(calcitonin binding);GO:0043005(neuron projection);GO:0043025(neuronal cell body);GO:0043488(regulation of mRNA stability);GO:0045762(positive regulation of adenylate cyclase activity);GO:0051384(response to glucocorticoid);GO:0072659(protein localization to plasma membrane) | 04080(Neuroactive ligand-receptor interaction);04380(Osteoclast differentiation) | NA | NA | calcitonin receptor [Source:HGNC Symbol;Acc:HGNC:1440] | 0.01 | 0.01 | 0.01 | 0.03 | 0.03 | 0.04 |
| ENSG00000005001 | PRSS22 | ENST00000161006;ENST00000570950 | GO:0004252(serine-type endopeptidase activity);GO:0005576(extracellular region);GO:0006508(proteolysis) | NA | NA | NA | protease, serine, 22 [Source:HGNC Symbol;Acc:HGNC:14368] | 0.06 | 0.06 | 0.07 | 0 | 0.01 | 0 |
| ENSG00000005073 | HOXA11 | ENST00000006015 | GO:0001501(skeletal system development);GO:0001656(metanephros development);GO:0001658(branching involved in ureteric bud morphogenesis);GO:0001759(organ induction);GO:0003677(DNA binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005667(transcription factor complex);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0007275(multicellular organismal development);GO:0007283(spermatogenesis);GO:0007338(single fertilization);GO:0007501(mesodermal cell fate specification);GO:0008584(male gonad development);GO:0009653(anatomical structure morphogenesis);GO:0009952(anterior/posterior pattern specification);GO:0009953(dorsal/ventral pattern formation);GO:0009954(proximal/distal pattern formation);GO:0010468(regulation of gene expression);GO:0010720(positive regulation of cell development);GO:0030326(embryonic limb morphogenesis);GO:0032330(regulation of chondrocyte differentiation);GO:0032332(positive regulation of chondrocyte differentiation);GO:0032993(protein-DNA complex);GO:0035115(embryonic forelimb morphogenesis);GO:0042733(embryonic digit morphogenesis);GO:0043234(protein complex);GO:0043565(sequence-specific DNA binding);GO:0045893(positive regulation of transcription, DNA-templated);GO:0048589(developmental growth);GO:0060065(uterus development);GO:0060272(embryonic skeletal joint morphogenesis);GO:0060351(cartilage development involved in endochondral bone morphogenesis) | NA | NA | NA | homeobox A11 [Source:HGNC Symbol;Acc:HGNC:5101] | 0 | 0 | 0 | 0.02 | 0.13 | 0.02 |
| ENSG00000005102 | MEOX1 | ENST00000329168;ENST00000549132 | GO:0000978(RNA polymerase II core promoter proximal region sequence-specific DNA binding);GO:0001046(core promoter sequence-specific DNA binding);GO:0001077(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription);GO:0001757(somite specification);GO:0003674(molecular_function);GO:0003677(DNA binding);GO:0003682(chromatin binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006355(regulation of transcription, DNA-templated);GO:0006366(transcription from RNA polymerase II promoter);GO:0007275(multicellular organismal development);GO:0008150(biological_process);GO:0043565(sequence-specific DNA binding);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0060218(hematopoietic stem cell differentiation);GO:0061053(somite development);GO:0061056(sclerotome development);GO:0071837(HMG box domain binding) | NA | NA | NA | mesenchyme homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7013] | 0.02 | 0.02 | 0.02 | 0 | 0 | 0 |
| ENSG00000005381 | MPO | ENST00000225275;ENST00000578493;ENST00000581022 | GO:0001878(response to yeast);GO:0002149(hypochlorous acid biosynthetic process);GO:0002679(respiratory burst involved in defense response);GO:0003682(chromatin binding);GO:0004601(peroxidase activity);GO:0005615(extracellular space);GO:0005634(nucleus);GO:0005739(mitochondrion);GO:0005764(lysosome);GO:0006952(defense response);GO:0006979(response to oxidative stress);GO:0008201(heparin binding);GO:0019430(removal of superoxide radicals);GO:0020037(heme binding);GO:0030141(secretory granule);GO:0034374(low-density lipoprotein particle remodeling);GO:0042582(azurophil granule);GO:0042744(hydrogen peroxide catabolic process);GO:0043066(negative regulation of apoptotic process);GO:0044130(negative regulation of growth of symbiont in host);GO:0046872(metal ion binding);GO:0050832(defense response to fungus);GO:0055114(oxidation-reduction process);GO:0070062(extracellular exosome) | 04145(Phagosome) | NA | NA | myeloperoxidase [Source:HGNC Symbol;Acc:HGNC:7218] | 0.13 | 0.15 | 0.15 | 0 | 0.04 | 0 |
| ENSG00000005513 | SOX8 | ENST00000293894 | GO:0000979(RNA polymerase II core promoter sequence-specific DNA binding);GO:0000981(sequence-specific DNA binding RNA polymerase II transcription factor activity);GO:0001649(osteoblast differentiation);GO:0001701(in utero embryonic development);GO:0001755(neural crest cell migration);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0007165(signal transduction);GO:0007283(spermatogenesis);GO:0007422(peripheral nervous system development);GO:0008134(transcription factor binding);GO:0008584(male gonad development);GO:0010628(positive regulation of gene expression);GO:0010817(regulation of hormone levels);GO:0014015(positive regulation of gliogenesis);GO:0033690(positive regulation of osteoblast proliferation);GO:0035914(skeletal muscle cell differentiation);GO:0043066(negative regulation of apoptotic process);GO:0043565(sequence-specific DNA binding);GO:0044798(nuclear transcription factor complex);GO:0045165(cell fate commitment);GO:0045444(fat cell differentiation);GO:0045662(negative regulation of myoblast differentiation);GO:0045892(negative regulation of transcription, DNA-templated);GO:0045893(positive regulation of transcription, DNA-templated);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046533(negative regulation of photoreceptor cell differentiation);GO:0046982(protein heterodimerization activity);GO:0048469(cell maturation);GO:0048484(enteric nervous system development);GO:0048709(oligodendrocyte differentiation);GO:0060009(Sertoli cell development);GO:0060018(astrocyte fate commitment);GO:0060041(retina development in camera-type eye);GO:0060221(retinal rod cell differentiation);GO:0060612(adipose tissue development);GO:0061138(morphogenesis of a branching epithelium);GO:0072034(renal vesicle induction);GO:0072197(ureter morphogenesis);GO:0072289(metanephric nephron tubule formation);GO:0090184(positive regulation of kidney development);GO:0090190(positive regulation of branching involved in ureteric bud morphogenesis) | NA | NA | NA | SRY (sex determining region Y)-box 8 [Source:HGNC Symbol;Acc:HGNC:11203] | 0.03 | 0.04 | 0.04 | 0 | 0 | 0 |
| ENSG00000005884 | ITGA3 | ENST00000506401;ENST00000505306;ENST00000320031;ENST00000570989;ENST00000510809;ENST00000507771;ENST00000515147;ENST00000506437;ENST00000514834 | GO:0001764(neuron migration);GO:0001948(glycoprotein binding);GO:0001968(fibronectin binding);GO:0002020(protease binding);GO:0005178(integrin binding);GO:0005515(protein binding);GO:0005518(collagen binding);GO:0005886(plasma membrane);GO:0005925(focal adhesion);GO:0007155(cell adhesion);GO:0007160(cell-matrix adhesion);GO:0007229(integrin-mediated signaling pathway);GO:0007507(heart development);GO:0007596(blood coagulation);GO:0007613(memory);GO:0008305(integrin complex);GO:0009897(external side of plasma membrane);GO:0009986(cell surface);GO:0010628(positive regulation of gene expression);GO:0010634(positive regulation of epithelial cell migration);GO:0010811(positive regulation of cell-substrate adhesion);GO:0010976(positive regulation of neuron projection development);GO:0016021(integral component of membrane);GO:0016323(basolateral plasma membrane);GO:0017015(regulation of transforming growth factor beta receptor signaling pathway);GO:0019904(protein domain specific binding);GO:0030111(regulation of Wnt signaling pathway);GO:0030198(extracellular matrix organization);GO:0030324(lung development);GO:0030426(growth cone);GO:0030510(regulation of BMP signaling pathway);GO:0031345(negative regulation of cell projection organization);GO:0031527(filopodium membrane);GO:0034667(integrin alpha3-beta1 complex);GO:0034698(response to gonadotropin);GO:0035024(negative regulation of Rho protein signal transduction);GO:0035640(exploration behavior);GO:0042493(response to drug);GO:0043235(receptor complex);GO:0043236(laminin binding);GO:0043588(skin development);GO:0044708(single-organism behavior);GO:0045202(synapse);GO:0046872(metal ion binding);GO:0046982(protein heterodimerization activity);GO:0048333(mesodermal cell differentiation);GO:0048471(perinuclear region of cytoplasm);GO:0050900(leukocyte migration);GO:0060076(excitatory synapse);GO:0060135(maternal process involved in female pregnancy);GO:0070062(extracellular exosome);GO:0071438(invadopodium membrane);GO:0071944(cell periphery);GO:0072006(nephron development);GO:0090004(positive regulation of establishment of protein localization to plasma membrane);GO:0097060(synaptic membrane);GO:0097062(dendritic spine maintenance);GO:0097205(renal filtration) | 04510(Focal adhesion);04512(ECM-receptor interaction);04640(Hematopoietic cell lineage);04810(Regulation of actin cytoskeleton);05200(Pathways in cancer);05222(Small cell lung cancer);05410(Hypertrophic cardiomyopathy (HCM));05412(Arrhythmogenic right ventricular cardiomyopathy (ARVC));05414(Dilated cardiomyopathy) | NA | NA | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) [Source:HGNC Symbol;Acc:HGNC:6139] | 0.41 | 0.43 | 0.43 | 0.47 | 0.50 | 0.49 |
| ENSG00000005961 | ITGA2B | ENST00000262407;ENST00000592462;ENST00000591990 | GO:0002576(platelet degranulation);GO:0002687(positive regulation of leukocyte migration);GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005925(focal adhesion);GO:0007155(cell adhesion);GO:0007160(cell-matrix adhesion);GO:0007229(integrin-mediated signaling pathway);GO:0007411(axon guidance);GO:0007596(blood coagulation);GO:0008305(integrin complex);GO:0009897(external side of plasma membrane);GO:0009986(cell surface);GO:0030168(platelet activation);GO:0030198(extracellular matrix organization);GO:0031092(platelet alpha granule membrane);GO:0042802(identical protein binding);GO:0046872(metal ion binding);GO:0050840(extracellular matrix binding);GO:0070051(fibrinogen binding);GO:0070062(extracellular exosome);GO:0070527(platelet aggregation);GO:0072562(blood microparticle) | 04510(Focal adhesion);04512(ECM-receptor interaction);04640(Hematopoietic cell lineage);04810(Regulation of actin cytoskeleton);05200(Pathways in cancer);05222(Small cell lung cancer);05410(Hypertrophic cardiomyopathy (HCM));05412(Arrhythmogenic right ventricular cardiomyopathy (ARVC));05414(Dilated cardiomyopathy) | NA | NA | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) [Source:HGNC Symbol;Acc:HGNC:6138] | 0.02 | 0.03 | 0.03 | 0.03 | 0.02 | 0.03 |
| ENSG00000006025 | OSBPL7 | ENST00000007414;ENST00000583167;ENST00000578461;ENST00000580140;ENST00000584698;ENST00000580226;ENST00000585051 | GO:0005515(protein binding);GO:0005776(autophagosome);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006869(lipid transport);GO:0015485(cholesterol binding);GO:0071397(cellular response to cholesterol);GO:0097038(perinuclear endoplasmic reticulum);GO:1901800(positive regulation of proteasomal protein catabolic process) | NA | NA | NA | oxysterol binding protein-like 7 [Source:HGNC Symbol;Acc:HGNC:16387] | 0.42 | 0.45 | 0.44 | 0.37 | 0.35 | 0.39 |
| ENSG00000006071 | ABCC8 | ENST00000302539;ENST00000530147 | GO:0005267(potassium channel activity);GO:0005524(ATP binding);GO:0005886(plasma membrane);GO:0005975(carbohydrate metabolic process);GO:0006112(energy reserve metabolic process);GO:0006810(transport);GO:0006813(potassium ion transport);GO:0007165(signal transduction);GO:0007268(synaptic transmission);GO:0008076(voltage-gated potassium channel complex);GO:0008152(metabolic process);GO:0008281(sulfonylurea receptor activity);GO:0009268(response to pH);GO:0010043(response to zinc ion);GO:0015079(potassium ion transmembrane transporter activity);GO:0016021(integral component of membrane);GO:0016887(ATPase activity);GO:0019905(syntaxin binding);GO:0030672(synaptic vesicle membrane);GO:0032496(response to lipopolysaccharide);GO:0032868(response to insulin);GO:0042383(sarcolemma);GO:0042493(response to drug);GO:0042626(ATPase activity, coupled to transmembrane movement of substances);GO:0043268(positive regulation of potassium ion transport);GO:0044281(small molecule metabolic process);GO:0044325(ion channel binding);GO:0046676(negative regulation of insulin secretion);GO:0050796(regulation of insulin secretion);GO:0055085(transmembrane transport);GO:0071310(cellular response to organic substance);GO:0071805(potassium ion transmembrane transport) | 02010(ABC transporters);04930(Type II diabetes mellitus) | NA | NA | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 [Source:HGNC Symbol;Acc:HGNC:59] | 0 | 0 | 0 | 0 | 0.01 | 0 |
| ENSG00000006116 | CACNG3 | ENST00000005284 | GO:0005245(voltage-gated calcium channel activity);GO:0005886(plasma membrane);GO:0005891(voltage-gated calcium channel complex);GO:0006816(calcium ion transport);GO:0007268(synaptic transmission);GO:0016021(integral component of membrane);GO:0030666(endocytic vesicle membrane);GO:0032281(alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex);GO:0070588(calcium ion transmembrane transport);GO:2000311(regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity) | 04010(MAPK signaling pathway);04260(Cardiac muscle contraction);05410(Hypertrophic cardiomyopathy (HCM));05412(Arrhythmogenic right ventricular cardiomyopathy (ARVC));05414(Dilated cardiomyopathy) | NA | NA | calcium channel, voltage-dependent, gamma subunit 3 [Source:HGNC Symbol;Acc:HGNC:1407] | 0.02 | 0.02 | 0.02 | 0 | 0 | 0 |
| ENSG00000006283 | CACNA1G | ENST00000354983;ENST00000416767 | GO:0001508(action potential);GO:0002027(regulation of heart rate);GO:0005216(ion channel activity);GO:0005245(voltage-gated calcium channel activity);GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0005891(voltage-gated calcium channel complex);GO:0006810(transport);GO:0006811(ion transport);GO:0007268(synaptic transmission);GO:0007411(axon guidance);GO:0008332(low voltage-gated calcium channel activity);GO:0010045(response to nickel cation);GO:0016020(membrane);GO:0034220(ion transmembrane transport);GO:0034765(regulation of ion transmembrane transport);GO:0042391(regulation of membrane potential);GO:0045956(positive regulation of calcium ion-dependent exocytosis);GO:0055085(transmembrane transport);GO:0060371(regulation of atrial cardiac muscle cell membrane depolarization);GO:0070509(calcium ion import);GO:0070588(calcium ion transmembrane transport);GO:0086010(membrane depolarization during action potential);GO:0097110(scaffold protein binding) | 04010(MAPK signaling pathway);04020(Calcium signaling pathway);04930(Type II diabetes mellitus) | NA | NA | calcium channel, voltage-dependent, T type, alpha 1G subunit [Source:HGNC Symbol;Acc:HGNC:1394] | 0.02 | 0.02 | 0.02 | 0.01 | 0.01 | 0.01 |
| ENSG00000006377 | DLX6 | ENST00000518156 | GO:0001501(skeletal system development);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005634(nucleus);GO:0006355(regulation of transcription, DNA-templated);GO:0007399(nervous system development);GO:0030326(embryonic limb morphogenesis);GO:0030855(epithelial cell differentiation);GO:0042472(inner ear morphogenesis);GO:0043565(sequence-specific DNA binding);GO:0048646(anatomical structure formation involved in morphogenesis);GO:0050679(positive regulation of epithelial cell proliferation);GO:0060021(palate development);GO:0060322(head development) | NA | NA | NA | distal-less homeobox 6 [Source:HGNC Symbol;Acc:HGNC:2919] | 0 | 0 | 0 | 0 | 0.02 | 0 |
| ENSG00000006432 | MAP3K9 | ENST00000611979;ENST00000554752;ENST00000555993;ENST00000553414;ENST00000381250;ENST00000554146;ENST00000554024 | GO:0000165(MAPK cascade);GO:0000186(activation of MAPKK activity);GO:0004672(protein kinase activity);GO:0004674(protein serine/threonine kinase activity);GO:0004706(JUN kinase kinase kinase activity);GO:0004708(MAP kinase kinase activity);GO:0004709(MAP kinase kinase kinase activity);GO:0004713(protein tyrosine kinase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005575(cellular_component);GO:0005622(intracellular);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0006468(protein phosphorylation);GO:0006915(apoptotic process);GO:0007256(activation of JNKK activity);GO:0007257(activation of JUN kinase activity);GO:0008219(cell death);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0018108(peptidyl-tyrosine phosphorylation);GO:0042803(protein homodimerization activity);GO:0043065(positive regulation of apoptotic process);GO:0046777(protein autophosphorylation) | NA | NA | NA | mitogen-activated protein kinase kinase kinase 9 [Source:HGNC Symbol;Acc:HGNC:6861] | 0.58 | 0.58 | 0.57 | 0.40 | 0.39 | 0.46 |
| ENSG00000006606 | CCL26 | ENST00000394905 | GO:0001938(positive regulation of endothelial cell proliferation);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0006935(chemotaxis);GO:0006954(inflammatory response);GO:0006955(immune response);GO:0007165(signal transduction);GO:0007267(cell-cell signaling);GO:0008009(chemokine activity);GO:0030335(positive regulation of cell migration);GO:0030838(positive regulation of actin filament polymerization);GO:0043547(positive regulation of GTPase activity);GO:0060326(cell chemotaxis) | 04060(Cytokine-cytokine receptor interaction);04062(Chemokine signaling pathway) | NA | NA | chemokine (C-C motif) ligand 26 [Source:HGNC Symbol;Acc:HGNC:10625] | 0 | 0 | 0 | 0 | 0.04 | 0 |
| ENSG00000006740 | ARHGAP44 | ENST00000379672;ENST00000580768;ENST00000538915;ENST00000584974 | GO:0005096(GTPase activator activity);GO:0005515(protein binding);GO:0005543(phospholipid binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0006887(exocytosis);GO:0007165(signal transduction);GO:0007264(small GTPase mediated signal transduction);GO:0030054(cell junction);GO:0031256(leading edge membrane);GO:0043197(dendritic spine);GO:0043547(positive regulation of GTPase activity);GO:0045202(synapse);GO:0051056(regulation of small GTPase mediated signal transduction);GO:0055037(recycling endosome) | NA | NA | NA | Rho GTPase activating protein 44 [Source:HGNC Symbol;Acc:HGNC:29096] | 0.16 | 0.16 | 0.17 | 0.07 | 0.05 | 0.06 |
| ENSG00000006747 | SCIN | ENST00000297029 | GO:0001786(phosphatidylserine binding);GO:0003779(actin binding);GO:0005509(calcium ion binding);GO:0005545(1-phosphatidylinositol binding);GO:0005546(phosphatidylinositol-4,5-bisphosphate binding);GO:0005737(cytoplasm);GO:0005856(cytoskeleton);GO:0005903(brush border);GO:0005938(cell cortex);GO:0008285(negative regulation of cell proliferation);GO:0017156(calcium ion-dependent exocytosis);GO:0032330(regulation of chondrocyte differentiation);GO:0042989(sequestering of actin monomers);GO:0043065(positive regulation of apoptotic process);GO:0045010(actin nucleation);GO:0045654(positive regulation of megakaryocyte differentiation);GO:0051014(actin filament severing);GO:0051015(actin filament binding);GO:0051047(positive regulation of secretion);GO:0051127(positive regulation of actin nucleation);GO:0051693(actin filament capping);GO:0070062(extracellular exosome) | 04666(Fc gamma R-mediated phagocytosis);04810(Regulation of actin cytoskeleton) | NA | NA | scinderin [Source:HGNC Symbol;Acc:HGNC:21695] | 0.02 | 0.01 | 0.01 | 0.08 | 0.06 | 0.08 |
| ENSG00000006788 | MYH13 | ENST00000418404 | GO:0000146(microfilament motor activity);GO:0003774(motor activity);GO:0003779(actin binding);GO:0005515(protein binding);GO:0005516(calmodulin binding);GO:0005524(ATP binding);GO:0005859(muscle myosin complex);GO:0006936(muscle contraction);GO:0008152(metabolic process);GO:0009267(cellular response to starvation);GO:0016459(myosin complex);GO:0030016(myofibril);GO:0032982(myosin filament);GO:0070062(extracellular exosome) | 04530(Tight junction);05416(Viral myocarditis) | NA | NA | myosin, heavy chain 13, skeletal muscle [Source:HGNC Symbol;Acc:HGNC:7571] | 0.01 | 0.01 | 0.01 | 0.00 | 0.00 | 0.01 |
| ENSG00000007001 | UPP2 | ENST00000605860;ENST00000005756;ENST00000489438 | GO:0003824(catalytic activity);GO:0004850(uridine phosphorylase activity);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0006206(pyrimidine nucleobase metabolic process);GO:0009116(nucleoside metabolic process);GO:0009166(nucleotide catabolic process);GO:0016763(transferase activity, transferring pentosyl groups);GO:0043097(pyrimidine nucleoside salvage);GO:0044206(UMP salvage);GO:0044281(small molecule metabolic process);GO:0045098(type III intermediate filament);GO:0046108(uridine metabolic process);GO:0046135(pyrimidine nucleoside catabolic process);GO:0055086(nucleobase-containing small molecule metabolic process) | 00240(Pyrimidine metabolism);00983(Drug metabolism - other enzymes);01100(Metabolic pathways) | NA | NA | uridine phosphorylase 2 [Source:HGNC Symbol;Acc:HGNC:23061] | 0.25 | 0.19 | 0.19 | 0.99 | 0.88 | 0.78 |
| ENSG00000007038 | PRSS21 | ENST00000450020 | GO:0004252(serine-type endopeptidase activity);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005886(plasma membrane);GO:0006508(proteolysis);GO:0007283(spermatogenesis);GO:0008236(serine-type peptidase activity);GO:0016020(membrane);GO:0031225(anchored component of membrane) | NA | NA | NA | protease, serine, 21 (testisin) [Source:HGNC Symbol;Acc:HGNC:9485] | 0.01 | 0.01 | 0.01 | 0.02 | 0.02 | 0.03 |
| ENSG00000007062 | PROM1 | ENST00000447510;ENST00000505450;ENST00000513448;ENST00000508167;ENST00000510224;ENST00000511153;ENST00000508940;ENST00000514967;ENST00000504842;ENST00000513108;ENST00000502501;ENST00000514693;ENST00000512304 | GO:0001750(photoreceptor outer segment);GO:0005515(protein binding);GO:0005615(extracellular space);GO:0005783(endoplasmic reticulum);GO:0005793(endoplasmic reticulum-Golgi intermediate compartment);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005902(microvillus);GO:0005903(brush border);GO:0009986(cell surface);GO:0010842(retina layer formation);GO:0016021(integral component of membrane);GO:0016324(apical plasma membrane);GO:0031528(microvillus membrane);GO:0031982(vesicle);GO:0032420(stereocilium);GO:0042622(photoreceptor outer segment membrane);GO:0042805(actinin binding);GO:0042995(cell projection);GO:0045296(cadherin binding);GO:0045494(photoreceptor cell maintenance);GO:0060042(retina morphogenesis in camera-type eye);GO:0060219(camera-type eye photoreceptor cell differentiation);GO:0070062(extracellular exosome);GO:0072112(glomerular visceral epithelial cell differentiation);GO:0072139(glomerular parietal epithelial cell differentiation);GO:2000768(positive regulation of nephron tubule epithelial cell differentiation) | NA | NA | NA | prominin 1 [Source:HGNC Symbol;Acc:HGNC:9454] | 0.31 | 0.31 | 0.31 | 1.52 | 1.10 | 1.45 |
| ENSG00000007129 | CEACAM21 | ENST00000618577;ENST00000407170;ENST00000482870;ENST00000457737;ENST00000187608;ENST00000401445;ENST00000632983 | GO:0005515(protein binding);GO:0016021(integral component of membrane) | NA | NA | NA | carcinoembryonic antigen-related cell adhesion molecule 21 [Source:HGNC Symbol;Acc:HGNC:28834] | 0.38 | 0.39 | 0.38 | 0.38 | 0.36 | 0.39 |
| ENSG00000007171 | NOS2 | ENST00000313735 | GO:0001666(response to hypoxia);GO:0001912(positive regulation of leukocyte mediated cytotoxicity);GO:0002227(innate immune response in mucosa);GO:0003958(NADPH-hemoprotein reductase activity);GO:0004517(nitric-oxide synthase activity);GO:0005102(receptor binding);GO:0005506(iron ion binding);GO:0005515(protein binding);GO:0005516(calmodulin binding);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005777(peroxisome);GO:0005829(cytosol);GO:0006527(arginine catabolic process);GO:0006801(superoxide metabolic process);GO:0006809(nitric oxide biosynthetic process);GO:0006954(inflammatory response);GO:0007263(nitric oxide mediated signal transduction);GO:0007596(blood coagulation);GO:0007623(circadian rhythm);GO:0009617(response to bacterium);GO:0010181(FMN binding);GO:0010629(negative regulation of gene expression);GO:0016491(oxidoreductase activity);GO:0018119(peptidyl-cysteine S-nitrosylation);GO:0020037(heme binding);GO:0030863(cortical cytoskeleton);GO:0031284(positive regulation of guanylate cyclase activity);GO:0032496(response to lipopolysaccharide);GO:0034617(tetrahydrobiopterin binding);GO:0034618(arginine binding);GO:0035690(cellular response to drug);GO:0042127(regulation of cell proliferation);GO:0042177(negative regulation of protein catabolic process);GO:0042742(defense response to bacterium);GO:0042803(protein homodimerization activity);GO:0043457(regulation of cellular respiration);GO:0045776(negative regulation of blood pressure);GO:0045909(positive regulation of vasodilation);GO:0048471(perinuclear region of cytoplasm);GO:0050660(flavin adenine dinucleotide binding);GO:0050661(NADP binding);GO:0050796(regulation of insulin secretion);GO:0050829(defense response to Gram-negative bacterium);GO:0051701(interaction with host);GO:0051712(positive regulation of killing of cells of other organism);GO:0055114(oxidation-reduction process);GO:0071222(cellular response to lipopolysaccharide);GO:0071346(cellular response to interferon-gamma);GO:0090382(phagosome maturation) | 00330(Arginine and proline metabolism);01100(Metabolic pathways);04020(Calcium signaling pathway);04146(Peroxisome);05140(Leishmaniasis);05142(Chagas disease (American trypanosomiasis));05145(Toxoplasmosis);05146(Amoebiasis);05152(Tuberculosis);05200(Pathways in cancer);05222(Small cell lung cancer) | K13240;K13241;K13242;K13253;K13427 | 1.14.13.39 | nitric oxide synthase 2, inducible [Source:HGNC Symbol;Acc:HGNC:7873] | 0.22 | 0.17 | 0.18 | 0.15 | 0.15 | 0.16 |
| ENSG00000007264 | MATK | ENST00000619596;ENST00000395040;ENST00000310132;ENST00000588983;ENST00000587180;ENST00000590028;ENST00000591059 | GO:0002009(morphogenesis of an epithelium);GO:0004672(protein kinase activity);GO:0004713(protein tyrosine kinase activity);GO:0004715(non-membrane spanning protein tyrosine kinase activity);GO:0005102(receptor binding);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005829(cytosol);GO:0006468(protein phosphorylation);GO:0007169(transmembrane receptor protein tyrosine kinase signaling pathway);GO:0007498(mesoderm development);GO:0008283(cell proliferation);GO:0008284(positive regulation of cell proliferation);GO:0016477(cell migration);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0030154(cell differentiation);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0038083(peptidyl-tyrosine autophosphorylation);GO:0045087(innate immune response) | NA | NA | NA | megakaryocyte-associated tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:6906] | 0.69 | 0.73 | 0.72 | 0.21 | 0.22 | 0.22 |
| ENSG00000007312 | CD79B | ENST00000392795;ENST00000006750;ENST00000559358;ENST00000349817;ENST00000558969;ENST00000583260 | GO:0004888(transmembrane signaling receptor activity);GO:0005515(protein binding);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006955(immune response);GO:0007165(signal transduction);GO:0007166(cell surface receptor signaling pathway);GO:0009897(external side of plasma membrane);GO:0016020(membrane);GO:0019815(B cell receptor complex);GO:0050853(B cell receptor signaling pathway);GO:0070062(extracellular exosome) | 04662(B cell receptor signaling pathway) | NA | NA | CD79b molecule, immunoglobulin-associated beta [Source:HGNC Symbol;Acc:HGNC:1699] | 1.17 | 1.06 | 1.04 | 0.94 | 0.72 | 0.94 |
| ENSG00000007314 | SCN4A | ENST00000578147;ENST00000581514 | GO:0001518(voltage-gated sodium channel complex);GO:0005216(ion channel activity);GO:0005248(voltage-gated sodium channel activity);GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006811(ion transport);GO:0006814(sodium ion transport);GO:0006936(muscle contraction);GO:0016020(membrane);GO:0019228(neuronal action potential);GO:0034765(regulation of ion transmembrane transport);GO:0035725(sodium ion transmembrane transport);GO:0055085(transmembrane transport);GO:0086010(membrane depolarization during action potential) | NA | NA | NA | sodium channel, voltage gated, type IV alpha subunit [Source:HGNC Symbol;Acc:HGNC:10591] | 0.07 | 0.06 | 0.06 | 0.05 | 0.08 | 0.05 |
| ENSG00000007350 | TKTL1 | ENST00000369915 | GO:0003824(catalytic activity);GO:0004802(transketolase activity);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006007(glucose catabolic process);GO:0006772(thiamine metabolic process);GO:0008152(metabolic process);GO:0046872(metal ion binding) | 00030(Pentose phosphate pathway);01100(Metabolic pathways) | K01662 | 2.2.1.7 | transketolase-like 1 [Source:HGNC Symbol;Acc:HGNC:11835] | 0.01 | 0.01 | 0.01 | 0 | 0.01 | 0 |
| ENSG00000007952 | NOX1 | ENST00000372966 | GO:0001525(angiogenesis);GO:0003081(regulation of systemic arterial blood pressure by renin-angiotensin);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005768(endosome);GO:0005769(early endosome);GO:0005886(plasma membrane);GO:0006739(NADP metabolic process);GO:0006801(superoxide metabolic process);GO:0006954(inflammatory response);GO:0007165(signal transduction);GO:0007264(small GTPase mediated signal transduction);GO:0008217(regulation of blood pressure);GO:0008284(positive regulation of cell proliferation);GO:0010575(positive regulation of vascular endothelial growth factor production);GO:0015992(proton transport);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0016175(superoxide-generating NADPH oxidase activity);GO:0016477(cell migration);GO:0016491(oxidoreductase activity);GO:0030054(cell junction);GO:0030171(voltage-gated proton channel activity);GO:0030198(extracellular matrix organization);GO:0034765(regulation of ion transmembrane transport);GO:0042554(superoxide anion generation);GO:0042743(hydrogen peroxide metabolic process);GO:0043020(NADPH oxidase complex);GO:0043410(positive regulation of MAPK cascade);GO:0045726(positive regulation of integrin biosynthetic process);GO:0045730(respiratory burst);GO:0046330(positive regulation of JNK cascade);GO:0046872(metal ion binding);GO:0048365(Rac GTPase binding);GO:0048661(positive regulation of smooth muscle cell proliferation);GO:0050661(NADP binding);GO:0051454(intracellular pH elevation);GO:0055114(oxidation-reduction process);GO:0071438(invadopodium membrane);GO:0071455(cellular response to hyperoxia);GO:0072592(oxygen metabolic process);GO:1902177(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway);GO:1990451(cellular stress response to acidic pH) | 04145(Phagosome);04380(Osteoclast differentiation);04670(Leukocyte transendothelial migration) | NA | NA | NADPH oxidase 1 [Source:HGNC Symbol;Acc:HGNC:7889] | 0 | 0 | 0 | 0.09 | 0.07 | 0.08 |
| ENSG00000007968 | E2F2 | ENST00000361729;ENST00000487237 | GO:0000278(mitotic cell cycle);GO:0001047(core promoter binding);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005667(transcription factor complex);GO:0006355(regulation of transcription, DNA-templated);GO:0006367(transcription initiation from RNA polymerase II promoter);GO:0008134(transcription factor binding);GO:0051726(regulation of cell cycle);GO:0072332(intrinsic apoptotic signaling pathway by p53 class mediator);GO:1990086(lens fiber cell apoptotic process) | 04110(Cell cycle);05200(Pathways in cancer);05212(Pancreatic cancer);05214(Glioma);05215(Prostate cancer);05218(Melanoma);05219(Bladder cancer);05220(Chronic myeloid leukemia);05222(Small cell lung cancer);05223(Non-small cell lung cancer) | NA | NA | E2F transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:3114] | 0.04 | 0.04 | 0.04 | 1.13 | 0.99 | 1.15 |
| ENSG00000008196 | TFAP2B | ENST00000393655;ENST00000489228 | GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000979(RNA polymerase II core promoter sequence-specific DNA binding);GO:0000981(sequence-specific DNA binding RNA polymerase II transcription factor activity);GO:0000983(RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity);GO:0001077(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription);GO:0001105(RNA polymerase II transcription coactivator activity);GO:0001106(RNA polymerase II transcription corepressor activity);GO:0001158(enhancer sequence-specific DNA binding);GO:0001822(kidney development);GO:0003091(renal water homeostasis);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0003713(transcription coactivator activity);GO:0003714(transcription corepressor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0006006(glucose metabolic process);GO:0006355(regulation of transcription, DNA-templated);GO:0006366(transcription from RNA polymerase II promoter);GO:0006915(apoptotic process);GO:0007423(sensory organ development);GO:0008284(positive regulation of cell proliferation);GO:0008285(negative regulation of cell proliferation);GO:0010842(retina layer formation);GO:0010960(magnesium ion homeostasis);GO:0030510(regulation of BMP signaling pathway);GO:0035136(forelimb morphogenesis);GO:0035137(hindlimb morphogenesis);GO:0035810(positive regulation of urine volume);GO:0035909(aorta morphogenesis);GO:0042593(glucose homeostasis);GO:0042803(protein homodimerization activity);GO:0043027(cysteine-type endopeptidase inhibitor activity involved in apoptotic process);GO:0043066(negative regulation of apoptotic process);GO:0043154(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process);GO:0043524(negative regulation of neuron apoptotic process);GO:0043525(positive regulation of neuron apoptotic process);GO:0043565(sequence-specific DNA binding);GO:0043588(skin development);GO:0045444(fat cell differentiation);GO:0045595(regulation of cell differentiation);GO:0045892(negative regulation of transcription, DNA-templated);GO:0045893(positive regulation of transcription, DNA-templated);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046982(protein heterodimerization activity);GO:0046983(protein dimerization activity);GO:0048485(sympathetic nervous system development);GO:0048856(anatomical structure development);GO:0050796(regulation of insulin secretion);GO:0055062(phosphate ion homeostasis);GO:0055074(calcium ion homeostasis);GO:0055075(potassium ion homeostasis);GO:0055078(sodium ion homeostasis);GO:0072017(distal tubule development);GO:0072044(collecting duct development);GO:0072210(metanephric nephron development);GO:0097070(ductus arteriosus closure);GO:0097275(cellular ammonia homeostasis);GO:0097276(cellular creatinine homeostasis);GO:0097277(cellular urea homeostasis) | NA | NA | NA | transcription factor AP-2 beta (activating enhancer binding protein 2 beta) [Source:HGNC Symbol;Acc:HGNC:11743] | 0 | 0 | 0 | 0.01 | 0.02 | 0.02 |
| ENSG00000008197 | TFAP2D | ENST00000008391 | GO:0000977(RNA polymerase II regulatory region sequence-specific DNA binding);GO:0000981(sequence-specific DNA binding RNA polymerase II transcription factor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005667(transcription factor complex);GO:0006357(regulation of transcription from RNA polymerase II promoter);GO:0042127(regulation of cell proliferation);GO:0043524(negative regulation of neuron apoptotic process);GO:0045893(positive regulation of transcription, DNA-templated);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048856(anatomical structure development);GO:0061379(inferior colliculus development) | NA | NA | NA | transcription factor AP-2 delta (activating enhancer binding protein 2 delta) [Source:HGNC Symbol;Acc:HGNC:15581] | 0 | 0 | 0 | 0 | 0.01 | 0 |
| ENSG00000008277 | ADAM22 | ENST00000398204;ENST00000398209;ENST00000398203;ENST00000478920;ENST00000413139;ENST00000476330 | GO:0004222(metalloendopeptidase activity);GO:0005178(integrin binding);GO:0005515(protein binding);GO:0006508(proteolysis);GO:0007155(cell adhesion);GO:0007162(negative regulation of cell adhesion);GO:0007417(central nervous system development);GO:0008270(zinc ion binding);GO:0008344(adult locomotory behavior);GO:0014037(Schwann cell differentiation);GO:0016021(integral component of membrane);GO:0022011(myelination in peripheral nervous system);GO:0030424(axon);GO:0042063(gliogenesis) | NA | NA | NA | ADAM metallopeptidase domain 22 [Source:HGNC Symbol;Acc:HGNC:201] | 0.24 | 0.24 | 0.23 | 0.15 | 0.13 | 0.14 |
| ENSG00000008516 | MMP25 | ENST00000336577;ENST00000575441 | GO:0004222(metalloendopeptidase activity);GO:0005509(calcium ion binding);GO:0005578(proteinaceous extracellular matrix);GO:0005886(plasma membrane);GO:0006508(proteolysis);GO:0006954(inflammatory response);GO:0008237(metallopeptidase activity);GO:0008270(zinc ion binding);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0031012(extracellular matrix);GO:0031225(anchored component of membrane);GO:0060022(hard palate development) | NA | NA | NA | matrix metallopeptidase 25 [Source:HGNC Symbol;Acc:HGNC:14246] | 0.48 | 0.48 | 0.49 | 0.43 | 0.33 | 0.45 |
| ENSG00000010310 | GIPR | ENST00000590918;ENST00000588816;ENST00000591224 | GO:0002029(desensitization of G-protein coupled receptor protein signaling pathway);GO:0004888(transmembrane signaling receptor activity);GO:0004930(G-protein coupled receptor activity);GO:0005886(plasma membrane);GO:0006091(generation of precursor metabolites and energy);GO:0007166(cell surface receptor signaling pathway);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007190(activation of adenylate cyclase activity);GO:0007204(positive regulation of cytosolic calcium ion concentration);GO:0007584(response to nutrient);GO:0009749(response to glucose);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0016519(gastric inhibitory peptide receptor activity);GO:0017046(peptide hormone binding);GO:0030819(positive regulation of cAMP biosynthetic process);GO:0031018(endocrine pancreas development);GO:0032024(positive regulation of insulin secretion);GO:0038192(gastric inhibitory peptide signaling pathway);GO:0048678(response to axon injury);GO:0051592(response to calcium ion);GO:0070542(response to fatty acid) | 04080(Neuroactive ligand-receptor interaction) | NA | NA | gastric inhibitory polypeptide receptor [Source:HGNC Symbol;Acc:HGNC:4271] | 0.03 | 0.04 | 0.04 | 0.18 | 0.15 | 0.20 |
| ENSG00000010319 | SEMA3G | ENST00000231721;ENST00000475739 | GO:0005515(protein binding);GO:0016020(membrane);GO:0070062(extracellular exosome) | 04360(Axon guidance) | NA | NA | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G [Source:HGNC Symbol;Acc:HGNC:30400] | 0.56 | 0.53 | 0.53 | 0.59 | 0.55 | 0.60 |
| ENSG00000010932 | FMO1 | ENST00000402921;ENST00000617670;ENST00000433267;ENST00000469112;ENST00000354841;ENST00000459868;ENST00000469711 | GO:0004497(monooxygenase activity);GO:0004499(N,N-dimethylaniline monooxygenase activity);GO:0005788(endoplasmic reticulum lumen);GO:0005789(endoplasmic reticulum membrane);GO:0006082(organic acid metabolic process);GO:0006805(xenobiotic metabolic process);GO:0006970(response to osmotic stress);GO:0009404(toxin metabolic process);GO:0016021(integral component of membrane);GO:0017144(drug metabolic process);GO:0032496(response to lipopolysaccharide);GO:0043231(intracellular membrane-bounded organelle);GO:0044281(small molecule metabolic process);GO:0050660(flavin adenine dinucleotide binding);GO:0050661(NADP binding);GO:0055114(oxidation-reduction process);GO:0070995(NADPH oxidation) | 00982(Drug metabolism - cytochrome P450) | NA | NA | flavin containing monooxygenase 1 [Source:HGNC Symbol;Acc:HGNC:3769] | 0.53 | 0.51 | 0.54 | 0.33 | 0.52 | 0.28 |
| ENSG00000011083 | SLC6A7 | ENST00000230671 | GO:0005328(neurotransmitter:sodium symporter activity);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006810(transport);GO:0006836(neurotransmitter transport);GO:0015824(proline transport);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0055085(transmembrane transport) | NA | NA | NA | solute carrier family 6 (neurotransmitter transporter), member 7 [Source:HGNC Symbol;Acc:HGNC:11054] | 0.03 | 0.04 | 0.04 | 0.01 | 0.01 | 0.01 |
| ENSG00000011201 | ANOS1 | ENST00000262648;ENST00000488294 | GO:0004867(serine-type endopeptidase inhibitor activity);GO:0005201(extracellular matrix structural constituent);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0005578(proteinaceous extracellular matrix);GO:0005615(extracellular space);GO:0005886(plasma membrane);GO:0006928(movement of cell or subcellular component);GO:0006935(chemotaxis);GO:0007155(cell adhesion);GO:0007411(axon guidance);GO:0008201(heparin binding);GO:0010466(negative regulation of peptidase activity);GO:0010951(negative regulation of endopeptidase activity);GO:0030414(peptidase inhibitor activity) | NA | NA | NA | anosmin 1 [Source:HGNC Symbol;Acc:HGNC:6211] | 0.33 | 0.28 | 0.29 | 0.21 | 0.18 | 0.21 |
| ENSG00000011332 | DPF1 | ENST00000614244 | GO:0003676(nucleic acid binding);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0006915(apoptotic process);GO:0007399(nervous system development);GO:0008270(zinc ion binding);GO:0046872(metal ion binding);GO:0071565(nBAF complex) | NA | NA | NA | D4, zinc and double PHD fingers family 1 [Source:HGNC Symbol;Acc:HGNC:20225] | 0 | 0 | 0 | 0.02 | 0.02 | 0.03 |
| ENSG00000011590 | ZBTB32 | ENST00000392197;ENST00000442282 | GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000228(nuclear chromosome);GO:0001817(regulation of cytokine production);GO:0003676(nucleic acid binding);GO:0003677(DNA binding);GO:0003714(transcription corepressor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0006281(DNA repair);GO:0006366(transcription from RNA polymerase II promoter);GO:0008270(zinc ion binding);GO:0019985(translesion synthesis);GO:0030097(hemopoiesis);GO:0042098(T cell proliferation);GO:0042769(DNA damage response, detection of DNA damage);GO:0046872(metal ion binding);GO:1903507(negative regulation of nucleic acid-templated transcription) | NA | NA | NA | zinc finger and BTB domain containing 32 [Source:HGNC Symbol;Acc:HGNC:16763] | 0.05 | 0.07 | 0.06 | 0.20 | 0.25 | 0.23 |
| ENSG00000011677 | GABRA3 | ENST00000370314;ENST00000535043;ENST00000497894 | GO:0004890(GABA-A receptor activity);GO:0005230(extracellular ligand-gated ion channel activity);GO:0005254(chloride channel activity);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006810(transport);GO:0006811(ion transport);GO:0007214(gamma-aminobutyric acid signaling pathway);GO:0007268(synaptic transmission);GO:0008503(benzodiazepine receptor activity);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0030054(cell junction);GO:0034220(ion transmembrane transport);GO:0034707(chloride channel complex);GO:0045211(postsynaptic membrane);GO:0055085(transmembrane transport);GO:1902476(chloride transmembrane transport) | NA | NA | NA | gamma-aminobutyric acid (GABA) A receptor, alpha 3 [Source:HGNC Symbol;Acc:HGNC:4077] | 0 | 0 | 0 | 0.28 | 0.23 | 0.28 |
| ENSG00000012124 | CD22 | ENST00000598537;ENST00000595419;ENST00000599717;ENST00000599799;ENST00000595780;ENST00000596492;ENST00000593867;ENST00000601769;ENST00000085219;ENST00000544992;ENST00000270311;ENST00000594250;ENST00000613136;ENST00000593704 | GO:0005515(protein binding);GO:0005887(integral component of plasma membrane);GO:0007155(cell adhesion);GO:0009897(external side of plasma membrane);GO:0016021(integral component of membrane);GO:0030246(carbohydrate binding);GO:0070062(extracellular exosome) | 04514(Cell adhesion molecules (CAMs));04640(Hematopoietic cell lineage);04662(B cell receptor signaling pathway) | NA | NA | CD22 molecule [Source:HGNC Symbol;Acc:HGNC:1643] | 0.65 | 0.67 | 0.68 | 0.11 | 0.08 | 0.11 |
| ENSG00000012171 | SEMA3B | ENST00000621029;ENST00000618865;ENST00000619119;ENST00000616701;ENST00000612509;ENST00000433753;ENST00000611418;ENST00000441915;ENST00000456560;ENST00000419007;ENST00000416295 | GO:0005515(protein binding);GO:0005783(endoplasmic reticulum);GO:0007267(cell-cell signaling);GO:0007411(axon guidance);GO:0016020(membrane);GO:0070062(extracellular exosome) | NA | NA | NA | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B [Source:HGNC Symbol;Acc:HGNC:10724] | 0.51 | 0.56 | 0.56 | 0.76 | 0.60 | 0.78 |
| ENSG00000012223 | LTF | ENST00000231751 | GO:0001503(ossification);GO:0001817(regulation of cytokine production);GO:0001895(retina homeostasis);GO:0002227(innate immune response in mucosa);GO:0003677(DNA binding);GO:0004252(serine-type endopeptidase activity);GO:0005506(iron ion binding);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006351(transcription, DNA-templated);GO:0006508(proteolysis);GO:0006811(ion transport);GO:0006959(humoral immune response);GO:0008201(heparin binding);GO:0008233(peptidase activity);GO:0019731(antibacterial humoral response);GO:0019732(antifungal humoral response);GO:0030141(secretory granule);GO:0031665(negative regulation of lipopolysaccharide-mediated signaling pathway);GO:0032680(regulation of tumor necrosis factor production);GO:0032780(negative regulation of ATPase activity);GO:0033214(iron assimilation by chelation and transport);GO:0033690(positive regulation of osteoblast proliferation);GO:0034145(positive regulation of toll-like receptor 4 signaling pathway);GO:0042581(specific granule);GO:0043066(negative regulation of apoptotic process);GO:0043123(positive regulation of I-kappaB kinase/NF-kappaB signaling);GO:0043539(protein serine/threonine kinase activator activity);GO:0044793(negative regulation by host of viral process);GO:0045071(negative regulation of viral genome replication);GO:0045669(positive regulation of osteoblast differentiation);GO:0048525(negative regulation of viral process);GO:0051092(positive regulation of NF-kappaB transcription factor activity);GO:0051701(interaction with host);GO:0052572(response to host immune response);GO:0060349(bone morphogenesis);GO:0070062(extracellular exosome);GO:0071902(positive regulation of protein serine/threonine kinase activity);GO:0090382(phagosome maturation);GO:0097013(phagocytic vesicle lumen);GO:1900159(positive regulation of bone mineralization involved in bone maturation);GO:1900229(negative regulation of single-species biofilm formation in or on host organism);GO:1902732(positive regulation of chondrocyte proliferation);GO:2000308(negative regulation of tumor necrosis factor (ligand) superfamily member 11 production);GO:2001205(negative regulation of osteoclast development) | NA | NA | NA | lactotransferrin [Source:HGNC Symbol;Acc:HGNC:6720] | 0.16 | 0.14 | 0.14 | 0.02 | 0.01 | 0.02 |
| ENSG00000013293 | SLC7A14 | ENST00000231706 | GO:0003333(amino acid transmembrane transport);GO:0005765(lysosomal membrane);GO:0005887(integral component of plasma membrane);GO:0010923(negative regulation of phosphatase activity);GO:0015171(amino acid transmembrane transporter activity);GO:0015179(L-amino acid transmembrane transporter activity);GO:0015297(antiporter activity);GO:0015807(L-amino acid transport);GO:0016020(membrane);GO:1902475(L-alpha-amino acid transmembrane transport) | NA | NA | NA | solute carrier family 7, member 14 [Source:HGNC Symbol;Acc:HGNC:29326] | 0.02 | 0.02 | 0.02 | 0.01 | 0.01 | 0.01 |
| ENSG00000013297 | CLDN11 | ENST00000064724;ENST00000486975;ENST00000477531;ENST00000480067 | GO:0005198(structural molecule activity);GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0005923(bicellular tight junction);GO:0007155(cell adhesion);GO:0007283(spermatogenesis);GO:0008366(axon ensheathment);GO:0016021(integral component of membrane);GO:0016338(calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules);GO:0042802(identical protein binding);GO:0043209(myelin sheath);GO:0045178(basal part of cell);GO:0070062(extracellular exosome) | NA | NA | NA | claudin 11 [Source:HGNC Symbol;Acc:HGNC:8514] | 0.43 | 0.44 | 0.44 | 0.06 | 0.07 | 0.06 |
| ENSG00000013588 | GPRC5A | ENST00000014914 | GO:0004930(G-protein coupled receptor activity);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0016021(integral component of membrane);GO:0030659(cytoplasmic vesicle membrane);GO:0043231(intracellular membrane-bounded organelle);GO:0070062(extracellular exosome) | NA | NA | NA | G protein-coupled receptor, class C, group 5, member A [Source:HGNC Symbol;Acc:HGNC:9836] | 0.03 | 0.03 | 0.03 | 0.02 | 0.00 | 0.01 |
| ENSG00000013619 | MAMLD1 | ENST00000370401;ENST00000358892;ENST00000262858;ENST00000426613;ENST00000464149 | GO:0003674(molecular_function);GO:0005575(cellular_component);GO:0005634(nucleus);GO:0006351(transcription, DNA-templated);GO:0006357(regulation of transcription from RNA polymerase II promoter);GO:0008584(male gonad development) | NA | NA | NA | mastermind-like domain containing 1 [Source:HGNC Symbol;Acc:HGNC:2568] | 0.46 | 0.48 | 0.47 | 0.50 | 0.52 | 0.53 |
| ENSG00000014257 | ACPP | ENST00000336375;ENST00000351273;ENST00000489084;ENST00000483689 | GO:0003993(acid phosphatase activity);GO:0005615(extracellular space);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005765(lysosomal membrane);GO:0005886(plasma membrane);GO:0006144(purine nucleobase metabolic process);GO:0006772(thiamine metabolic process);GO:0008253(5'-nucleotidase activity);GO:0009117(nucleotide metabolic process);GO:0012506(vesicle membrane);GO:0016021(integral component of membrane);GO:0016311(dephosphorylation);GO:0016791(phosphatase activity);GO:0030175(filopodium);GO:0042131(thiamine phosphate phosphatase activity);GO:0042802(identical protein binding);GO:0046085(adenosine metabolic process);GO:0051930(regulation of sensory perception of pain);GO:0052642(lysophosphatidic acid phosphatase activity);GO:0060168(positive regulation of adenosine receptor signaling pathway);GO:0070062(extracellular exosome) | 00740(Riboflavin metabolism) | NA | NA | acid phosphatase, prostate [Source:HGNC Symbol;Acc:HGNC:125] | 0.09 | 0.11 | 0.11 | 0.08 | 0.07 | 0.09 |
| ENSG00000015133 | CCDC88C | ENST00000556726;ENST00000389857;ENST00000334448;ENST00000557455;ENST00000555995;ENST00000557507;ENST00000554051;ENST00000554872;ENST00000553437;ENST00000389856;ENST00000553403;ENST00000554165;ENST00000556767 | GO:0001932(regulation of protein phosphorylation);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0016055(Wnt signaling pathway);GO:0030165(PDZ domain binding);GO:0031098(stress-activated protein kinase signaling cascade);GO:0031648(protein destabilization);GO:0043621(protein self-association);GO:0051260(protein homooligomerization) | NA | NA | NA | coiled-coil domain containing 88C [Source:HGNC Symbol;Acc:HGNC:19967] | 1.09 | 1.11 | 1.10 | 0.63 | 0.89 | 0.62 |
| ENSG00000015413 | DPEP1 | ENST00000421184;ENST00000565249;ENST00000564281;ENST00000568281;ENST00000393092;ENST00000561484;ENST00000261615 | GO:0005515(protein binding);GO:0005615(extracellular space);GO:0005634(nucleus);GO:0005886(plasma membrane);GO:0006508(proteolysis);GO:0006691(leukotriene metabolic process);GO:0006749(glutathione metabolic process);GO:0006805(xenobiotic metabolic process);GO:0008235(metalloexopeptidase activity);GO:0008237(metallopeptidase activity);GO:0008239(dipeptidyl-peptidase activity);GO:0008270(zinc ion binding);GO:0016324(apical plasma membrane);GO:0016805(dipeptidase activity);GO:0016999(antibiotic metabolic process);GO:0019369(arachidonic acid metabolic process);GO:0030054(cell junction);GO:0030336(negative regulation of cell migration);GO:0031225(anchored component of membrane);GO:0031528(microvillus membrane);GO:0034235(GPI anchor binding);GO:0035690(cellular response to drug);GO:0043027(cysteine-type endopeptidase inhibitor activity involved in apoptotic process);GO:0043066(negative regulation of apoptotic process);GO:0043154(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process);GO:0044281(small molecule metabolic process);GO:0045177(apical part of cell);GO:0046872(metal ion binding);GO:0050667(homocysteine metabolic process);GO:0070062(extracellular exosome);GO:0070573(metallodipeptidase activity);GO:0071277(cellular response to calcium ion);GO:0071732(cellular response to nitric oxide);GO:0072340(cellular lactam catabolic process);GO:0072341(modified amino acid binding) | NA | NA | NA | dipeptidase 1 (renal) [Source:HGNC Symbol;Acc:HGNC:3002] | 0.15 | 0.16 | 0.15 | 0.34 | 0.30 | 0.38 |
| ENSG00000016082 | ISL1 | ENST00000230658 | GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000978(RNA polymerase II core promoter proximal region sequence-specific DNA binding);GO:0001077(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription);GO:0001102(RNA polymerase II activating transcription factor binding);GO:0001105(RNA polymerase II transcription coactivator activity);GO:0001158(enhancer sequence-specific DNA binding);GO:0001755(neural crest cell migration);GO:0003007(heart morphogenesis);GO:0003139(secondary heart field specification);GO:0003148(outflow tract septum morphogenesis);GO:0003151(outflow tract morphogenesis);GO:0003203(endocardial cushion morphogenesis);GO:0003215(cardiac right ventricle morphogenesis);GO:0003266(regulation of secondary heart field cardioblast proliferation);GO:0003677(DNA binding);GO:0003682(chromatin binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0006355(regulation of transcription, DNA-templated);GO:0007507(heart development);GO:0008270(zinc ion binding);GO:0008284(positive regulation of cell proliferation);GO:0010468(regulation of gene expression);GO:0010575(positive regulation of vascular endothelial growth factor production);GO:0016922(ligand-dependent nuclear receptor binding);GO:0021520(spinal cord motor neuron cell fate specification);GO:0021522(spinal cord motor neuron differentiation);GO:0021524(visceral motor neuron differentiation);GO:0021559(trigeminal nerve development);GO:0021983(pituitary gland development);GO:0030182(neuron differentiation);GO:0030331(estrogen receptor binding);GO:0031016(pancreas development);GO:0031103(axon regeneration);GO:0031290(retinal ganglion cell axon guidance);GO:0032024(positive regulation of insulin secretion);GO:0032725(positive regulation of granulocyte macrophage colony-stimulating factor production);GO:0032729(positive regulation of interferon-gamma production);GO:0032730(positive regulation of interleukin-1 alpha production);GO:0032731(positive regulation of interleukin-1 beta production);GO:0032735(positive regulation of interleukin-12 production);GO:0032755(positive regulation of interleukin-6 production);GO:0032760(positive regulation of tumor necrosis factor production);GO:0033147(negative regulation of intracellular estrogen receptor signaling pathway);GO:0035066(positive regulation of histone acetylation);GO:0042517(positive regulation of tyrosine phosphorylation of Stat3 protein);GO:0043388(positive regulation of DNA binding);GO:0043425(bHLH transcription factor binding);GO:0043524(negative regulation of neuron apoptotic process);GO:0043565(sequence-specific DNA binding);GO:0045665(negative regulation of neuron differentiation);GO:0045766(positive regulation of angiogenesis);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048663(neuron fate commitment);GO:0048665(neuron fate specification);GO:0048762(mesenchymal cell differentiation);GO:0048880(sensory system development);GO:0048935(peripheral nervous system neuron development);GO:0048936(peripheral nervous system neuron axonogenesis);GO:0050728(negative regulation of inflammatory response);GO:0055010(ventricular cardiac muscle tissue morphogenesis);GO:0060037(pharyngeal system development);GO:0060379(cardiac muscle cell myoblast differentiation);GO:0060384(innervation);GO:0060413(atrial septum morphogenesis);GO:0060913(cardiac cell fate determination);GO:0071385(cellular response to glucocorticoid stimulus);GO:0071657(positive regulation of granulocyte colony-stimulating factor production);GO:0090074(negative regulation of protein homodimerization activity);GO:0090090(negative regulation of canonical Wnt signaling pathway);GO:1901258(positive regulation of macrophage colony-stimulating factor production) | NA | NA | NA | ISL LIM homeobox 1 [Source:HGNC Symbol;Acc:HGNC:6132] | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 |
| ENSG00000016402 | IL20RA | ENST00000541547;ENST00000316649;ENST00000367748;ENST00000367746 | GO:0004896(cytokine receptor activity);GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0016021(integral component of membrane);GO:0019221(cytokine-mediated signaling pathway);GO:0042015(interleukin-20 binding);GO:0045124(regulation of bone resorption);GO:2001244(positive regulation of intrinsic apoptotic signaling pathway) | 04060(Cytokine-cytokine receptor interaction);04630(Jak-STAT signaling pathway) | NA | NA | interleukin 20 receptor, alpha [Source:HGNC Symbol;Acc:HGNC:6003] | 0.05 | 0.05 | 0.05 | 0 | 0.11 | 0 |
| ENSG00000016602 | CLCA4 | ENST00000370563 | GO:0005229(intracellular calcium activated chloride channel activity);GO:0005254(chloride channel activity);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006508(proteolysis);GO:0006810(transport);GO:0006821(chloride transport);GO:0008237(metallopeptidase activity);GO:0016324(apical plasma membrane);GO:0034220(ion transmembrane transport);GO:0046872(metal ion binding);GO:0055085(transmembrane transport);GO:0070062(extracellular exosome);GO:1902476(chloride transmembrane transport) | 04740(Olfactory transduction);04972(Pancreatic secretion) | NA | NA | chloride channel accessory 4 [Source:HGNC Symbol;Acc:HGNC:2018] | 0.01 | 0.01 | 0.01 | 0 | 0 | 0 |
| ENSG00000017483 | SLC38A5 | ENST00000595796;ENST00000619100;ENST00000480105;ENST00000440085;ENST00000413668 | GO:0003333(amino acid transmembrane transport);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006811(ion transport);GO:0006865(amino acid transport);GO:0015171(amino acid transmembrane transporter activity);GO:0015175(neutral amino acid transmembrane transporter activity);GO:0015187(glycine transmembrane transporter activity);GO:0015804(neutral amino acid transport);GO:0015816(glycine transport);GO:0055085(transmembrane transport) | NA | NA | NA | solute carrier family 38, member 5 [Source:HGNC Symbol;Acc:HGNC:18070] | 0.16 | 0.17 | 0.17 | 0.42 | 0.33 | 0.44 |
| ENSG00000018280 | SLC11A1 | ENST00000468221;ENST00000233202;ENST00000473367;ENST00000465984;ENST00000492413;ENST00000483487;ENST00000490536;ENST00000468721 | GO:0000060(protein import into nucleus, translocation);GO:0001818(negative regulation of cytokine production);GO:0001819(positive regulation of cytokine production);GO:0002309(T cell proliferation involved in immune response);GO:0002369(T cell cytokine production);GO:0002606(positive regulation of dendritic cell antigen processing and presentation);GO:0002827(positive regulation of T-helper 1 type immune response);GO:0003674(molecular_function);GO:0005215(transporter activity);GO:0005384(manganese ion transmembrane transporter activity);GO:0005575(cellular_component);GO:0005764(lysosome);GO:0005770(late endosome);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006810(transport);GO:0006826(iron ion transport);GO:0006828(manganese ion transport);GO:0006876(cellular cadmium ion homeostasis);GO:0006879(cellular iron ion homeostasis);GO:0006909(phagocytosis);GO:0006954(inflammatory response);GO:0006955(immune response);GO:0007035(vacuolar acidification);GO:0009279(cell outer membrane);GO:0009617(response to bacterium);GO:0010008(endosome membrane);GO:0010628(positive regulation of gene expression);GO:0015707(nitrite transport);GO:0016020(membrane);GO:0030670(phagocytic vesicle membrane);GO:0031902(late endosome membrane);GO:0032147(activation of protein kinase activity);GO:0032496(response to lipopolysaccharide);GO:0032623(interleukin-2 production);GO:0032632(interleukin-3 production);GO:0032729(positive regulation of interferon-gamma production);GO:0034341(response to interferon-gamma);GO:0042060(wound healing);GO:0042116(macrophage activation);GO:0042742(defense response to bacterium);GO:0042803(protein homodimerization activity);GO:0042832(defense response to protozoan);GO:0043091(L-arginine import);GO:0045342(MHC class II biosynthetic process);GO:0045730(respiratory burst);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046915(transition metal ion transmembrane transporter activity);GO:0048002(antigen processing and presentation of peptide antigen);GO:0048255(mRNA stabilization);GO:0050766(positive regulation of phagocytosis);GO:0050829(defense response to Gram-negative bacterium);GO:0051139(metal ion:proton antiporter activity);GO:0051701(interaction with host);GO:0055072(iron ion homeostasis);GO:0055085(transmembrane transport);GO:0060586(multicellular organismal iron ion homeostasis);GO:0070574(cadmium ion transmembrane transport);GO:0070821(tertiary granule membrane);GO:0070839(divalent metal ion export);GO:0071421(manganese ion transmembrane transport);GO:0090382(phagosome maturation) | 04142(Lysosome);04978(Mineral absorption) | NA | NA | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 [Source:HGNC Symbol;Acc:HGNC:10907] | 0.14 | 0.13 | 0.13 | 0.12 | 0.10 | 0.14 |
| ENSG00000018607 | ZNF806 | ENST00000438300 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0.01 | 0.01 | 0.01 |
| ENSG00000018625 | ATP1A2 | ENST00000478587;ENST00000361216;ENST00000468587 | GO:0000166(nucleotide binding);GO:0001504(neurotransmitter uptake);GO:0002026(regulation of the force of heart contraction);GO:0002087(regulation of respiratory gaseous exchange by neurological system process);GO:0005391(sodium:potassium-exchanging ATPase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005737(cytoplasm);GO:0005768(endosome);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005890(sodium:potassium-exchanging ATPase complex);GO:0005901(caveola);GO:0006813(potassium ion transport);GO:0006814(sodium ion transport);GO:0006883(cellular sodium ion homeostasis);GO:0006937(regulation of muscle contraction);GO:0006940(regulation of smooth muscle contraction);GO:0006942(regulation of striated muscle contraction);GO:0008152(metabolic process);GO:0008217(regulation of blood pressure);GO:0008344(adult locomotory behavior);GO:0008542(visual learning);GO:0010107(potassium ion import);GO:0010881(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion);GO:0014704(intercalated disc);GO:0015991(ATP hydrolysis coupled proton transport);GO:0016021(integral component of membrane);GO:0019229(regulation of vasoconstriction);GO:0019829(cation-transporting ATPase activity);GO:0030007(cellular potassium ion homeostasis);GO:0030315(T-tubule);GO:0034220(ion transmembrane transport);GO:0035094(response to nicotine);GO:0035725(sodium ion transmembrane transport);GO:0036376(sodium ion export from cell);GO:0040011(locomotion);GO:0042383(sarcolemma);GO:0043005(neuron projection);GO:0043197(dendritic spine);GO:0043209(myelin sheath);GO:0045202(synapse);GO:0045822(negative regulation of heart contraction);GO:0045988(negative regulation of striated muscle contraction);GO:0046872(metal ion binding);GO:0051087(chaperone binding);GO:0051481(negative regulation of cytosolic calcium ion concentration);GO:0055085(transmembrane transport);GO:0055119(relaxation of cardiac muscle);GO:0060048(cardiac muscle contraction);GO:0071260(cellular response to mechanical stimulus);GO:0071383(cellular response to steroid hormone stimulus);GO:0086004(regulation of cardiac muscle cell contraction);GO:0086012(membrane depolarization during cardiac muscle cell action potential);GO:0086064(cell communication by electrical coupling involved in cardiac conduction);GO:1903170(negative regulation of calcium ion transmembrane transport);GO:1903280(negative regulation of calcium:sodium antiporter activity);GO:1903416(response to glycoside);GO:1903561(extracellular vesicle);GO:1990239(steroid hormone binding) | 04260(Cardiac muscle contraction);04960(Aldosterone-regulated sodium reabsorption);04961(Endocrine and other factor-regulated calcium reabsorption);04964(Proximal tubule bicarbonate reclamation);04970(Salivary secretion);04971(Gastric acid secretion);04972(Pancreatic secretion);04973(Carbohydrate digestion and absorption);04974(Protein digestion and absorption);04976(Bile secretion);04978(Mineral absorption) | NA | NA | ATPase, Na+/K+ transporting, alpha 2 polypeptide [Source:HGNC Symbol;Acc:HGNC:800] | 0.11 | 0.11 | 0.12 | 0.09 | 0.10 | 0.09 |
| ENSG00000019102 | VSIG2 | ENST00000326621;ENST00000403470 | GO:0005515(protein binding);GO:0005887(integral component of plasma membrane);GO:0016020(membrane) | NA | NA | NA | V-set and immunoglobulin domain containing 2 [Source:HGNC Symbol;Acc:HGNC:17149] | 1.03 | 1.03 | 1.07 | 0.03 | 0.03 | 0.04 |
| ENSG00000019144 | PHLDB1 | ENST00000361417;ENST00000530708;ENST00000600882;ENST00000530994;ENST00000621027;ENST00000356063;ENST00000532639;ENST00000525427;ENST00000527259;ENST00000526374;ENST00000617208;ENST00000532517;ENST00000614369;ENST00000601898;ENST00000534140;ENST00000612681;ENST00000526699;ENST00000392852;ENST00000531987;ENST00000526826;ENST00000525226;ENST00000526537;ENST00000620788 | GO:0005515(protein binding);GO:0010470(regulation of gastrulation);GO:0010717(regulation of epithelial to mesenchymal transition);GO:0045180(basal cortex);GO:0070507(regulation of microtubule cytoskeleton organization);GO:1904261(positive regulation of basement membrane assembly involved in embryonic body morphogenesis) | NA | NA | NA | pleckstrin homology-like domain, family B, member 1 [Source:HGNC Symbol;Acc:HGNC:23697] | 0.55 | 0.58 | 0.58 | 0.22 | 0.24 | 0.24 |
| ENSG00000019186 | CYP24A1 | ENST00000216862;ENST00000460643;ENST00000395954;ENST00000487593;ENST00000472970 | GO:0001649(osteoblast differentiation);GO:0005506(iron ion binding);GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0006766(vitamin metabolic process);GO:0006805(xenobiotic metabolic process);GO:0008202(steroid metabolic process);GO:0008403(25-hydroxycholecalciferol-24-hydroxylase activity);GO:0016491(oxidoreductase activity);GO:0016705(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen);GO:0020037(heme binding);GO:0030342(1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity);GO:0033280(response to vitamin D);GO:0042359(vitamin D metabolic process);GO:0042369(vitamin D catabolic process);GO:0044281(small molecule metabolic process);GO:0055114(oxidation-reduction process);GO:0070561(vitamin D receptor signaling pathway) | NA | NA | NA | cytochrome P450, family 24, subfamily A, polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:2602] | 0 | 0 | 0 | 0.47 | 0.32 | 0.51 |
| ENSG00000019485 | PRDM11 | ENST00000526442;ENST00000622142;ENST00000534751;ENST00000528980 | GO:0003682(chromatin binding);GO:0005515(protein binding);GO:0008168(methyltransferase activity);GO:0032259(methylation) | NA | NA | NA | PR domain containing 11 [Source:HGNC Symbol;Acc:HGNC:13996] | 0.26 | 0.25 | 0.25 | 0.20 | 0.38 | 0.20 |
| ENSG00000019505 | SYT13 | ENST00000020926 | GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0016079(synaptic vesicle exocytosis);GO:0016192(vesicle-mediated transport);GO:0019905(syntaxin binding);GO:0030133(transport vesicle);GO:0030276(clathrin binding);GO:0048791(calcium ion-dependent exocytosis of neurotransmitter) | NA | NA | NA | synaptotagmin XIII [Source:HGNC Symbol;Acc:HGNC:14962] | 0.13 | 0.13 | 0.13 | 0.19 | 0.14 | 0.20 |
| ENSG00000019549 | SNAI2 | ENST00000020945;ENST00000396822 | GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000790(nuclear chromatin);GO:0001078(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription);GO:0001649(osteoblast differentiation);GO:0001837(epithelial to mesenchymal transition);GO:0003198(epithelial to mesenchymal transition involved in endocardial cushion formation);GO:0003273(cell migration involved in endocardial cushion formation);GO:0003682(chromatin binding);GO:0003705(RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006933(negative regulation of cell adhesion involved in substrate-bound cell migration);GO:0007219(Notch signaling pathway);GO:0007605(sensory perception of sound);GO:0009314(response to radiation);GO:0010839(negative regulation of keratinocyte proliferation);GO:0010957(negative regulation of vitamin D biosynthetic process);GO:0014032(neural crest cell development);GO:0016477(cell migration);GO:0030335(positive regulation of cell migration);GO:0032331(negative regulation of chondrocyte differentiation);GO:0032642(regulation of chemokine production);GO:0033629(negative regulation of cell adhesion mediated by integrin);GO:0035066(positive regulation of histone acetylation);GO:0035414(negative regulation of catenin import into nucleus);GO:0035921(desmosome disassembly);GO:0043066(negative regulation of apoptotic process);GO:0043473(pigmentation);GO:0043518(negative regulation of DNA damage response, signal transduction by p53 class mediator);GO:0043565(sequence-specific DNA binding);GO:0044344(cellular response to fibroblast growth factor stimulus);GO:0045600(positive regulation of fat cell differentiation);GO:0045667(regulation of osteoblast differentiation);GO:0046872(metal ion binding);GO:0050872(white fat cell differentiation);GO:0060021(palate development);GO:0060070(canonical Wnt signaling pathway);GO:0060429(epithelium development);GO:0060536(cartilage morphogenesis);GO:0060693(regulation of branching involved in salivary gland morphogenesis);GO:0070563(negative regulation of vitamin D receptor signaling pathway);GO:0071364(cellular response to epidermal growth factor stimulus);GO:0071479(cellular response to ionizing radiation);GO:0090090(negative regulation of canonical Wnt signaling pathway);GO:1900387(negative regulation of cell-cell adhesion by negative regulation of transcription from RNA polymerase II promoter);GO:1902230(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage);GO:2000647(negative regulation of stem cell proliferation);GO:2000810(regulation of bicellular tight junction assembly);GO:2000811(negative regulation of anoikis);GO:2001240(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand) | 04520(Adherens junction) | NA | NA | snail family zinc finger 2 [Source:HGNC Symbol;Acc:HGNC:11094] | 0.32 | 0.30 | 0.30 | 0.25 | 0.34 | 0.27 |
| ENSG00000020633 | RUNX3 | ENST00000399916;ENST00000308873;ENST00000496967 | GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000790(nuclear chromatin);GO:0000977(RNA polymerase II regulatory region sequence-specific DNA binding);GO:0000981(sequence-specific DNA binding RNA polymerase II transcription factor activity);GO:0001503(ossification);GO:0002062(chondrocyte differentiation);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0006355(regulation of transcription, DNA-templated);GO:0006357(regulation of transcription from RNA polymerase II promoter);GO:0006366(transcription from RNA polymerase II promoter);GO:0006468(protein phosphorylation);GO:0007411(axon guidance);GO:0030097(hemopoiesis);GO:0030182(neuron differentiation);GO:0031069(hair follicle morphogenesis);GO:0031175(neuron projection development);GO:0032609(interferon-gamma production);GO:0043231(intracellular membrane-bounded organelle);GO:0045595(regulation of cell differentiation);GO:0045786(negative regulation of cell cycle);GO:0048469(cell maturation);GO:0048935(peripheral nervous system neuron development);GO:0050680(negative regulation of epithelial cell proliferation);GO:2001238(positive regulation of extrinsic apoptotic signaling pathway) | NA | NA | NA | runt-related transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:10473] | 1.26 | 1.11 | 1.14 | 0.82 | 0.72 | 0.91 |
| ENSG00000021645 | NRXN3 | ENST00000554738;ENST00000554719;ENST00000557081;ENST00000281127;ENST00000555073;ENST00000553803;ENST00000556003 | GO:0001525(angiogenesis);GO:0004872(receptor activity);GO:0004888(transmembrane signaling receptor activity);GO:0005246(calcium channel regulator activity);GO:0005515(protein binding);GO:0005623(cell);GO:0005887(integral component of plasma membrane);GO:0007158(neuron cell-cell adhesion);GO:0007165(signal transduction);GO:0007268(synaptic transmission);GO:0007269(neurotransmitter secretion);GO:0007411(axon guidance);GO:0007416(synapse assembly);GO:0007612(learning);GO:0016021(integral component of membrane);GO:0030534(adult behavior);GO:0035176(social behavior);GO:0043234(protein complex);GO:0046872(metal ion binding);GO:0050839(cell adhesion molecule binding);GO:0051965(positive regulation of synapse assembly);GO:0071625(vocalization behavior);GO:0090129(positive regulation of synapse maturation);GO:0097109(neuroligin family protein binding) | 04514(Cell adhesion molecules (CAMs)) | NA | NA | neurexin 3 [Source:HGNC Symbol;Acc:HGNC:8010] | 0.01 | 0.01 | 0.01 | 0.04 | 0.27 | 0.05 |
| ENSG00000021762 | OSBPL5 | ENST00000478260;ENST00000263650;ENST00000389989;ENST00000498536;ENST00000348039;ENST00000534491;ENST00000532951;ENST00000459995;ENST00000533234;ENST00000465323;ENST00000477622;ENST00000526122;ENST00000533721;ENST00000534157;ENST00000528124 | GO:0005789(endoplasmic reticulum membrane);GO:0005829(cytosol);GO:0006869(lipid transport);GO:0006893(Golgi to plasma membrane transport);GO:0008142(oxysterol binding);GO:0008203(cholesterol metabolic process);GO:0015485(cholesterol binding);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0030301(cholesterol transport) | NA | NA | NA | oxysterol binding protein-like 5 [Source:HGNC Symbol;Acc:HGNC:16392] | 0.82 | 0.82 | 0.81 | 0.14 | 0.13 | 0.13 |
| ENSG00000022355 | GABRA1 | ENST00000428797 | GO:0004890(GABA-A receptor activity);GO:0005230(extracellular ligand-gated ion channel activity);GO:0005254(chloride channel activity);GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006810(transport);GO:0006811(ion transport);GO:0007165(signal transduction);GO:0007214(gamma-aminobutyric acid signaling pathway);GO:0007268(synaptic transmission);GO:0008144(drug binding);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0016917(GABA receptor activity);GO:0030054(cell junction);GO:0034220(ion transmembrane transport);GO:0034707(chloride channel complex);GO:0045211(postsynaptic membrane);GO:0051932(synaptic transmission, GABAergic);GO:0055085(transmembrane transport);GO:0071420(cellular response to histamine);GO:1902476(chloride transmembrane transport);GO:1902710(GABA receptor complex) | 04080(Neuroactive ligand-receptor interaction) | NA | NA | gamma-aminobutyric acid (GABA) A receptor, alpha 1 [Source:HGNC Symbol;Acc:HGNC:4075] | 0 | 0 | 0 | 0 | 0.01 | 0 |
| ENSG00000022556 | NLRP2 | ENST00000543010;ENST00000540597;ENST00000427260;ENST00000543277;ENST00000381637;ENST00000586512;ENST00000542755 | GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005737(cytoplasm);GO:0006954(inflammatory response);GO:0032090(Pyrin domain binding);GO:0043280(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process);GO:0045087(innate immune response);GO:0050718(positive regulation of interleukin-1 beta secretion) | NA | NA | NA | NLR family, pyrin domain containing 2 [Source:HGNC Symbol;Acc:HGNC:22948] | 0.20 | 0.21 | 0.22 | 0.24 | 0.21 | 0.26 |
| ENSG00000022567 | SLC45A4 | ENST00000519067;ENST00000517878;ENST00000520137;ENST00000519986;ENST00000521804 | GO:0006810(transport);GO:0016021(integral component of membrane) | NA | NA | NA | solute carrier family 45, member 4 [Source:HGNC Symbol;Acc:HGNC:29196] | 0.38 | 0.25 | 0.24 | 0.52 | 0.66 | 0.50 |
| ENSG00000026559 | KCNG1 | ENST00000371571;ENST00000506387;ENST00000433903 | GO:0005216(ion channel activity);GO:0005251(delayed rectifier potassium channel activity);GO:0005267(potassium channel activity);GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0006811(ion transport);GO:0006813(potassium ion transport);GO:0007268(synaptic transmission);GO:0008076(voltage-gated potassium channel complex);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0034765(regulation of ion transmembrane transport);GO:0043231(intracellular membrane-bounded organelle);GO:0051260(protein homooligomerization);GO:0055085(transmembrane transport);GO:0071805(potassium ion transmembrane transport) | NA | NA | NA | potassium channel, voltage gated modifier subfamily G, member 1 [Source:HGNC Symbol;Acc:HGNC:6248] | 0.04 | 0.04 | 0.04 | 0.01 | 0.02 | 0.01 |
| ENSG00000026652 | AGPAT4 | ENST00000366911;ENST00000320285;ENST00000437165;ENST00000436279;ENST00000366905 | GO:0003841(1-acylglycerol-3-phosphate O-acyltransferase activity);GO:0005515(protein binding);GO:0005789(endoplasmic reticulum membrane);GO:0006644(phospholipid metabolic process);GO:0006654(phosphatidic acid biosynthetic process);GO:0008152(metabolic process);GO:0008654(phospholipid biosynthetic process);GO:0016021(integral component of membrane);GO:0016024(CDP-diacylglycerol biosynthetic process);GO:0016746(transferase activity, transferring acyl groups);GO:0019432(triglyceride biosynthetic process);GO:0044255(cellular lipid metabolic process);GO:0044281(small molecule metabolic process);GO:0046474(glycerophospholipid biosynthetic process) | 00561(Glycerolipid metabolism);00564(Glycerophospholipid metabolism);01100(Metabolic pathways) | NA | NA | 1-acylglycerol-3-phosphate O-acyltransferase 4 [Source:HGNC Symbol;Acc:HGNC:20885] | 0.43 | 0.44 | 0.45 | 0.23 | 0.21 | 0.23 |
| ENSG00000027644 | INSRR | ENST00000368195 | GO:0004672(protein kinase activity);GO:0004713(protein tyrosine kinase activity);GO:0004714(transmembrane receptor protein tyrosine kinase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005887(integral component of plasma membrane);GO:0006468(protein phosphorylation);GO:0007169(transmembrane receptor protein tyrosine kinase signaling pathway);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0018108(peptidyl-tyrosine phosphorylation);GO:0030238(male sex determination);GO:0031532(actin cytoskeleton reorganization);GO:0043235(receptor complex);GO:0043548(phosphatidylinositol 3-kinase binding);GO:0043560(insulin receptor substrate binding);GO:0046777(protein autophosphorylation);GO:0071469(cellular response to alkaline pH) | 04810(Regulation of actin cytoskeleton);05215(Prostate cancer) | NA | NA | insulin receptor-related receptor [Source:HGNC Symbol;Acc:HGNC:6093] | 0.01 | 0.02 | 0.02 | 0.01 | 0.01 | 0.01 |
| ENSG00000027869 | SH2D2A | ENST00000368198;ENST00000368199;ENST00000392306;ENST00000468744;ENST00000486350;ENST00000495306 | GO:0001525(angiogenesis);GO:0005070(SH3/SH2 adaptor activity);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0007165(signal transduction);GO:0008283(cell proliferation);GO:0009967(positive regulation of signal transduction);GO:0017124(SH3 domain binding);GO:0030154(cell differentiation);GO:0048010(vascular endothelial growth factor receptor signaling pathway) | 04370(VEGF signaling pathway) | NA | NA | SH2 domain containing 2A [Source:HGNC Symbol;Acc:HGNC:10821] | 0.49 | 0.44 | 0.44 | 0.59 | 0.50 | 0.65 |
| ENSG00000028277 | POU2F2 | ENST00000389341;ENST00000560558;ENST00000526816;ENST00000560804;ENST00000534559;ENST00000560398;ENST00000529952;ENST00000598842;ENST00000530982;ENST00000531773;ENST00000524801;ENST00000558596 | GO:0000978(RNA polymerase II core promoter proximal region sequence-specific DNA binding);GO:0001077(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription);GO:0002335(mature B cell differentiation);GO:0002380(immunoglobulin secretion involved in immune response);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0006366(transcription from RNA polymerase II promoter);GO:0006959(humoral immune response);GO:0019904(protein domain specific binding);GO:0043565(sequence-specific DNA binding);GO:0045893(positive regulation of transcription, DNA-templated);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048305(immunoglobulin secretion);GO:0048469(cell maturation) | NA | NA | NA | POU class 2 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:9213] | 0.27 | 0.27 | 0.28 | 0.21 | 0.17 | 0.22 |
| ENSG00000029534 | ANK1 | ENST00000289734;ENST00000314214;ENST00000265709;ENST00000524227 | GO:0005198(structural molecule activity);GO:0005200(structural constituent of cytoskeleton);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005829(cytosol);GO:0005856(cytoskeleton);GO:0005886(plasma membrane);GO:0006887(exocytosis);GO:0006888(ER to Golgi vesicle-mediated transport);GO:0007010(cytoskeleton organization);GO:0007165(signal transduction);GO:0007411(axon guidance);GO:0008093(cytoskeletal adaptor activity);GO:0010638(positive regulation of organelle organization);GO:0014731(spectrin-associated cytoskeleton);GO:0016323(basolateral plasma membrane);GO:0016529(sarcoplasmic reticulum);GO:0019899(enzyme binding);GO:0030018(Z disc);GO:0030507(spectrin binding);GO:0030673(axolemma);GO:0031430(M band);GO:0031672(A band);GO:0042383(sarcolemma);GO:0043005(neuron projection);GO:0045199(maintenance of epithelial cell apical/basal polarity);GO:0045211(postsynaptic membrane);GO:0051117(ATPase binding);GO:0072661(protein targeting to plasma membrane) | NA | NA | NA | ankyrin 1, erythrocytic [Source:HGNC Symbol;Acc:HGNC:492] | 0.03 | 0.04 | 0.04 | 0.06 | 0.05 | 0.06 |
| ENSG00000029559 | IBSP | ENST00000226284 | GO:0001503(ossification);GO:0001649(osteoblast differentiation);GO:0003674(molecular_function);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0007155(cell adhesion);GO:0016020(membrane);GO:0030198(extracellular matrix organization);GO:0031214(biomineral tissue development);GO:0031988(membrane-bounded vesicle);GO:0071363(cellular response to growth factor stimulus) | NA | NA | NA | integrin-binding sialoprotein [Source:HGNC Symbol;Acc:HGNC:5341] | 0 | 0 | 0 | 0 | 0.08 | 0 |
| ENSG00000030304 | MUSK | ENST00000416899 | GO:0001934(positive regulation of protein phosphorylation);GO:0004672(protein kinase activity);GO:0004713(protein tyrosine kinase activity);GO:0004714(transmembrane receptor protein tyrosine kinase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006355(regulation of transcription, DNA-templated);GO:0006468(protein phosphorylation);GO:0007169(transmembrane receptor protein tyrosine kinase signaling pathway);GO:0007275(multicellular organismal development);GO:0007528(neuromuscular junction development);GO:0007613(memory);GO:0008582(regulation of synaptic growth at neuromuscular junction);GO:0010628(positive regulation of gene expression);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0018108(peptidyl-tyrosine phosphorylation);GO:0030054(cell junction);GO:0030154(cell differentiation);GO:0030198(extracellular matrix organization);GO:0031594(neuromuscular junction);GO:0043113(receptor clustering);GO:0043235(receptor complex);GO:0043525(positive regulation of neuron apoptotic process);GO:0045202(synapse);GO:0045211(postsynaptic membrane);GO:0046777(protein autophosphorylation);GO:0071340(skeletal muscle acetylcholine-gated channel clustering);GO:2000541(positive regulation of protein geranylgeranylation) | NA | NA | NA | muscle, skeletal, receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7525] | 0.08 | 0.07 | 0.07 | 0.01 | 0.01 | 0.01 |
| ENSG00000030419 | IKZF2 | ENST00000451136;ENST00000434687;ENST00000484040;ENST00000374319;ENST00000412444;ENST00000439848;ENST00000431520;ENST00000452786;ENST00000442445 | GO:0003674(molecular_function);GO:0003676(nucleic acid binding);GO:0003677(DNA binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0006351(transcription, DNA-templated);GO:0008150(biological_process);GO:0042803(protein homodimerization activity);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046872(metal ion binding);GO:0046982(protein heterodimerization activity) | NA | NA | NA | IKAROS family zinc finger 2 (Helios) [Source:HGNC Symbol;Acc:HGNC:13177] | 0.31 | 0.33 | 0.32 | 0.30 | 0.24 | 0.29 |
| ENSG00000034053 | APBA2 | ENST00000558402;ENST00000559709;ENST00000560283;ENST00000382938 | GO:0001540(beta-amyloid binding);GO:0001701(in utero embryonic development);GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0007268(synaptic transmission);GO:0007399(nervous system development);GO:0007626(locomotory behavior);GO:0008021(synaptic vesicle);GO:0010468(regulation of gene expression);GO:0015031(protein transport);GO:0035264(multicellular organism growth) | NA | NA | NA | amyloid beta (A4) precursor protein-binding, family A, member 2 [Source:HGNC Symbol;Acc:HGNC:579] | 0.38 | 0.40 | 0.40 | 0.10 | 0.10 | 0.12 |
| ENSG00000034239 | EFCAB1 | ENST00000433756;ENST00000262103 | GO:0005509(calcium ion binding) | NA | NA | NA | EF-hand calcium binding domain 1 [Source:HGNC Symbol;Acc:HGNC:25678] | 0.06 | 0.06 | 0.06 | 0 | 0 | 0 |
| ENSG00000034971 | MYOC | ENST00000037502 | GO:0001649(osteoblast differentiation);GO:0001953(negative regulation of cell-matrix adhesion);GO:0001968(fibronectin binding);GO:0005109(frizzled binding);GO:0005515(protein binding);GO:0005578(proteinaceous extracellular matrix);GO:0005615(extracellular space);GO:0005741(mitochondrial outer membrane);GO:0005743(mitochondrial inner membrane);GO:0005758(mitochondrial intermembrane space);GO:0005783(endoplasmic reticulum);GO:0005791(rough endoplasmic reticulum);GO:0005794(Golgi apparatus);GO:0005929(cilium);GO:0014068(positive regulation of phosphatidylinositol 3-kinase signaling);GO:0014734(skeletal muscle hypertrophy);GO:0016023(cytoplasmic membrane-bounded vesicle);GO:0022011(myelination in peripheral nervous system);GO:0030335(positive regulation of cell migration);GO:0030971(receptor tyrosine kinase binding);GO:0031012(extracellular matrix);GO:0031175(neuron projection development);GO:0031410(cytoplasmic vesicle);GO:0032027(myosin light chain binding);GO:0033268(node of Ranvier);GO:0035024(negative regulation of Rho protein signal transduction);GO:0038031(non-canonical Wnt signaling pathway via JNK cascade);GO:0038133(ERBB2-ERBB3 signaling pathway);GO:0043408(regulation of MAPK cascade);GO:0045162(clustering of voltage-gated sodium channels);GO:0051496(positive regulation of stress fiber assembly);GO:0051497(negative regulation of stress fiber assembly);GO:0051894(positive regulation of focal adhesion assembly);GO:0051897(positive regulation of protein kinase B signaling);GO:0051901(positive regulation of mitochondrial depolarization);GO:0060348(bone development);GO:0070062(extracellular exosome);GO:1900026(positive regulation of substrate adhesion-dependent cell spreading) | NA | NA | NA | myocilin, trabecular meshwork inducible glucocorticoid response [Source:HGNC Symbol;Acc:HGNC:7610] | 0 | 0 | 0 | 0.01 | 0.01 | 0.01 |
| ENSG00000035664 | DAPK2 | ENST00000261891;ENST00000559007;ENST00000557867;ENST00000612884;ENST00000558076;ENST00000561162;ENST00000559306 | GO:0004672(protein kinase activity);GO:0004674(protein serine/threonine kinase activity);GO:0004683(calmodulin-dependent protein kinase activity);GO:0005515(protein binding);GO:0005516(calmodulin binding);GO:0005524(ATP binding);GO:0005737(cytoplasm);GO:0006468(protein phosphorylation);GO:0006915(apoptotic process);GO:0010506(regulation of autophagy);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0031410(cytoplasmic vesicle);GO:0034423(autophagosome lumen);GO:0035556(intracellular signal transduction);GO:0042802(identical protein binding);GO:0042981(regulation of apoptotic process);GO:0043276(anoikis);GO:0046777(protein autophosphorylation);GO:2001242(regulation of intrinsic apoptotic signaling pathway) | 05200(Pathways in cancer);05219(Bladder cancer) | NA | NA | death-associated protein kinase 2 [Source:HGNC Symbol;Acc:HGNC:2675] | 0.26 | 0.29 | 0.29 | 0.20 | 0.36 | 0.21 |
| ENSG00000035720 | STAP1 | ENST00000265404 | GO:0001784(phosphotyrosine binding);GO:0005068(transmembrane receptor protein tyrosine kinase adaptor activity);GO:0005070(SH3/SH2 adaptor activity);GO:0005515(protein binding);GO:0005543(phospholipid binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0007169(transmembrane receptor protein tyrosine kinase signaling pathway);GO:0010628(positive regulation of gene expression);GO:0010760(negative regulation of macrophage chemotaxis);GO:0019901(protein kinase binding);GO:0042326(negative regulation of phosphorylation);GO:0043234(protein complex);GO:0050861(positive regulation of B cell receptor signaling pathway);GO:0060100(positive regulation of phagocytosis, engulfment);GO:0071222(cellular response to lipopolysaccharide);GO:1900028(negative regulation of ruffle assembly);GO:1902227(negative regulation of macrophage colony-stimulating factor signaling pathway);GO:1903980(positive regulation of microglial cell activation);GO:1903997(positive regulation of non-membrane spanning protein tyrosine kinase activity);GO:1904151(positive regulation of microglial cell mediated cytotoxicity);GO:2000251(positive regulation of actin cytoskeleton reorganization) | NA | NA | NA | signal transducing adaptor family member 1 [Source:HGNC Symbol;Acc:HGNC:24133] | 0.16 | 0.12 | 0.11 | 0.26 | 0.23 | 0.28 |
| ENSG00000036448 | MYOM2 | ENST00000262113;ENST00000519518;ENST00000520072;ENST00000612167;ENST00000520298;ENST00000520779;ENST00000518513 | GO:0005515(protein binding);GO:0005739(mitochondrion);GO:0006936(muscle contraction);GO:0008307(structural constituent of muscle);GO:0031430(M band);GO:0032982(myosin filament) | NA | NA | NA | myomesin 2 [Source:HGNC Symbol;Acc:HGNC:7614] | 0.39 | 0.43 | 0.43 | 0.08 | 0.08 | 0.09 |
| ENSG00000036530 | CYP46A1 | ENST00000554611;ENST00000261835;ENST00000380228;ENST00000554176;ENST00000556313;ENST00000556822 | GO:0005506(iron ion binding);GO:0005783(endoplasmic reticulum);GO:0005789(endoplasmic reticulum membrane);GO:0006699(bile acid biosynthetic process);GO:0006707(cholesterol catabolic process);GO:0006805(xenobiotic metabolic process);GO:0007399(nervous system development);GO:0008206(bile acid metabolic process);GO:0008395(steroid hydroxylase activity);GO:0016021(integral component of membrane);GO:0016125(sterol metabolic process);GO:0016705(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen);GO:0020037(heme binding);GO:0033781(cholesterol 24-hydroxylase activity);GO:0044281(small molecule metabolic process);GO:0055114(oxidation-reduction process) | NA | NA | NA | cytochrome P450, family 46, subfamily A, polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:2641] | 0.09 | 0.09 | 0.09 | 0.07 | 0.04 | 0.06 |
Transcript expression profiling:
| t_id | class_code | chr | strand | start | end | t_name | num_exons | length | gene_id | gene_name | GO | KEGG | KO_ENTRY | EC | Description | cov.EM01_M | FPKM.EM01_M | cov.EM02_M | FPKM.EM02_M | cov.EM03_M | FPKM.EM03_M | cov.KTY01_K | FPKM.KTY01_K | cov.KTY02_K | FPKM.KTY02_K | cov.KTY03_K | FPKM.KTY03_K |
| 1 | "=" | chr1 | + | 11869 | 14409 | ENST00000456328 | 3 | 1657 | MSTRG.2 | DDX11L1 | NA | NA | NA | NA | NA | 0.38 | 0.06 | 0.38 | 0.07 | 0.38 | 0.07 | 0.17 | 0.02 | 0.24 | 0.03 | 0.17 | 0.03 |
| 2 | "=" | chr1 | + | 12010 | 13670 | ENST00000450305 | 6 | 632 | MSTRG.2 | DDX11L1 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.01 | 0.00 | 0 | 0 |
| 3 | "=" | chr1 | - | 14404 | 29570 | ENST00000488147 | 11 | 1351 | MSTRG.3 | WASH7P | NA | NA | NA | NA | NA | 15.53 | 2.28 | 12.93 | 2.43 | 13.07 | 2.43 | 13.54 | 1.97 | 13.30 | 1.87 | 11.16 | 1.88 |
| 4 | i | chr1 | - | 14592 | 14814 | MSTRG.4.1 | 1 | 223 | MSTRG.4 | WASH7P | NA | NA | NA | NA | NA | 9.91 | 1.46 | 7.90 | 1.49 | 7.90 | 1.47 | 1.20 | 0.17 | 1.41 | 0.20 | 1.14 | 0.19 |
| 5 | "=" | chr1 | - | 17369 | 17436 | ENST00000619216 | 1 | 68 | MSTRG.5 | MIR6859-1 | NA | NA | NA | NA | NA | 9.60 | 1.41 | 4.53 | 0.85 | 5.80 | 1.08 | 1.71 | 0.25 | 2.47 | 0.35 | 1.21 | 0.20 |
| 9 | "=" | chr1 | - | 34554 | 36081 | ENST00000417324 | 3 | 1187 | ENSG00000237613 | FAM138A | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 0.13 | 0.02 | 0.21 | 0.03 | 0.13 | 0.02 |
| 12 | "=" | chr1 | + | 62948 | 63887 | ENST00000492842 | 1 | 940 | ENSG00000240361 | OR4G11P | NA | NA | NA | NA | NA | 0.08 | 0.01 | 0.08 | 0.02 | 0.08 | 0.01 | 0 | 0 | 0 | 0 | 0 | 0 |
| 13 | "=" | chr1 | + | 69091 | 70008 | ENST00000335137 | 1 | 918 | ENSG00000186092 | OR4F5 | GO:0004888(transmembrane signaling receptor activity);GO:0004930(G-protein coupled receptor activity);GO:0004984(olfactory receptor activity);GO:0005886(plasma membrane);GO:0007186(G-protein coupled receptor signaling pathway);GO:0016021(integral component of membrane);GO:0050907(detection of chemical stimulus involved in sensory perception);GO:0050911(detection of chemical stimulus involved in sensory perception of smell) | NA | NA | NA | olfactory receptor, family 4, subfamily F, member 5 [Source:HGNC Symbol;Acc:HGNC:14825] | 0 | 0 | 0 | 0 | 0 | 0 | 0.16 | 0.02 | 0.16 | 0.02 | 0.16 | 0.03 |
| 14 | "=" | chr1 | - | 89295 | 120932 | ENST00000466430 | 4 | 2748 | ENSG00000238009 | RP11-34P13.7 | NA | NA | NA | NA | NA | 4.34 | 0.64 | 3.59 | 0.68 | 3.59 | 0.67 | 5.19 | 0.75 | 4.53 | 0.64 | 4.53 | 0.76 |
| 15 | "=" | chr1 | - | 89551 | 91105 | ENST00000495576 | 2 | 1319 | ENSG00000239945 | RP11-34P13.8 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 1.04 | 0.15 | 0 | 0 | 0 | 0 |
| 17 | "=" | chr1 | - | 110953 | 129173 | ENST00000471248 | 3 | 629 | ENSG00000238009 | RP11-34P13.7 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 0.12 | 0.02 | 0.12 | 0.02 | 0.12 | 0.02 |
| 18 | "=" | chr1 | - | 120725 | 133723 | ENST00000610542 | 3 | 727 | ENSG00000238009 | RP11-34P13.7 | NA | NA | NA | NA | NA | 0.15 | 0.02 | 0.15 | 0.03 | 0.15 | 0.03 | 0 | 0 | 0.11 | 0.02 | 0.11 | 0.02 |
| 19 | "=" | chr1 | - | 129081 | 133566 | ENST00000453576 | 2 | 336 | ENSG00000238009 | RP11-34P13.7 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 0.18 | 0.03 | 0 | 0 | 0 | 0 |
| 20 | "=" | chr1 | + | 131025 | 134836 | ENST00000442987 | 1 | 3812 | ENSG00000233750 | CICP27 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 3.22 | 0.47 | 0 | 0 | 2.83 | 0.48 |
| 21 | "=" | chr1 | - | 135141 | 135895 | ENST00000494149 | 1 | 755 | ENSG00000268903 | RP11-34P13.15 | NA | NA | NA | NA | NA | 4.50 | 0.66 | 2.99 | 0.56 | 3.13 | 0.58 | 0 | 0 | 0 | 0 | 0 | 0 |
| 23 | "=" | chr1 | - | 139790 | 140339 | ENST00000493797 | 2 | 323 | MSTRG.1 | RP11-34P13.14 | NA | NA | NA | NA | NA | 6.71 | 0.99 | 6.59 | 1.24 | 6.61 | 1.23 | 5.29 | 0.77 | 4.94 | 0.69 | 5.06 | 0.85 |
| 24 | "=" | chr1 | - | 141474 | 149707 | ENST00000484859 | 2 | 4860 | MSTRG.7 | RP11-34P13.13 | NA | NA | NA | NA | NA | 3.19 | 0.47 | 2.46 | 0.46 | 2.52 | 0.47 | 4.92 | 0.71 | 4.89 | 0.69 | 4.62 | 0.78 |
| 25 | "=" | chr1 | - | 142808 | 146831 | ENST00000490997 | 3 | 518 | MSTRG.7 | RP11-34P13.13 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 1.27 | 0.18 | 0.80 | 0.11 | 0.76 | 0.13 |
| 26 | "=" | chr1 | - | 146386 | 173862 | ENST00000466557 | 8 | 1301 | MSTRG.7 | RP11-34P13.13 | NA | NA | NA | NA | NA | 10.51 | 1.54 | 8.09 | 1.52 | 8.11 | 1.51 | 13.51 | 1.96 | 10.73 | 1.50 | 10.81 | 1.82 |
| 28 | "=" | chr1 | + | 160446 | 161525 | ENST00000496488 | 2 | 457 | MSTRG.9 | RP11-34P13.9 | NA | NA | NA | NA | NA | 1.14 | 0.17 | 1.14 | 0.22 | 1.14 | 0.21 | 3.02 | 0.44 | 3.02 | 0.42 | 3.02 | 0.51 |
| 29 | "=" | chr1 | - | 165889 | 168767 | ENST00000491962 | 3 | 278 | MSTRG.7 | RP11-34P13.13 | NA | NA | NA | NA | NA | 0.36 | 0.05 | 0.74 | 0.14 | 0.74 | 0.14 | 0.03 | 0.00 | 0.01 | 0.00 | 0.03 | 0.00 |
| 30 | "=" | chr1 | + | 182393 | 184158 | ENST00000624431 | 3 | 718 | ENSG00000279928 | FO538757.3 | NA | NA | NA | NA | Protein LOC102725121 [Source:UniProtKB/TrEMBL;Acc:A0A096LP88] | 0.42 | 0.06 | 0.42 | 0.08 | 0.42 | 0.08 | 0.05 | 0.01 | 0.05 | 0.01 | 0.05 | 0.01 |
| 31 | j | chr1 | - | 184878 | 188023 | MSTRG.10.1 | 7 | 1186 | MSTRG.10 | FO538757.2 | NA | NA | NA | NA | NA | 12.69 | 1.87 | 0 | 0 | 0 | 0 | 17.40 | 2.53 | 0.41 | 0.06 | 13.40 | 2.26 |
| 32 | "=" | chr1 | - | 184923 | 195411 | ENST00000623834 | 9 | 1376 | MSTRG.10 | FO538757.2 | GO:0003779(actin binding);GO:0005769(early endosome);GO:0034314(Arp2/3 complex-mediated actin nucleation);GO:0043014(alpha-tubulin binding);GO:0071203(WASH complex) | NA | NA | NA | Uncharacterized protein [Source:UniProtKB/TrEMBL;Acc:A0A096LP26] | 0.09 | 0.01 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 33 | "=" | chr1 | - | 184925 | 195411 | ENST00000623083 | 10 | 1689 | MSTRG.10 | FO538757.2 | GO:0003779(actin binding);GO:0005769(early endosome);GO:0034314(Arp2/3 complex-mediated actin nucleation);GO:0043014(alpha-tubulin binding);GO:0071203(WASH complex) | NA | NA | NA | Uncharacterized protein [Source:UniProtKB/TrEMBL;Acc:A0A096LP26] | 8.98 | 1.32 | 12.66 | 2.38 | 12.87 | 2.39 | 6.58 | 0.96 | 8.80 | 1.23 | 6.26 | 1.06 |
| 34 | "=" | chr1 | - | 184927 | 200322 | ENST00000624735 | 13 | 1608 | MSTRG.10 | FO538757.2 | GO:0003779(actin binding);GO:0005769(early endosome);GO:0034314(Arp2/3 complex-mediated actin nucleation);GO:0043014(alpha-tubulin binding);GO:0071203(WASH complex) | NA | NA | NA | Uncharacterized protein [Source:UniProtKB/TrEMBL;Acc:A0A096LP26] | 2.19 | 0.32 | 2.58 | 0.49 | 2.57 | 0.48 | 0.70 | 0.10 | 4.43 | 0.62 | 0.62 | 0.11 |
| 35 | "=" | chr1 | - | 187891 | 187958 | ENST00000612080 | 1 | 68 | MSTRG.10 | MIR6859-2 | NA | NA | NA | NA | NA | 1.09 | 0.16 | 1.00 | 0.19 | 1.00 | 0.19 | 0 | 0 | 0 | 0 | 0 | 0 |
| 37 | "=" | chr1 | - | 257864 | 264733 | ENST00000442116 | 2 | 1292 | ENSG00000228463 | AP006222.2 | NA | NA | NA | NA | NA | 1.76 | 0.26 | 1.49 | 0.28 | 1.50 | 0.28 | 0 | 0 | 0.29 | 0.04 | 0 | 0 |
| 40 | "=" | chr1 | - | 266361 | 297502 | ENST00000424587 | 4 | 2257 | ENSG00000228463 | AP006222.2 | NA | NA | NA | NA | NA | 1.18 | 0.17 | 0.80 | 0.15 | 0.80 | 0.15 | 0.75 | 0.11 | 0.71 | 0.10 | 0.58 | 0.10 |
| 41 | "=" | chr1 | - | 287517 | 289370 | ENST00000335577 | 2 | 510 | ENSG00000228463 | AP006222.2 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 0.15 | 0.02 | 0.15 | 0.02 | 0.15 | 0.02 |
| 42 | "=" | chr1 | - | 347982 | 348366 | ENST00000458203 | 1 | 385 | ENSG00000236679 | RPL23AP24 | NA | NA | NA | NA | NA | 0.28 | 0.04 | 0.18 | 0.03 | 0.15 | 0.03 | 0.62 | 0.09 | 0.87 | 0.12 | 0.66 | 0.11 |
| 43 | "=" | chr1 | - | 357383 | 359681 | ENST00000441866 | 3 | 676 | MSTRG.12 | RP5-857K21.15 | NA | NA | NA | NA | NA | 0.07 | 0.01 | 0.07 | 0.01 | 0.07 | 0.01 | 0.26 | 0.04 | 0.15 | 0.02 | 0.15 | 0.02 |
| 48 | "=" | chr1 | - | 365615 | 379972 | ENST00000440163 | 3 | 462 | MSTRG.14 | RP4-669L17.10 | NA | NA | NA | NA | NA | 0.55 | 0.08 | 0.55 | 0.10 | 0.55 | 0.10 | 0 | 0 | 0 | 0 | 0 | 0 |
| 49 | "=" | chr1 | - | 373182 | 485208 | ENST00000455207 | 3 | 413 | MSTRG.14 | RP4-669L17.10 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| 50 | "=" | chr1 | + | 439870 | 440232 | ENST00000437905 | 1 | 363 | MSTRG.15 | WBP1LP7 | NA | NA | NA | NA | NA | 0.14 | 0.02 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 52 | "=" | chr1 | - | 476531 | 497259 | ENST00000455464 | 3 | 735 | MSTRG.14 | RP4-669L17.10 | NA | NA | NA | NA | NA | 2.96 | 0.43 | 3.15 | 0.59 | 3.18 | 0.59 | 2.63 | 0.38 | 0.98 | 0.14 | 2.07 | 0.35 |
| 53 | "=" | chr1 | - | 476738 | 489710 | ENST00000613471 | 3 | 727 | MSTRG.14 | RP4-669L17.10 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.54 | 0.08 | 0 | 0 |
| 54 | "=" | chr1 | - | 484832 | 495476 | ENST00000601814 | 3 | 635 | MSTRG.14 | RP4-669L17.10 | NA | NA | NA | NA | NA | 6.04 | 0.89 | 5.59 | 1.05 | 5.59 | 1.04 | 2.99 | 0.43 | 4.36 | 0.61 | 3.08 | 0.52 |
| 57 | "=" | chr1 | + | 487101 | 489906 | ENST00000432723 | 2 | 2477 | MSTRG.17 | CICP7 | NA | NA | NA | NA | NA | 0.46 | 0.07 | 0.35 | 0.07 | 0.37 | 0.07 | 1.11 | 0.16 | 1.14 | 0.16 | 1.01 | 0.17 |
| 58 | "=" | chr1 | - | 491225 | 493241 | ENST00000514436 | 2 | 1239 | MSTRG.18 | RP4-669L17.8 | NA | NA | NA | NA | NA | 2.26 | 0.33 | 1.42 | 0.27 | 1.49 | 0.28 | 3.96 | 0.58 | 4.78 | 0.67 | 3.80 | 0.64 |
| 59 | "=" | chr1 | - | 494382 | 496665 | ENST00000419160 | 2 | 607 | MSTRG.14 | RP4-669L17.10 | NA | NA | NA | NA | NA | 9.36 | 1.38 | 7.88 | 1.48 | 7.88 | 1.46 | 9.95 | 1.45 | 9.15 | 1.28 | 8.75 | 1.48 |
| 60 | "=" | chr1 | - | 494464 | 501617 | ENST00000440038 | 4 | 746 | MSTRG.14 | RP4-669L17.10 | NA | NA | NA | NA | NA | 3.24 | 0.48 | 1.66 | 0.31 | 1.66 | 0.31 | 0.81 | 0.12 | 0.72 | 0.10 | 0.81 | 0.14 |
| 61 | "=" | chr1 | - | 494876 | 499175 | ENST00000423728 | 3 | 573 | MSTRG.14 | RP4-669L17.10 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 19.85 | 2.88 | 5.35 | 0.75 | 0.23 | 0.04 |
| 62 | "=" | chr1 | - | 497134 | 498456 | ENST00000599771 | 3 | 457 | MSTRG.14 | RP4-669L17.10 | NA | NA | NA | NA | NA | 11.29 | 1.66 | 8.53 | 1.61 | 8.68 | 1.61 | 8.05 | 1.17 | 7.38 | 1.03 | 6.53 | 1.10 |
| 63 | "=" | chr1 | - | 497240 | 499002 | ENST00000601486 | 4 | 696 | MSTRG.14 | RP4-669L17.10 | NA | NA | NA | NA | NA | 1.37 | 0.20 | 2.21 | 0.42 | 2.12 | 0.39 | 0.03 | 0.00 | 0 | 0 | 0 | 0 |
| 64 | "=" | chr1 | - | 497275 | 498976 | ENST00000616947 | 2 | 603 | MSTRG.14 | RP4-669L17.10 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 6.31 | 0.92 | 0.11 | 0.02 | 0.10 | 0.02 |
| 69 | "=" | chr1 | - | 585989 | 588453 | ENST00000417636 | 3 | 842 | ENSG00000231709 | RP5-857K21.1 | NA | NA | NA | NA | NA | 0.06 | 0.01 | 0.06 | 0.01 | 0.06 | 0.01 | 0.21 | 0.03 | 0.12 | 0.02 | 0.12 | 0.02 |
| 74 | "=" | chr1 | - | 601436 | 720200 | ENST00000440200 | 3 | 413 | ENSG00000230021 | RP5-857K21.4 | NA | NA | NA | NA | NA | 0.99 | 0.15 | 0.99 | 0.19 | 0.99 | 0.18 | 0 | 0 | 0 | 0 | 0 | 0 |
| 75 | "=" | chr1 | - | 627377 | 629010 | ENST00000452176 | 3 | 802 | ENSG00000223659 | RP5-857K21.5 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.11 | 0.02 | 0 | 0 |
| 85 | "=" | chr1 | + | 674842 | 675265 | ENST00000438434 | 1 | 424 | ENSG00000268663 | WBP1LP6 | NA | NA | NA | NA | NA | 0.12 | 0.02 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 87 | "=" | chr1 | - | 701936 | 720150 | ENST00000441245 | 3 | 629 | ENSG00000230021 | RP5-857K21.4 | NA | NA | NA | NA | NA | 0.91 | 0.13 | 0.90 | 0.17 | 0.90 | 0.17 | 0.17 | 0.03 | 0.14 | 0.02 | 0.14 | 0.02 |
| 89 | "=" | chr1 | - | 711342 | 720200 | ENST00000414688 | 2 | 750 | ENSG00000230021 | RP5-857K21.4 | NA | NA | NA | NA | NA | 1.55 | 0.23 | 1.51 | 0.28 | 1.51 | 0.28 | 4.54 | 0.66 | 3.77 | 0.53 | 3.87 | 0.65 |
| 92 | "=" | chr1 | + | 722092 | 724903 | ENST00000440782 | 2 | 2455 | ENSG00000229376 | CICP3 | NA | NA | NA | NA | NA | 1.11 | 0.16 | 0.87 | 0.16 | 0.86 | 0.16 | 0.89 | 0.13 | 1.41 | 0.20 | 0.80 | 0.14 |
| 93 | "=" | chr1 | - | 726231 | 728147 | ENST00000506640 | 2 | 1236 | ENSG00000224956 | RP11-206L10.1 | NA | NA | NA | NA | NA | 2.67 | 0.39 | 2.12 | 0.40 | 2.12 | 0.39 | 3.36 | 0.49 | 3.79 | 0.53 | 2.97 | 0.50 |
| 94 | "=" | chr1 | - | 741813 | 750016 | ENST00000416385 | 2 | 4860 | MSTRG.11 | RP11-206L10.3 | NA | NA | NA | NA | NA | 9.91 | 1.46 | 2.00 | 0.38 | 2.06 | 0.38 | 9.08 | 1.32 | 7.40 | 1.04 | 7.61 | 1.28 |
| 96 | "=" | chr1 | - | 759032 | 764925 | ENST00000417659 | 2 | 295 | MSTRG.19 | RP11-206L10.5 | NA | NA | NA | NA | NA | 4.49 | 0.66 | 3.76 | 0.71 | 3.70 | 0.69 | 4.38 | 0.64 | 4.57 | 0.64 | 4.23 | 0.71 |
| 97 | "=" | chr1 | + | 760911 | 761989 | ENST00000422528 | 2 | 456 | MSTRG.20 | RP11-206L10.4 | NA | NA | NA | NA | NA | 0.99 | 0.15 | 0.99 | 0.19 | 0.99 | 0.18 | 3.85 | 0.56 | 3.85 | 0.54 | 2.81 | 0.47 |
| 98 | "=" | chr1 | - | 764857 | 778626 | ENST00000428504 | 7 | 1317 | MSTRG.19 | RP11-206L10.2 | NA | NA | NA | NA | NA | 16.59 | 2.44 | 12.35 | 2.32 | 12.32 | 2.29 | 17.69 | 2.57 | 17.21 | 2.41 | 16.08 | 2.71 |
| 99 | "=" | chr1 | + | 778770 | 784690 | ENST00000434264 | 3 | 844 | MSTRG.21 | RP11-206L10.9 | NA | NA | NA | NA | NA | 2.14 | 0.32 | 2.28 | 0.43 | 2.28 | 0.42 | 0.54 | 0.08 | 0.60 | 0.08 | 0.49 | 0.08 |
| 100 | "=" | chr1 | + | 778782 | 782191 | ENST00000457084 | 2 | 566 | MSTRG.21 | RP11-206L10.9 | NA | NA | NA | NA | NA | 2.45 | 0.36 | 1.81 | 0.34 | 1.81 | 0.34 | 11.29 | 1.64 | 10.71 | 1.50 | 10.45 | 1.76 |
| 101 | "=" | chr1 | + | 778930 | 784655 | ENST00000589899 | 4 | 809 | MSTRG.21 | RP11-206L10.9 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 5.03 | 0.73 | 4.62 | 0.65 | 4.59 | 0.77 |
| 102 | "=" | chr1 | + | 778937 | 784429 | ENST00000609830 | 4 | 669 | MSTRG.21 | RP11-206L10.9 | NA | NA | NA | NA | NA | 2.20 | 0.32 | 1.69 | 0.32 | 1.69 | 0.31 | 0 | 0 | 0 | 0 | 0 | 0 |
| 104 | c | chr1 | + | 784370 | 784759 | ENST00000585826 | 1 | 390 | MSTRG.21 | RP11-206L10.9 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.66 | 0.23 | 0 | 0 |
| 105 | "=" | chr1 | + | 784370 | 784977 | ENST00000592547 | 1 | 608 | MSTRG.21 | RP11-206L10.9 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.06 | 0.15 | 4.15 | 0.70 |
| 108 | "=" | chr1 | + | 784370 | 801876 | ENST00000585768 | 2 | 394 | MSTRG.21 | RP11-206L10.9 | NA | NA | NA | NA | NA | 1.51 | 0.22 | 0.72 | 0.13 | 0.72 | 0.13 | 0.38 | 0.06 | 1.09 | 0.15 | 0.38 | 0.06 |
| 109 | "=" | chr1 | + | 784370 | 804832 | ENST00000590848 | 5 | 726 | MSTRG.21 | RP11-206L10.9 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.21 | 0.45 | 0 | 0 |
| 111 | "=" | chr1 | + | 784370 | 805270 | ENST00000587530 | 4 | 1024 | MSTRG.21 | RP11-206L10.9 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 0.59 | 0.09 | 0 | 0 | 0 | 0 |
| 112 | "=" | chr1 | + | 784370 | 806459 | ENST00000593022 | 4 | 693 | MSTRG.21 | RP11-206L10.9 | NA | NA | NA | NA | NA | 0.02 | 0.00 | 0.02 | 0.00 | 0.02 | 0.00 | 0 | 0 | 0 | 0 | 0 | 0 |
| 114 | "=" | chr1 | + | 784370 | 809729 | ENST00000588951 | 4 | 607 | MSTRG.21 | RP11-206L10.9 | NA | NA | NA | NA | NA | 1.23 | 0.18 | 0.80 | 0.15 | 0.80 | 0.15 | 0 | 0 | 0 | 0 | 0 | 0 |
| 115 | "=" | chr1 | + | 784396 | 807321 | ENST00000586288 | 7 | 1040 | MSTRG.21 | RP11-206L10.9 | NA | NA | NA | NA | NA | 2.16 | 0.32 | 1.86 | 0.35 | 1.86 | 0.34 | 3.75 | 0.54 | 0.67 | 0.09 | 3.86 | 0.65 |
| 117 | "=" | chr1 | - | 800879 | 817712 | ENST00000447500 | 5 | 872 | MSTRG.22 | RP11-206L10.8 | NA | NA | NA | NA | NA | 1.89 | 0.28 | 1.47 | 0.28 | 1.47 | 0.27 | 1.85 | 0.27 | 1.03 | 0.14 | 0.97 | 0.16 |
| 118 | "=" | chr1 | + | 804799 | 807465 | ENST00000443772 | 2 | 417 | MSTRG.21 | RP11-206L10.9 | NA | NA | NA | NA | NA | 4.09 | 0.60 | 3.46 | 0.65 | 3.46 | 0.64 | 0 | 0 | 0 | 0 | 0 | 0 |
| 119 | "=" | chr1 | + | 804932 | 810060 | ENST00000412115 | 3 | 581 | MSTRG.21 | RP11-206L10.9 | NA | NA | NA | NA | NA | 0.10 | 0.01 | 0.11 | 0.02 | 0.11 | 0.02 | 7.11 | 1.03 | 5.82 | 0.82 | 5.82 | 0.98 |
| 120 | "=" | chr1 | - | 805799 | 810161 | ENST00000590817 | 3 | 238 | MSTRG.22 | RP11-206L10.8 | NA | NA | NA | NA | NA | 2.67 | 0.39 | 2.26 | 0.42 | 2.26 | 0.42 | 4.57 | 0.66 | 4.47 | 0.63 | 3.62 | 0.61 |
| 121 | i | chr1 | - | 814689 | 814989 | MSTRG.23.1 | 1 | 301 | MSTRG.23 | RP11-206L10.8 | NA | NA | NA | NA | NA | 1.40 | 0.21 | 7.81 | 1.47 | 7.81 | 1.45 | 4.41 | 0.64 | 4.90 | 0.69 | 4.41 | 0.74 |
| 122 | "=" | chr1 | + | 817371 | 819837 | ENST00000326734 | 2 | 1947 | MSTRG.24 | FAM87B | NA | NA | NA | NA | NA | 2.82 | 0.42 | 1.91 | 0.36 | 1.99 | 0.37 | 1.27 | 0.18 | 1.43 | 0.20 | 1.04 | 0.18 |
| 123 | "=" | chr1 | + | 825138 | 849592 | ENST00000624927 | 3 | 677 | MSTRG.25 | LINC01128 | NA | NA | NA | NA | NA | 3.21 | 0.47 | 2.99 | 0.56 | 2.99 | 0.55 | 3.40 | 0.49 | 5.00 | 0.70 | 3.97 | 0.67 |
| 126 | "=" | chr1 | + | 827608 | 859446 | ENST00000445118 | 5 | 6606 | MSTRG.25 | LINC01128 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 2.43 | 0.35 | 4.55 | 0.64 | 4.21 | 0.71 |
| 128 | "=" | chr1 | + | 827661 | 851987 | ENST00000610067 | 5 | 550 | MSTRG.25 | LINC01128 | NA | NA | NA | NA | NA | 1.35 | 0.20 | 1.04 | 0.20 | 1.19 | 0.22 | 0 | 0 | 0 | 0 | 0 | 0 |
| 129 | "=" | chr1 | + | 827661 | 852090 | ENST00000608189 | 6 | 824 | MSTRG.25 | LINC01128 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 0 | 0 | 1.89 | 0.27 | 0 | 0 | 1.29 | 0.22 |
| 130 | "=" | chr1 | + | 827667 | 841738 | ENST00000441765 | 3 | 750 | MSTRG.25 | LINC01128 | NA | NA | NA | NA | NA | 7.78 | 1.14 | 5.12 | 0.96 | 5.12 | 0.95 | 0 | 0 | 0 | 0 | 0 | 0 |
| 132 | "=" | chr1 | + | 827673 | 853626 | ENST00000449005 | 6 | 874 | MSTRG.25 | LINC01128 | NA | NA | NA | NA | NA | 10.62 | 1.56 | 8.15 | 1.53 | 8.17 | 1.52 | 5.61 | 0.81 | 1.86 | 0.26 | 2.76 | 0.46 |
| 133 | "=" | chr1 | + | 827699 | 852766 | ENST00000416570 | 5 | 612 | MSTRG.25 | LINC01128 | NA | NA | NA | NA | NA | 6.71 | 0.99 | 3.70 | 0.70 | 3.70 | 0.69 | 0 | 0 | 0.88 | 0.12 | 0 | 0 |
| 134 | "=" | chr1 | + | 827700 | 853522 | ENST00000623070 | 4 | 494 | MSTRG.25 | LINC01128 | NA | NA | NA | NA | NA | 0.41 | 0.06 | 0.43 | 0.08 | 0.44 | 0.08 | 0 | 0 | 0 | 0 | 0 | 0 |
| 135 | "=" | chr1 | + | 827721 | 852090 | ENST00000609009 | 6 | 767 | MSTRG.25 | LINC01128 | NA | NA | NA | NA | NA | 3.29 | 0.48 | 2.68 | 0.50 | 2.71 | 0.50 | 1.12 | 0.16 | 1.24 | 0.17 | 1.14 | 0.19 |
| 136 | "=" | chr1 | + | 827821 | 852515 | ENST00000622921 | 3 | 724 | MSTRG.25 | LINC01128 | NA | NA | NA | NA | NA | 2.18 | 0.32 | 1.41 | 0.27 | 1.47 | 0.27 | 0.52 | 0.08 | 0.51 | 0.07 | 0.60 | 0.10 |
| 137 | i | chr1 | + | 829231 | 830430 | MSTRG.27.1 | 1 | 1200 | MSTRG.27 | LINC01128 | NA | NA | NA | NA | NA | 0 | 0 | 9.20 | 1.73 | 9.20 | 1.71 | 0 | 0 | 0 | 0 | 0 | 0 |
| 138 | "=" | chr1 | + | 831605 | 842020 | ENST00000415295 | 2 | 894 | MSTRG.25 | LINC01128 | NA | NA | NA | NA | NA | 0.46 | 0.07 | 0.35 | 0.07 | 0.35 | 0.06 | 5.05 | 0.73 | 5.05 | 0.71 | 5.05 | 0.85 |
| 139 | "=" | chr1 | + | 851348 | 852752 | ENST00000425657 | 2 | 845 | MSTRG.25 | LINC01128 | NA | NA | NA | NA | NA | 5.15 | 0.76 | 3.93 | 0.74 | 3.93 | 0.73 | 1.91 | 0.28 | 1.41 | 0.20 | 1.77 | 0.30 |
| 140 | "=" | chr1 | - | 868071 | 876903 | ENST00000446136 | 3 | 1807 | MSTRG.28 | FAM41C | NA | NA | NA | NA | NA | 3.21 | 0.47 | 2.79 | 0.53 | 2.96 | 0.55 | 4.46 | 0.65 | 4.67 | 0.65 | 3.64 | 0.61 |
| 145 | "=" | chr1 | + | 911435 | 914948 | ENST00000448179 | 2 | 3043 | ENSG00000230699 | RP11-54O7.1 | NA | NA | NA | NA | NA | 2.98 | 0.44 | 2.58 | 0.49 | 2.58 | 0.48 | 3.23 | 0.47 | 2.93 | 0.41 | 3.23 | 0.54 |
| 147 | "=" | chr1 | - | 916865 | 921016 | ENST00000609207 | 1 | 4152 | ENSG00000223764 | RP11-54O7.3 | NA | NA | NA | NA | NA | 0.65 | 0.10 | 0.47 | 0.09 | 0.54 | 0.10 | 0 | 0 | 0 | 0 | 0 | 0 |
| 150 | "=" | chr1 | + | 924880 | 939291 | ENST00000420190 | 7 | 626 | MSTRG.33 | SAMD11 | GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0003713(transcription coactivator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0032093(SAM domain binding);GO:0042731(PH domain binding);GO:0043621(protein self-association);GO:1903506(regulation of nucleic acid-templated transcription) | NA | NA | NA | sterile alpha motif domain containing 11 [Source:HGNC Symbol;Acc:HGNC:28706] | 2.57 | 0.38 | 2.58 | 0.49 | 2.58 | 0.48 | 0 | 0 | 0 | 0 | 0 | 0 |
| 151 | "=" | chr1 | + | 925150 | 935793 | ENST00000437963 | 5 | 387 | MSTRG.33 | SAMD11 | GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0003713(transcription coactivator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0032093(SAM domain binding);GO:0042731(PH domain binding);GO:0043621(protein self-association);GO:1903506(regulation of nucleic acid-templated transcription) | NA | NA | NA | sterile alpha motif domain containing 11 [Source:HGNC Symbol;Acc:HGNC:28706] | 0.13 | 0.02 | 0.13 | 0.03 | 0.13 | 0.02 | 0 | 0 | 0 | 0 | 0 | 0 |
| 160 | "=" | chr1 | + | 925741 | 944581 | ENST00000622503 | 14 | 2557 | MSTRG.33 | SAMD11 | GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0003713(transcription coactivator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0032093(SAM domain binding);GO:0042731(PH domain binding);GO:0043621(protein self-association);GO:1903506(regulation of nucleic acid-templated transcription) | NA | NA | NA | sterile alpha motif domain containing 11 [Source:HGNC Symbol;Acc:HGNC:28706] | 0.30 | 0.04 | 0.33 | 0.06 | 0.33 | 0.06 | 0.33 | 0.05 | 0.51 | 0.07 | 0.31 | 0.05 |
| 161 | "=" | chr1 | + | 930312 | 944575 | ENST00000341065 | 12 | 2191 | MSTRG.33 | SAMD11 | GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0003713(transcription coactivator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0032093(SAM domain binding);GO:0042731(PH domain binding);GO:0043621(protein self-association);GO:1903506(regulation of nucleic acid-templated transcription) | NA | NA | NA | sterile alpha motif domain containing 11 [Source:HGNC Symbol;Acc:HGNC:28706] | 8.31 | 1.22 | 5.94 | 1.12 | 5.94 | 1.10 | 0 | 0 | 0 | 0 | 0 | 0 |
| 162 | "=" | chr1 | + | 939275 | 944259 | ENST00000455979 | 7 | 1731 | MSTRG.33 | SAMD11 | GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0003713(transcription coactivator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0032093(SAM domain binding);GO:0042731(PH domain binding);GO:0043621(protein self-association);GO:1903506(regulation of nucleic acid-templated transcription) | NA | NA | NA | sterile alpha motif domain containing 11 [Source:HGNC Symbol;Acc:HGNC:28706] | 3.49 | 0.51 | 3.62 | 0.68 | 3.62 | 0.67 | 0 | 0 | 0 | 0 | 0 | 0 |
| 164 | "=" | chr1 | + | 941076 | 942994 | ENST00000474461 | 4 | 862 | MSTRG.33 | SAMD11 | GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0003713(transcription coactivator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0032093(SAM domain binding);GO:0042731(PH domain binding);GO:0043621(protein self-association);GO:1903506(regulation of nucleic acid-templated transcription) | NA | NA | NA | sterile alpha motif domain containing 11 [Source:HGNC Symbol;Acc:HGNC:28706] | 0.53 | 0.08 | 0.33 | 0.06 | 0.33 | 0.06 | 0 | 0 | 0 | 0 | 0 | 0 |
| 165 | "=" | chr1 | + | 942103 | 942802 | ENST00000466827 | 2 | 542 | MSTRG.33 | SAMD11 | GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0003713(transcription coactivator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0032093(SAM domain binding);GO:0042731(PH domain binding);GO:0043621(protein self-association);GO:1903506(regulation of nucleic acid-templated transcription) | NA | NA | NA | sterile alpha motif domain containing 11 [Source:HGNC Symbol;Acc:HGNC:28706] | 0 | 0 | 0 | 0 | 0 | 0 | 0.32 | 0.05 | 0 | 0 | 0 | 0 |
document location:
summary/3_1_transcript_expression/4_genes_fpkm_expression.xlsx
summary/3_1_transcript_expression/5_isoforms_fpkm_expression.xlsx
Class code typies and definitions:
| class code | Description |
|---|---|
| =/0 | Complete match (mRNA, lncRNA etc) |
| c | Contained |
| j | Potentially novel isoform (fragment): at least one splice junction is hared with a reference transcript |
| e | Single exon transfrag overlapping a reference exon and at least 10 bp of a reference intron, indicating a possible pre-mRNA fragment. |
| i | A transfrag falling entirely within a reference intron |
| o | Generic exonic overlap with a reference transcript |
| p | Possible polymerase run-on fragment (within 2Kbases of a reference transcript) |
| r | Repeat. Currently determined by looking at the soft-masked reference sequence and applied to transcripts where at least 50% of the are lower casebases |
| u | Unknown, intergenic transcript |
| x | Exonic overlap with reference on the opposite strand |
| s | An intron of the transfrag overlaps a reference intron on the opposite strand (likely due to read mapping errors) |
| . | (.tracking file only, indicates multiple classifications) |
Differentially expressed genes:
| gene_id | gene_name | transcript_id | GO | KEGG | KO_ENTRY | EC | Description | FPKM.KTY01_K | FPKM.KTY02_K | FPKM.KTY03_K | FPKM.EM01_M | FPKM.EM02_M | FPKM.EM03_M | fc | log2(fc) | pval | qval | regulation | significant |
| ENSG00000042088 | TDP1 | ENST00000555880 | GO:0000012(single strand break repair);GO:0003690(double-stranded DNA binding);GO:0003697(single-stranded DNA binding);GO:0004527(exonuclease activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006281(DNA repair);GO:0006302(double-strand break repair);GO:0008081(phosphoric diester hydrolase activity);GO:0017005(3'-tyrosyl-DNA phosphodiesterase activity);GO:0090305(nucleic acid phosphodiester bond hydrolysis) | NA | NA | NA | tyrosyl-DNA phosphodiesterase 1 [Source:HGNC Symbol;Acc:HGNC:18884] | 1.65 | 2.00 | 1.97 | 0.54 | 0.56 | 0.57 | 2.87 | 1.52 | 0.04 | 0.14 | up | yes |
| ENSG00000090975 | PITPNM2 | ENST00000542749 | GO:0005509(calcium ion binding);GO:0005622(intracellular);GO:0006810(transport);GO:0008152(metabolic process);GO:0008289(lipid binding);GO:0012505(endomembrane system);GO:0016021(integral component of membrane);GO:0043231(intracellular membrane-bounded organelle);GO:0046872(metal ion binding) | NA | NA | NA | phosphatidylinositol transfer protein, membrane-associated 2 [Source:HGNC Symbol;Acc:HGNC:21044] | 0.53 | 0.45 | 0.50 | 2.07 | 2.03 | 2.05 | 0.47 | -1.09 | 0.19 | 0.35 | down | no |
| ENSG00000121211 | MND1 | ENST00000240488 | GO:0003677(DNA binding);GO:0005634(nucleus);GO:0006310(DNA recombination);GO:0051321(meiotic cell cycle) | NA | NA | NA | meiotic nuclear divisions 1 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:24839] | 1.77 | 1.52 | 1.66 | 0.12 | 0.07 | 0.07 | 2.47 | 1.31 | 0.03 | 0.13 | up | yes |
| ENSG00000137841 | PLCB2 | ENST00000456256 | GO:0004435(phosphatidylinositol phospholipase C activity);GO:0004629(phospholipase C activity);GO:0004871(signal transducer activity);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0006629(lipid metabolic process);GO:0006644(phospholipid metabolic process);GO:0007165(signal transduction);GO:0007202(activation of phospholipase C activity);GO:0007268(synaptic transmission);GO:0008081(phosphoric diester hydrolase activity);GO:0008152(metabolic process);GO:0016042(lipid catabolic process);GO:0035556(intracellular signal transduction);GO:0043647(inositol phosphate metabolic process);GO:0044281(small molecule metabolic process);GO:0050913(sensory perception of bitter taste) | 00562(Inositol phosphate metabolism);01100(Metabolic pathways);04020(Calcium signaling pathway);04062(Chemokine signaling pathway);04070(Phosphatidylinositol signaling system);04270(Vascular smooth muscle contraction);04310(Wnt signaling pathway);04540(Gap junction);04720(Long-term potentiation);04724(Glutamatergic synapse);04725(Cholinergic synapse);04730(Long-term depression);04742(Taste transduction);04912(GnRH signaling pathway);04916(Melanogenesis);04961(Endocrine and other factor-regulated calcium reabsorption);04970(Salivary secretion);04971(Gastric acid secretion);04972(Pancreatic secretion);04973(Carbohydrate digestion and absorption);05010(Alzheimer's disease);05016(Huntington's disease);05142(Chagas disease (American trypanosomiasis));05143(African trypanosomiasis);05146(Amoebiasis) | K01116;K05857;K05858;K05859;K05860;K05861;K19006 | 3.1.4.11 | phospholipase C, beta 2 [Source:HGNC Symbol;Acc:HGNC:9055] | 0.64 | 0.61 | 0.70 | 1.75 | 1.75 | 1.74 | 0.21 | -2.26 | 0.20 | 0.36 | down | no |
| ENSG00000139354 | GAS2L3 | ENST00000266754 | GO:0000226(microtubule cytoskeleton organization);GO:0003779(actin binding);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005856(cytoskeleton);GO:0005874(microtubule);GO:0007050(cell cycle arrest);GO:0008017(microtubule binding);GO:0015629(actin cytoskeleton);GO:0015630(microtubule cytoskeleton);GO:0030036(actin cytoskeleton organization) | NA | NA | NA | growth arrest-specific 2 like 3 [Source:HGNC Symbol;Acc:HGNC:27475] | 1.23 | 1.25 | 1.23 | 0.30 | 0.30 | 0.30 | 3.57 | 1.83 | 0.17 | 0.33 | up | no |
| ENSG00000143110 | C1orf162 | ENST00000369718 | GO:0016021(integral component of membrane) | NA | NA | NA | chromosome 1 open reading frame 162 [Source:HGNC Symbol;Acc:HGNC:28344] | 0.57 | 0.51 | 0.55 | 2.04 | 2.22 | 2.23 | 0.13 | -2.94 | 0.02 | 0.09 | down | yes |
| ENSG00000149548 | CCDC15 | ENST00000344762 | GO:0005813(centrosome) | NA | NA | NA | coiled-coil domain containing 15 [Source:HGNC Symbol;Acc:HGNC:25798] | 1.72 | 1.45 | 1.63 | 0.52 | 0.56 | 0.55 | 1.35 | 0.44 | 0.60 | 0.73 | up | no |
| ENSG00000162396 | PARS2 | ENST00000371279 | GO:0000166(nucleotide binding);GO:0004812(aminoacyl-tRNA ligase activity);GO:0004827(proline-tRNA ligase activity);GO:0005524(ATP binding);GO:0005739(mitochondrion);GO:0005759(mitochondrial matrix);GO:0006418(tRNA aminoacylation for protein translation);GO:0006433(prolyl-tRNA aminoacylation);GO:0010467(gene expression) | 00970(Aminoacyl-tRNA biosynthesis) | NA | NA | prolyl-tRNA synthetase 2, mitochondrial (putative) [Source:HGNC Symbol;Acc:HGNC:30563] | 7.93 | 6.49 | 7.93 | 0 | 0.01 | 0.01 | 1.73 | 0.79 | 0.29 | 0.46 | up | no |
| ENSG00000174175 | SELP | ENST00000367788 | GO:0001530(lipopolysaccharide binding);GO:0001948(glycoprotein binding);GO:0002576(platelet degranulation);GO:0002687(positive regulation of leukocyte migration);GO:0002691(regulation of cellular extravasation);GO:0005515(protein binding);GO:0005615(extracellular space);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006954(inflammatory response);GO:0007155(cell adhesion);GO:0007157(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules);GO:0007159(leukocyte cell-cell adhesion);GO:0007596(blood coagulation);GO:0008201(heparin binding);GO:0009897(external side of plasma membrane);GO:0010572(positive regulation of platelet activation);GO:0014068(positive regulation of phosphatidylinositol 3-kinase signaling);GO:0014070(response to organic cyclic compound);GO:0016020(membrane);GO:0016337(single organismal cell-cell adhesion);GO:0030168(platelet activation);GO:0030246(carbohydrate binding);GO:0031088(platelet dense granule membrane);GO:0031092(platelet alpha granule membrane);GO:0032496(response to lipopolysaccharide);GO:0033623(regulation of integrin activation);GO:0033691(sialic acid binding);GO:0042806(fucose binding);GO:0043208(glycosphingolipid binding);GO:0045785(positive regulation of cell adhesion);GO:0048306(calcium-dependent protein binding);GO:0050829(defense response to Gram-negative bacterium);GO:0050900(leukocyte migration);GO:0050901(leukocyte tethering or rolling);GO:0070492(oligosaccharide binding) | 04514(Cell adhesion molecules (CAMs));05144(Malaria);05150(Staphylococcus aureus infection) | NA | NA | selectin P (granule membrane protein 140kDa, antigen CD62) [Source:HGNC Symbol;Acc:HGNC:10721] | 0.20 | 0.19 | 0.19 | 1.86 | 1.88 | 1.87 | 0.36 | -1.46 | 0.00 | 0.02 | down | yes |
| ENSG00000174326 | SLC16A11 | ENST00000308009 | GO:0005789(endoplasmic reticulum membrane);GO:0006629(lipid metabolic process);GO:0008028(monocarboxylic acid transmembrane transporter activity);GO:0015293(symporter activity);GO:0015718(monocarboxylic acid transport);GO:0016021(integral component of membrane);GO:0034220(ion transmembrane transport);GO:0055085(transmembrane transport) | NA | NA | NA | solute carrier family 16, member 11 [Source:HGNC Symbol;Acc:HGNC:23093] | 3.54 | 2.81 | 3.53 | 1.28 | 1.11 | 1.13 | 0.67 | -0.58 | 0.63 | 0.76 | down | no |
| ENSG00000174371 | EXO1 | ENST00000366548 | GO:0002455(humoral immune response mediated by circulating immunoglobulin);GO:0003677(DNA binding);GO:0003824(catalytic activity);GO:0004518(nuclease activity);GO:0004523(RNA-DNA hybrid ribonuclease activity);GO:0004527(exonuclease activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0006281(DNA repair);GO:0006298(mismatch repair);GO:0006310(DNA recombination);GO:0008409(5'-3' exonuclease activity);GO:0016446(somatic hypermutation of immunoglobulin genes);GO:0016788(hydrolase activity, acting on ester bonds);GO:0035312(5'-3' exodeoxyribonuclease activity);GO:0043566(structure-specific DNA binding);GO:0045145(single-stranded DNA 5'-3' exodeoxyribonuclease activity);GO:0045190(isotype switching);GO:0046872(metal ion binding);GO:0048256(flap endonuclease activity);GO:0051321(meiotic cell cycle);GO:0051908(double-stranded DNA 5'-3' exodeoxyribonuclease activity);GO:0090305(nucleic acid phosphodiester bond hydrolysis);GO:0090502(RNA phosphodiester bond hydrolysis, endonucleolytic) | 03430(Mismatch repair) | NA | NA | exonuclease 1 [Source:HGNC Symbol;Acc:HGNC:3511] | 2.40 | 2.21 | 2.34 | 0.02 | 0.03 | 0.03 | 1.58 | 0.66 | 0.22 | 0.39 | up | no |
| ENSG00000196302 | RP11-497H16.5 | ENST00000508439 | NA | NA | NA | NA | NA | 1.84 | 2.10 | 1.73 | 4.31 | 4.26 | 4.35 | 1.52 | 0.61 | 0.19 | 0.35 | up | no |
| ENSG00000197272 | IL27 | ENST00000356897 | GO:0005102(receptor binding);GO:0005125(cytokine activity);GO:0005515(protein binding);GO:0005615(extracellular space);GO:0006954(inflammatory response);GO:0009617(response to bacterium);GO:0042129(regulation of T cell proliferation);GO:0045078(positive regulation of interferon-gamma biosynthetic process);GO:0045087(innate immune response);GO:0045523(interleukin-27 receptor binding);GO:0045625(regulation of T-helper 1 cell differentiation);GO:0050688(regulation of defense response to virus) | NA | NA | NA | interleukin 27 [Source:HGNC Symbol;Acc:HGNC:19157] | 0.42 | 0.44 | 0.48 | 3.19 | 3.24 | 3.22 | 0.25 | -1.98 | 0.01 | 0.06 | down | yes |
| ENSG00000202538 | RNU4-2 | ENST00000365668 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 18.91 | 18.69 | 18.74 | 0.05 | -4.25 | 0.00 | 0.00 | down | yes |
| ENSG00000227077 | AC107983.4 | ENST00000442562 | NA | NA | NA | NA | NA | 4.06 | 0 | 0 | 0 | 0 | 0 | 0.04 | -4.59 | 0.75 | 0.84 | down | no |
| ENSG00000237039 | AC018738.2 | ENST00000441378 | NA | NA | NA | NA | NA | 2.57 | 0 | 0 | 0 | 0 | 0 | 0.08 | -3.60 | 0.75 | 0.84 | down | no |
| ENSG00000268089 | GABRQ | ENST00000598523 | GO:0004888(transmembrane signaling receptor activity);GO:0004890(GABA-A receptor activity);GO:0005230(extracellular ligand-gated ion channel activity);GO:0005254(chloride channel activity);GO:0005326(neurotransmitter transporter activity);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006810(transport);GO:0006811(ion transport);GO:0006836(neurotransmitter transport);GO:0007165(signal transduction);GO:0007268(synaptic transmission);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0030054(cell junction);GO:0034220(ion transmembrane transport);GO:0034707(chloride channel complex);GO:0043235(receptor complex);GO:0045211(postsynaptic membrane);GO:0055085(transmembrane transport);GO:1902476(chloride transmembrane transport) | NA | NA | NA | gamma-aminobutyric acid (GABA) A receptor, theta [Source:HGNC Symbol;Acc:HGNC:14454] | 2.38 | 1.89 | 2.41 | 0 | 0 | 0 | 0.77 | -0.38 | 0.55 | 0.70 | down | no |
| MSTRG.10002 | EIF2AK4 | ENST00000558557 | GO:0004672(protein kinase activity);GO:0004674(protein serine/threonine kinase activity);GO:0004694(eukaryotic translation initiation factor 2alpha kinase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005622(intracellular);GO:0006446(regulation of translational initiation);GO:0006468(protein phosphorylation);GO:0009267(cellular response to starvation);GO:0010998(regulation of translational initiation by eIF2 alpha phosphorylation);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0017148(negative regulation of translation);GO:0022626(cytosolic ribosome);GO:0030968(endoplasmic reticulum unfolded protein response);GO:0042803(protein homodimerization activity);GO:0043558(regulation of translational initiation in response to stress) | 04141(Protein processing in endoplasmic reticulum);05160(Hepatitis C);05162(Measles);05164(Influenza A) | NA | NA | eukaryotic translation initiation factor 2 alpha kinase 4 [Source:HGNC Symbol;Acc:HGNC:19687] | 6.45 | 6.28 | 6.52 | 6.75 | 6.86 | 6.82 | 10.45 | 3.39 | 0.21 | 0.38 | up | no |
| MSTRG.10005 | SRP14 | ENST00000267884 | GO:0003723(RNA binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005786(signal recognition particle, endoplasmic reticulum targeting);GO:0005829(cytosol);GO:0006412(translation);GO:0006613(cotranslational protein targeting to membrane);GO:0006614(SRP-dependent cotranslational protein targeting to membrane);GO:0008312(7S RNA binding);GO:0010467(gene expression);GO:0030942(endoplasmic reticulum signal peptide binding);GO:0042493(response to drug);GO:0044267(cellular protein metabolic process);GO:0044822(poly(A) RNA binding);GO:0045047(protein targeting to ER);GO:0045171(intercellular bridge);GO:0048500(signal recognition particle);GO:0070062(extracellular exosome) | 03060(Protein export) | NA | NA | signal recognition particle 14kDa (homologous Alu RNA binding protein) [Source:HGNC Symbol;Acc:HGNC:11299] | 14.64 | 20.40 | 14.89 | 10.34 | 10.68 | 10.71 | 21.38 | 4.42 | 0.05 | 0.16 | up | no |
| MSTRG.10010 | BUB1B | ENST00000287598 | GO:0000278(mitotic cell cycle);GO:0000776(kinetochore);GO:0000777(condensed chromosome kinetochore);GO:0000778(condensed nuclear chromosome kinetochore);GO:0000940(condensed chromosome outer kinetochore);GO:0004672(protein kinase activity);GO:0004674(protein serine/threonine kinase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005680(anaphase-promoting complex);GO:0005737(cytoplasm);GO:0005815(microtubule organizing center);GO:0005829(cytosol);GO:0006468(protein phosphorylation);GO:0006915(apoptotic process);GO:0007067(mitotic nuclear division);GO:0007091(metaphase/anaphase transition of mitotic cell cycle);GO:0007093(mitotic cell cycle checkpoint);GO:0007094(mitotic spindle assembly checkpoint);GO:0007264(small GTPase mediated signal transduction);GO:0008283(cell proliferation);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0031145(anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process);GO:0034501(protein localization to kinetochore);GO:0048471(perinuclear region of cytoplasm);GO:0051233(spindle midzone);GO:0051301(cell division);GO:0051436(negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle);GO:0051439(regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle);GO:0071459(protein localization to chromosome, centromeric region) | 04110(Cell cycle) | NA | NA | BUB1 mitotic checkpoint serine/threonine kinase B [Source:HGNC Symbol;Acc:HGNC:1149] | 1.66 | 1.71 | 1.62 | 0.07 | 0.07 | 0.07 | 11.07 | 3.47 | 0.00 | 0.01 | up | yes |
| MSTRG.10016 | KNSTRN | ENST00000608100 | GO:0000070(mitotic sister chromatid segregation);GO:0000776(kinetochore);GO:0000777(condensed chromosome kinetochore);GO:0000922(spindle pole);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0007051(spindle organization);GO:0007059(chromosome segregation);GO:0015630(microtubule cytoskeleton);GO:0035371(microtubule plus-end);GO:0051301(cell division);GO:0051988(regulation of attachment of spindle microtubules to kinetochore);GO:0072686(mitotic spindle) | NA | NA | NA | kinetochore-localized astrin/SPAG5 binding protein [Source:HGNC Symbol;Acc:HGNC:30767] | 4.26 | 2.83 | 4.38 | 1.04 | 1.10 | 1.09 | 0.02 | -5.64 | 0.07 | 0.18 | down | no |
| MSTRG.10017 | IVD | ENST00000487418 | GO:0003995(acyl-CoA dehydrogenase activity);GO:0005654(nucleoplasm);GO:0005739(mitochondrion);GO:0005759(mitochondrial matrix);GO:0006552(leucine catabolic process);GO:0008152(metabolic process);GO:0008470(isovaleryl-CoA dehydrogenase activity);GO:0009083(branched-chain amino acid catabolic process);GO:0016627(oxidoreductase activity, acting on the CH-CH group of donors);GO:0031966(mitochondrial membrane);GO:0034641(cellular nitrogen compound metabolic process);GO:0044281(small molecule metabolic process);GO:0050660(flavin adenine dinucleotide binding);GO:0055114(oxidation-reduction process) | 00280(Valine, leucine and isoleucine degradation);01100(Metabolic pathways) | NA | NA | isovaleryl-CoA dehydrogenase [Source:HGNC Symbol;Acc:HGNC:6186] | 5.49 | 5.67 | 5.51 | 12.25 | 17.85 | 17.81 | 0.12 | -3.03 | 0.37 | 0.55 | down | no |
| MSTRG.10022 | RPUSD2 | ENST00000315616 | GO:0001522(pseudouridine synthesis);GO:0003723(RNA binding);GO:0005575(cellular_component);GO:0008150(biological_process);GO:0009451(RNA modification);GO:0009982(pseudouridine synthase activity);GO:0044822(poly(A) RNA binding) | NA | NA | NA | RNA pseudouridylate synthase domain containing 2 [Source:HGNC Symbol;Acc:HGNC:24180] | 4.71 | 4.25 | 4.65 | 1.65 | 1.66 | 1.64 | 1.10 | 0.14 | 0.70 | 0.81 | up | no |
| MSTRG.10026 | CASC5 | ENST00000399668 | GO:0000278(mitotic cell cycle);GO:0000777(condensed chromosome kinetochore);GO:0001669(acrosomal vesicle);GO:0001675(acrosome assembly);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0006334(nucleosome assembly);GO:0007067(mitotic nuclear division);GO:0007264(small GTPase mediated signal transduction);GO:0008608(attachment of spindle microtubules to kinetochore);GO:0010923(negative regulation of phosphatase activity);GO:0034080(CENP-A containing nucleosome assembly);GO:0034501(protein localization to kinetochore);GO:0051301(cell division);GO:0070062(extracellular exosome);GO:0071173(spindle assembly checkpoint) | NA | NA | NA | cancer susceptibility candidate 5 [Source:HGNC Symbol;Acc:HGNC:24054] | 3.99 | 4.46 | 4.06 | 0.60 | 0.60 | 0.60 | 6.52 | 2.70 | 0.00 | 0.01 | up | yes |
| MSTRG.10047 | CHP1 | ENST00000334660 | GO:0000139(Golgi membrane);GO:0001578(microtubule bundle formation);GO:0001933(negative regulation of protein phosphorylation);GO:0004860(protein kinase inhibitor activity);GO:0005215(transporter activity);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005783(endoplasmic reticulum);GO:0005793(endoplasmic reticulum-Golgi intermediate compartment);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005925(focal adhesion);GO:0005975(carbohydrate metabolic process);GO:0006469(negative regulation of protein kinase activity);GO:0006611(protein export from nucleus);GO:0006813(potassium ion transport);GO:0007264(small GTPase mediated signal transduction);GO:0008017(microtubule binding);GO:0010923(negative regulation of phosphatase activity);GO:0015459(potassium channel regulator activity);GO:0015630(microtubule cytoskeleton);GO:0017156(calcium ion-dependent exocytosis);GO:0019900(kinase binding);GO:0022406(membrane docking);GO:0030133(transport vesicle);GO:0030203(glycosaminoglycan metabolic process);GO:0030212(hyaluronan metabolic process);GO:0030214(hyaluronan catabolic process);GO:0031122(cytoplasmic microtubule organization);GO:0031397(negative regulation of protein ubiquitination);GO:0031953(negative regulation of protein autophosphorylation);GO:0032088(negative regulation of NF-kappaB transcription factor activity);GO:0032417(positive regulation of sodium:proton antiporter activity);GO:0042308(negative regulation of protein import into nucleus);GO:0044281(small molecule metabolic process);GO:0048306(calcium-dependent protein binding);GO:0050821(protein stabilization);GO:0051222(positive regulation of protein transport);GO:0051259(protein oligomerization);GO:0051453(regulation of intracellular pH);GO:0060050(positive regulation of protein glycosylation);GO:0061024(membrane organization);GO:0061025(membrane fusion);GO:0070062(extracellular exosome);GO:0070885(negative regulation of calcineurin-NFAT signaling cascade);GO:0071468(cellular response to acidic pH);GO:0090314(positive regulation of protein targeting to membrane);GO:1901214(regulation of neuron death) | 04010(MAPK signaling pathway);04020(Calcium signaling pathway);04114(Oocyte meiosis);04210(Apoptosis);04310(Wnt signaling pathway);04360(Axon guidance);04370(VEGF signaling pathway);04650(Natural killer cell mediated cytotoxicity);04660(T cell receptor signaling pathway);04662(B cell receptor signaling pathway);04720(Long-term potentiation);04724(Glutamatergic synapse);05010(Alzheimer's disease);05014(Amyotrophic lateral sclerosis (ALS));05152(Tuberculosis) | NA | NA | calcineurin-like EF-hand protein 1 [Source:HGNC Symbol;Acc:HGNC:17433] | 43.52 | 36.99 | 43.37 | 27.14 | 26.68 | 26.83 | 0.40 | -1.31 | 0.15 | 0.30 | down | no |
| MSTRG.10049 | OIP5 | ENST00000220514 | GO:0000775(chromosome, centromeric region);GO:0000785(chromatin);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0006334(nucleosome assembly);GO:0007067(mitotic nuclear division);GO:0007154(cell communication);GO:0010369(chromocenter);GO:0015030(Cajal body);GO:0034080(CENP-A containing nucleosome assembly);GO:0051301(cell division) | NA | NA | NA | Opa interacting protein 5 [Source:HGNC Symbol;Acc:HGNC:20300] | 3.13 | 3.70 | 3.18 | 0.43 | 0.41 | 0.41 | 9.45 | 3.24 | 0.01 | 0.05 | up | yes |
| MSTRG.1005 | PPAP2B | ENST00000459962 | GO:0001568(blood vessel development);GO:0001702(gastrulation with mouth forming second);GO:0001933(negative regulation of protein phosphorylation);GO:0003824(catalytic activity);GO:0004721(phosphoprotein phosphatase activity);GO:0005178(integrin binding);GO:0005515(protein binding);GO:0005789(endoplasmic reticulum membrane);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005912(adherens junction);GO:0006629(lipid metabolic process);GO:0006644(phospholipid metabolic process);GO:0006665(sphingolipid metabolic process);GO:0007155(cell adhesion);GO:0008195(phosphatidate phosphatase activity);GO:0008354(germ cell migration);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0016311(dephosphorylation);GO:0016337(single organismal cell-cell adhesion);GO:0030111(regulation of Wnt signaling pathway);GO:0030148(sphingolipid biosynthetic process);GO:0034109(homotypic cell-cell adhesion);GO:0042392(sphingosine-1-phosphate phosphatase activity);GO:0042577(lipid phosphatase activity);GO:0044281(small molecule metabolic process);GO:0044328(canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration);GO:0044329(canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion);GO:0044330(canonical Wnt signaling pathway involved in positive regulation of wound healing);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0050821(protein stabilization);GO:0051091(positive regulation of sequence-specific DNA binding transcription factor activity);GO:0060020(Bergmann glial cell differentiation);GO:0060070(canonical Wnt signaling pathway);GO:0070062(extracellular exosome);GO:1902068(regulation of sphingolipid mediated signaling pathway) | 00561(Glycerolipid metabolism);00564(Glycerophospholipid metabolism);00565(Ether lipid metabolism);00600(Sphingolipid metabolism);01100(Metabolic pathways);04666(Fc gamma R-mediated phagocytosis);04975(Fat digestion and absorption) | NA | NA | phosphatidic acid phosphatase type 2B [Source:HGNC Symbol;Acc:HGNC:9229] | 6.08 | 5.61 | 6.02 | 8.06 | 8.24 | 8.20 | 0.23 | -2.15 | 0.00 | 0.02 | down | yes |
| MSTRG.10050 | NUSAP1 | ENST00000559596;ENST00000414849 | GO:0000070(mitotic sister chromatid segregation);GO:0000281(mitotic cytokinesis);GO:0003677(DNA binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005694(chromosome);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005819(spindle);GO:0005874(microtubule);GO:0005876(spindle microtubule);GO:0007076(mitotic chromosome condensation);GO:0008017(microtubule binding);GO:0040001(establishment of mitotic spindle localization);GO:0044822(poly(A) RNA binding);GO:0045840(positive regulation of mitotic nuclear division) | NA | NA | NA | nucleolar and spindle associated protein 1 [Source:HGNC Symbol;Acc:HGNC:18538] | 8.65 | 9.05 | 8.88 | 1.29 | 1.24 | 1.22 | 4.35 | 2.12 | 0.03 | 0.11 | up | yes |
| MSTRG.10052 | NDUFAF1 | ENST00000260361 | GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005747(mitochondrial respiratory chain complex I);GO:0006120(mitochondrial electron transport, NADH to ubiquinone);GO:0006461(protein complex assembly);GO:0051082(unfolded protein binding) | NA | NA | NA | NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 [Source:HGNC Symbol;Acc:HGNC:18828] | 4.97 | 4.71 | 5.03 | 5.58 | 5.99 | 5.93 | 0.26 | -1.93 | 0.01 | 0.08 | down | yes |
| MSTRG.10053 | RTF1 | ENST00000389629 | GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0001711(endodermal cell fate commitment);GO:0001832(blastocyst growth);GO:0003677(DNA binding);GO:0003697(single-stranded DNA binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0006352(DNA-templated transcription, initiation);GO:0016055(Wnt signaling pathway);GO:0016570(histone modification);GO:0016593(Cdc73/Paf1 complex);GO:0019827(stem cell maintenance);GO:0032968(positive regulation of transcription elongation from RNA polymerase II promoter);GO:0044822(poly(A) RNA binding);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0051571(positive regulation of histone H3-K4 methylation);GO:0080182(histone H3-K4 trimethylation) | NA | NA | NA | Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:28996] | 6.43 | 5.88 | 6.46 | 2.93 | 4.62 | 4.61 | 0.18 | -2.44 | 0.41 | 0.58 | down | no |
| MSTRG.10055 | RPAP1 | ENST00000304330 | GO:0003677(DNA binding);GO:0003899(DNA-directed RNA polymerase activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0006366(transcription from RNA polymerase II promoter) | NA | NA | NA | RNA polymerase II associated protein 1 [Source:HGNC Symbol;Acc:HGNC:24567] | 3.61 | 3.36 | 3.75 | 2.20 | 2.25 | 2.23 | 0.67 | -0.59 | 0.04 | 0.14 | down | no |
| MSTRG.10056 | VPS39 | ENST00000318006 | GO:0005515(protein binding);GO:0005765(lysosomal membrane);GO:0006886(intracellular protein transport);GO:0016192(vesicle-mediated transport);GO:0030897(HOPS complex);GO:0031902(late endosome membrane) | NA | NA | NA | vacuolar protein sorting 39 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:20593] | 5.25 | 4.93 | 5.19 | 3.93 | 3.95 | 4.01 | 1.20 | 0.26 | 0.63 | 0.75 | up | no |
| MSTRG.10070 | EHD4 | ENST00000220325;ENST00000612090 | GO:0003676(nucleic acid binding);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005525(GTP binding);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005783(endoplasmic reticulum);GO:0005886(plasma membrane);GO:0006907(pinocytosis);GO:0016020(membrane);GO:0030100(regulation of endocytosis);GO:0031901(early endosome membrane);GO:0032456(endocytic recycling);GO:0048471(perinuclear region of cytoplasm);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051260(protein homooligomerization);GO:0055038(recycling endosome membrane);GO:0070062(extracellular exosome);GO:0071363(cellular response to growth factor stimulus) | 04144(Endocytosis) | NA | NA | EH-domain containing 4 [Source:HGNC Symbol;Acc:HGNC:3245] | 4.52 | 3.73 | 4.59 | 2.35 | 2.35 | 2.34 | 0.36 | -1.48 | 0.07 | 0.19 | down | no |
| MSTRG.10074 | TMEM87A | ENST00000389834 | GO:0016021(integral component of membrane) | NA | NA | NA | transmembrane protein 87A [Source:HGNC Symbol;Acc:HGNC:24522] | 3.91 | 3.74 | 3.96 | 3.37 | 3.51 | 3.48 | 0.72 | -0.48 | 0.01 | 0.06 | down | no |
| MSTRG.10075 | CAPN3 | ENST00000357568 | GO:0001896(autolysis);GO:0003824(catalytic activity);GO:0004198(calcium-dependent cysteine-type endopeptidase activity);GO:0004871(signal transducer activity);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006461(protein complex assembly);GO:0006508(proteolysis);GO:0006915(apoptotic process);GO:0007165(signal transduction);GO:0007517(muscle organ development);GO:0008233(peptidase activity);GO:0008234(cysteine-type peptidase activity);GO:0008307(structural constituent of muscle);GO:0014718(positive regulation of satellite cell activation involved in skeletal muscle regeneration);GO:0014850(response to muscle activity);GO:0030016(myofibril);GO:0030018(Z disc);GO:0030239(myofibril assembly);GO:0030315(T-tubule);GO:0031402(sodium ion binding);GO:0031432(titin binding);GO:0032947(protein complex scaffold);GO:0033234(negative regulation of protein sumoylation);GO:0043066(negative regulation of apoptotic process);GO:0043122(regulation of I-kappaB kinase/NF-kappaB signaling);GO:0043234(protein complex);GO:0045214(sarcomere organization);GO:0045661(regulation of myoblast differentiation);GO:0045862(positive regulation of proteolysis);GO:0045892(negative regulation of transcription, DNA-templated);GO:0045893(positive regulation of transcription, DNA-templated);GO:0046716(muscle cell cellular homeostasis);GO:0050790(regulation of catalytic activity);GO:0051092(positive regulation of NF-kappaB transcription factor activity);GO:0051281(positive regulation of release of sequestered calcium ion into cytosol);GO:0051592(response to calcium ion);GO:0055103(ligase regulator activity);GO:0061061(muscle structure development);GO:0070315(G1 to G0 transition involved in cell differentiation);GO:0071277(cellular response to calcium ion);GO:0071472(cellular response to salt stress);GO:0072657(protein localization to membrane);GO:0097264(self proteolysis) | NA | NA | NA | calpain 3, (p94) [Source:HGNC Symbol;Acc:HGNC:1480] | 1.27 | 1.24 | 1.30 | 3.05 | 3.03 | 3.04 | 1.09 | 0.12 | 0.96 | 0.98 | up | no |
| MSTRG.10079 | SNAP23 | ENST00000249647 | GO:0002553(histamine secretion by mast cell);GO:0005484(SNAP receptor activity);GO:0005515(protein binding);GO:0005623(cell);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005886(plasma membrane);GO:0005925(focal adhesion);GO:0006887(exocytosis);GO:0006892(post-Golgi vesicle-mediated transport);GO:0006903(vesicle targeting);GO:0015031(protein transport);GO:0016082(synaptic vesicle priming);GO:0019905(syntaxin binding);GO:0031201(SNARE complex);GO:0031410(cytoplasmic vesicle);GO:0031629(synaptic vesicle fusion to presynaptic membrane);GO:0042581(specific granule);GO:0042582(azurophil granule);GO:0042629(mast cell granule);GO:0043005(neuron projection);GO:0045202(synapse);GO:0061024(membrane organization);GO:0061025(membrane fusion);GO:0070062(extracellular exosome) | 04130(SNARE interactions in vesicular transport) | NA | NA | synaptosomal-associated protein, 23kDa [Source:HGNC Symbol;Acc:HGNC:11131] | 5.17 | 4.93 | 5.02 | 2.77 | 2.73 | 2.81 | 0.26 | -1.93 | 0.10 | 0.22 | down | no |
| MSTRG.10089 | UBR1 | ENST00000290650 | GO:0000151(ubiquitin ligase complex);GO:0000502(proteasome complex);GO:0004842(ubiquitin-protein transferase activity);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0006511(ubiquitin-dependent protein catabolic process);GO:0008270(zinc ion binding);GO:0016567(protein ubiquitination);GO:0016874(ligase activity);GO:0030163(protein catabolic process);GO:0032007(negative regulation of TOR signaling);GO:0061630(ubiquitin protein ligase activity);GO:0070728(leucine binding);GO:0071233(cellular response to leucine);GO:0071596(ubiquitin-dependent protein catabolic process via the N-end rule pathway) | NA | NA | NA | ubiquitin protein ligase E3 component n-recognin 1 [Source:HGNC Symbol;Acc:HGNC:16808] | 5.89 | 5.50 | 5.92 | 3.86 | 3.77 | 3.76 | 0.88 | -0.18 | 0.66 | 0.78 | down | no |
| MSTRG.1009 | PRKAA2 | ENST00000371244 | GO:0003682(chromatin binding);GO:0004672(protein kinase activity);GO:0004674(protein serine/threonine kinase activity);GO:0004679(AMP-activated protein kinase activity);GO:0004712(protein serine/threonine/tyrosine kinase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0006112(energy reserve metabolic process);GO:0006355(regulation of transcription, DNA-templated);GO:0006367(transcription initiation from RNA polymerase II promoter);GO:0006468(protein phosphorylation);GO:0006633(fatty acid biosynthetic process);GO:0006695(cholesterol biosynthetic process);GO:0006853(carnitine shuttle);GO:0006914(autophagy);GO:0006950(response to stress);GO:0006996(organelle organization);GO:0007005(mitochondrion organization);GO:0007050(cell cycle arrest);GO:0007165(signal transduction);GO:0008286(insulin receptor signaling pathway);GO:0008610(lipid biosynthetic process);GO:0010467(gene expression);GO:0010468(regulation of gene expression);GO:0010508(positive regulation of autophagy);GO:0014850(response to muscle activity);GO:0016055(Wnt signaling pathway);GO:0016241(regulation of macroautophagy);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0031588(AMP-activated protein kinase complex);GO:0031669(cellular response to nutrient levels);GO:0032007(negative regulation of TOR signaling);GO:0035174(histone serine kinase activity);GO:0035404(histone-serine phosphorylation);GO:0035556(intracellular signal transduction);GO:0035690(cellular response to drug);GO:0042149(cellular response to glucose starvation);GO:0042304(regulation of fatty acid biosynthetic process);GO:0042593(glucose homeostasis);GO:0042752(regulation of circadian rhythm);GO:0043066(negative regulation of apoptotic process);GO:0044255(cellular lipid metabolic process);GO:0044281(small molecule metabolic process);GO:0045821(positive regulation of glycolytic process);GO:0046872(metal ion binding);GO:0047322([hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity);GO:0048511(rhythmic process);GO:0050405([acetyl-CoA carboxylase] kinase activity);GO:0055089(fatty acid homeostasis);GO:0061024(membrane organization);GO:0071380(cellular response to prostaglandin E stimulus);GO:2000505(regulation of energy homeostasis) | 04140(Regulation of autophagy);04150(mTOR signaling pathway);04910(Insulin signaling pathway);04920(Adipocytokine signaling pathway);05410(Hypertrophic cardiomyopathy (HCM)) | NA | NA | protein kinase, AMP-activated, alpha 2 catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9377] | 9.82 | 9.55 | 9.79 | 0.82 | 0.80 | 0.80 | 5.08 | 2.35 | 0.00 | 0.02 | up | yes |
| MSTRG.10094 | CCNDBP1 | ENST00000566515 | GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0007049(cell cycle);GO:0051726(regulation of cell cycle) | NA | NA | NA | cyclin D-type binding-protein 1 [Source:HGNC Symbol;Acc:HGNC:1587] | 4.24 | 3.87 | 4.22 | 2.73 | 2.76 | 2.77 | 215.99 | 7.75 | 0.03 | 0.11 | up | yes |
| MSTRG.1011 | C8A | ENST00000361249 | GO:0001848(complement binding);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0005579(membrane attack complex);GO:0005615(extracellular space);GO:0006955(immune response);GO:0006956(complement activation);GO:0006957(complement activation, alternative pathway);GO:0006958(complement activation, classical pathway);GO:0016020(membrane);GO:0019835(cytolysis);GO:0030449(regulation of complement activation);GO:0032403(protein complex binding);GO:0045087(innate immune response);GO:0070062(extracellular exosome);GO:0072562(blood microparticle) | 04610(Complement and coagulation cascades);05020(Prion diseases);05146(Amoebiasis);05322(Systemic lupus erythematosus) | NA | NA | complement component 8, alpha polypeptide [Source:HGNC Symbol;Acc:HGNC:1352] | 80.41 | 63.66 | 80.60 | 212.62 | 215.06 | 214.67 | 0.04 | -4.52 | 0.01 | 0.07 | down | yes |
| MSTRG.10110 | MFAP1 | ENST00000267812 | GO:0001527(microfibril);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0008150(biological_process);GO:0030198(extracellular matrix organization);GO:0044822(poly(A) RNA binding) | NA | NA | NA | microfibrillar-associated protein 1 [Source:HGNC Symbol;Acc:HGNC:7032] | 5.55 | 6.40 | 5.43 | 2.56 | 2.56 | 2.55 | 6.58 | 2.72 | 0.01 | 0.06 | up | yes |
| MSTRG.10111 | WDR76 | ENST00000263795 | GO:0005515(protein binding) | NA | NA | NA | WD repeat domain 76 [Source:HGNC Symbol;Acc:HGNC:25773] | 3.20 | 2.96 | 3.25 | 0.27 | 0.26 | 0.26 | 1.52 | 0.61 | 0.25 | 0.42 | up | no |
| MSTRG.10117 | PDIA3 | ENST00000300289 | GO:0002474(antigen processing and presentation of peptide antigen via MHC class I);GO:0002479(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent);GO:0003756(protein disulfide isomerase activity);GO:0004197(cysteine-type endopeptidase activity);GO:0004629(phospholipase C activity);GO:0005515(protein binding);GO:0005623(cell);GO:0005634(nucleus);GO:0005783(endoplasmic reticulum);GO:0005788(endoplasmic reticulum lumen);GO:0005790(smooth endoplasmic reticulum);GO:0005925(focal adhesion);GO:0006457(protein folding);GO:0006508(proteolysis);GO:0006606(protein import into nucleus);GO:0006621(protein retention in ER lumen);GO:0007165(signal transduction);GO:0008152(metabolic process);GO:0009986(cell surface);GO:0015036(disulfide oxidoreductase activity);GO:0016853(isomerase activity);GO:0018279(protein N-linked glycosylation via asparagine);GO:0034975(protein folding in endoplasmic reticulum);GO:0034976(response to endoplasmic reticulum stress);GO:0042470(melanosome);GO:0042590(antigen processing and presentation of exogenous peptide antigen via MHC class I);GO:0043209(myelin sheath);GO:0043687(post-translational protein modification);GO:0044267(cellular protein metabolic process);GO:0044822(poly(A) RNA binding);GO:0045454(cell redox homeostasis);GO:0055114(oxidation-reduction process);GO:0070062(extracellular exosome);GO:2001238(positive regulation of extrinsic apoptotic signaling pathway) | 04141(Protein processing in endoplasmic reticulum);04612(Antigen processing and presentation) | NA | NA | protein disulfide isomerase family A, member 3 [Source:HGNC Symbol;Acc:HGNC:4606] | 93.10 | 96.67 | 93.48 | 48.00 | 49.23 | 49.35 | 2.34 | 1.23 | 0.03 | 0.13 | up | yes |
| MSTRG.10119 | HYPK | ENST00000381359;ENST00000249786;ENST00000445816;ENST00000402131;ENST00000403425;ENST00000409614;ENST00000442995 | GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm) | NA | NA | NA | huntingtin interacting protein K [Source:HGNC Symbol;Acc:HGNC:18418] | 15.91 | 17.52 | 15.65 | 10.61 | 10.85 | 10.83 | 2.90 | 1.54 | 0.05 | 0.16 | up | no |
| MSTRG.10122 | CASC4 | ENST00000299957;ENST00000345795 | GO:0005794(Golgi apparatus);GO:0016021(integral component of membrane) | NA | NA | NA | cancer susceptibility candidate 4 [Source:HGNC Symbol;Acc:HGNC:24892] | 4.56 | 4.33 | 4.47 | 5.99 | 6.11 | 6.11 | 0.71 | -0.49 | 0.14 | 0.28 | down | no |
| MSTRG.10127 | CTDSPL2 | ENST00000260327 | GO:0004721(phosphoprotein phosphatase activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0006470(protein dephosphorylation);GO:0016311(dephosphorylation);GO:0016791(phosphatase activity);GO:0030514(negative regulation of BMP signaling pathway);GO:0046827(positive regulation of protein export from nucleus) | NA | NA | NA | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 [Source:HGNC Symbol;Acc:HGNC:26936] | 3.11 | 3.22 | 3.08 | 2.02 | 1.41 | 1.41 | 6.61 | 2.72 | 0.23 | 0.40 | up | no |
| MSTRG.10131 | EIF3J | ENST00000261868 | GO:0001731(formation of translation preinitiation complex);GO:0002181(cytoplasmic translation);GO:0003743(translation initiation factor activity);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005852(eukaryotic translation initiation factor 3 complex);GO:0006412(translation);GO:0006413(translational initiation);GO:0006446(regulation of translational initiation);GO:0010467(gene expression);GO:0016282(eukaryotic 43S preinitiation complex);GO:0033290(eukaryotic 48S preinitiation complex);GO:0044267(cellular protein metabolic process) | 03013(RNA transport) | NA | NA | eukaryotic translation initiation factor 3, subunit J [Source:HGNC Symbol;Acc:HGNC:3270] | 10.85 | 11.13 | 10.82 | 4.52 | 4.34 | 4.34 | 3.27 | 1.71 | 0.03 | 0.12 | up | yes |
| MSTRG.10133 | SPG11 | ENST00000261866 | GO:0005515(protein binding);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0016021(integral component of membrane);GO:0031410(cytoplasmic vesicle);GO:0070062(extracellular exosome) | NA | NA | NA | spastic paraplegia 11 (autosomal recessive) [Source:HGNC Symbol;Acc:HGNC:11226] | 10.69 | 10.40 | 10.79 | 8.74 | 8.72 | 8.72 | 1.67 | 0.74 | 0.46 | 0.62 | up | no |
| MSTRG.10137 | B2M | ENST00000558401;ENST00000559720;ENST00000544417;ENST00000561424;ENST00000559916;ENST00000349264;ENST00000559907;ENST00000561139 | GO:0000139(Golgi membrane);GO:0001895(retina homeostasis);GO:0001916(positive regulation of T cell mediated cytotoxicity);GO:0001948(glycoprotein binding);GO:0002237(response to molecule of bacterial origin);GO:0002474(antigen processing and presentation of peptide antigen via MHC class I);GO:0002479(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent);GO:0002480(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent);GO:0002481(antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0005737(cytoplasm);GO:0005788(endoplasmic reticulum lumen);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0005925(focal adhesion);GO:0006955(immune response);GO:0009897(external side of plasma membrane);GO:0012507(ER to Golgi transport vesicle membrane);GO:0016020(membrane);GO:0016032(viral process);GO:0019221(cytokine-mediated signaling pathway);GO:0030670(phagocytic vesicle membrane);GO:0031901(early endosome membrane);GO:0031905(early endosome lumen);GO:0033077(T cell differentiation in thymus);GO:0042026(protein refolding);GO:0042493(response to drug);GO:0042590(antigen processing and presentation of exogenous peptide antigen via MHC class I);GO:0042612(MHC class I protein complex);GO:0042802(identical protein binding);GO:0045087(innate immune response);GO:0046686(response to cadmium ion);GO:0050690(regulation of defense response to virus by virus);GO:0050776(regulation of immune response);GO:0055072(iron ion homeostasis);GO:0060333(interferon-gamma-mediated signaling pathway);GO:0070062(extracellular exosome);GO:1900121(negative regulation of receptor binding) | NA | NA | NA | beta-2-microglobulin [Source:HGNC Symbol;Acc:HGNC:914] | 64.39 | 55.13 | 65.17 | 74.80 | 83.65 | 83.51 | 0.12 | -3.03 | 0.01 | 0.06 | down | yes |
| MSTRG.10138 | TRIM69 | ENST00000560141 | GO:0004842(ubiquitin-protein transferase activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005886(plasma membrane);GO:0006915(apoptotic process);GO:0008270(zinc ion binding);GO:0016567(protein ubiquitination);GO:0016607(nuclear speck);GO:0016874(ligase activity);GO:0043231(intracellular membrane-bounded organelle) | NA | NA | NA | tripartite motif containing 69 [Source:HGNC Symbol;Acc:HGNC:17857] | 1.36 | 1.11 | 1.47 | 1.93 | 1.96 | 1.97 | 0.12 | -3.08 | 0.01 | 0.08 | down | yes |
| MSTRG.10140 | SORD2P | ENST00000558556 | NA | NA | NA | NA | NA | 1.08 | 1.55 | 1.15 | 6.35 | 6.39 | 6.39 | 3.93 | 1.97 | 0.25 | 0.41 | up | no |
| MSTRG.10144 | SORD | ENST00000267814 | GO:0003939(L-iditol 2-dehydrogenase activity);GO:0005615(extracellular space);GO:0005739(mitochondrion);GO:0005829(cytosol);GO:0005975(carbohydrate metabolic process);GO:0006000(fructose metabolic process);GO:0006006(glucose metabolic process);GO:0006060(sorbitol metabolic process);GO:0006062(sorbitol catabolic process);GO:0006970(response to osmotic stress);GO:0008270(zinc ion binding);GO:0009725(response to hormone);GO:0016020(membrane);GO:0016491(oxidoreductase activity);GO:0030246(carbohydrate binding);GO:0030317(sperm motility);GO:0031514(motile cilium);GO:0031667(response to nutrient levels);GO:0031966(mitochondrial membrane);GO:0042493(response to drug);GO:0042802(identical protein binding);GO:0044281(small molecule metabolic process);GO:0046370(fructose biosynthetic process);GO:0046686(response to cadmium ion);GO:0046688(response to copper ion);GO:0051160(L-xylitol catabolic process);GO:0051164(L-xylitol metabolic process);GO:0051287(NAD binding);GO:0055114(oxidation-reduction process);GO:0070062(extracellular exosome) | NA | NA | NA | sorbitol dehydrogenase [Source:HGNC Symbol;Acc:HGNC:11184] | 9.60 | 11.37 | 9.77 | 46.39 | 46.76 | 46.61 | 0.81 | -0.31 | 0.67 | 0.79 | down | no |
| MSTRG.10155 | GATM | ENST00000396659;ENST00000558362;ENST00000558336;ENST00000558916;ENST00000558163;ENST00000558537;ENST00000561148;ENST00000558118 | GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0005758(mitochondrial intermembrane space);GO:0006600(creatine metabolic process);GO:0006601(creatine biosynthetic process);GO:0006979(response to oxidative stress);GO:0007584(response to nutrient);GO:0010033(response to organic substance);GO:0015067(amidinotransferase activity);GO:0015068(glycine amidinotransferase activity);GO:0016813(hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines);GO:0034641(cellular nitrogen compound metabolic process);GO:0042246(tissue regeneration);GO:0043434(response to peptide hormone);GO:0044281(small molecule metabolic process);GO:0046689(response to mercury ion);GO:0070062(extracellular exosome);GO:1990402(embryonic liver development) | 00260(Glycine, serine and threonine metabolism);00330(Arginine and proline metabolism);01100(Metabolic pathways) | NA | NA | glycine amidinotransferase (L-arginine:glycine amidinotransferase) [Source:HGNC Symbol;Acc:HGNC:4175] | 25.80 | 87.19 | 25.77 | 254.13 | 253.20 | 253.36 | 6131.43 | 12.58 | 0.07 | 0.18 | up | no |
| MSTRG.10168 | SQRDL | ENST00000260324 | GO:0000096(sulfur amino acid metabolic process);GO:0000098(sulfur amino acid catabolic process);GO:0005743(mitochondrial inner membrane);GO:0016491(oxidoreductase activity);GO:0034641(cellular nitrogen compound metabolic process);GO:0044281(small molecule metabolic process);GO:0048038(quinone binding);GO:0055114(oxidation-reduction process);GO:0070221(sulfide oxidation, using sulfide:quinone oxidoreductase);GO:0070224(sulfide:quinone oxidoreductase activity);GO:0070813(hydrogen sulfide metabolic process) | NA | NA | NA | sulfide quinone reductase-like (yeast) [Source:HGNC Symbol;Acc:HGNC:20390] | 11.59 | 10.24 | 11.53 | 9.90 | 9.97 | 9.87 | 0.29 | -1.77 | 0.10 | 0.23 | down | no |
| MSTRG.1017 | C8B | ENST00000371237;ENST00000535057;ENST00000543257;ENST00000465658 | GO:0005515(protein binding);GO:0005576(extracellular region);GO:0005579(membrane attack complex);GO:0005615(extracellular space);GO:0006955(immune response);GO:0006956(complement activation);GO:0006957(complement activation, alternative pathway);GO:0006958(complement activation, classical pathway);GO:0016020(membrane);GO:0019835(cytolysis);GO:0030449(regulation of complement activation);GO:0032403(protein complex binding);GO:0045087(innate immune response);GO:0070062(extracellular exosome);GO:1903561(extracellular vesicle) | 04610(Complement and coagulation cascades);05020(Prion diseases);05146(Amoebiasis);05322(Systemic lupus erythematosus) | NA | NA | complement component 8, beta polypeptide [Source:HGNC Symbol;Acc:HGNC:1353] | 22.44 | 19.95 | 22.55 | 188.76 | 189.58 | 190.07 | 0.04 | -4.57 | 0.00 | 0.03 | down | yes |
| MSTRG.10171 | MYEF2 | ENST00000267836 | GO:0000166(nucleotide binding);GO:0003676(nucleic acid binding);GO:0003677(DNA binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0006351(transcription, DNA-templated);GO:0014902(myotube differentiation);GO:0030182(neuron differentiation);GO:0044822(poly(A) RNA binding) | NA | NA | NA | myelin expression factor 2 [Source:HGNC Symbol;Acc:HGNC:17940] | 1.70 | 1.31 | 1.67 | 0.07 | 0.08 | 0.08 | 1.69 | 0.75 | 0.19 | 0.35 | up | no |
| MSTRG.10179 | DUT | ENST00000331200;ENST00000558472;ENST00000455976 | GO:0000287(magnesium ion binding);GO:0004170(dUTP diphosphatase activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0006139(nucleobase-containing compound metabolic process);GO:0006206(pyrimidine nucleobase metabolic process);GO:0006226(dUMP biosynthetic process);GO:0006260(DNA replication);GO:0016787(hydrolase activity);GO:0044281(small molecule metabolic process);GO:0044822(poly(A) RNA binding);GO:0046080(dUTP metabolic process);GO:0046081(dUTP catabolic process);GO:0046134(pyrimidine nucleoside biosynthetic process);GO:0055086(nucleobase-containing small molecule metabolic process);GO:0070062(extracellular exosome) | 00240(Pyrimidine metabolism);01100(Metabolic pathways) | K01520 | 3.6.1.23 | deoxyuridine triphosphatase [Source:HGNC Symbol;Acc:HGNC:3078] | 7.85 | 7.28 | 7.90 | 3.92 | 4.23 | 4.21 | 0.82 | -0.29 | 0.29 | 0.47 | down | no |
| MSTRG.10180 | FBN1 | ENST00000316623 | GO:0001501(skeletal system development);GO:0001527(microfibril);GO:0001656(metanephros development);GO:0001822(kidney development);GO:0005178(integrin binding);GO:0005201(extracellular matrix structural constituent);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0005578(proteinaceous extracellular matrix);GO:0005604(basement membrane);GO:0005615(extracellular space);GO:0007507(heart development);GO:0009653(anatomical structure morphogenesis);GO:0022617(extracellular matrix disassembly);GO:0030023(extracellular matrix constituent conferring elasticity);GO:0030198(extracellular matrix organization);GO:0031012(extracellular matrix);GO:0032403(protein complex binding);GO:0035582(sequestering of BMP in extracellular matrix);GO:0035583(sequestering of TGFbeta in extracellular matrix);GO:0043010(camera-type eye development);GO:0048048(embryonic eye morphogenesis);GO:0048050(post-embryonic eye morphogenesis);GO:0070062(extracellular exosome);GO:0071560(cellular response to transforming growth factor beta stimulus);GO:0090287(regulation of cellular response to growth factor stimulus);GO:1990314(cellular response to insulin-like growth factor stimulus) | NA | NA | NA | fibrillin 1 [Source:HGNC Symbol;Acc:HGNC:3603] | 1.91 | 1.73 | 1.95 | 4.68 | 4.68 | 4.67 | 0.24 | -2.08 | 0.00 | 0.04 | down | yes |
| MSTRG.10188 | EID1 | ENST00000530028 | GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0003714(transcription corepressor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0006351(transcription, DNA-templated);GO:0007049(cell cycle);GO:0016235(aggresome);GO:0030154(cell differentiation);GO:0035034(histone acetyltransferase regulator activity);GO:0035035(histone acetyltransferase binding);GO:0035065(regulation of histone acetylation);GO:0045892(negative regulation of transcription, DNA-templated) | NA | NA | NA | EP300 interacting inhibitor of differentiation 1 [Source:HGNC Symbol;Acc:HGNC:1191] | 19.41 | 21.74 | 19.35 | 16.27 | 24.78 | 24.73 | 0.56 | -0.85 | 0.82 | 0.89 | down | no |
| MSTRG.10194 | COPS2 | ENST00000388901;ENST00000299259 | GO:0003714(transcription corepressor activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006366(transcription from RNA polymerase II promoter);GO:0007165(signal transduction);GO:0008180(COP9 signalosome);GO:0008283(cell proliferation);GO:0010388(cullin deneddylation);GO:0035914(skeletal muscle cell differentiation);GO:0045892(negative regulation of transcription, DNA-templated);GO:1903507(negative regulation of nucleic acid-templated transcription) | NA | NA | NA | COP9 signalosome subunit 2 [Source:HGNC Symbol;Acc:HGNC:30747] | 6.22 | 5.40 | 6.10 | 2.51 | 2.88 | 2.88 | 0.50 | -1.00 | 0.17 | 0.32 | down | no |
| MSTRG.10196 | GALK2 | ENST00000559883;ENST00000559963 | GO:0004335(galactokinase activity);GO:0005524(ATP binding);GO:0005737(cytoplasm);GO:0005975(carbohydrate metabolic process);GO:0006012(galactose metabolic process);GO:0033858(N-acetylgalactosamine kinase activity);GO:0046835(carbohydrate phosphorylation) | 00052(Galactose metabolism);00520(Amino sugar and nucleotide sugar metabolism);01100(Metabolic pathways) | NA | NA | galactokinase 2 [Source:HGNC Symbol;Acc:HGNC:4119] | 2.16 | 2.27 | 2.22 | 1.90 | 1.81 | 1.83 | 5.43 | 2.44 | 0.04 | 0.13 | up | yes |
| MSTRG.1020 | OMA1 | ENST00000371226;ENST00000456980;ENST00000419242 | GO:0002024(diet induced thermogenesis);GO:0004222(metalloendopeptidase activity);GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0006006(glucose metabolic process);GO:0006508(proteolysis);GO:0006515(misfolded or incompletely synthesized protein catabolic process);GO:0006629(lipid metabolic process);GO:0006950(response to stress);GO:0007005(mitochondrion organization);GO:0010637(negative regulation of mitochondrial fusion);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0031966(mitochondrial membrane);GO:0034982(mitochondrial protein processing);GO:0042407(cristae formation);GO:0046872(metal ion binding);GO:0097009(energy homeostasis) | NA | NA | NA | OMA1 zinc metallopeptidase [Source:HGNC Symbol;Acc:HGNC:29661] | 3.07 | 2.65 | 3.06 | 2.15 | 2.15 | 2.15 | 0.62 | -0.68 | 0.14 | 0.29 | down | no |
| MSTRG.10210 | SLC27A2 | ENST00000267842 | GO:0000038(very long-chain fatty acid metabolic process);GO:0001561(fatty acid alpha-oxidation);GO:0001676(long-chain fatty acid metabolic process);GO:0003824(catalytic activity);GO:0004467(long-chain fatty acid-CoA ligase activity);GO:0005102(receptor binding);GO:0005524(ATP binding);GO:0005739(mitochondrion);GO:0005777(peroxisome);GO:0005778(peroxisomal membrane);GO:0005779(integral component of peroxisomal membrane);GO:0005783(endoplasmic reticulum);GO:0005788(endoplasmic reticulum lumen);GO:0005789(endoplasmic reticulum membrane);GO:0006635(fatty acid beta-oxidation);GO:0006699(bile acid biosynthetic process);GO:0008152(metabolic process);GO:0008206(bile acid metabolic process);GO:0015245(fatty acid transporter activity);GO:0015908(fatty acid transport);GO:0016021(integral component of membrane);GO:0019899(enzyme binding);GO:0030176(integral component of endoplasmic reticulum membrane);GO:0031957(very long-chain fatty acid-CoA ligase activity);GO:0042760(very long-chain fatty acid catabolic process);GO:0044255(cellular lipid metabolic process);GO:0044281(small molecule metabolic process);GO:0044539(long-chain fatty acid import);GO:0050197(phytanate-CoA ligase activity);GO:0070062(extracellular exosome);GO:0070251(pristanate-CoA ligase activity);GO:0097089(methyl-branched fatty acid metabolic process) | 03320(PPAR signaling pathway);04146(Peroxisome) | K01897;K15013 | 6.2.1.3 | solute carrier family 27 (fatty acid transporter), member 2 [Source:HGNC Symbol;Acc:HGNC:10996] | 5.04 | 7.58 | 4.94 | 33.61 | 33.76 | 33.98 | 4.21 | 2.07 | 0.21 | 0.37 | up | no |
| MSTRG.10212 | GABPB1 | ENST00000560825 | GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0006351(transcription, DNA-templated);GO:0006357(regulation of transcription from RNA polymerase II promoter);GO:0006996(organelle organization);GO:0007005(mitochondrion organization);GO:0044212(transcription regulatory region DNA binding);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046982(protein heterodimerization activity) | NA | NA | NA | GA binding protein transcription factor, beta subunit 1 [Source:HGNC Symbol;Acc:HGNC:4074] | 1.76 | 1.64 | 1.63 | 0.51 | 1.35 | 1.35 | 10.91 | 3.45 | 0.19 | 0.35 | up | no |
| MSTRG.10222 | TRPM7 | ENST00000560955 | GO:0001726(ruffle);GO:0003779(actin binding);GO:0004674(protein serine/threonine kinase activity);GO:0005216(ion channel activity);GO:0005262(calcium channel activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005623(cell);GO:0005886(plasma membrane);GO:0006468(protein phosphorylation);GO:0006811(ion transport);GO:0006812(cation transport);GO:0006816(calcium ion transport);GO:0010961(cellular magnesium ion homeostasis);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0016301(kinase activity);GO:0016340(calcium-dependent cell-matrix adhesion);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0017022(myosin binding);GO:0031032(actomyosin structure organization);GO:0034220(ion transmembrane transport);GO:0046777(protein autophosphorylation);GO:0046872(metal ion binding);GO:0055085(transmembrane transport);GO:0070266(necroptotic process);GO:0070588(calcium ion transmembrane transport) | NA | NA | NA | transient receptor potential cation channel, subfamily M, member 7 [Source:HGNC Symbol;Acc:HGNC:17994] | 5.99 | 5.71 | 5.89 | 6.92 | 6.83 | 6.88 | 0.13 | -2.96 | 0.03 | 0.12 | down | yes |
| MSTRG.10224 | SPPL2A | ENST00000261854 | GO:0004190(aspartic-type endopeptidase activity);GO:0005515(protein binding);GO:0005765(lysosomal membrane);GO:0005886(plasma membrane);GO:0006508(proteolysis);GO:0006509(membrane protein ectodomain proteolysis);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0030660(Golgi-associated vesicle membrane);GO:0031293(membrane protein intracellular domain proteolysis);GO:0031902(late endosome membrane);GO:0033619(membrane protein proteolysis);GO:0042500(aspartic endopeptidase activity, intramembrane cleaving);GO:0042803(protein homodimerization activity);GO:0050776(regulation of immune response);GO:0070062(extracellular exosome);GO:0071458(integral component of cytoplasmic side of endoplasmic reticulum membrane);GO:0071556(integral component of lumenal side of endoplasmic reticulum membrane) | NA | NA | NA | signal peptide peptidase like 2A [Source:HGNC Symbol;Acc:HGNC:30227] | 8.63 | 9.46 | 8.73 | 7.74 | 7.60 | 7.62 | 2.17 | 1.11 | 0.03 | 0.12 | up | yes |
| MSTRG.10228 | AP4E1 | ENST00000261842 | GO:0005488(binding);GO:0005905(coated pit);GO:0006886(intracellular protein transport);GO:0006892(post-Golgi vesicle-mediated transport);GO:0016192(vesicle-mediated transport);GO:0030117(membrane coat);GO:0031904(endosome lumen);GO:0032588(trans-Golgi network membrane);GO:0061024(membrane organization) | 04142(Lysosome) | NA | NA | adaptor-related protein complex 4, epsilon 1 subunit [Source:HGNC Symbol;Acc:HGNC:573] | 3.19 | 3.07 | 3.17 | 1.46 | 1.40 | 1.39 | 1.61 | 0.69 | 0.11 | 0.25 | up | no |
| MSTRG.10239 | TMOD3 | ENST00000308580 | GO:0003779(actin binding);GO:0005523(tropomyosin binding);GO:0005856(cytoskeleton);GO:0005865(striated muscle thin filament);GO:0006936(muscle contraction);GO:0007015(actin filament organization);GO:0030016(myofibril);GO:0030036(actin cytoskeleton organization);GO:0030239(myofibril assembly);GO:0048821(erythrocyte development);GO:0051694(pointed-end actin filament capping);GO:1901992(positive regulation of mitotic cell cycle phase transition) | NA | NA | NA | tropomodulin 3 (ubiquitous) [Source:HGNC Symbol;Acc:HGNC:11873] | 5.04 | 4.94 | 5.07 | 3.18 | 3.20 | 3.21 | 1.19 | 0.26 | 0.00 | 0.04 | up | no |
| MSTRG.10248 | LEO1 | ENST00000299601 | GO:0001711(endodermal cell fate commitment);GO:0005515(protein binding);GO:0005654(nucleoplasm);GO:0005730(nucleolus);GO:0006351(transcription, DNA-templated);GO:0006378(mRNA polyadenylation);GO:0010390(histone monoubiquitination);GO:0016055(Wnt signaling pathway);GO:0016593(Cdc73/Paf1 complex);GO:0019827(stem cell maintenance);GO:0031442(positive regulation of mRNA 3'-end processing);GO:0032968(positive regulation of transcription elongation from RNA polymerase II promoter);GO:0033523(histone H2B ubiquitination);GO:0045638(negative regulation of myeloid cell differentiation);GO:0045944(positive regulation of transcription from RNA polymerase II promoter) | NA | NA | NA | Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:30401] | 18.48 | 16.67 | 18.31 | 6.47 | 6.64 | 6.60 | 1.16 | 0.21 | 0.64 | 0.76 | up | no |
| MSTRG.10249 | MAPK6 | ENST00000261845 | GO:0000165(MAPK cascade);GO:0004672(protein kinase activity);GO:0004674(protein serine/threonine kinase activity);GO:0004707(MAP kinase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006468(protein phosphorylation);GO:0007049(cell cycle);GO:0007165(signal transduction);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0019901(protein kinase binding);GO:0046982(protein heterodimerization activity) | NA | NA | NA | mitogen-activated protein kinase 6 [Source:HGNC Symbol;Acc:HGNC:6879] | 32.56 | 31.13 | 32.55 | 8.19 | 8.10 | 8.11 | 2.60 | 1.38 | 0.01 | 0.07 | up | yes |
| MSTRG.10256 | BCL2L10 | ENST00000260442 | GO:0005515(protein binding);GO:0005739(mitochondrion);GO:0005741(mitochondrial outer membrane);GO:0005829(cytosol);GO:0006919(activation of cysteine-type endopeptidase activity involved in apoptotic process);GO:0007283(spermatogenesis);GO:0007292(female gamete generation);GO:0008630(intrinsic apoptotic signaling pathway in response to DNA damage);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0031965(nuclear membrane);GO:0042803(protein homodimerization activity);GO:0042981(regulation of apoptotic process);GO:0043065(positive regulation of apoptotic process);GO:0043066(negative regulation of apoptotic process);GO:0046982(protein heterodimerization activity);GO:0097192(extrinsic apoptotic signaling pathway in absence of ligand);GO:2001240(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand);GO:2001243(negative regulation of intrinsic apoptotic signaling pathway) | NA | NA | NA | BCL2-like 10 (apoptosis facilitator) [Source:HGNC Symbol;Acc:HGNC:993] | 0.02 | 0.02 | 0.02 | 2.33 | 2.17 | 2.16 | 0.36 | -1.46 | 0.04 | 0.13 | down | yes |
| MSTRG.10258 | GNB5 | ENST00000358784 | GO:0001750(photoreceptor outer segment);GO:0001917(photoreceptor inner segment);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005886(plasma membrane);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007603(phototransduction, visible light);GO:0008152(metabolic process);GO:0016056(rhodopsin mediated signaling pathway);GO:0022400(regulation of rhodopsin mediated signaling pathway);GO:0031682(G-protein gamma-subunit binding);GO:0043209(myelin sheath);GO:0051087(chaperone binding);GO:1901386(negative regulation of voltage-gated calcium channel activity) | 04062(Chemokine signaling pathway);04724(Glutamatergic synapse);04725(Cholinergic synapse) | NA | NA | guanine nucleotide binding protein (G protein), beta 5 [Source:HGNC Symbol;Acc:HGNC:4401] | 3.76 | 3.23 | 3.86 | 0.65 | 0.66 | 0.66 | 1.54 | 0.63 | 0.49 | 0.65 | up | no |
| MSTRG.10263 | MYO5C | ENST00000261839 | GO:0003774(motor activity);GO:0003779(actin binding);GO:0005515(protein binding);GO:0005516(calmodulin binding);GO:0005524(ATP binding);GO:0008152(metabolic process);GO:0016459(myosin complex);GO:0070062(extracellular exosome) | NA | NA | NA | myosin VC [Source:HGNC Symbol;Acc:HGNC:7604] | 6.51 | 6.24 | 6.61 | 1.12 | 1.11 | 1.13 | 2.78 | 1.48 | 0.00 | 0.03 | up | yes |
| MSTRG.10271 | FAM214A | ENST00000534964 | GO:0005515(protein binding) | NA | NA | NA | family with sequence similarity 214, member A [Source:HGNC Symbol;Acc:HGNC:25609] | 2.29 | 2.37 | 2.30 | 4.46 | 4.46 | 4.50 | 0.99 | -0.01 | 0.98 | 0.99 | down | no |
| MSTRG.10276 | ONECUT1 | ENST00000305901 | GO:0001077(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription);GO:0001228(RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription);GO:0001889(liver development);GO:0001952(regulation of cell-matrix adhesion);GO:0002064(epithelial cell development);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005634(nucleus);GO:0006006(glucose metabolic process);GO:0006355(regulation of transcription, DNA-templated);GO:0006357(regulation of transcription from RNA polymerase II promoter);GO:0006366(transcription from RNA polymerase II promoter);GO:0007219(Notch signaling pathway);GO:0007492(endoderm development);GO:0009653(anatomical structure morphogenesis);GO:0030154(cell differentiation);GO:0030183(B cell differentiation);GO:0030335(positive regulation of cell migration);GO:0030512(negative regulation of transforming growth factor beta receptor signaling pathway);GO:0031016(pancreas development);GO:0031018(endocrine pancreas development);GO:0042384(cilium assembly);GO:0045165(cell fate commitment);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048536(spleen development) | 04950(Maturity onset diabetes of the young) | NA | NA | one cut homeobox 1 [Source:HGNC Symbol;Acc:HGNC:8138] | 3.33 | 2.79 | 2.64 | 5.93 | 4.25 | 4.29 | 2.29 | 1.20 | 0.68 | 0.79 | up | no |
| MSTRG.10278 | WDR72 | ENST00000567224;ENST00000614174 | GO:0005515(protein binding);GO:0005737(cytoplasm) | NA | NA | NA | WD repeat domain 72 [Source:HGNC Symbol;Acc:HGNC:26790] | 0.55 | 1.47 | 0.54 | 7.33 | 7.38 | 7.38 | 14.92 | 3.90 | 0.12 | 0.26 | up | no |
| MSTRG.10286 | RSL24D1 | ENST00000260443 | GO:0003735(structural constituent of ribosome);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0005840(ribosome);GO:0006412(translation);GO:0042254(ribosome biogenesis) | NA | NA | NA | ribosomal L24 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:18479] | 12.94 | 14.16 | 13.18 | 3.08 | 3.27 | 3.26 | 5.74 | 2.52 | 0.03 | 0.13 | up | yes |
| MSTRG.10287 | RAB27A | ENST00000336787 | GO:0001750(photoreceptor outer segment);GO:0003924(GTPase activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0005622(intracellular);GO:0005764(lysosome);GO:0005770(late endosome);GO:0005794(Golgi apparatus);GO:0006605(protein targeting);GO:0006886(intracellular protein transport);GO:0006887(exocytosis);GO:0006904(vesicle docking involved in exocytosis);GO:0006913(nucleocytoplasmic transport);GO:0007165(signal transduction);GO:0007264(small GTPase mediated signal transduction);GO:0007596(blood coagulation);GO:0008152(metabolic process);GO:0009306(protein secretion);GO:0010628(positive regulation of gene expression);GO:0015031(protein transport);GO:0016020(membrane);GO:0016192(vesicle-mediated transport);GO:0016324(apical plasma membrane);GO:0019003(GDP binding);GO:0019882(antigen processing and presentation);GO:0019904(protein domain specific binding);GO:0030141(secretory granule);GO:0030318(melanocyte differentiation);GO:0030425(dendrite);GO:0030667(secretory granule membrane);GO:0031489(myosin V binding);GO:0032400(melanosome localization);GO:0032402(melanosome transport);GO:0032482(Rab protein signal transduction);GO:0032585(multivesicular body membrane);GO:0033093(Weibel-Palade body);GO:0036257(multivesicular body organization);GO:0042470(melanosome);GO:0043316(cytotoxic T cell degranulation);GO:0043320(natural killer cell degranulation);GO:0043473(pigmentation);GO:0044267(cellular protein metabolic process);GO:0045921(positive regulation of exocytosis);GO:0048489(synaptic vesicle transport);GO:0050766(positive regulation of phagocytosis);GO:0051875(pigment granule localization);GO:0051904(pigment granule transport);GO:0070062(extracellular exosome);GO:0070382(exocytic vesicle);GO:0071985(multivesicular body sorting pathway);GO:0097278(complement-dependent cytotoxicity);GO:1903307(positive regulation of regulated secretory pathway);GO:1903428(positive regulation of reactive oxygen species biosynthetic process);GO:1903435(positive regulation of constitutive secretory pathway);GO:1990182(exosomal secretion) | NA | NA | NA | RAB27A, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9766] | 1.70 | 1.52 | 1.78 | 2.76 | 2.75 | 2.75 | 0.13 | -2.99 | 0.53 | 0.68 | down | no |
| MSTRG.10292 | CCPG1 | ENST00000442196;ENST00000310958;ENST00000569205 | GO:0003674(molecular_function);GO:0005515(protein binding);GO:0007049(cell cycle);GO:0008284(positive regulation of cell proliferation);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0045787(positive regulation of cell cycle);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:2001106(regulation of Rho guanyl-nucleotide exchange factor activity) | NA | NA | NA | cell cycle progression 1 [Source:HGNC Symbol;Acc:HGNC:24227] | 4.33 | 5.99 | 5.92 | 4.73 | 4.91 | 4.92 | 2.30 | 1.20 | 0.55 | 0.69 | up | no |
| MSTRG.10297 | NEDD4 | ENST00000508342;ENST00000506154;ENST00000508075;ENST00000557845 | GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000151(ubiquitin ligase complex);GO:0000785(chromatin);GO:0002250(adaptive immune response);GO:0003151(outflow tract morphogenesis);GO:0003197(endocardial cushion development);GO:0004842(ubiquitin-protein transferase activity);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005938(cell cortex);GO:0006513(protein monoubiquitination);GO:0006622(protein targeting to lysosome);GO:0007041(lysosomal transport);GO:0007528(neuromuscular junction development);GO:0010766(negative regulation of sodium ion transport);GO:0010768(negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage);GO:0014068(positive regulation of phosphatidylinositol 3-kinase signaling);GO:0016020(membrane);GO:0016327(apicolateral plasma membrane);GO:0016567(protein ubiquitination);GO:0016874(ligase activity);GO:0019089(transmission of virus);GO:0019221(cytokine-mediated signaling pathway);GO:0019871(sodium channel inhibitor activity);GO:0019904(protein domain specific binding);GO:0030948(negative regulation of vascular endothelial growth factor receptor signaling pathway);GO:0031175(neuron projection development);GO:0031623(receptor internalization);GO:0031698(beta-2 adrenergic receptor binding);GO:0032801(receptor catabolic process);GO:0034644(cellular response to UV);GO:0034765(regulation of ion transmembrane transport);GO:0042110(T cell activation);GO:0042391(regulation of membrane potential);GO:0042787(protein ubiquitination involved in ubiquitin-dependent protein catabolic process);GO:0042921(glucocorticoid receptor signaling pathway);GO:0043130(ubiquitin binding);GO:0043162(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway);GO:0044111(development involved in symbiotic interaction);GO:0045732(positive regulation of protein catabolic process);GO:0046824(positive regulation of nucleocytoplasmic transport);GO:0048471(perinuclear region of cytoplasm);GO:0048514(blood vessel morphogenesis);GO:0048814(regulation of dendrite morphogenesis);GO:0050807(regulation of synapse organization);GO:0050815(phosphoserine binding);GO:0050816(phosphothreonine binding);GO:0050847(progesterone receptor signaling pathway);GO:0051592(response to calcium ion);GO:0061630(ubiquitin protein ligase activity);GO:0070062(extracellular exosome);GO:0070063(RNA polymerase binding);GO:0070064(proline-rich region binding);GO:0070534(protein K63-linked ubiquitination);GO:1901016(regulation of potassium ion transmembrane transporter activity);GO:2000650(negative regulation of sodium ion transmembrane transporter activity) | 04120(Ubiquitin mediated proteolysis);04144(Endocytosis) | NA | NA | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:HGNC:7727] | 19.23 | 19.23 | 19.56 | 8.26 | 8.02 | 8.00 | 2.12 | 1.08 | 0.02 | 0.11 | up | yes |
| MSTRG.103 | CEP104 | ENST00000378230 | GO:0005488(binding);GO:0005814(centriole) | NA | NA | NA | centrosomal protein 104kDa [Source:HGNC Symbol;Acc:HGNC:24866] | 5.35 | 4.52 | 5.39 | 3.20 | 3.08 | 3.08 | 0.46 | -1.12 | 0.21 | 0.37 | down | no |
| MSTRG.1030 | MYSM1 | ENST00000472487 | GO:0003677(DNA binding);GO:0003682(chromatin binding);GO:0003713(transcription coactivator activity);GO:0004843(ubiquitin-specific protease activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0006338(chromatin remodeling);GO:0006351(transcription, DNA-templated);GO:0008237(metallopeptidase activity);GO:0015630(microtubule cytoskeleton);GO:0030334(regulation of cell migration);GO:0032403(protein complex binding);GO:0035522(monoubiquitinated histone H2A deubiquitination);GO:0042393(histone binding);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046872(metal ion binding);GO:0051797(regulation of hair follicle development) | NA | NA | NA | Myb-like, SWIRM and MPN domains 1 [Source:HGNC Symbol;Acc:HGNC:29401] | 6.81 | 5.46 | 6.57 | 2.66 | 2.54 | 2.56 | 1.33 | 0.41 | 0.86 | 0.91 | up | no |
| MSTRG.10316 | ZNF280D | ENST00000267807 | GO:0000977(RNA polymerase II regulatory region sequence-specific DNA binding);GO:0000981(sequence-specific DNA binding RNA polymerase II transcription factor activity);GO:0005634(nucleus);GO:0006351(transcription, DNA-templated);GO:0006357(regulation of transcription from RNA polymerase II promoter);GO:0046872(metal ion binding) | NA | NA | NA | zinc finger protein 280D [Source:HGNC Symbol;Acc:HGNC:25953] | 1.99 | 1.98 | 1.95 | 2.63 | 2.63 | 2.61 | 1.46 | 0.54 | 0.38 | 0.55 | up | no |
| MSTRG.1032 | JUN | ENST00000371222 | GO:0000228(nuclear chromosome);GO:0000790(nuclear chromatin);GO:0000978(RNA polymerase II core promoter proximal region sequence-specific DNA binding);GO:0000980(RNA polymerase II distal enhancer sequence-specific DNA binding);GO:0000981(sequence-specific DNA binding RNA polymerase II transcription factor activity);GO:0001077(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription);GO:0001102(RNA polymerase II activating transcription factor binding);GO:0001190(RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription);GO:0001525(angiogenesis);GO:0001774(microglial cell activation);GO:0001836(release of cytochrome c from mitochondria);GO:0001889(liver development);GO:0001938(positive regulation of endothelial cell proliferation);GO:0002224(toll-like receptor signaling pathway);GO:0002755(MyD88-dependent toll-like receptor signaling pathway);GO:0002756(MyD88-independent toll-like receptor signaling pathway);GO:0003151(outflow tract morphogenesis);GO:0003677(DNA binding);GO:0003682(chromatin binding);GO:0003690(double-stranded DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0003705(RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity);GO:0003713(transcription coactivator activity);GO:0005096(GTPase activator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005667(transcription factor complex);GO:0005719(nuclear euchromatin);GO:0005829(cytosol);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0006366(transcription from RNA polymerase II promoter);GO:0007179(transforming growth factor beta receptor signaling pathway);GO:0007184(SMAD protein import into nucleus);GO:0007568(aging);GO:0007612(learning);GO:0007623(circadian rhythm);GO:0008134(transcription factor binding);GO:0008284(positive regulation of cell proliferation);GO:0008285(negative regulation of cell proliferation);GO:0009314(response to radiation);GO:0009612(response to mechanical stimulus);GO:0009987(cellular process);GO:0010033(response to organic substance);GO:0010941(regulation of cell death);GO:0014070(response to organic cyclic compound);GO:0017053(transcriptional repressor complex);GO:0019899(enzyme binding);GO:0030224(monocyte differentiation);GO:0031103(axon regeneration);GO:0031953(negative regulation of protein autophosphorylation);GO:0032496(response to lipopolysaccharide);GO:0032870(cellular response to hormone stimulus);GO:0034097(response to cytokine);GO:0034134(toll-like receptor 2 signaling pathway);GO:0034138(toll-like receptor 3 signaling pathway);GO:0034142(toll-like receptor 4 signaling pathway);GO:0034146(toll-like receptor 5 signaling pathway);GO:0034162(toll-like receptor 9 signaling pathway);GO:0034166(toll-like receptor 10 signaling pathway);GO:0035026(leading edge cell differentiation);GO:0035497(cAMP response element binding);GO:0035666(TRIF-dependent toll-like receptor signaling pathway);GO:0035994(response to muscle stretch);GO:0038095(Fc-epsilon receptor signaling pathway);GO:0038123(toll-like receptor TLR1:TLR2 signaling pathway);GO:0038124(toll-like receptor TLR6:TLR2 signaling pathway);GO:0042127(regulation of cell proliferation);GO:0042493(response to drug);GO:0042542(response to hydrogen peroxide);GO:0043065(positive regulation of apoptotic process);GO:0043066(negative regulation of apoptotic process);GO:0043392(negative regulation of DNA binding);GO:0043524(negative regulation of neuron apoptotic process);GO:0043525(positive regulation of neuron apoptotic process);GO:0043547(positive regulation of GTPase activity);GO:0043565(sequence-specific DNA binding);GO:0043922(negative regulation by host of viral transcription);GO:0043923(positive regulation by host of viral transcription);GO:0044212(transcription regulatory region DNA binding);GO:0044822(poly(A) RNA binding);GO:0045087(innate immune response);GO:0045597(positive regulation of cell differentiation);GO:0045657(positive regulation of monocyte differentiation);GO:0045740(positive regulation of DNA replication);GO:0045892(negative regulation of transcription, DNA-templated);GO:0045893(positive regulation of transcription, DNA-templated);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0048146(positive regulation of fibroblast proliferation);GO:0048661(positive regulation of smooth muscle cell proliferation);GO:0051090(regulation of sequence-specific DNA binding transcription factor activity);GO:0051365(cellular response to potassium ion starvation);GO:0051403(stress-activated MAPK cascade);GO:0051591(response to cAMP);GO:0051726(regulation of cell cycle);GO:0051899(membrane depolarization);GO:0060395(SMAD protein signal transduction);GO:0070412(R-SMAD binding);GO:0071277(cellular response to calcium ion);GO:0071837(HMG box domain binding);GO:1990441(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress);GO:2000144(positive regulation of DNA-templated transcription, initiation) | 04010(MAPK signaling pathway);04012(ErbB signaling pathway);04310(Wnt signaling pathway);04380(Osteoclast differentiation);04510(Focal adhesion);04620(Toll-like receptor signaling pathway);04660(T cell receptor signaling pathway);04662(B cell receptor signaling pathway);04722(Neurotrophin signaling pathway);04912(GnRH signaling pathway);05120(Epithelial cell signaling in Helicobacter pylori infection);05140(Leishmaniasis);05142(Chagas disease (American trypanosomiasis));05164(Influenza A);05200(Pathways in cancer);05210(Colorectal cancer);05211(Renal cell carcinoma);05323(Rheumatoid arthritis) | NA | NA | jun proto-oncogene [Source:HGNC Symbol;Acc:HGNC:6204] | 50.53 | 44.05 | 51.43 | 71.24 | 71.51 | 71.74 | 0.18 | -2.45 | 0.01 | 0.08 | down | yes |
| MSTRG.10323 | TCF12 | ENST00000557843;ENST00000560887;ENST00000543579;ENST00000343827 | GO:0000790(nuclear chromatin);GO:0000978(RNA polymerase II core promoter proximal region sequence-specific DNA binding);GO:0001077(RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005667(transcription factor complex);GO:0005737(cytoplasm);GO:0006357(regulation of transcription from RNA polymerase II promoter);GO:0006366(transcription from RNA polymerase II promoter);GO:0006955(immune response);GO:0007517(muscle organ development);GO:0008134(transcription factor binding);GO:0010628(positive regulation of gene expression);GO:0035326(enhancer binding);GO:0035497(cAMP response element binding);GO:0042803(protein homodimerization activity);GO:0043425(bHLH transcription factor binding);GO:0044212(transcription regulatory region DNA binding);GO:0045666(positive regulation of neuron differentiation);GO:0045893(positive regulation of transcription, DNA-templated);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046332(SMAD binding);GO:0046982(protein heterodimerization activity);GO:0046983(protein dimerization activity);GO:0070888(E-box binding);GO:0071837(HMG box domain binding);GO:0090575(RNA polymerase II transcription factor complex) | NA | NA | NA | transcription factor 12 [Source:HGNC Symbol;Acc:HGNC:11623] | 4.23 | 4.06 | 4.04 | 3.99 | 4.16 | 4.18 | 0.36 | -1.47 | 0.42 | 0.59 | down | no |
| MSTRG.10333 | AQP9 | ENST00000558772;ENST00000219919;ENST00000536493 | GO:0005215(transporter activity);GO:0005275(amine transmembrane transporter activity);GO:0005345(purine nucleobase transmembrane transporter activity);GO:0005350(pyrimidine nucleobase transmembrane transporter activity);GO:0005372(water transmembrane transporter activity);GO:0005623(cell);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006810(transport);GO:0006833(water transport);GO:0006863(purine nucleobase transport);GO:0006955(immune response);GO:0006970(response to osmotic stress);GO:0007588(excretion);GO:0008152(metabolic process);GO:0009992(cellular water homeostasis);GO:0010033(response to organic substance);GO:0015166(polyol transmembrane transporter activity);GO:0015204(urea transmembrane transporter activity);GO:0015250(water channel activity);GO:0015254(glycerol channel activity);GO:0015288(porin activity);GO:0015722(canalicular bile acid transport);GO:0015791(polyol transport);GO:0015793(glycerol transport);GO:0015837(amine transport);GO:0015855(pyrimidine nucleobase transport);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0016323(basolateral plasma membrane);GO:0030104(water homeostasis);GO:0034220(ion transmembrane transport);GO:0043231(intracellular membrane-bounded organelle);GO:0046689(response to mercury ion);GO:0046942(carboxylic acid transport);GO:0046943(carboxylic acid transmembrane transporter activity);GO:0055085(transmembrane transport);GO:0071320(cellular response to cAMP);GO:0071918(urea transmembrane transport);GO:0072531(pyrimidine-containing compound transmembrane transport) | NA | NA | NA | aquaporin 9 [Source:HGNC Symbol;Acc:HGNC:643] | 23.45 | 18.05 | 23.25 | 67.82 | 150.60 | 150.58 | 0.00 | -9.74 | 0.17 | 0.32 | down | no |
| MSTRG.10359 | SLTM | ENST00000380516 | GO:0000166(nucleotide binding);GO:0003676(nucleic acid binding);GO:0005654(nucleoplasm);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0006915(apoptotic process);GO:0044822(poly(A) RNA binding) | NA | NA | NA | SAFB-like, transcription modulator [Source:HGNC Symbol;Acc:HGNC:20709] | 5.15 | 5.17 | 5.19 | 4.11 | 4.01 | 4.00 | 3.28 | 1.71 | 0.05 | 0.15 | up | yes |
| MSTRG.10364 | CCNB2 | ENST00000288207 | GO:0000086(G2/M transition of mitotic cell cycle);GO:0000278(mitotic cell cycle);GO:0001701(in utero embryonic development);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005813(centrosome);GO:0005829(cytosol);GO:0007067(mitotic nuclear division);GO:0007077(mitotic nuclear envelope disassembly);GO:0015630(microtubule cytoskeleton);GO:0016020(membrane);GO:0040007(growth);GO:0043029(T cell homeostasis);GO:0048538(thymus development);GO:0051301(cell division);GO:0051726(regulation of cell cycle) | 04110(Cell cycle);04114(Oocyte meiosis);04115(p53 signaling pathway);04914(Progesterone-mediated oocyte maturation) | NA | NA | cyclin B2 [Source:HGNC Symbol;Acc:HGNC:1580] | 4.72 | 5.92 | 4.81 | 0.05 | 0.07 | 0.07 | 59.13 | 5.89 | 0.00 | 0.05 | up | yes |
| MSTRG.10367 | MYO1E | ENST00000288235 | GO:0000146(microfilament motor activity);GO:0001570(vasculogenesis);GO:0001701(in utero embryonic development);GO:0001822(kidney development);GO:0003094(glomerular filtration);GO:0003774(motor activity);GO:0005515(protein binding);GO:0005516(calmodulin binding);GO:0005524(ATP binding);GO:0005737(cytoplasm);GO:0005856(cytoskeleton);GO:0005903(brush border);GO:0005911(cell-cell junction);GO:0005912(adherens junction);GO:0006807(nitrogen compound metabolic process);GO:0006897(endocytosis);GO:0008152(metabolic process);GO:0015629(actin cytoskeleton);GO:0016459(myosin complex);GO:0030048(actin filament-based movement);GO:0030097(hemopoiesis);GO:0032836(glomerular basement membrane development);GO:0035091(phosphatidylinositol binding);GO:0035166(post-embryonic hemopoiesis);GO:0042623(ATPase activity, coupled);GO:0045334(clathrin-coated endocytic vesicle);GO:0048008(platelet-derived growth factor receptor signaling pathway);GO:0051015(actin filament binding);GO:0070062(extracellular exosome);GO:0072015(glomerular visceral epithelial cell development) | NA | NA | NA | myosin IE [Source:HGNC Symbol;Acc:HGNC:7599] | 12.73 | 10.95 | 12.72 | 6.19 | 6.33 | 6.35 | 0.50 | -0.99 | 0.08 | 0.20 | down | no |
| MSTRG.1038 | HOOK1 | ENST00000371208;ENST00000466803 | GO:0003779(actin binding);GO:0005515(protein binding);GO:0005874(microtubule);GO:0007032(endosome organization);GO:0007040(lysosome organization);GO:0007275(multicellular organismal development);GO:0007286(spermatid development);GO:0008333(endosome to lysosome transport);GO:0015031(protein transport);GO:0015630(microtubule cytoskeleton);GO:0030897(HOPS complex);GO:0042802(identical protein binding);GO:0045022(early endosome to late endosome transport);GO:0070695(FHF complex) | NA | NA | NA | hook microtubule-tethering protein 1 [Source:HGNC Symbol;Acc:HGNC:19884] | 24.43 | 23.75 | 24.11 | 8.14 | 8.34 | 8.22 | 2.21 | 1.14 | 0.01 | 0.06 | up | yes |
| MSTRG.10382 | BNIP2 | ENST00000607373 | GO:0001824(blastocyst development);GO:0005096(GTPase activator activity);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005635(nuclear envelope);GO:0005737(cytoplasm);GO:0005814(centriole);GO:0005829(cytosol);GO:0006915(apoptotic process);GO:0031616(spindle pole centrosome);GO:0042692(muscle cell differentiation);GO:0042802(identical protein binding);GO:0043066(negative regulation of apoptotic process);GO:0043231(intracellular membrane-bounded organelle);GO:0043410(positive regulation of MAPK cascade);GO:0043547(positive regulation of GTPase activity);GO:0045666(positive regulation of neuron differentiation);GO:0048471(perinuclear region of cytoplasm);GO:0051057(positive regulation of small GTPase mediated signal transduction);GO:0051146(striated muscle cell differentiation);GO:0051149(positive regulation of muscle cell differentiation);GO:0051297(centrosome organization) | NA | NA | NA | BCL2/adenovirus E1B 19kDa interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:1083] | 2.37 | 2.16 | 2.42 | 3.06 | 3.33 | 3.33 | 2176.13 | 11.09 | 0.03 | 0.13 | up | yes |
| MSTRG.10385 | ANXA2 | ENST00000451270;ENST00000421017 | GO:0001525(angiogenesis);GO:0001726(ruffle);GO:0001765(membrane raft assembly);GO:0001934(positive regulation of protein phosphorylation);GO:0002091(negative regulation of receptor internalization);GO:0004859(phospholipase inhibitor activity);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005544(calcium-dependent phospholipid binding);GO:0005546(phosphatidylinositol-4,5-bisphosphate binding);GO:0005604(basement membrane);GO:0005615(extracellular space);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005765(lysosomal membrane);GO:0005768(endosome);GO:0005769(early endosome);GO:0005811(lipid particle);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005938(cell cortex);GO:0006900(membrane budding);GO:0007589(body fluid secretion);GO:0008092(cytoskeletal protein binding);GO:0009986(cell surface);GO:0016020(membrane);GO:0016323(basolateral plasma membrane);GO:0017137(Rab GTPase binding);GO:0019834(phospholipase A2 inhibitor activity);GO:0019897(extrinsic component of plasma membrane);GO:0030199(collagen fibril organization);GO:0030496(midbody);GO:0030546(receptor activator activity);GO:0031012(extracellular matrix);GO:0031340(positive regulation of vesicle fusion);GO:0031902(late endosome membrane);GO:0031982(vesicle);GO:0032804(negative regulation of low-density lipoprotein particle receptor catabolic process);GO:0035749(myelin sheath adaxonal region);GO:0036035(osteoclast development);GO:0042383(sarcolemma);GO:0042470(melanosome);GO:0042730(fibrinolysis);GO:0043086(negative regulation of catalytic activity);GO:0043220(Schmidt-Lanterman incisure);GO:0043234(protein complex);GO:0044354(macropinosome);GO:0044548(S100 protein binding);GO:0044822(poly(A) RNA binding);GO:0045121(membrane raft);GO:0048146(positive regulation of fibroblast proliferation);GO:0048306(calcium-dependent protein binding);GO:0048471(perinuclear region of cytoplasm);GO:0051099(positive regulation of binding);GO:0051290(protein heterotetramerization);GO:0070062(extracellular exosome);GO:0072661(protein targeting to plasma membrane);GO:1900121(negative regulation of receptor binding);GO:1990667(PCSK9-AnxA2 complex);GO:2000273(positive regulation of receptor activity) | NA | NA | NA | annexin A2 [Source:HGNC Symbol;Acc:HGNC:537] | 26.66 | 28.24 | 25.34 | 6.01 | 5.69 | 5.76 | 15.37 | 3.94 | 0.00 | 0.01 | up | yes |
| MSTRG.10388 | VPS13C | ENST00000249837;ENST00000395898 | GO:0005622(intracellular);GO:0005623(cell);GO:0006623(protein targeting to vacuole);GO:0019898(extrinsic component of membrane);GO:0045053(protein retention in Golgi apparatus);GO:0070062(extracellular exosome) | NA | NA | NA | vacuolar protein sorting 13 homolog C (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:23594] | 13.29 | 11.14 | 13.16 | 8.55 | 8.28 | 8.27 | 0.44 | -1.18 | 0.24 | 0.40 | down | no |
| MSTRG.10393 | RORA | ENST00000335670;ENST00000261523;ENST00000449337;ENST00000560300 | GO:0000977(RNA polymerase II regulatory region sequence-specific DNA binding);GO:0001046(core promoter sequence-specific DNA binding);GO:0001222(transcription corepressor binding);GO:0001223(transcription coactivator binding);GO:0001525(angiogenesis);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0003707(steroid hormone receptor activity);GO:0004879(ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0006367(transcription initiation from RNA polymerase II promoter);GO:0006805(xenobiotic metabolic process);GO:0006809(nitric oxide biosynthetic process);GO:0007623(circadian rhythm);GO:0008013(beta-catenin binding);GO:0008134(transcription factor binding);GO:0008142(oxysterol binding);GO:0008270(zinc ion binding);GO:0008589(regulation of smoothened signaling pathway);GO:0010467(gene expression);GO:0010575(positive regulation of vascular endothelial growth factor production);GO:0010906(regulation of glucose metabolic process);GO:0019218(regulation of steroid metabolic process);GO:0021702(cerebellar Purkinje cell differentiation);GO:0021930(cerebellar granule cell precursor proliferation);GO:0030522(intracellular receptor signaling pathway);GO:0032922(circadian regulation of gene expression);GO:0036315(cellular response to sterol);GO:0042692(muscle cell differentiation);GO:0042752(regulation of circadian rhythm);GO:0042753(positive regulation of circadian rhythm);GO:0043030(regulation of macrophage activation);GO:0043124(negative regulation of I-kappaB kinase/NF-kappaB signaling);GO:0043401(steroid hormone mediated signaling pathway);GO:0043565(sequence-specific DNA binding);GO:0045599(negative regulation of fat cell differentiation);GO:0045893(positive regulation of transcription, DNA-templated);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046068(cGMP metabolic process);GO:0050728(negative regulation of inflammatory response);GO:0060850(regulation of transcription involved in cell fate commitment);GO:0070328(triglyceride homeostasis);GO:0071347(cellular response to interleukin-1);GO:0071356(cellular response to tumor necrosis factor);GO:0071456(cellular response to hypoxia);GO:0072539(T-helper 17 cell differentiation);GO:0098531(direct ligand regulated sequence-specific DNA binding transcription factor activity);GO:2000188(regulation of cholesterol homeostasis) | 04710(Circadian rhythm - mammal) | NA | NA | RAR-related orphan receptor A [Source:HGNC Symbol;Acc:HGNC:10258] | 1.34 | 1.54 | 1.30 | 3.02 | 3.04 | 3.05 | 1.33 | 0.41 | 0.34 | 0.51 | up | no |
| MSTRG.10395 | CYCSP38 | ENST00000559840 | NA | NA | NA | NA | NA | 0 | 0 | 0 | 0 | 2.02 | 1.99 | 0.01 | -6.98 | 0.47 | 0.63 | down | no |
| MSTRG.1040 | FGGY | ENST00000413489 | GO:0003674(molecular_function);GO:0005575(cellular_component);GO:0005737(cytoplasm);GO:0005975(carbohydrate metabolic process);GO:0016301(kinase activity);GO:0016773(phosphotransferase activity, alcohol group as acceptor);GO:0046835(carbohydrate phosphorylation);GO:0070050(neuron cellular homeostasis) | NA | NA | NA | FGGY carbohydrate kinase domain containing [Source:HGNC Symbol;Acc:HGNC:25610] | 1.75 | 1.43 | 1.75 | 2.04 | 2.21 | 2.23 | 0.19 | -2.43 | 0.02 | 0.11 | down | yes |
| MSTRG.10404 | RPS27L | ENST00000439025 | GO:0003735(structural constituent of ribosome);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005840(ribosome);GO:0006281(DNA repair);GO:0006412(translation);GO:0006919(activation of cysteine-type endopeptidase activity involved in apoptotic process);GO:0006974(cellular response to DNA damage stimulus);GO:0008494(translation activator activity);GO:0008656(cysteine-type endopeptidase activator activity involved in apoptotic process);GO:0031571(mitotic G1 DNA damage checkpoint);GO:0042771(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator);GO:0044822(poly(A) RNA binding);GO:0045727(positive regulation of translation);GO:0046872(metal ion binding) | 03010(Ribosome) | NA | NA | ribosomal protein S27-like [Source:HGNC Symbol;Acc:HGNC:18476] | 2.00 | 2.54 | 2.01 | 2.91 | 2.87 | 2.89 | 0.46 | -1.11 | 0.70 | 0.80 | down | no |
| MSTRG.10405 | TPM1 | ENST00000358278;ENST00000559556;ENST00000404484;ENST00000560959 | GO:0001701(in utero embryonic development);GO:0001725(stress fiber);GO:0003065(positive regulation of heart rate by epinephrine);GO:0003779(actin binding);GO:0005200(structural constituent of cytoskeleton);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005856(cytoskeleton);GO:0005862(muscle thin filament tropomyosin);GO:0006928(movement of cell or subcellular component);GO:0006936(muscle contraction);GO:0006937(regulation of muscle contraction);GO:0007010(cytoskeleton organization);GO:0008016(regulation of heart contraction);GO:0008092(cytoskeletal protein binding);GO:0008307(structural constituent of muscle);GO:0030016(myofibril);GO:0030017(sarcomere);GO:0030049(muscle filament sliding);GO:0030336(negative regulation of cell migration);GO:0031529(ruffle organization);GO:0031941(filamentous actin);GO:0032059(bleb);GO:0032587(ruffle membrane);GO:0032781(positive regulation of ATPase activity);GO:0034614(cellular response to reactive oxygen species);GO:0042060(wound healing);GO:0045214(sarcomere organization);GO:0045785(positive regulation of cell adhesion);GO:0051496(positive regulation of stress fiber assembly);GO:0055010(ventricular cardiac muscle tissue morphogenesis);GO:0060048(cardiac muscle contraction) | 04260(Cardiac muscle contraction);05410(Hypertrophic cardiomyopathy (HCM));05414(Dilated cardiomyopathy) | NA | NA | tropomyosin 1 (alpha) [Source:HGNC Symbol;Acc:HGNC:12010] | 1.96 | 2.95 | 1.99 | 2.60 | 2.29 | 2.28 | 12.26 | 3.62 | 0.21 | 0.37 | up | no |
| MSTRG.10408 | RAB8B | ENST00000321437;ENST00000559927 | GO:0003924(GTPase activity);GO:0005102(receptor binding);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0005622(intracellular);GO:0005739(mitochondrion);GO:0005768(endosome);GO:0005778(peroxisomal membrane);GO:0005886(plasma membrane);GO:0006886(intracellular protein transport);GO:0006904(vesicle docking involved in exocytosis);GO:0006913(nucleocytoplasmic transport);GO:0007165(signal transduction);GO:0007264(small GTPase mediated signal transduction);GO:0008021(synaptic vesicle);GO:0008152(metabolic process);GO:0009306(protein secretion);GO:0015031(protein transport);GO:0016020(membrane);GO:0016079(synaptic vesicle exocytosis);GO:0017157(regulation of exocytosis);GO:0019003(GDP binding);GO:0019882(antigen processing and presentation);GO:0030140(trans-Golgi network transport vesicle);GO:0030667(secretory granule membrane);GO:0030670(phagocytic vesicle membrane);GO:0030911(TPR domain binding);GO:0031346(positive regulation of cell projection organization);GO:0031410(cytoplasmic vesicle);GO:0032482(Rab protein signal transduction);GO:0032869(cellular response to insulin stimulus);GO:0034332(adherens junction organization);GO:0045046(protein import into peroxisome membrane);GO:0045335(phagocytic vesicle);GO:0048210(Golgi vesicle fusion to target membrane);GO:0048471(perinuclear region of cytoplasm);GO:0051286(cell tip);GO:0051461(positive regulation of corticotropin secretion);GO:0070062(extracellular exosome);GO:0072659(protein localization to plasma membrane) | NA | NA | NA | RAB8B, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:30273] | 1.91 | 0.51 | 0.52 | 4.01 | 2.44 | 2.50 | 0.58 | -0.80 | 0.91 | 0.95 | down | no |
Differentially expressed transcripts:
| t_id | class_code | chr | strand | start | end | t_name | num_exons | length | gene_id | gene_name | GO | KEGG | KO_ENTRY | EC | Description | cov.KTY01_K | FPKM.KTY01_K | cov.KTY02_K | FPKM.KTY02_K | cov.KTY03_K | FPKM.KTY03_K | cov.EM01_M | FPKM.EM01_M | cov.EM02_M | FPKM.EM02_M | cov.EM03_M | FPKM.EM03_M | fc | log2(fc) | pval | qval | regulation | significant |
| 199 | "=" | chr1 | + | 1020123 | 1056116 | ENST00000379370 | 36 | 7323 | MSTRG.35 | AGRN | GO:0001523(retinoid metabolic process);GO:0002162(dystroglycan binding);GO:0005200(structural constituent of cytoskeleton);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0005604(basement membrane);GO:0005605(basal lamina);GO:0005615(extracellular space);GO:0005737(cytoplasm);GO:0005796(Golgi lumen);GO:0005886(plasma membrane);GO:0005975(carbohydrate metabolic process);GO:0006024(glycosaminoglycan biosynthetic process);GO:0006027(glycosaminoglycan catabolic process);GO:0007009(plasma membrane organization);GO:0007165(signal transduction);GO:0007213(G-protein coupled acetylcholine receptor signaling pathway);GO:0007268(synaptic transmission);GO:0007411(axon guidance);GO:0007528(neuromuscular junction development);GO:0007603(phototransduction, visible light);GO:0008582(regulation of synaptic growth at neuromuscular junction);GO:0009986(cell surface);GO:0010469(regulation of receptor activity);GO:0016021(integral component of membrane);GO:0030054(cell junction);GO:0030198(extracellular matrix organization);GO:0030203(glycosaminoglycan metabolic process);GO:0030204(chondroitin sulfate metabolic process);GO:0030548(acetylcholine receptor regulator activity);GO:0031012(extracellular matrix);GO:0033691(sialic acid binding);GO:0035374(chondroitin sulfate binding);GO:0043113(receptor clustering);GO:0043202(lysosomal lumen);GO:0043236(laminin binding);GO:0043395(heparan sulfate proteoglycan binding);GO:0043525(positive regulation of neuron apoptotic process);GO:0043547(positive regulation of GTPase activity);GO:0044281(small molecule metabolic process);GO:0045162(clustering of voltage-gated sodium channels);GO:0045202(synapse);GO:0045213(neurotransmitter receptor metabolic process);GO:0045887(positive regulation of synaptic growth at neuromuscular junction);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0050808(synapse organization);GO:0051491(positive regulation of filopodium assembly);GO:0070062(extracellular exosome) | 04512(ECM-receptor interaction) | NA | NA | agrin [Source:HGNC Symbol;Acc:HGNC:329] | 69.17 | 10.05 | 80.84 | 11.34 | 60.21 | 10.15 | 83.79 | 12.32 | 66.53 | 12.53 | 67.16 | 12.46 | 3.03 | 1.60 | 0.02 | 0.06 | up | yes |
| 254 | "=" | chr1 | - | 1211326 | 1214132 | ENST00000379236 | 7 | 1068 | MSTRG.36 | TNFRSF4 | GO:0005031(tumor necrosis factor-activated receptor activity);GO:0005515(protein binding);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0006954(inflammatory response);GO:0006955(immune response);GO:0006968(cellular defense response);GO:0009897(external side of plasma membrane);GO:0009986(cell surface);GO:0030890(positive regulation of B cell proliferation);GO:0033209(tumor necrosis factor-mediated signaling pathway);GO:0042098(T cell proliferation);GO:0042981(regulation of apoptotic process);GO:0043433(negative regulation of sequence-specific DNA binding transcription factor activity);GO:0045859(regulation of protein kinase activity);GO:0045892(negative regulation of transcription, DNA-templated);GO:0050710(negative regulation of cytokine secretion);GO:0051024(positive regulation of immunoglobulin secretion) | 04060(Cytokine-cytokine receptor interaction) | NA | NA | tumor necrosis factor receptor superfamily, member 4 [Source:HGNC Symbol;Acc:HGNC:11918] | 21.96 | 3.19 | 17.11 | 2.40 | 17.92 | 3.02 | 2.47 | 0.36 | 2.18 | 0.41 | 2.18 | 0.40 | 0.25 | -1.99 | 0.01 | 0.04 | down | yes |
| 257 | "=" | chr1 | - | 1216908 | 1232001 | ENST00000360001 | 7 | 1956 | MSTRG.37 | SDF4 | GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005770(late endosome);GO:0005794(Golgi apparatus);GO:0005796(Golgi lumen);GO:0005886(plasma membrane);GO:0009650(UV protection);GO:0016020(membrane);GO:0017156(calcium ion-dependent exocytosis);GO:0021549(cerebellum development);GO:0032059(bleb);GO:0042802(identical protein binding);GO:0045444(fat cell differentiation);GO:0045471(response to ethanol);GO:0070062(extracellular exosome);GO:0070625(zymogen granule exocytosis) | NA | NA | NA | stromal cell derived factor 4 [Source:HGNC Symbol;Acc:HGNC:24188] | 144.44 | 20.98 | 156.11 | 21.89 | 127.41 | 21.48 | 235.53 | 34.63 | 184.24 | 34.69 | 187.48 | 34.79 | 0.90 | -0.16 | 0.53 | 0.65 | down | no |
| 264 | "=" | chr1 | + | 1232265 | 1235041 | ENST00000379198 | 1 | 2777 | MSTRG.38 | B3GALT6 | GO:0000139(Golgi membrane);GO:0005797(Golgi medial cisterna);GO:0005975(carbohydrate metabolic process);GO:0006024(glycosaminoglycan biosynthetic process);GO:0006486(protein glycosylation);GO:0008378(galactosyltransferase activity);GO:0008499(UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity);GO:0015012(heparan sulfate proteoglycan biosynthetic process);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0030203(glycosaminoglycan metabolic process);GO:0030204(chondroitin sulfate metabolic process);GO:0030206(chondroitin sulfate biosynthetic process);GO:0032580(Golgi cisterna membrane);GO:0035250(UDP-galactosyltransferase activity);GO:0044281(small molecule metabolic process);GO:0047220(galactosylxylosylprotein 3-beta-galactosyltransferase activity) | 00532(Glycosaminoglycan biosynthesis - chondroitin sulfate);00534(Glycosaminoglycan biosynthesis - heparan sulfate);01100(Metabolic pathways) | NA | NA | UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 [Source:HGNC Symbol;Acc:HGNC:17978] | 0 | 0 | 36.10 | 5.06 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7352734607.22 | 32.78 | 0.00 | 0.02 | up | yes |
| 377 | "=" | chr1 | + | 1324767 | 1328897 | ENST00000343938 | 3 | 2190 | MSTRG.54 | CPTP | GO:0005543(phospholipid binding);GO:0005548(phospholipid transporter activity);GO:0005640(nuclear outer membrane);GO:0005737(cytoplasm);GO:0005794(Golgi apparatus);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006665(sphingolipid metabolic process);GO:0006687(glycosphingolipid metabolic process);GO:0010008(endosome membrane);GO:0017089(glycolipid transporter activity);GO:0044281(small molecule metabolic process);GO:0046836(glycolipid transport);GO:0051861(glycolipid binding);GO:1902387(ceramide 1-phosphate binding);GO:1902388(ceramide 1-phosphate transporter activity);GO:1902389(ceramide 1-phosphate transport) | NA | NA | NA | ceramide-1-phosphate transfer protein [Source:HGNC Symbol;Acc:HGNC:28116] | 29.14 | 4.23 | 32.65 | 4.58 | 25.23 | 4.25 | 58.24 | 8.56 | 45.67 | 8.60 | 46.32 | 8.60 | 1.18 | 0.24 | 0.24 | 0.38 | up | no |
| 380 | "=" | chr1 | - | 1335276 | 1349112 | ENST00000378891 | 15 | 2926 | MSTRG.41 | DVL1 | GO:0001505(regulation of neurotransmitter levels);GO:0001932(regulation of protein phosphorylation);GO:0001933(negative regulation of protein phosphorylation);GO:0001934(positive regulation of protein phosphorylation);GO:0005109(frizzled binding);GO:0005515(protein binding);GO:0005829(cytosol);GO:0005874(microtubule);GO:0006366(transcription from RNA polymerase II promoter);GO:0006469(negative regulation of protein kinase activity);GO:0007269(neurotransmitter secretion);GO:0007409(axonogenesis);GO:0007411(axon guidance);GO:0007528(neuromuscular junction development);GO:0010976(positive regulation of neuron projection development);GO:0015630(microtubule cytoskeleton);GO:0016023(cytoplasmic membrane-bounded vesicle);GO:0016328(lateral plasma membrane);GO:0019899(enzyme binding);GO:0019901(protein kinase binding);GO:0021915(neural tube development);GO:0022007(convergent extension involved in neural plate elongation);GO:0030136(clathrin-coated vesicle);GO:0030177(positive regulation of Wnt signaling pathway);GO:0030424(axon);GO:0030425(dendrite);GO:0030426(growth cone);GO:0031122(cytoplasmic microtubule organization);GO:0031410(cytoplasmic vesicle);GO:0032091(negative regulation of protein binding);GO:0032436(positive regulation of proteasomal ubiquitin-dependent protein catabolic process);GO:0034504(protein localization to nucleus);GO:0035176(social behavior);GO:0035372(protein localization to microtubule);GO:0035556(intracellular signal transduction);GO:0042802(identical protein binding);GO:0043025(neuronal cell body);GO:0043113(receptor clustering);GO:0045202(synapse);GO:0045893(positive regulation of transcription, DNA-templated);GO:0048365(Rac GTPase binding);GO:0048668(collateral sprouting);GO:0048675(axon extension);GO:0048813(dendrite morphogenesis);GO:0050808(synapse organization);GO:0060029(convergent extension involved in organogenesis);GO:0060070(canonical Wnt signaling pathway);GO:0060071(Wnt signaling pathway, planar cell polarity pathway);GO:0060134(prepulse inhibition);GO:0071340(skeletal muscle acetylcholine-gated channel clustering);GO:0090090(negative regulation of canonical Wnt signaling pathway);GO:0090103(cochlea morphogenesis);GO:0090179(planar cell polarity pathway involved in neural tube closure);GO:0090263(positive regulation of canonical Wnt signaling pathway) | 04310(Wnt signaling pathway);04330(Notch signaling pathway);05200(Pathways in cancer);05217(Basal cell carcinoma) | NA | NA | dishevelled segment polarity protein 1 [Source:HGNC Symbol;Acc:HGNC:3084] | 41.61 | 6.04 | 56.52 | 7.93 | 38.71 | 6.53 | 56.25 | 8.27 | 44.67 | 8.41 | 47.93 | 8.90 | 9.18 | 3.20 | 0.06 | 0.13 | up | no |
| 381 | "=" | chr1 | - | 1335276 | 1349350 | ENST00000378888 | 15 | 3239 | MSTRG.41 | DVL1 | GO:0001505(regulation of neurotransmitter levels);GO:0001932(regulation of protein phosphorylation);GO:0001933(negative regulation of protein phosphorylation);GO:0001934(positive regulation of protein phosphorylation);GO:0005109(frizzled binding);GO:0005515(protein binding);GO:0005829(cytosol);GO:0005874(microtubule);GO:0006366(transcription from RNA polymerase II promoter);GO:0006469(negative regulation of protein kinase activity);GO:0007269(neurotransmitter secretion);GO:0007409(axonogenesis);GO:0007411(axon guidance);GO:0007528(neuromuscular junction development);GO:0010976(positive regulation of neuron projection development);GO:0015630(microtubule cytoskeleton);GO:0016023(cytoplasmic membrane-bounded vesicle);GO:0016328(lateral plasma membrane);GO:0019899(enzyme binding);GO:0019901(protein kinase binding);GO:0021915(neural tube development);GO:0022007(convergent extension involved in neural plate elongation);GO:0030136(clathrin-coated vesicle);GO:0030177(positive regulation of Wnt signaling pathway);GO:0030424(axon);GO:0030425(dendrite);GO:0030426(growth cone);GO:0031122(cytoplasmic microtubule organization);GO:0031410(cytoplasmic vesicle);GO:0032091(negative regulation of protein binding);GO:0032436(positive regulation of proteasomal ubiquitin-dependent protein catabolic process);GO:0034504(protein localization to nucleus);GO:0035176(social behavior);GO:0035372(protein localization to microtubule);GO:0035556(intracellular signal transduction);GO:0042802(identical protein binding);GO:0043025(neuronal cell body);GO:0043113(receptor clustering);GO:0045202(synapse);GO:0045893(positive regulation of transcription, DNA-templated);GO:0048365(Rac GTPase binding);GO:0048668(collateral sprouting);GO:0048675(axon extension);GO:0048813(dendrite morphogenesis);GO:0050808(synapse organization);GO:0060029(convergent extension involved in organogenesis);GO:0060070(canonical Wnt signaling pathway);GO:0060071(Wnt signaling pathway, planar cell polarity pathway);GO:0060134(prepulse inhibition);GO:0071340(skeletal muscle acetylcholine-gated channel clustering);GO:0090090(negative regulation of canonical Wnt signaling pathway);GO:0090103(cochlea morphogenesis);GO:0090179(planar cell polarity pathway involved in neural tube closure);GO:0090263(positive regulation of canonical Wnt signaling pathway) | 04310(Wnt signaling pathway);04330(Notch signaling pathway);05200(Pathways in cancer);05217(Basal cell carcinoma) | NA | NA | dishevelled segment polarity protein 1 [Source:HGNC Symbol;Acc:HGNC:3084] | 30.59 | 4.44 | 48.88 | 6.85 | 23.73 | 4.00 | 15.98 | 2.35 | 10.43 | 1.96 | 10.88 | 2.02 | 379.85 | 8.57 | 0.00 | 0.02 | up | yes |
| 391 | "=" | chr1 | - | 1352691 | 1358535 | ENST00000309212 | 10 | 2273 | MSTRG.42 | MXRA8 | GO:0003674(molecular_function);GO:0005515(protein binding);GO:0009986(cell surface);GO:0016021(integral component of membrane);GO:0060857(establishment of glial blood-brain barrier);GO:0070062(extracellular exosome) | NA | NA | NA | matrix-remodelling associated 8 [Source:HGNC Symbol;Acc:HGNC:7542] | 3.87 | 0.56 | 1.03 | 0.15 | 3.48 | 0.59 | 19.57 | 2.88 | 13.76 | 2.59 | 14.50 | 2.69 | 0.01 | -6.81 | 0.01 | 0.05 | down | yes |
| 399 | "=" | chr1 | - | 1373730 | 1375157 | ENST00000338370 | 3 | 1072 | MSTRG.43 | AURKAIP1 | GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0006996(organelle organization);GO:0032543(mitochondrial translation);GO:0043231(intracellular membrane-bounded organelle);GO:0045839(negative regulation of mitotic nuclear division);GO:0045862(positive regulation of proteolysis);GO:0070124(mitochondrial translational initiation);GO:0070125(mitochondrial translational elongation);GO:0070126(mitochondrial translational termination) | NA | NA | NA | aurora kinase A interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:24114] | 40.44 | 5.87 | 25.15 | 3.53 | 33.53 | 5.65 | 10.51 | 1.55 | 6.98 | 1.31 | 6.99 | 1.30 | 0.02 | -5.46 | 0.06 | 0.13 | down | no |
| 400 | "=" | chr1 | - | 1373730 | 1375495 | ENST00000338338 | 4 | 1047 | MSTRG.43 | AURKAIP1 | GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0006996(organelle organization);GO:0032543(mitochondrial translation);GO:0043231(intracellular membrane-bounded organelle);GO:0045839(negative regulation of mitotic nuclear division);GO:0045862(positive regulation of proteolysis);GO:0070124(mitochondrial translational initiation);GO:0070125(mitochondrial translational elongation);GO:0070126(mitochondrial translational termination) | NA | NA | NA | aurora kinase A interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:24114] | 78.52 | 11.41 | 93.88 | 13.16 | 69.50 | 11.72 | 64.70 | 9.51 | 54.26 | 10.22 | 54.37 | 10.09 | 4.53 | 2.18 | 0.09 | 0.18 | up | no |
| 402 | "=" | chr1 | - | 1373737 | 1375173 | ENST00000378853 | 4 | 875 | MSTRG.43 | AURKAIP1 | GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0006996(organelle organization);GO:0032543(mitochondrial translation);GO:0043231(intracellular membrane-bounded organelle);GO:0045839(negative regulation of mitotic nuclear division);GO:0045862(positive regulation of proteolysis);GO:0070124(mitochondrial translational initiation);GO:0070125(mitochondrial translational elongation);GO:0070126(mitochondrial translational termination) | NA | NA | NA | aurora kinase A interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:24114] | 96.40 | 14.00 | 101.93 | 14.29 | 82.02 | 13.83 | 122.09 | 17.95 | 93.38 | 17.58 | 93.57 | 17.36 | 1.16 | 0.22 | 0.47 | 0.61 | up | no |
| 410 | "=" | chr1 | - | 1386495 | 1399312 | ENST00000400809 | 11 | 2305 | MSTRG.44 | CCNL2 | GO:0000079(regulation of cyclin-dependent protein serine/threonine kinase activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005730(nucleolus);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0016607(nuclear speck);GO:0019901(protein kinase binding);GO:0030054(cell junction);GO:0043231(intracellular membrane-bounded organelle) | NA | NA | NA | cyclin L2 [Source:HGNC Symbol;Acc:HGNC:20570] | 6.12 | 0.89 | 6.83 | 0.96 | 4.67 | 0.79 | 33.77 | 4.96 | 6.39 | 1.20 | 21.62 | 4.01 | 4.77 | 2.25 | 0.83 | 0.88 | up | no |
| 435 | "=" | chr1 | - | 1401908 | 1407313 | ENST00000344843 | 4 | 721 | MSTRG.46 | MRPL20 | GO:0003735(structural constituent of ribosome);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0005761(mitochondrial ribosome);GO:0005840(ribosome);GO:0006412(translation);GO:0006996(organelle organization);GO:0019843(rRNA binding);GO:0032543(mitochondrial translation);GO:0044822(poly(A) RNA binding);GO:0070124(mitochondrial translational initiation);GO:0070125(mitochondrial translational elongation);GO:0070126(mitochondrial translational termination) | NA | NA | NA | mitochondrial ribosomal protein L20 [Source:HGNC Symbol;Acc:HGNC:14478] | 198.64 | 28.85 | 285.31 | 40.01 | 177.18 | 29.87 | 214.86 | 31.59 | 165.70 | 31.20 | 167.53 | 31.09 | 43.10 | 5.43 | 0.00 | 0.02 | up | yes |
| 456 | "=" | chr1 | + | 1435671 | 1442882 | ENST00000476993 | 3 | 4511 | MSTRG.48 | VWA1 | GO:0005515(protein binding);GO:0005576(extracellular region);GO:0005578(proteinaceous extracellular matrix);GO:0005604(basement membrane);GO:0005614(interstitial matrix);GO:0005615(extracellular space);GO:0030198(extracellular matrix organization);GO:0042802(identical protein binding);GO:0048266(behavioral response to pain);GO:0070062(extracellular exosome) | NA | NA | NA | von Willebrand factor A domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30910] | 42.37 | 6.15 | 41.31 | 5.79 | 35.06 | 5.91 | 55.83 | 8.21 | 43.46 | 8.18 | 44.04 | 8.17 | 0.50 | -1.01 | 0.05 | 0.12 | down | no |
| 466 | "=" | chr1 | + | 1512151 | 1534685 | ENST00000378756 | 16 | 2492 | MSTRG.55 | ATAD3A | GO:0005524(ATP binding);GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0016021(integral component of membrane);GO:0016049(cell growth);GO:0042645(mitochondrial nucleoid);GO:0043066(negative regulation of apoptotic process) | NA | NA | NA | ATPase family, AAA domain containing 3A [Source:HGNC Symbol;Acc:HGNC:25567] | 36.14 | 5.25 | 54.77 | 7.68 | 41.76 | 7.04 | 25.71 | 3.78 | 19.09 | 3.60 | 19.19 | 3.56 | 22.24 | 4.48 | 0.14 | 0.25 | up | no |
| 476 | "=" | chr1 | - | 1541673 | 1574869 | ENST00000291386 | 5 | 1290 | MSTRG.56 | SSU72 | GO:0004721(phosphoprotein phosphatase activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006378(mRNA polyadenylation);GO:0006397(mRNA processing);GO:0008420(CTD phosphatase activity);GO:0070940(dephosphorylation of RNA polymerase II C-terminal domain) | NA | NA | NA | SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:25016] | 68.25 | 9.91 | 117.08 | 16.42 | 89.92 | 15.16 | 61.68 | 9.07 | 47.54 | 8.95 | 48.37 | 8.98 | 43.22 | 5.43 | 0.22 | 0.36 | up | no |
| 535 | "=" | chr1 | - | 1635738 | 1659012 | ENST00000611150 | 19 | 2350 | MSTRG.63 | CDK11B | GO:0004672(protein kinase activity);GO:0005524(ATP binding);GO:0006468(protein phosphorylation);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0051301(cell division) | NA | NA | NA | cyclin-dependent kinase 11B [Source:HGNC Symbol;Acc:HGNC:1729] | 0 | 0 | 0 | 0 | 0 | 0 | 11.94 | 1.75 | 12.19 | 2.30 | 13.00 | 2.41 | 0.20 | -2.32 | 0.34 | 0.48 | down | no |
| 583 | "=" | chr1 | - | 1751232 | 1778470 | ENST00000341426 | 12 | 3235 | MSTRG.60 | NADK | GO:0003951(NAD+ kinase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005829(cytosol);GO:0006741(NADP biosynthetic process);GO:0006766(vitamin metabolic process);GO:0006767(water-soluble vitamin metabolic process);GO:0008152(metabolic process);GO:0016310(phosphorylation);GO:0019674(NAD metabolic process);GO:0044281(small molecule metabolic process);GO:0046034(ATP metabolic process);GO:0046872(metal ion binding) | 00760(Nicotinate and nicotinamide metabolism);01100(Metabolic pathways) | K00858 | 2.7.1.23 | NAD kinase [Source:HGNC Symbol;Acc:HGNC:29831] | 76.21 | 11.07 | 104.64 | 14.67 | 66.40 | 11.20 | 129.75 | 19.08 | 102.01 | 19.21 | 103.08 | 19.13 | 15.03 | 3.91 | 0.01 | 0.03 | up | yes |
| 607 | "=" | chr1 | - | 1787987 | 1794197 | ENST00000461893 | 3 | 2438 | MSTRG.61 | GNB1 | GO:0001664(G-protein coupled receptor binding);GO:0001750(photoreceptor outer segment);GO:0001917(photoreceptor inner segment);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005765(lysosomal membrane);GO:0005834(heterotrimeric G-protein complex);GO:0005886(plasma membrane);GO:0006112(energy reserve metabolic process);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007191(adenylate cyclase-activating dopamine receptor signaling pathway);GO:0007200(phospholipase C-activating G-protein coupled receptor signaling pathway);GO:0007204(positive regulation of cytosolic calcium ion concentration);GO:0007213(G-protein coupled acetylcholine receptor signaling pathway);GO:0007265(Ras protein signal transduction);GO:0007268(synaptic transmission);GO:0007596(blood coagulation);GO:0007603(phototransduction, visible light);GO:0008283(cell proliferation);GO:0010659(cardiac muscle cell apoptotic process);GO:0016020(membrane);GO:0016056(rhodopsin mediated signaling pathway);GO:0022400(regulation of rhodopsin mediated signaling pathway);GO:0030168(platelet activation);GO:0030425(dendrite);GO:0030507(spectrin binding);GO:0031702(type 1 angiotensin receptor binding);GO:0032403(protein complex binding);GO:0042622(photoreceptor outer segment membrane);GO:0043209(myelin sheath);GO:0044281(small molecule metabolic process);GO:0044297(cell body);GO:0050909(sensory perception of taste);GO:0051020(GTPase binding);GO:0060041(retina development in camera-type eye);GO:0070062(extracellular exosome);GO:0071377(cellular response to glucagon stimulus);GO:0071380(cellular response to prostaglandin E stimulus);GO:0071456(cellular response to hypoxia);GO:0071870(cellular response to catecholamine stimulus);GO:0097381(photoreceptor disc membrane);GO:1903561(extracellular vesicle) | 04062(Chemokine signaling pathway);04724(Glutamatergic synapse);04725(Cholinergic synapse);04742(Taste transduction);04744(Phototransduction) | NA | NA | guanine nucleotide binding protein (G protein), beta polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:4396] | 1.89 | 0.27 | 2.86 | 0.40 | 1.74 | 0.29 | 20.16 | 2.96 | 17.93 | 3.38 | 18.09 | 3.36 | 0.72 | -0.47 | 0.72 | 0.80 | down | no |
| 608 | "=" | chr1 | - | 1789061 | 1818386 | ENST00000471354 | 7 | 1512 | MSTRG.61 | GNB1 | GO:0001664(G-protein coupled receptor binding);GO:0001750(photoreceptor outer segment);GO:0001917(photoreceptor inner segment);GO:0003924(GTPase activity);GO:0004871(signal transducer activity);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005765(lysosomal membrane);GO:0005834(heterotrimeric G-protein complex);GO:0005886(plasma membrane);GO:0006112(energy reserve metabolic process);GO:0007165(signal transduction);GO:0007186(G-protein coupled receptor signaling pathway);GO:0007191(adenylate cyclase-activating dopamine receptor signaling pathway);GO:0007200(phospholipase C-activating G-protein coupled receptor signaling pathway);GO:0007204(positive regulation of cytosolic calcium ion concentration);GO:0007213(G-protein coupled acetylcholine receptor signaling pathway);GO:0007265(Ras protein signal transduction);GO:0007268(synaptic transmission);GO:0007596(blood coagulation);GO:0007603(phototransduction, visible light);GO:0008283(cell proliferation);GO:0010659(cardiac muscle cell apoptotic process);GO:0016020(membrane);GO:0016056(rhodopsin mediated signaling pathway);GO:0022400(regulation of rhodopsin mediated signaling pathway);GO:0030168(platelet activation);GO:0030425(dendrite);GO:0030507(spectrin binding);GO:0031702(type 1 angiotensin receptor binding);GO:0032403(protein complex binding);GO:0042622(photoreceptor outer segment membrane);GO:0043209(myelin sheath);GO:0044281(small molecule metabolic process);GO:0044297(cell body);GO:0050909(sensory perception of taste);GO:0051020(GTPase binding);GO:0060041(retina development in camera-type eye);GO:0070062(extracellular exosome);GO:0071377(cellular response to glucagon stimulus);GO:0071380(cellular response to prostaglandin E stimulus);GO:0071456(cellular response to hypoxia);GO:0071870(cellular response to catecholamine stimulus);GO:0097381(photoreceptor disc membrane);GO:1903561(extracellular vesicle) | 04062(Chemokine signaling pathway);04724(Glutamatergic synapse);04725(Cholinergic synapse);04742(Taste transduction);04744(Phototransduction) | NA | NA | guanine nucleotide binding protein (G protein), beta polypeptide 1 [Source:HGNC Symbol;Acc:HGNC:4396] | 1.35 | 0.20 | 2.79 | 0.39 | 1.46 | 0.25 | 35.91 | 5.28 | 25.84 | 4.87 | 26.10 | 4.84 | 1.25 | 0.32 | 0.62 | 0.73 | up | no |
| 655 | "=" | chr1 | + | 2104716 | 2185393 | ENST00000400920 | 15 | 2009 | MSTRG.69 | PRKCZ | GO:0000226(microtubule cytoskeleton organization);GO:0001954(positive regulation of cell-matrix adhesion);GO:0004672(protein kinase activity);GO:0004674(protein serine/threonine kinase activity);GO:0004697(protein kinase C activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005635(nuclear envelope);GO:0005737(cytoplasm);GO:0005768(endosome);GO:0005815(microtubule organizing center);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005911(cell-cell junction);GO:0005923(bicellular tight junction);GO:0005938(cell cortex);GO:0006468(protein phosphorylation);GO:0006954(inflammatory response);GO:0007165(signal transduction);GO:0007166(cell surface receptor signaling pathway);GO:0007179(transforming growth factor beta receptor signaling pathway);GO:0007596(blood coagulation);GO:0007616(long-term memory);GO:0008284(positive regulation of cell proliferation);GO:0008286(insulin receptor signaling pathway);GO:0015459(potassium channel regulator activity);GO:0016020(membrane);GO:0016324(apical plasma membrane);GO:0016363(nuclear matrix);GO:0016477(cell migration);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0018105(peptidyl-serine phosphorylation);GO:0019901(protein kinase binding);GO:0019904(protein domain specific binding);GO:0030010(establishment of cell polarity);GO:0030054(cell junction);GO:0030168(platelet activation);GO:0031252(cell leading edge);GO:0031333(negative regulation of protein complex assembly);GO:0031532(actin cytoskeleton reorganization);GO:0031584(activation of phospholipase D activity);GO:0031941(filamentous actin);GO:0032148(activation of protein kinase B activity);GO:0032753(positive regulation of interleukin-4 production);GO:0032869(cellular response to insulin stimulus);GO:0034613(cellular protein localization);GO:0035556(intracellular signal transduction);GO:0035748(myelin sheath abaxonal region);GO:0043066(negative regulation of apoptotic process);GO:0043203(axon hillock);GO:0043231(intracellular membrane-bounded organelle);GO:0043234(protein complex);GO:0043274(phospholipase binding);GO:0043560(insulin receptor substrate binding);GO:0045121(membrane raft);GO:0045179(apical cortex);GO:0045630(positive regulation of T-helper 2 cell differentiation);GO:0046326(positive regulation of glucose import);GO:0046627(negative regulation of insulin receptor signaling pathway);GO:0046628(positive regulation of insulin receptor signaling pathway);GO:0046872(metal ion binding);GO:0047496(vesicle transport along microtubule);GO:0048010(vascular endothelial growth factor receptor signaling pathway);GO:0048471(perinuclear region of cytoplasm);GO:0050732(negative regulation of peptidyl-tyrosine phosphorylation);GO:0050806(positive regulation of synaptic transmission);GO:0051092(positive regulation of NF-kappaB transcription factor activity);GO:0051222(positive regulation of protein transport);GO:0051291(protein heterooligomerization);GO:0051346(negative regulation of hydrolase activity);GO:0051899(membrane depolarization);GO:0060081(membrane hyperpolarization);GO:0060291(long-term synaptic potentiation);GO:0070062(extracellular exosome);GO:0070374(positive regulation of ERK1 and ERK2 cascade);GO:0070528(protein kinase C signaling);GO:0071889(14-3-3 protein binding);GO:0072659(protein localization to plasma membrane);GO:1990138(neuron projection extension);GO:2000463(positive regulation of excitatory postsynaptic membrane potential);GO:2000553(positive regulation of T-helper 2 cell cytokine production);GO:2000664(positive regulation of interleukin-5 secretion);GO:2000667(positive regulation of interleukin-13 secretion);GO:2001181(positive regulation of interleukin-10 secretion) | 04062(Chemokine signaling pathway);04144(Endocytosis);04530(Tight junction);04910(Insulin signaling pathway);04930(Type II diabetes mellitus) | NA | NA | protein kinase C, zeta [Source:HGNC Symbol;Acc:HGNC:9412] | 0 | 0 | 0 | 0 | 0 | 0 | 21.20 | 3.12 | 15.65 | 2.95 | 15.96 | 2.96 | 0.27 | -1.86 | 0.02 | 0.06 | down | yes |
| 713 | "=" | chr1 | + | 2391833 | 2403749 | ENST00000630837 | 7 | 1349 | MSTRG.78 | RER1 | GO:0003674(molecular_function);GO:0005793(endoplasmic reticulum-Golgi intermediate compartment);GO:0005794(Golgi apparatus);GO:0006890(retrograde vesicle-mediated transport, Golgi to ER);GO:0007528(neuromuscular junction development);GO:0009986(cell surface);GO:0016021(integral component of membrane);GO:0030173(integral component of Golgi membrane);GO:0033130(acetylcholine receptor binding);GO:0071340(skeletal muscle acetylcholine-gated channel clustering);GO:0090004(positive regulation of establishment of protein localization to plasma membrane) | NA | NA | NA | retention in endoplasmic reticulum sorting receptor 1 [Source:HGNC Symbol;Acc:HGNC:30309] | 85.37 | 12.40 | 85.03 | 11.92 | 74.27 | 12.52 | 47.95 | 7.05 | 37.66 | 7.09 | 38.42 | 7.13 | 0.98 | -0.03 | 0.78 | 0.85 | down | no |
| 714 | "=" | chr1 | + | 2391833 | 2405444 | ENST00000605895 | 7 | 3044 | MSTRG.78 | RER1 | GO:0003674(molecular_function);GO:0005793(endoplasmic reticulum-Golgi intermediate compartment);GO:0005794(Golgi apparatus);GO:0006890(retrograde vesicle-mediated transport, Golgi to ER);GO:0007528(neuromuscular junction development);GO:0009986(cell surface);GO:0016021(integral component of membrane);GO:0030173(integral component of Golgi membrane);GO:0033130(acetylcholine receptor binding);GO:0071340(skeletal muscle acetylcholine-gated channel clustering);GO:0090004(positive regulation of establishment of protein localization to plasma membrane) | NA | NA | NA | retention in endoplasmic reticulum sorting receptor 1 [Source:HGNC Symbol;Acc:HGNC:30309] | 86.69 | 12.59 | 84.01 | 11.78 | 74.16 | 12.50 | 50.95 | 7.49 | 40.05 | 7.54 | 40.66 | 7.55 | 0.75 | -0.41 | 0.01 | 0.04 | down | no |
| 722 | "=" | chr1 | - | 2404819 | 2412571 | ENST00000447513 | 6 | 1997 | MSTRG.79 | PEX10 | GO:0005515(protein binding);GO:0005622(intracellular);GO:0005777(peroxisome);GO:0005778(peroxisomal membrane);GO:0005779(integral component of peroxisomal membrane);GO:0007031(peroxisome organization);GO:0008022(protein C-terminus binding);GO:0008270(zinc ion binding);GO:0016558(protein import into peroxisome matrix) | 04146(Peroxisome) | NA | NA | peroxisomal biogenesis factor 10 [Source:HGNC Symbol;Acc:HGNC:8851] | 48.16 | 7.00 | 46.70 | 6.55 | 40.38 | 6.81 | 18.74 | 2.76 | 15.06 | 2.84 | 15.07 | 2.80 | 1.12 | 0.16 | 0.54 | 0.66 | up | no |
| 739 | "=" | chr1 | - | 2508533 | 2526628 | ENST00000378466 | 19 | 2677 | MSTRG.80 | PANK4 | GO:0004594(pantothenate kinase activity);GO:0005524(ATP binding);GO:0005737(cytoplasm);GO:0015937(coenzyme A biosynthetic process);GO:0016310(phosphorylation) | 00770(Pantothenate and CoA biosynthesis);01100(Metabolic pathways) | K00867;K00896;K03525;K09680 | 2.7.1.33 | pantothenate kinase 4 [Source:HGNC Symbol;Acc:HGNC:19366] | 19.69 | 2.86 | 24.09 | 3.38 | 16.63 | 2.80 | 11.09 | 1.63 | 3.02 | 0.57 | 3.11 | 0.58 | 37.63 | 5.23 | 0.37 | 0.52 | up | no |
| 782 | "=" | chr1 | + | 2586775 | 2591468 | ENST00000419916 | 7 | 2749 | MSTRG.83 | FAM213B | GO:0001516(prostaglandin biosynthetic process);GO:0005737(cytoplasm);GO:0005783(endoplasmic reticulum);GO:0005829(cytosol);GO:0016616(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor);GO:0019369(arachidonic acid metabolic process);GO:0019371(cyclooxygenase pathway);GO:0043209(myelin sheath);GO:0044281(small molecule metabolic process);GO:0047017(prostaglandin-F synthase activity);GO:0055114(oxidation-reduction process);GO:0070062(extracellular exosome) | NA | NA | NA | family with sequence similarity 213, member B [Source:HGNC Symbol;Acc:HGNC:28390] | 19.01 | 2.76 | 20.67 | 2.90 | 18.74 | 3.16 | 6.78 | 1.00 | 5.60 | 1.05 | 5.47 | 1.01 | 1.57 | 0.65 | 0.54 | 0.66 | up | no |
| 849 | "=" | chr1 | + | 3625002 | 3630127 | ENST00000378344 | 5 | 2414 | MSTRG.87 | TPRG1L | GO:0003674(molecular_function);GO:0008021(synaptic vesicle);GO:0008150(biological_process);GO:0030054(cell junction);GO:0042802(identical protein binding);GO:0070062(extracellular exosome) | NA | NA | NA | tumor protein p63 regulated 1-like [Source:HGNC Symbol;Acc:HGNC:27007] | 68.84 | 10.00 | 15.13 | 2.12 | 56.91 | 9.60 | 124.65 | 18.32 | 94.99 | 17.89 | 96.24 | 17.86 | 0.00 | -23.31 | 0.00 | 0.02 | down | yes |
| 853 | "=" | chr1 | - | 3630767 | 3650073 | ENST00000270708 | 12 | 1665 | MSTRG.95 | WRAP73 | GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005813(centrosome) | NA | NA | NA | WD repeat containing, antisense to TP73 [Source:HGNC Symbol;Acc:HGNC:12759] | 43.18 | 6.27 | 42.85 | 6.01 | 36.42 | 6.14 | 14.42 | 2.12 | 12.99 | 2.45 | 12.00 | 2.23 | 1.31 | 0.39 | 0.69 | 0.78 | up | no |
| 889 | "=" | chr1 | + | 3772788 | 3775982 | ENST00000444870 | 4 | 546 | MSTRG.91 | SMIM1 | GO:0016021(integral component of membrane);GO:0070062(extracellular exosome) | NA | NA | NA | small integral membrane protein 1 (Vel blood group) [Source:HGNC Symbol;Acc:HGNC:44204] | 38.55 | 5.60 | 38.32 | 5.37 | 36.27 | 6.11 | 19.98 | 2.94 | 14.18 | 2.67 | 14.71 | 2.73 | 0.85 | -0.23 | 0.84 | 0.89 | down | no |
| 892 | "=" | chr1 | - | 3778558 | 3796504 | ENST00000378251 | 7 | 4310 | MSTRG.92 | LRRC47 | GO:0003723(RNA binding);GO:0004826(phenylalanine-tRNA ligase activity);GO:0005515(protein binding);GO:0044822(poly(A) RNA binding) | NA | NA | NA | leucine rich repeat containing 47 [Source:HGNC Symbol;Acc:HGNC:29207] | 96.41 | 14.00 | 84.99 | 11.92 | 81.96 | 13.82 | 54.69 | 8.04 | 43.31 | 8.16 | 44.00 | 8.16 | 0.26 | -1.95 | 0.00 | 0.02 | down | yes |
| 897 | "=" | chr1 | - | 3812081 | 3857199 | ENST00000378230 | 22 | 6424 | MSTRG.103 | CEP104 | GO:0005488(binding);GO:0005814(centriole) | NA | NA | NA | centrosomal protein 104kDa [Source:HGNC Symbol;Acc:HGNC:24866] | 43.66 | 6.34 | 38.31 | 5.37 | 37.88 | 6.39 | 25.62 | 3.77 | 19.29 | 3.63 | 19.60 | 3.64 | 0.27 | -1.88 | 0.05 | 0.11 | down | yes |
| 973 | "=" | chr1 | + | 6046114 | 6098855 | ENST00000458166 | 14 | 1336 | MSTRG.107 | KCNAB2 | GO:0002244(hematopoietic progenitor cell differentiation);GO:0004033(aldo-keto reductase (NADP) activity);GO:0005249(voltage-gated potassium channel activity);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005874(microtubule);GO:0005886(plasma membrane);GO:0006813(potassium ion transport);GO:0007268(synaptic transmission);GO:0008076(voltage-gated potassium channel complex);GO:0014069(postsynaptic density);GO:0015459(potassium channel regulator activity);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0030054(cell junction);GO:0030424(axon);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0043679(axon terminus);GO:0044224(juxtaparanode region of axon);GO:0045202(synapse);GO:0050905(neuromuscular process);GO:0055114(oxidation-reduction process);GO:0070995(NADPH oxidation);GO:0071805(potassium ion transmembrane transport);GO:1901379(regulation of potassium ion transmembrane transport);GO:1990031(pinceau fiber);GO:2000008(regulation of protein localization to cell surface) | NA | NA | NA | potassium channel, voltage gated subfamily A regulatory beta subunit 2 [Source:HGNC Symbol;Acc:HGNC:6229] | 0 | 0 | 0 | 0 | 0 | 0 | 30.32 | 4.46 | 22.98 | 4.33 | 23.13 | 4.29 | 0.20 | -2.33 | 0.00 | 0.02 | down | yes |
| 983 | "=" | chr1 | - | 6185020 | 6199612 | ENST00000234875 | 4 | 2078 | MSTRG.108 | RPL22 | GO:0000184(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay);GO:0003723(RNA binding);GO:0003735(structural constituent of ribosome);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005840(ribosome);GO:0005925(focal adhesion);GO:0006412(translation);GO:0006413(translational initiation);GO:0006414(translational elongation);GO:0006415(translational termination);GO:0006614(SRP-dependent cotranslational protein targeting to membrane);GO:0008201(heparin binding);GO:0010467(gene expression);GO:0016032(viral process);GO:0019058(viral life cycle);GO:0019083(viral transcription);GO:0022625(cytosolic large ribosomal subunit);GO:0030529(ribonucleoprotein complex);GO:0044267(cellular protein metabolic process);GO:0044822(poly(A) RNA binding);GO:0046632(alpha-beta T cell differentiation);GO:0070062(extracellular exosome) | 03010(Ribosome) | NA | NA | ribosomal protein L22 [Source:HGNC Symbol;Acc:HGNC:10315] | 208.35 | 30.27 | 262.35 | 36.79 | 196.49 | 33.13 | 110.57 | 16.25 | 122.78 | 23.12 | 124.42 | 23.09 | 4.31 | 2.11 | 0.62 | 0.73 | up | no |
| 987 | "=" | chr1 | - | 6186723 | 6199553 | ENST00000465387 | 4 | 508 | MSTRG.108 | RPL22 | GO:0000184(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay);GO:0003723(RNA binding);GO:0003735(structural constituent of ribosome);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005840(ribosome);GO:0005925(focal adhesion);GO:0006412(translation);GO:0006413(translational initiation);GO:0006414(translational elongation);GO:0006415(translational termination);GO:0006614(SRP-dependent cotranslational protein targeting to membrane);GO:0008201(heparin binding);GO:0010467(gene expression);GO:0016032(viral process);GO:0019058(viral life cycle);GO:0019083(viral transcription);GO:0022625(cytosolic large ribosomal subunit);GO:0030529(ribonucleoprotein complex);GO:0044267(cellular protein metabolic process);GO:0044822(poly(A) RNA binding);GO:0046632(alpha-beta T cell differentiation);GO:0070062(extracellular exosome) | 03010(Ribosome) | NA | NA | ribosomal protein L22 [Source:HGNC Symbol;Acc:HGNC:10315] | 15.33 | 2.23 | 19.96 | 2.80 | 13.84 | 2.33 | 50.17 | 7.38 | 7.95 | 1.50 | 8.06 | 1.49 | 101.54 | 6.67 | 0.62 | 0.73 | up | no |
| 1001 | "=" | chr1 | - | 6221193 | 6235940 | ENST00000343813 | 5 | 4771 | MSTRG.111 | ICMT | GO:0001701(in utero embryonic development);GO:0001889(liver development);GO:0003880(protein C-terminal carboxyl O-methyltransferase activity);GO:0004671(protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity);GO:0005783(endoplasmic reticulum);GO:0005789(endoplasmic reticulum membrane);GO:0006464(cellular protein modification process);GO:0006479(protein methylation);GO:0006481(C-terminal protein methylation);GO:0006612(protein targeting to membrane);GO:0008104(protein localization);GO:0008140(cAMP response element binding protein binding);GO:0008284(positive regulation of cell proliferation);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0035264(multicellular organism growth);GO:0046498(S-adenosylhomocysteine metabolic process);GO:0046499(S-adenosylmethioninamine metabolic process);GO:0046578(regulation of Ras protein signal transduction) | NA | NA | NA | isoprenylcysteine carboxyl methyltransferase [Source:HGNC Symbol;Acc:HGNC:5350] | 56.75 | 8.24 | 56.42 | 7.91 | 46.52 | 7.84 | 42.31 | 6.22 | 32.49 | 6.12 | 33.01 | 6.13 | 1.08 | 0.12 | 0.81 | 0.87 | up | no |
| 1011 | "=" | chr1 | - | 6264273 | 6360707 | ENST00000377845 | 9 | 1432 | MSTRG.112 | ACOT7 | GO:0000062(fatty-acyl-CoA binding);GO:0005515(protein binding);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0005829(cytosol);GO:0009062(fatty acid catabolic process);GO:0015937(coenzyme A biosynthetic process);GO:0016290(palmitoyl-CoA hydrolase activity);GO:0036042(long-chain fatty acyl-CoA binding);GO:0036114(medium-chain fatty-acyl-CoA catabolic process);GO:0036116(long-chain fatty-acyl-CoA catabolic process);GO:0042803(protein homodimerization activity);GO:0043005(neuron projection);GO:0044297(cell body);GO:0047617(acyl-CoA hydrolase activity);GO:0051792(medium-chain fatty acid biosynthetic process);GO:0052689(carboxylic ester hydrolase activity);GO:0070062(extracellular exosome);GO:1900535(palmitic acid biosynthetic process) | 01040(Biosynthesis of unsaturated fatty acids) | NA | NA | acyl-CoA thioesterase 7 [Source:HGNC Symbol;Acc:HGNC:24157] | 20.65 | 3.00 | 16.93 | 2.37 | 16.87 | 2.84 | 30.79 | 4.53 | 24.53 | 4.62 | 25.16 | 4.67 | 0.10 | -3.32 | 0.00 | 0.02 | down | yes |
| 1012 | "=" | chr1 | - | 6264273 | 6385813 | ENST00000377855 | 9 | 1614 | MSTRG.112 | ACOT7 | GO:0000062(fatty-acyl-CoA binding);GO:0005515(protein binding);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0005829(cytosol);GO:0009062(fatty acid catabolic process);GO:0015937(coenzyme A biosynthetic process);GO:0016290(palmitoyl-CoA hydrolase activity);GO:0036042(long-chain fatty acyl-CoA binding);GO:0036114(medium-chain fatty-acyl-CoA catabolic process);GO:0036116(long-chain fatty-acyl-CoA catabolic process);GO:0042803(protein homodimerization activity);GO:0043005(neuron projection);GO:0044297(cell body);GO:0047617(acyl-CoA hydrolase activity);GO:0051792(medium-chain fatty acid biosynthetic process);GO:0052689(carboxylic ester hydrolase activity);GO:0070062(extracellular exosome);GO:1900535(palmitic acid biosynthetic process) | 01040(Biosynthesis of unsaturated fatty acids) | NA | NA | acyl-CoA thioesterase 7 [Source:HGNC Symbol;Acc:HGNC:24157] | 57.17 | 8.30 | 53.89 | 7.56 | 49.83 | 8.40 | 0.24 | 0.04 | 0.24 | 0.04 | 0.24 | 0.04 | 2.87 | 1.52 | 0.00 | 0.02 | up | yes |
| 1041 | "=" | chr1 | + | 6450374 | 6451949 | ENST00000475479 | 3 | 360 | MSTRG.119 | ESPN | GO:0003779(actin binding);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005903(brush border);GO:0007605(sensory perception of sound);GO:0007626(locomotory behavior);GO:0017124(SH3 domain binding);GO:0030046(parallel actin filament bundle assembly);GO:0031941(filamentous actin);GO:0032420(stereocilium);GO:0032421(stereocilium bundle);GO:0032426(stereocilium bundle tip);GO:0051015(actin filament binding);GO:0051017(actin filament bundle assembly);GO:0051491(positive regulation of filopodium assembly);GO:0051494(negative regulation of cytoskeleton organization) | NA | NA | NA | espin [Source:HGNC Symbol;Acc:HGNC:13281] | 0 | 0 | 0 | 0 | 0 | 0 | 11.77 | 1.73 | 12.02 | 2.26 | 11.28 | 2.09 | 0.23 | -2.13 | 0.28 | 0.42 | down | no |
| 1045 | "=" | chr1 | + | 6460508 | 6461370 | ENST00000468561 | 2 | 664 | MSTRG.119 | ESPN | GO:0003779(actin binding);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0005903(brush border);GO:0007605(sensory perception of sound);GO:0007626(locomotory behavior);GO:0017124(SH3 domain binding);GO:0030046(parallel actin filament bundle assembly);GO:0031941(filamentous actin);GO:0032420(stereocilium);GO:0032421(stereocilium bundle);GO:0032426(stereocilium bundle tip);GO:0051015(actin filament binding);GO:0051017(actin filament bundle assembly);GO:0051491(positive regulation of filopodium assembly);GO:0051494(negative regulation of cytoskeleton organization) | NA | NA | NA | espin [Source:HGNC Symbol;Acc:HGNC:13281] | 0 | 0 | 0 | 0 | 0 | 0 | 20.82 | 3.06 | 16.00 | 3.01 | 16.33 | 3.03 | 0.25 | -1.98 | 0.00 | 0.01 | down | yes |
| 1078 | "=" | chr1 | - | 6521347 | 6554535 | ENST00000377705 | 12 | 6649 | MSTRG.114 | NOL9 | GO:0000448(cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA));GO:0000460(maturation of 5.8S rRNA);GO:0003723(RNA binding);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005634(nucleus);GO:0005730(nucleolus);GO:0006396(RNA processing);GO:0016020(membrane);GO:0016310(phosphorylation);GO:0051731(polynucleotide 5'-hydroxyl-kinase activity) | NA | NA | NA | nucleolar protein 9 [Source:HGNC Symbol;Acc:HGNC:26265] | 38.26 | 5.56 | 36.16 | 5.07 | 32.90 | 5.55 | 16.53 | 2.43 | 12.62 | 2.38 | 12.95 | 2.40 | 0.76 | -0.40 | 0.26 | 0.40 | down | no |
| 1094 | "=" | chr1 | + | 6585302 | 6589280 | ENST00000482360 | 7 | 2484 | MSTRG.118 | ZBTB48 | GO:0003676(nucleic acid binding);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0005515(protein binding);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated);GO:0046872(metal ion binding) | NA | NA | NA | zinc finger and BTB domain containing 48 [Source:HGNC Symbol;Acc:HGNC:4930] | 2.17 | 0.32 | 2.39 | 0.34 | 2.42 | 0.41 | 13.76 | 2.02 | 11.97 | 2.25 | 12.09 | 2.24 | 0.29 | -1.81 | 0.15 | 0.26 | down | no |
| 1105 | "=" | chr1 | + | 6613685 | 6624033 | ENST00000377648 | 4 | 3681 | MSTRG.124 | PHF13 | GO:0000278(mitotic cell cycle);GO:0003682(chromatin binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0007059(chromosome segregation);GO:0007076(mitotic chromosome condensation);GO:0008270(zinc ion binding);GO:0016568(chromatin modification);GO:0035064(methylated histone binding);GO:0051301(cell division) | NA | NA | NA | PHD finger protein 13 [Source:HGNC Symbol;Acc:HGNC:22983] | 23.90 | 3.47 | 41.38 | 5.80 | 34.39 | 5.80 | 9.11 | 1.34 | 0.30 | 0.06 | 0.30 | 0.06 | 394.84 | 8.63 | 0.39 | 0.53 | up | no |
| 1118 | "=" | chr1 | - | 6634168 | 6701924 | ENST00000377577 | 16 | 3311 | MSTRG.126 | DNAJC11 | GO:0005515(protein binding);GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0070062(extracellular exosome) | NA | NA | NA | DnaJ (Hsp40) homolog, subfamily C, member 11 [Source:HGNC Symbol;Acc:HGNC:25570] | 101.39 | 14.73 | 95.71 | 13.42 | 87.81 | 14.81 | 50.94 | 7.49 | 38.84 | 7.31 | 39.47 | 7.32 | 0.64 | -0.64 | 0.20 | 0.33 | down | no |
| 1124 | "=" | chr1 | - | 6653809 | 6701804 | ENST00000485073 | 5 | 613 | MSTRG.126 | DNAJC11 | GO:0005515(protein binding);GO:0005739(mitochondrion);GO:0005743(mitochondrial inner membrane);GO:0070062(extracellular exosome) | NA | NA | NA | DnaJ (Hsp40) homolog, subfamily C, member 11 [Source:HGNC Symbol;Acc:HGNC:25570] | 3.36 | 0.49 | 3.54 | 0.50 | 3.32 | 0.56 | 15.77 | 2.32 | 12.69 | 2.39 | 13.23 | 2.45 | 0.34 | -1.57 | 0.06 | 0.13 | down | no |
| 1146 | "=" | chr1 | + | 6853095 | 6872045 | ENST00000472283 | 2 | 384 | MSTRG.129 | CAMTA1 | GO:0003677(DNA binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006351(transcription, DNA-templated);GO:0006355(regulation of transcription, DNA-templated) | NA | NA | NA | calmodulin binding transcription activator 1 [Source:HGNC Symbol;Acc:HGNC:18806] | 0 | 0 | 0 | 0 | 0 | 0 | 13.40 | 1.97 | 12.50 | 2.35 | 12.50 | 2.32 | 0.24 | -2.09 | 0.18 | 0.30 | down | no |
| 1162 | "=" | chr1 | + | 7772707 | 7779806 | ENST00000470357 | 5 | 954 | MSTRG.127 | VAMP3 | GO:0000149(SNARE binding);GO:0001921(positive regulation of receptor recycling);GO:0005484(SNAP receptor activity);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006461(protein complex assembly);GO:0006887(exocytosis);GO:0006904(vesicle docking involved in exocytosis);GO:0006906(vesicle fusion);GO:0008021(synaptic vesicle);GO:0009986(cell surface);GO:0016021(integral component of membrane);GO:0016192(vesicle-mediated transport);GO:0016324(apical plasma membrane);GO:0017075(syntaxin-1 binding);GO:0017156(calcium ion-dependent exocytosis);GO:0030054(cell junction);GO:0030136(clathrin-coated vesicle);GO:0030141(secretory granule);GO:0030665(clathrin-coated vesicle membrane);GO:0031201(SNARE complex);GO:0031410(cytoplasmic vesicle);GO:0034446(substrate adhesion-dependent cell spreading);GO:0035493(SNARE complex assembly);GO:0042147(retrograde transport, endosome to Golgi);GO:0043001(Golgi to plasma membrane protein transport);GO:0043005(neuron projection);GO:0043229(intracellular organelle);GO:0043231(intracellular membrane-bounded organelle);GO:0055037(recycling endosome);GO:0061025(membrane fusion);GO:1903531(negative regulation of secretion by cell) | 04130(SNARE interactions in vesicular transport);04145(Phagosome) | NA | NA | vesicle-associated membrane protein 3 [Source:HGNC Symbol;Acc:HGNC:12644] | 27.56 | 4.00 | 24.36 | 3.42 | 23.69 | 3.99 | 8.84 | 1.30 | 5.02 | 0.94 | 5.37 | 1.00 | 0.73 | -0.45 | 0.82 | 0.88 | down | no |
| 1178 | "=" | chr1 | - | 7843083 | 7853512 | ENST00000377516 | 7 | 1601 | MSTRG.142 | UTS2 | GO:0001666(response to hypoxia);GO:0003105(negative regulation of glomerular filtration);GO:0005102(receptor binding);GO:0005179(hormone activity);GO:0005576(extracellular region);GO:0005615(extracellular space);GO:0006936(muscle contraction);GO:0007204(positive regulation of cytosolic calcium ion concentration);GO:0007268(synaptic transmission);GO:0008217(regulation of blood pressure);GO:0010459(negative regulation of heart rate);GO:0010460(positive regulation of heart rate);GO:0010763(positive regulation of fibroblast migration);GO:0010841(positive regulation of circadian sleep/wake cycle, wakefulness);GO:0032224(positive regulation of synaptic transmission, cholinergic);GO:0032967(positive regulation of collagen biosynthetic process);GO:0033574(response to testosterone);GO:0035811(negative regulation of urine volume);GO:0035814(negative regulation of renal sodium excretion);GO:0042312(regulation of vasodilation);GO:0042493(response to drug);GO:0045597(positive regulation of cell differentiation);GO:0045766(positive regulation of angiogenesis);GO:0045776(negative regulation of blood pressure);GO:0045777(positive regulation of blood pressure);GO:0045909(positive regulation of vasodilation);GO:0046005(positive regulation of circadian sleep/wake cycle, REM sleep);GO:0046676(negative regulation of insulin secretion);GO:0048146(positive regulation of fibroblast proliferation) | NA | NA | NA | urotensin 2 [Source:HGNC Symbol;Acc:HGNC:12636] | 20.96 | 3.05 | 19.03 | 2.67 | 19.47 | 3.28 | 0 | 0 | 0 | 0 | 0 | 0 | 0.85 | -0.23 | 0.72 | 0.80 | down | no |
| 1187 | "=" | chr1 | + | 7954291 | 7985052 | ENST00000493373 | 7 | 624 | MSTRG.143 | PARK7 | GO:0000785(chromatin);GO:0001933(negative regulation of protein phosphorylation);GO:0001963(synaptic transmission, dopaminergic);GO:0003713(transcription coactivator activity);GO:0003729(mRNA binding);GO:0005102(receptor binding);GO:0005507(copper ion binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0005747(mitochondrial respiratory chain complex I);GO:0005758(mitochondrial intermembrane space);GO:0005759(mitochondrial matrix);GO:0005783(endoplasmic reticulum);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006469(negative regulation of protein kinase activity);GO:0006508(proteolysis);GO:0006517(protein deglycosylation);GO:0006914(autophagy);GO:0006954(inflammatory response);GO:0007005(mitochondrion organization);GO:0007265(Ras protein signal transduction);GO:0007338(single fertilization);GO:0008134(transcription factor binding);GO:0008233(peptidase activity);GO:0008344(adult locomotory behavior);GO:0010273(detoxification of copper ion);GO:0010628(positive regulation of gene expression);GO:0010629(negative regulation of gene expression);GO:0016532(superoxide dismutase copper chaperone activity);GO:0016605(PML body);GO:0016684(oxidoreductase activity, acting on peroxide as acceptor);GO:0018323(enzyme active site formation via L-cysteine sulfinic acid);GO:0019172(glyoxalase III activity);GO:0019243(methylglyoxal catabolic process to D-lactate);GO:0019899(enzyme binding);GO:0019900(kinase binding);GO:0019955(cytokine binding);GO:0030424(axon);GO:0031397(negative regulation of protein ubiquitination);GO:0032091(negative regulation of protein binding);GO:0032148(activation of protein kinase B activity);GO:0032435(negative regulation of proteasomal ubiquitin-dependent protein catabolic process);GO:0032757(positive regulation of interleukin-8 production);GO:0033138(positive regulation of peptidyl-serine phosphorylation);GO:0033234(negative regulation of protein sumoylation);GO:0034599(cellular response to oxidative stress);GO:0034614(cellular response to reactive oxygen species);GO:0036470(tyrosine 3-monooxygenase activator activity);GO:0036471(cellular response to glyoxal);GO:0036478(L-dopa decarboxylase activator activity);GO:0042177(negative regulation of protein catabolic process);GO:0042542(response to hydrogen peroxide);GO:0042743(hydrogen peroxide metabolic process);GO:0042802(identical protein binding);GO:0042803(protein homodimerization activity);GO:0043005(neuron projection);GO:0043066(negative regulation of apoptotic process);GO:0043523(regulation of neuron apoptotic process);GO:0043524(negative regulation of neuron apoptotic process);GO:0044297(cell body);GO:0044388(small protein activating enzyme binding);GO:0044390(ubiquitin-like protein conjugating enzyme binding);GO:0045121(membrane raft);GO:0045340(mercury ion binding);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046295(glycolate biosynthetic process);GO:0046826(negative regulation of protein export from nucleus);GO:0050681(androgen receptor binding);GO:0050727(regulation of inflammatory response);GO:0050787(detoxification of mercury ion);GO:0050821(protein stabilization);GO:0051091(positive regulation of sequence-specific DNA binding transcription factor activity);GO:0051444(negative regulation of ubiquitin-protein transferase activity);GO:0051583(dopamine uptake involved in synaptic transmission);GO:0051881(regulation of mitochondrial membrane potential);GO:0051897(positive regulation of protein kinase B signaling);GO:0051899(membrane depolarization);GO:0051920(peroxiredoxin activity);GO:0060081(membrane hyperpolarization);GO:0060548(negative regulation of cell death);GO:0060765(regulation of androgen receptor signaling pathway);GO:0070062(extracellular exosome);GO:0070301(cellular response to hydrogen peroxide);GO:0070491(repressing transcription factor binding);GO:0090073(positive regulation of protein homodimerization activity);GO:0097110(scaffold protein binding);GO:1900182(positive regulation of protein localization to nucleus);GO:1901215(negative regulation of neuron death);GO:1901671(positive regulation of superoxide dismutase activity);GO:1901984(negative regulation of protein acetylation);GO:1902177(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway);GO:1902236(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway);GO:1902903(regulation of fibril organization);GO:1902958(positive regulation of mitochondrial electron transport, NADH to ubiquinone);GO:1903073(negative regulation of death-inducing signaling complex assembly);GO:1903094(negative regulation of protein K48-linked deubiquitination);GO:1903122(negative regulation of TRAIL-activated apoptotic signaling pathway);GO:1903135(cupric ion binding);GO:1903136(cuprous ion binding);GO:1903168(positive regulation of pyrroline-5-carboxylate reductase activity);GO:1903178(positive regulation of tyrosine 3-monooxygenase activity);GO:1903181(positive regulation of dopamine biosynthetic process);GO:1903190(glyoxal catabolic process);GO:1903197(positive regulation of L-dopa biosynthetic process);GO:1903200(positive regulation of L-dopa decarboxylase activity);GO:1903202(negative regulation of oxidative stress-induced cell death);GO:1903204(negative regulation of oxidative stress-induced neuron death);GO:1903206(negative regulation of hydrogen peroxide-induced cell death);GO:1903208(negative regulation of hydrogen peroxide-induced neuron death);GO:1903377(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway);GO:1903384(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway);GO:1903428(positive regulation of reactive oxygen species biosynthetic process);GO:1903599(positive regulation of mitochondrion degradation);GO:1990381(ubiquitin-specific protease binding);GO:1990422(glyoxalase (glycolic acid-forming) activity);GO:2000157(negative regulation of ubiquitin-specific protease activity);GO:2000277(positive regulation of oxidative phosphorylation uncoupler activity);GO:2000679(positive regulation of transcription regulatory region DNA binding);GO:2000825(positive regulation of androgen receptor activity);GO:2001237(negative regulation of extrinsic apoptotic signaling pathway);GO:2001268(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway) | 05012(Parkinson's disease) | NA | NA | parkinson protein 7 [Source:HGNC Symbol;Acc:HGNC:16369] | 32.85 | 4.77 | 38.65 | 5.42 | 31.60 | 5.33 | 2.91 | 0.43 | 2.23 | 0.42 | 2.67 | 0.50 | 8.68 | 3.12 | 0.05 | 0.12 | up | no |
| 1189 | "=" | chr1 | + | 7961663 | 7985279 | ENST00000338639 | 7 | 949 | MSTRG.143 | PARK7 | GO:0000785(chromatin);GO:0001933(negative regulation of protein phosphorylation);GO:0001963(synaptic transmission, dopaminergic);GO:0003713(transcription coactivator activity);GO:0003729(mRNA binding);GO:0005102(receptor binding);GO:0005507(copper ion binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0005747(mitochondrial respiratory chain complex I);GO:0005758(mitochondrial intermembrane space);GO:0005759(mitochondrial matrix);GO:0005783(endoplasmic reticulum);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006469(negative regulation of protein kinase activity);GO:0006508(proteolysis);GO:0006517(protein deglycosylation);GO:0006914(autophagy);GO:0006954(inflammatory response);GO:0007005(mitochondrion organization);GO:0007265(Ras protein signal transduction);GO:0007338(single fertilization);GO:0008134(transcription factor binding);GO:0008233(peptidase activity);GO:0008344(adult locomotory behavior);GO:0010273(detoxification of copper ion);GO:0010628(positive regulation of gene expression);GO:0010629(negative regulation of gene expression);GO:0016532(superoxide dismutase copper chaperone activity);GO:0016605(PML body);GO:0016684(oxidoreductase activity, acting on peroxide as acceptor);GO:0018323(enzyme active site formation via L-cysteine sulfinic acid);GO:0019172(glyoxalase III activity);GO:0019243(methylglyoxal catabolic process to D-lactate);GO:0019899(enzyme binding);GO:0019900(kinase binding);GO:0019955(cytokine binding);GO:0030424(axon);GO:0031397(negative regulation of protein ubiquitination);GO:0032091(negative regulation of protein binding);GO:0032148(activation of protein kinase B activity);GO:0032435(negative regulation of proteasomal ubiquitin-dependent protein catabolic process);GO:0032757(positive regulation of interleukin-8 production);GO:0033138(positive regulation of peptidyl-serine phosphorylation);GO:0033234(negative regulation of protein sumoylation);GO:0034599(cellular response to oxidative stress);GO:0034614(cellular response to reactive oxygen species);GO:0036470(tyrosine 3-monooxygenase activator activity);GO:0036471(cellular response to glyoxal);GO:0036478(L-dopa decarboxylase activator activity);GO:0042177(negative regulation of protein catabolic process);GO:0042542(response to hydrogen peroxide);GO:0042743(hydrogen peroxide metabolic process);GO:0042802(identical protein binding);GO:0042803(protein homodimerization activity);GO:0043005(neuron projection);GO:0043066(negative regulation of apoptotic process);GO:0043523(regulation of neuron apoptotic process);GO:0043524(negative regulation of neuron apoptotic process);GO:0044297(cell body);GO:0044388(small protein activating enzyme binding);GO:0044390(ubiquitin-like protein conjugating enzyme binding);GO:0045121(membrane raft);GO:0045340(mercury ion binding);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046295(glycolate biosynthetic process);GO:0046826(negative regulation of protein export from nucleus);GO:0050681(androgen receptor binding);GO:0050727(regulation of inflammatory response);GO:0050787(detoxification of mercury ion);GO:0050821(protein stabilization);GO:0051091(positive regulation of sequence-specific DNA binding transcription factor activity);GO:0051444(negative regulation of ubiquitin-protein transferase activity);GO:0051583(dopamine uptake involved in synaptic transmission);GO:0051881(regulation of mitochondrial membrane potential);GO:0051897(positive regulation of protein kinase B signaling);GO:0051899(membrane depolarization);GO:0051920(peroxiredoxin activity);GO:0060081(membrane hyperpolarization);GO:0060548(negative regulation of cell death);GO:0060765(regulation of androgen receptor signaling pathway);GO:0070062(extracellular exosome);GO:0070301(cellular response to hydrogen peroxide);GO:0070491(repressing transcription factor binding);GO:0090073(positive regulation of protein homodimerization activity);GO:0097110(scaffold protein binding);GO:1900182(positive regulation of protein localization to nucleus);GO:1901215(negative regulation of neuron death);GO:1901671(positive regulation of superoxide dismutase activity);GO:1901984(negative regulation of protein acetylation);GO:1902177(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway);GO:1902236(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway);GO:1902903(regulation of fibril organization);GO:1902958(positive regulation of mitochondrial electron transport, NADH to ubiquinone);GO:1903073(negative regulation of death-inducing signaling complex assembly);GO:1903094(negative regulation of protein K48-linked deubiquitination);GO:1903122(negative regulation of TRAIL-activated apoptotic signaling pathway);GO:1903135(cupric ion binding);GO:1903136(cuprous ion binding);GO:1903168(positive regulation of pyrroline-5-carboxylate reductase activity);GO:1903178(positive regulation of tyrosine 3-monooxygenase activity);GO:1903181(positive regulation of dopamine biosynthetic process);GO:1903190(glyoxal catabolic process);GO:1903197(positive regulation of L-dopa biosynthetic process);GO:1903200(positive regulation of L-dopa decarboxylase activity);GO:1903202(negative regulation of oxidative stress-induced cell death);GO:1903204(negative regulation of oxidative stress-induced neuron death);GO:1903206(negative regulation of hydrogen peroxide-induced cell death);GO:1903208(negative regulation of hydrogen peroxide-induced neuron death);GO:1903377(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway);GO:1903384(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway);GO:1903428(positive regulation of reactive oxygen species biosynthetic process);GO:1903599(positive regulation of mitochondrion degradation);GO:1990381(ubiquitin-specific protease binding);GO:1990422(glyoxalase (glycolic acid-forming) activity);GO:2000157(negative regulation of ubiquitin-specific protease activity);GO:2000277(positive regulation of oxidative phosphorylation uncoupler activity);GO:2000679(positive regulation of transcription regulatory region DNA binding);GO:2000825(positive regulation of androgen receptor activity);GO:2001237(negative regulation of extrinsic apoptotic signaling pathway);GO:2001268(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway) | 05012(Parkinson's disease) | NA | NA | parkinson protein 7 [Source:HGNC Symbol;Acc:HGNC:16369] | 492.88 | 71.60 | 531.63 | 74.55 | 417.68 | 70.42 | 290.74 | 42.74 | 224.40 | 42.26 | 227.14 | 42.15 | 3.12 | 1.64 | 0.00 | 0.02 | up | yes |
| 1191 | "=" | chr1 | + | 7961701 | 7985281 | ENST00000377493 | 6 | 795 | MSTRG.143 | PARK7 | GO:0000785(chromatin);GO:0001933(negative regulation of protein phosphorylation);GO:0001963(synaptic transmission, dopaminergic);GO:0003713(transcription coactivator activity);GO:0003729(mRNA binding);GO:0005102(receptor binding);GO:0005507(copper ion binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0005747(mitochondrial respiratory chain complex I);GO:0005758(mitochondrial intermembrane space);GO:0005759(mitochondrial matrix);GO:0005783(endoplasmic reticulum);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006469(negative regulation of protein kinase activity);GO:0006508(proteolysis);GO:0006517(protein deglycosylation);GO:0006914(autophagy);GO:0006954(inflammatory response);GO:0007005(mitochondrion organization);GO:0007265(Ras protein signal transduction);GO:0007338(single fertilization);GO:0008134(transcription factor binding);GO:0008233(peptidase activity);GO:0008344(adult locomotory behavior);GO:0010273(detoxification of copper ion);GO:0010628(positive regulation of gene expression);GO:0010629(negative regulation of gene expression);GO:0016532(superoxide dismutase copper chaperone activity);GO:0016605(PML body);GO:0016684(oxidoreductase activity, acting on peroxide as acceptor);GO:0018323(enzyme active site formation via L-cysteine sulfinic acid);GO:0019172(glyoxalase III activity);GO:0019243(methylglyoxal catabolic process to D-lactate);GO:0019899(enzyme binding);GO:0019900(kinase binding);GO:0019955(cytokine binding);GO:0030424(axon);GO:0031397(negative regulation of protein ubiquitination);GO:0032091(negative regulation of protein binding);GO:0032148(activation of protein kinase B activity);GO:0032435(negative regulation of proteasomal ubiquitin-dependent protein catabolic process);GO:0032757(positive regulation of interleukin-8 production);GO:0033138(positive regulation of peptidyl-serine phosphorylation);GO:0033234(negative regulation of protein sumoylation);GO:0034599(cellular response to oxidative stress);GO:0034614(cellular response to reactive oxygen species);GO:0036470(tyrosine 3-monooxygenase activator activity);GO:0036471(cellular response to glyoxal);GO:0036478(L-dopa decarboxylase activator activity);GO:0042177(negative regulation of protein catabolic process);GO:0042542(response to hydrogen peroxide);GO:0042743(hydrogen peroxide metabolic process);GO:0042802(identical protein binding);GO:0042803(protein homodimerization activity);GO:0043005(neuron projection);GO:0043066(negative regulation of apoptotic process);GO:0043523(regulation of neuron apoptotic process);GO:0043524(negative regulation of neuron apoptotic process);GO:0044297(cell body);GO:0044388(small protein activating enzyme binding);GO:0044390(ubiquitin-like protein conjugating enzyme binding);GO:0045121(membrane raft);GO:0045340(mercury ion binding);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046295(glycolate biosynthetic process);GO:0046826(negative regulation of protein export from nucleus);GO:0050681(androgen receptor binding);GO:0050727(regulation of inflammatory response);GO:0050787(detoxification of mercury ion);GO:0050821(protein stabilization);GO:0051091(positive regulation of sequence-specific DNA binding transcription factor activity);GO:0051444(negative regulation of ubiquitin-protein transferase activity);GO:0051583(dopamine uptake involved in synaptic transmission);GO:0051881(regulation of mitochondrial membrane potential);GO:0051897(positive regulation of protein kinase B signaling);GO:0051899(membrane depolarization);GO:0051920(peroxiredoxin activity);GO:0060081(membrane hyperpolarization);GO:0060548(negative regulation of cell death);GO:0060765(regulation of androgen receptor signaling pathway);GO:0070062(extracellular exosome);GO:0070301(cellular response to hydrogen peroxide);GO:0070491(repressing transcription factor binding);GO:0090073(positive regulation of protein homodimerization activity);GO:0097110(scaffold protein binding);GO:1900182(positive regulation of protein localization to nucleus);GO:1901215(negative regulation of neuron death);GO:1901671(positive regulation of superoxide dismutase activity);GO:1901984(negative regulation of protein acetylation);GO:1902177(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway);GO:1902236(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway);GO:1902903(regulation of fibril organization);GO:1902958(positive regulation of mitochondrial electron transport, NADH to ubiquinone);GO:1903073(negative regulation of death-inducing signaling complex assembly);GO:1903094(negative regulation of protein K48-linked deubiquitination);GO:1903122(negative regulation of TRAIL-activated apoptotic signaling pathway);GO:1903135(cupric ion binding);GO:1903136(cuprous ion binding);GO:1903168(positive regulation of pyrroline-5-carboxylate reductase activity);GO:1903178(positive regulation of tyrosine 3-monooxygenase activity);GO:1903181(positive regulation of dopamine biosynthetic process);GO:1903190(glyoxal catabolic process);GO:1903197(positive regulation of L-dopa biosynthetic process);GO:1903200(positive regulation of L-dopa decarboxylase activity);GO:1903202(negative regulation of oxidative stress-induced cell death);GO:1903204(negative regulation of oxidative stress-induced neuron death);GO:1903206(negative regulation of hydrogen peroxide-induced cell death);GO:1903208(negative regulation of hydrogen peroxide-induced neuron death);GO:1903377(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway);GO:1903384(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway);GO:1903428(positive regulation of reactive oxygen species biosynthetic process);GO:1903599(positive regulation of mitochondrion degradation);GO:1990381(ubiquitin-specific protease binding);GO:1990422(glyoxalase (glycolic acid-forming) activity);GO:2000157(negative regulation of ubiquitin-specific protease activity);GO:2000277(positive regulation of oxidative phosphorylation uncoupler activity);GO:2000679(positive regulation of transcription regulatory region DNA binding);GO:2000825(positive regulation of androgen receptor activity);GO:2001237(negative regulation of extrinsic apoptotic signaling pathway);GO:2001268(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway) | 05012(Parkinson's disease) | NA | NA | parkinson protein 7 [Source:HGNC Symbol;Acc:HGNC:16369] | 22.59 | 3.28 | 25.27 | 3.54 | 20.73 | 3.49 | 3.04 | 0.45 | 1.54 | 0.29 | 1.54 | 0.29 | 6.79 | 2.76 | 0.11 | 0.20 | up | no |
| 1193 | "=" | chr1 | + | 7961894 | 7985250 | ENST00000377491 | 7 | 977 | MSTRG.143 | PARK7 | GO:0000785(chromatin);GO:0001933(negative regulation of protein phosphorylation);GO:0001963(synaptic transmission, dopaminergic);GO:0003713(transcription coactivator activity);GO:0003729(mRNA binding);GO:0005102(receptor binding);GO:0005507(copper ion binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0005747(mitochondrial respiratory chain complex I);GO:0005758(mitochondrial intermembrane space);GO:0005759(mitochondrial matrix);GO:0005783(endoplasmic reticulum);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006469(negative regulation of protein kinase activity);GO:0006508(proteolysis);GO:0006517(protein deglycosylation);GO:0006914(autophagy);GO:0006954(inflammatory response);GO:0007005(mitochondrion organization);GO:0007265(Ras protein signal transduction);GO:0007338(single fertilization);GO:0008134(transcription factor binding);GO:0008233(peptidase activity);GO:0008344(adult locomotory behavior);GO:0010273(detoxification of copper ion);GO:0010628(positive regulation of gene expression);GO:0010629(negative regulation of gene expression);GO:0016532(superoxide dismutase copper chaperone activity);GO:0016605(PML body);GO:0016684(oxidoreductase activity, acting on peroxide as acceptor);GO:0018323(enzyme active site formation via L-cysteine sulfinic acid);GO:0019172(glyoxalase III activity);GO:0019243(methylglyoxal catabolic process to D-lactate);GO:0019899(enzyme binding);GO:0019900(kinase binding);GO:0019955(cytokine binding);GO:0030424(axon);GO:0031397(negative regulation of protein ubiquitination);GO:0032091(negative regulation of protein binding);GO:0032148(activation of protein kinase B activity);GO:0032435(negative regulation of proteasomal ubiquitin-dependent protein catabolic process);GO:0032757(positive regulation of interleukin-8 production);GO:0033138(positive regulation of peptidyl-serine phosphorylation);GO:0033234(negative regulation of protein sumoylation);GO:0034599(cellular response to oxidative stress);GO:0034614(cellular response to reactive oxygen species);GO:0036470(tyrosine 3-monooxygenase activator activity);GO:0036471(cellular response to glyoxal);GO:0036478(L-dopa decarboxylase activator activity);GO:0042177(negative regulation of protein catabolic process);GO:0042542(response to hydrogen peroxide);GO:0042743(hydrogen peroxide metabolic process);GO:0042802(identical protein binding);GO:0042803(protein homodimerization activity);GO:0043005(neuron projection);GO:0043066(negative regulation of apoptotic process);GO:0043523(regulation of neuron apoptotic process);GO:0043524(negative regulation of neuron apoptotic process);GO:0044297(cell body);GO:0044388(small protein activating enzyme binding);GO:0044390(ubiquitin-like protein conjugating enzyme binding);GO:0045121(membrane raft);GO:0045340(mercury ion binding);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0046295(glycolate biosynthetic process);GO:0046826(negative regulation of protein export from nucleus);GO:0050681(androgen receptor binding);GO:0050727(regulation of inflammatory response);GO:0050787(detoxification of mercury ion);GO:0050821(protein stabilization);GO:0051091(positive regulation of sequence-specific DNA binding transcription factor activity);GO:0051444(negative regulation of ubiquitin-protein transferase activity);GO:0051583(dopamine uptake involved in synaptic transmission);GO:0051881(regulation of mitochondrial membrane potential);GO:0051897(positive regulation of protein kinase B signaling);GO:0051899(membrane depolarization);GO:0051920(peroxiredoxin activity);GO:0060081(membrane hyperpolarization);GO:0060548(negative regulation of cell death);GO:0060765(regulation of androgen receptor signaling pathway);GO:0070062(extracellular exosome);GO:0070301(cellular response to hydrogen peroxide);GO:0070491(repressing transcription factor binding);GO:0090073(positive regulation of protein homodimerization activity);GO:0097110(scaffold protein binding);GO:1900182(positive regulation of protein localization to nucleus);GO:1901215(negative regulation of neuron death);GO:1901671(positive regulation of superoxide dismutase activity);GO:1901984(negative regulation of protein acetylation);GO:1902177(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway);GO:1902236(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway);GO:1902903(regulation of fibril organization);GO:1902958(positive regulation of mitochondrial electron transport, NADH to ubiquinone);GO:1903073(negative regulation of death-inducing signaling complex assembly);GO:1903094(negative regulation of protein K48-linked deubiquitination);GO:1903122(negative regulation of TRAIL-activated apoptotic signaling pathway);GO:1903135(cupric ion binding);GO:1903136(cuprous ion binding);GO:1903168(positive regulation of pyrroline-5-carboxylate reductase activity);GO:1903178(positive regulation of tyrosine 3-monooxygenase activity);GO:1903181(positive regulation of dopamine biosynthetic process);GO:1903190(glyoxal catabolic process);GO:1903197(positive regulation of L-dopa biosynthetic process);GO:1903200(positive regulation of L-dopa decarboxylase activity);GO:1903202(negative regulation of oxidative stress-induced cell death);GO:1903204(negative regulation of oxidative stress-induced neuron death);GO:1903206(negative regulation of hydrogen peroxide-induced cell death);GO:1903208(negative regulation of hydrogen peroxide-induced neuron death);GO:1903377(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway);GO:1903384(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway);GO:1903428(positive regulation of reactive oxygen species biosynthetic process);GO:1903599(positive regulation of mitochondrion degradation);GO:1990381(ubiquitin-specific protease binding);GO:1990422(glyoxalase (glycolic acid-forming) activity);GO:2000157(negative regulation of ubiquitin-specific protease activity);GO:2000277(positive regulation of oxidative phosphorylation uncoupler activity);GO:2000679(positive regulation of transcription regulatory region DNA binding);GO:2000825(positive regulation of androgen receptor activity);GO:2001237(negative regulation of extrinsic apoptotic signaling pathway);GO:2001268(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway) | 05012(Parkinson's disease) | NA | NA | parkinson protein 7 [Source:HGNC Symbol;Acc:HGNC:16369] | 47.73 | 6.93 | 48.19 | 6.76 | 44.14 | 7.44 | 5.79 | 0.85 | 5.16 | 0.97 | 5.13 | 0.95 | 1.89 | 0.92 | 0.31 | 0.45 | up | no |
| 1199 | "=" | chr1 | - | 8004404 | 8026283 | ENST00000474874 | 3 | 479 | MSTRG.146 | ERRFI1 | GO:0005096(GTPase activator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006950(response to stress);GO:0007175(negative regulation of epidermal growth factor-activated receptor activity);GO:0017124(SH3 domain binding);GO:0019900(kinase binding);GO:0019901(protein kinase binding);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031267(small GTPase binding);GO:0031953(negative regulation of protein autophosphorylation);GO:0032691(negative regulation of interleukin-1 beta production);GO:0032869(cellular response to insulin stimulus);GO:0032966(negative regulation of collagen biosynthetic process);GO:0036120(cellular response to platelet-derived growth factor stimulus);GO:0042059(negative regulation of epidermal growth factor receptor signaling pathway);GO:0042536(negative regulation of tumor necrosis factor biosynthetic process);GO:0043547(positive regulation of GTPase activity);GO:0043589(skin morphogenesis);GO:0045616(regulation of keratinocyte differentiation);GO:0048286(lung alveolus development);GO:0060426(lung vasculature development);GO:0060428(lung epithelium development);GO:0061469(regulation of type B pancreatic cell proliferation);GO:0070373(negative regulation of ERK1 and ERK2 cascade);GO:0071364(cellular response to epidermal growth factor stimulus);GO:0071474(cellular hyperosmotic response);GO:0071549(cellular response to dexamethasone stimulus);GO:1903243(negative regulation of cardiac muscle hypertrophy in response to stress) | NA | NA | NA | ERBB receptor feedback inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:18185] | 3.63 | 0.53 | 3.15 | 0.44 | 3.16 | 0.53 | 16.02 | 2.35 | 13.11 | 2.47 | 13.11 | 2.43 | 0.20 | -2.34 | 0.00 | 0.02 | down | yes |
| 1200 | "=" | chr1 | - | 8011719 | 8026308 | ENST00000377482 | 4 | 3104 | MSTRG.146 | ERRFI1 | GO:0005096(GTPase activator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006950(response to stress);GO:0007175(negative regulation of epidermal growth factor-activated receptor activity);GO:0017124(SH3 domain binding);GO:0019900(kinase binding);GO:0019901(protein kinase binding);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031267(small GTPase binding);GO:0031953(negative regulation of protein autophosphorylation);GO:0032691(negative regulation of interleukin-1 beta production);GO:0032869(cellular response to insulin stimulus);GO:0032966(negative regulation of collagen biosynthetic process);GO:0036120(cellular response to platelet-derived growth factor stimulus);GO:0042059(negative regulation of epidermal growth factor receptor signaling pathway);GO:0042536(negative regulation of tumor necrosis factor biosynthetic process);GO:0043547(positive regulation of GTPase activity);GO:0043589(skin morphogenesis);GO:0045616(regulation of keratinocyte differentiation);GO:0048286(lung alveolus development);GO:0060426(lung vasculature development);GO:0060428(lung epithelium development);GO:0061469(regulation of type B pancreatic cell proliferation);GO:0070373(negative regulation of ERK1 and ERK2 cascade);GO:0071364(cellular response to epidermal growth factor stimulus);GO:0071474(cellular hyperosmotic response);GO:0071549(cellular response to dexamethasone stimulus);GO:1903243(negative regulation of cardiac muscle hypertrophy in response to stress) | NA | NA | NA | ERBB receptor feedback inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:18185] | 116.16 | 16.87 | 135.04 | 18.94 | 98.30 | 16.57 | 423.62 | 62.28 | 333.97 | 62.89 | 340.24 | 63.14 | 1.19 | 0.25 | 0.57 | 0.69 | up | no |
| 1202 | "=" | chr1 | - | 8013427 | 8015633 | ENST00000467067 | 2 | 2097 | MSTRG.146 | ERRFI1 | GO:0005096(GTPase activator activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0006950(response to stress);GO:0007175(negative regulation of epidermal growth factor-activated receptor activity);GO:0017124(SH3 domain binding);GO:0019900(kinase binding);GO:0019901(protein kinase binding);GO:0031234(extrinsic component of cytoplasmic side of plasma membrane);GO:0031267(small GTPase binding);GO:0031953(negative regulation of protein autophosphorylation);GO:0032691(negative regulation of interleukin-1 beta production);GO:0032869(cellular response to insulin stimulus);GO:0032966(negative regulation of collagen biosynthetic process);GO:0036120(cellular response to platelet-derived growth factor stimulus);GO:0042059(negative regulation of epidermal growth factor receptor signaling pathway);GO:0042536(negative regulation of tumor necrosis factor biosynthetic process);GO:0043547(positive regulation of GTPase activity);GO:0043589(skin morphogenesis);GO:0045616(regulation of keratinocyte differentiation);GO:0048286(lung alveolus development);GO:0060426(lung vasculature development);GO:0060428(lung epithelium development);GO:0061469(regulation of type B pancreatic cell proliferation);GO:0070373(negative regulation of ERK1 and ERK2 cascade);GO:0071364(cellular response to epidermal growth factor stimulus);GO:0071474(cellular hyperosmotic response);GO:0071549(cellular response to dexamethasone stimulus);GO:1903243(negative regulation of cardiac muscle hypertrophy in response to stress) | NA | NA | NA | ERBB receptor feedback inhibitor 1 [Source:HGNC Symbol;Acc:HGNC:18185] | 78.08 | 11.34 | 68.29 | 9.58 | 66.83 | 11.27 | 211.64 | 31.11 | 161.27 | 30.37 | 163.42 | 30.33 | 0.06 | -4.03 | 0.01 | 0.03 | down | yes |
| 1256 | "=" | chr1 | - | 8861002 | 8878690 | ENST00000234590 | 12 | 1783 | MSTRG.149 | ENO1 | GO:0000015(phosphopyruvate hydratase complex);GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000287(magnesium ion binding);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0003714(transcription corepressor activity);GO:0004634(phosphopyruvate hydratase activity);GO:0005515(protein binding);GO:0005615(extracellular space);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0006094(gluconeogenesis);GO:0006096(glycolytic process);GO:0006351(transcription, DNA-templated);GO:0009615(response to virus);GO:0016020(membrane);GO:0030308(negative regulation of cell growth);GO:0031430(M band);GO:0044281(small molecule metabolic process);GO:0044822(poly(A) RNA binding);GO:0045892(negative regulation of transcription, DNA-templated);GO:0051020(GTPase binding);GO:0061621(canonical glycolysis);GO:0070062(extracellular exosome) | 00010(Glycolysis / Gluconeogenesis);01100(Metabolic pathways);03018(RNA degradation) | K01689 | 4.2.1.11 | enolase 1, (alpha) [Source:HGNC Symbol;Acc:HGNC:3350] | 3576.75 | 519.56 | 3029.23 | 424.77 | 3097.99 | 522.33 | 706.47 | 103.86 | 561.99 | 105.83 | 570.22 | 105.82 | 0.36 | -1.47 | 0.01 | 0.03 | down | yes |
| 1257 | "=" | chr1 | - | 8861005 | 8871297 | ENST00000464920 | 9 | 2266 | MSTRG.149 | ENO1 | GO:0000015(phosphopyruvate hydratase complex);GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000287(magnesium ion binding);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0003714(transcription corepressor activity);GO:0004634(phosphopyruvate hydratase activity);GO:0005515(protein binding);GO:0005615(extracellular space);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0006094(gluconeogenesis);GO:0006096(glycolytic process);GO:0006351(transcription, DNA-templated);GO:0009615(response to virus);GO:0016020(membrane);GO:0030308(negative regulation of cell growth);GO:0031430(M band);GO:0044281(small molecule metabolic process);GO:0044822(poly(A) RNA binding);GO:0045892(negative regulation of transcription, DNA-templated);GO:0051020(GTPase binding);GO:0061621(canonical glycolysis);GO:0070062(extracellular exosome) | 00010(Glycolysis / Gluconeogenesis);01100(Metabolic pathways);03018(RNA degradation) | NA | NA | enolase 1, (alpha) [Source:HGNC Symbol;Acc:HGNC:3350] | 89.36 | 12.98 | 6.60 | 0.93 | 67.84 | 11.44 | 7.73 | 1.14 | 6.25 | 1.18 | 6.32 | 1.17 | 0.00 | -32.46 | 0.00 | 0.02 | down | yes |
| 1262 | "=" | chr1 | - | 8871352 | 8878676 | ENST00000492343 | 3 | 826 | MSTRG.149 | ENO1 | GO:0000015(phosphopyruvate hydratase complex);GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000287(magnesium ion binding);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0003714(transcription corepressor activity);GO:0004634(phosphopyruvate hydratase activity);GO:0005515(protein binding);GO:0005615(extracellular space);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0006094(gluconeogenesis);GO:0006096(glycolytic process);GO:0006351(transcription, DNA-templated);GO:0009615(response to virus);GO:0016020(membrane);GO:0030308(negative regulation of cell growth);GO:0031430(M band);GO:0044281(small molecule metabolic process);GO:0044822(poly(A) RNA binding);GO:0045892(negative regulation of transcription, DNA-templated);GO:0051020(GTPase binding);GO:0061621(canonical glycolysis);GO:0070062(extracellular exosome) | 00010(Glycolysis / Gluconeogenesis);01100(Metabolic pathways);03018(RNA degradation) | NA | NA | enolase 1, (alpha) [Source:HGNC Symbol;Acc:HGNC:3350] | 26.95 | 3.92 | 12.61 | 1.77 | 20.96 | 3.53 | 11.61 | 1.71 | 9.00 | 1.70 | 9.07 | 1.68 | 0.00 | -8.89 | 0.01 | 0.03 | down | yes |
| 1263 | "=" | chr1 | - | 8874856 | 8879249 | ENST00000489867 | 2 | 732 | MSTRG.149 | ENO1 | GO:0000015(phosphopyruvate hydratase complex);GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0000287(magnesium ion binding);GO:0003677(DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0003714(transcription corepressor activity);GO:0004634(phosphopyruvate hydratase activity);GO:0005515(protein binding);GO:0005615(extracellular space);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0006094(gluconeogenesis);GO:0006096(glycolytic process);GO:0006351(transcription, DNA-templated);GO:0009615(response to virus);GO:0016020(membrane);GO:0030308(negative regulation of cell growth);GO:0031430(M band);GO:0044281(small molecule metabolic process);GO:0044822(poly(A) RNA binding);GO:0045892(negative regulation of transcription, DNA-templated);GO:0051020(GTPase binding);GO:0061621(canonical glycolysis);GO:0070062(extracellular exosome) | 00010(Glycolysis / Gluconeogenesis);01100(Metabolic pathways);03018(RNA degradation) | NA | NA | enolase 1, (alpha) [Source:HGNC Symbol;Acc:HGNC:3350] | 0.77 | 0.11 | 34.95 | 4.90 | 0.39 | 0.07 | 4.75 | 0.70 | 5.55 | 1.05 | 7.75 | 1.44 | 510315261.33 | 28.93 | 0.02 | 0.06 | up | yes |
| 1305 | "=" | chr1 | + | 9234775 | 9271337 | ENST00000377403 | 5 | 9146 | MSTRG.176 | H6PD | GO:0004345(glucose-6-phosphate dehydrogenase activity);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0005788(endoplasmic reticulum lumen);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0006098(pentose-phosphate shunt);GO:0006739(NADP metabolic process);GO:0017057(6-phosphogluconolactonase activity);GO:0030246(carbohydrate binding);GO:0043231(intracellular membrane-bounded organelle);GO:0047936(glucose 1-dehydrogenase [NAD(P)] activity);GO:0050661(NADP binding);GO:0055114(oxidation-reduction process);GO:0097305(response to alcohol) | 00030(Pentose phosphate pathway);01100(Metabolic pathways) | K01504;K02564;K01057;K07404 | 3.5.99.6;3.1.1.31 | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) [Source:HGNC Symbol;Acc:HGNC:4795] | 96.06 | 13.95 | 30.78 | 4.32 | 80.36 | 13.55 | 11.55 | 1.70 | 16.60 | 3.13 | 14.73 | 2.73 | 0.00 | -17.79 | 0.00 | 0.02 | down | yes |
| 1306 | "=" | chr1 | + | 9239844 | 9267898 | ENST00000602477 | 5 | 5590 | MSTRG.176 | H6PD | GO:0004345(glucose-6-phosphate dehydrogenase activity);GO:0005737(cytoplasm);GO:0005739(mitochondrion);GO:0005788(endoplasmic reticulum lumen);GO:0005975(carbohydrate metabolic process);GO:0006006(glucose metabolic process);GO:0006098(pentose-phosphate shunt);GO:0006739(NADP metabolic process);GO:0017057(6-phosphogluconolactonase activity);GO:0030246(carbohydrate binding);GO:0043231(intracellular membrane-bounded organelle);GO:0047936(glucose 1-dehydrogenase [NAD(P)] activity);GO:0050661(NADP binding);GO:0055114(oxidation-reduction process);GO:0097305(response to alcohol) | 00030(Pentose phosphate pathway);01100(Metabolic pathways) | K01504;K02564;K01057;K07404 | 3.5.99.6;3.1.1.31 | hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) [Source:HGNC Symbol;Acc:HGNC:4795] | 13.27 | 1.93 | 57.59 | 8.08 | 10.68 | 1.80 | 97.25 | 14.30 | 39.40 | 7.42 | 63.98 | 11.87 | 1354978.17 | 20.37 | 0.01 | 0.05 | up | yes |
| 1317 | "=" | chr1 | + | 9588922 | 9604954 | ENST00000340305 | 6 | 3851 | MSTRG.181 | TMEM201 | GO:0005515(protein binding);GO:0005521(lamin binding);GO:0005637(nuclear inner membrane);GO:0007097(nuclear migration);GO:0010761(fibroblast migration);GO:0016021(integral component of membrane);GO:0031965(nuclear membrane);GO:0051015(actin filament binding) | NA | NA | NA | transmembrane protein 201 [Source:HGNC Symbol;Acc:HGNC:33719] | 13.67 | 1.99 | 25.85 | 3.62 | 11.99 | 2.02 | 5.31 | 0.78 | 4.05 | 0.76 | 4.13 | 0.77 | 399.19 | 8.64 | 0.00 | 0.02 | up | yes |
| 1324 | "=" | chr1 | + | 9651745 | 9728919 | ENST00000377346 | 24 | 5203 | MSTRG.184 | PIK3CD | GO:0001779(natural killer cell differentiation);GO:0001782(B cell homeostasis);GO:0001816(cytokine production);GO:0002250(adaptive immune response);GO:0002551(mast cell chemotaxis);GO:0002679(respiratory burst involved in defense response);GO:0005488(binding);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0005886(plasma membrane);GO:0005942(phosphatidylinositol 3-kinase complex);GO:0006468(protein phosphorylation);GO:0006644(phospholipid metabolic process);GO:0006661(phosphatidylinositol biosynthetic process);GO:0006954(inflammatory response);GO:0007165(signal transduction);GO:0007166(cell surface receptor signaling pathway);GO:0007173(epidermal growth factor receptor signaling pathway);GO:0008543(fibroblast growth factor receptor signaling pathway);GO:0010628(positive regulation of gene expression);GO:0010818(T cell chemotaxis);GO:0014065(phosphatidylinositol 3-kinase signaling);GO:0016303(1-phosphatidylinositol-3-kinase activity);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0016773(phosphotransferase activity, alcohol group as acceptor);GO:0030101(natural killer cell activation);GO:0030168(platelet activation);GO:0030217(T cell differentiation);GO:0030335(positive regulation of cell migration);GO:0030593(neutrophil chemotaxis);GO:0035004(phosphatidylinositol 3-kinase activity);GO:0035005(1-phosphatidylinositol-4-phosphate 3-kinase activity);GO:0035747(natural killer cell chemotaxis);GO:0035754(B cell chemotaxis);GO:0036092(phosphatidylinositol-3-phosphate biosynthetic process);GO:0038095(Fc-epsilon receptor signaling pathway);GO:0042110(T cell activation);GO:0042113(B cell activation);GO:0042629(mast cell granule);GO:0043303(mast cell degranulation);GO:0044281(small molecule metabolic process);GO:0045087(innate immune response);GO:0046854(phosphatidylinositol phosphorylation);GO:0046934(phosphatidylinositol-4,5-bisphosphate 3-kinase activity);GO:0048011(neurotrophin TRK receptor signaling pathway);GO:0048015(phosphatidylinositol-mediated signaling);GO:0048872(homeostasis of number of cells);GO:0050832(defense response to fungus);GO:0050852(T cell receptor signaling pathway);GO:0050853(B cell receptor signaling pathway);GO:0060374(mast cell differentiation);GO:0072672(neutrophil extravasation) | 00562(Inositol phosphate metabolism);04012(ErbB signaling pathway);04062(Chemokine signaling pathway);04070(Phosphatidylinositol signaling system);04150(mTOR signaling pathway);04210(Apoptosis);04370(VEGF signaling pathway);04380(Osteoclast differentiation);04510(Focal adhesion);04620(Toll-like receptor signaling pathway);04630(Jak-STAT signaling pathway);04650(Natural killer cell mediated cytotoxicity);04660(T cell receptor signaling pathway);04662(B cell receptor signaling pathway);04664(Fc epsilon RI signaling pathway);04666(Fc gamma R-mediated phagocytosis);04670(Leukocyte transendothelial migration);04722(Neurotrophin signaling pathway);04725(Cholinergic synapse);04810(Regulation of actin cytoskeleton);04910(Insulin signaling pathway);04914(Progesterone-mediated oocyte maturation);04930(Type II diabetes mellitus);04960(Aldosterone-regulated sodium reabsorption);04973(Carbohydrate digestion and absorption);05100(Bacterial invasion of epithelial cells);05142(Chagas disease (American trypanosomiasis));05145(Toxoplasmosis);05146(Amoebiasis);05160(Hepatitis C);05162(Measles);05164(Influenza A);05200(Pathways in cancer);05210(Colorectal cancer);05211(Renal cell carcinoma);05212(Pancreatic cancer);05213(Endometrial cancer);05214(Glioma);05215(Prostate cancer);05218(Melanoma);05220(Chronic myeloid leukemia);05221(Acute myeloid leukemia);05222(Small cell lung cancer);05223(Non-small cell lung cancer) | NA | NA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta [Source:HGNC Symbol;Acc:HGNC:8977] | 14.32 | 2.08 | 10.76 | 1.51 | 11.68 | 1.97 | 26.93 | 3.96 | 21.01 | 3.96 | 21.40 | 3.97 | 0.06 | -4.12 | 0.00 | 0.02 | down | yes |
| 1343 | "=" | chr1 | - | 9850109 | 9910336 | ENST00000400904 | 5 | 1206 | MSTRG.182 | CTNNBIP1 | GO:0000122(negative regulation of transcription from RNA polymerase II promoter);GO:0001658(branching involved in ureteric bud morphogenesis);GO:0002528(regulation of vascular permeability involved in acute inflammatory response);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0008013(beta-catenin binding);GO:0009952(anterior/posterior pattern specification);GO:0016055(Wnt signaling pathway);GO:0030178(negative regulation of Wnt signaling pathway);GO:0030877(beta-catenin destruction complex);GO:0031333(negative regulation of protein complex assembly);GO:0032091(negative regulation of protein binding);GO:0043392(negative regulation of DNA binding);GO:0043433(negative regulation of sequence-specific DNA binding transcription factor activity);GO:0045657(positive regulation of monocyte differentiation);GO:0045669(positive regulation of osteoblast differentiation);GO:0048662(negative regulation of smooth muscle cell proliferation);GO:0060633(negative regulation of transcription initiation from RNA polymerase II promoter);GO:0070016(armadillo repeat domain binding);GO:0072201(negative regulation of mesenchymal cell proliferation) | 04310(Wnt signaling pathway) | NA | NA | catenin, beta interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:16913] | 28.18 | 4.09 | 26.60 | 3.73 | 24.84 | 4.19 | 10.81 | 1.59 | 8.98 | 1.69 | 9.18 | 1.70 | 0.62 | -0.70 | 0.11 | 0.21 | down | no |
| 1348 | "=" | chr1 | - | 9928939 | 9943329 | ENST00000377223 | 8 | 2281 | MSTRG.191 | LZIC | GO:0008013(beta-catenin binding);GO:0010212(response to ionizing radiation) | NA | NA | NA | leucine zipper and CTNNBIP1 domain containing [Source:HGNC Symbol;Acc:HGNC:17497] | 30.29 | 4.40 | 32.81 | 4.60 | 24.58 | 4.14 | 13.44 | 1.98 | 12.72 | 2.40 | 12.72 | 2.36 | 2.57 | 1.36 | 0.43 | 0.57 | up | no |
| 1354 | "=" | chr1 | + | 9943428 | 9985498 | ENST00000377205 | 5 | 3781 | MSTRG.194 | NMNAT1 | GO:0000309(nicotinamide-nucleotide adenylyltransferase activity);GO:0003824(catalytic activity);GO:0004515(nicotinate-nucleotide adenylyltransferase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0006766(vitamin metabolic process);GO:0006767(water-soluble vitamin metabolic process);GO:0009058(biosynthetic process);GO:0009435(NAD biosynthetic process);GO:0016779(nucleotidyltransferase activity);GO:0019674(NAD metabolic process);GO:0044281(small molecule metabolic process) | 00760(Nicotinate and nicotinamide metabolism);01100(Metabolic pathways) | K00969 | 2.7.7.18 | nicotinamide nucleotide adenylyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:17877] | 2.60 | 0.38 | 18.99 | 2.66 | 16.38 | 2.76 | 4.12 | 0.61 | 3.32 | 0.63 | 3.33 | 0.62 | 609.53 | 9.25 | 0.38 | 0.53 | up | no |
| 1355 | "=" | chr1 | + | 9943429 | 9983669 | ENST00000462686 | 6 | 1818 | MSTRG.194 | NMNAT1 | GO:0000309(nicotinamide-nucleotide adenylyltransferase activity);GO:0003824(catalytic activity);GO:0004515(nicotinate-nucleotide adenylyltransferase activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0006766(vitamin metabolic process);GO:0006767(water-soluble vitamin metabolic process);GO:0009058(biosynthetic process);GO:0009435(NAD biosynthetic process);GO:0016779(nucleotidyltransferase activity);GO:0019674(NAD metabolic process);GO:0044281(small molecule metabolic process) | 00760(Nicotinate and nicotinamide metabolism);01100(Metabolic pathways) | K00969 | 2.7.7.18 | nicotinamide nucleotide adenylyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:17877] | 20.08 | 2.92 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.00 | -11.63 | 0.42 | 0.56 | down | no |
| 1362 | "=" | chr1 | + | 9997216 | 10016020 | ENST00000294435 | 4 | 636 | MSTRG.190 | RBP7 | GO:0005215(transporter activity);GO:0005501(retinoid binding);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0006810(transport);GO:0008289(lipid binding);GO:0016918(retinal binding);GO:0019841(retinol binding) | NA | NA | NA | retinol binding protein 7, cellular [Source:HGNC Symbol;Acc:HGNC:30316] | 28.67 | 4.16 | 25.02 | 3.51 | 23.39 | 3.94 | 8.33 | 1.22 | 7.47 | 1.41 | 7.47 | 1.39 | 0.43 | -1.23 | 0.16 | 0.28 | down | no |
| 1363 | "=" | chr1 | + | 10032832 | 10180367 | ENST00000253251 | 27 | 4772 | MSTRG.197 | UBE4B | GO:0000151(ubiquitin ligase complex);GO:0004842(ubiquitin-protein transferase activity);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005737(cytoplasm);GO:0006511(ubiquitin-dependent protein catabolic process);GO:0008626(granzyme-mediated apoptotic signaling pathway);GO:0009411(response to UV);GO:0016567(protein ubiquitination);GO:0016874(ligase activity);GO:0019899(enzyme binding);GO:0034450(ubiquitin-ubiquitin ligase activity);GO:0042787(protein ubiquitination involved in ubiquitin-dependent protein catabolic process);GO:0043161(proteasome-mediated ubiquitin-dependent protein catabolic process) | 04120(Ubiquitin mediated proteolysis);04141(Protein processing in endoplasmic reticulum) | NA | NA | ubiquitination factor E4B [Source:HGNC Symbol;Acc:HGNC:12500] | 95.11 | 13.82 | 86.52 | 12.13 | 81.72 | 13.78 | 42.48 | 6.24 | 33.22 | 6.26 | 33.80 | 6.27 | 0.45 | -1.15 | 0.01 | 0.05 | down | yes |
| 1377 | "=" | chr1 | + | 10210805 | 10308597 | ENST00000377093 | 21 | 7565 | MSTRG.202 | KIF1B | GO:0003777(microtubule motor activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005739(mitochondrion);GO:0005871(kinesin complex);GO:0005874(microtubule);GO:0005875(microtubule associated complex);GO:0006915(apoptotic process);GO:0007018(microtubule-based movement);GO:0007270(neuron-neuron synaptic transmission);GO:0007274(neuromuscular synaptic transmission);GO:0008017(microtubule binding);GO:0008089(anterograde axon cargo transport);GO:0008152(metabolic process);GO:0008574(ATP-dependent microtubule motor activity, plus-end-directed);GO:0016192(vesicle-mediated transport);GO:0016887(ATPase activity);GO:0019894(kinesin binding);GO:0030659(cytoplasmic vesicle membrane);GO:0030705(cytoskeleton-dependent intracellular transport);GO:0031410(cytoplasmic vesicle);GO:0043005(neuron projection);GO:0047497(mitochondrion transport along microtubule) | NA | NA | NA | kinesin family member 1B [Source:HGNC Symbol;Acc:HGNC:16636] | 5.08 | 0.74 | 13.36 | 1.87 | 4.50 | 0.76 | 13.76 | 2.02 | 20.79 | 3.91 | 20.48 | 3.80 | 70.98 | 6.15 | 0.37 | 0.52 | up | no |
| 1378 | "=" | chr1 | + | 10210805 | 10377937 | ENST00000263934 | 47 | 6816 | MSTRG.202 | KIF1B | GO:0003777(microtubule motor activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005739(mitochondrion);GO:0005871(kinesin complex);GO:0005874(microtubule);GO:0005875(microtubule associated complex);GO:0006915(apoptotic process);GO:0007018(microtubule-based movement);GO:0007270(neuron-neuron synaptic transmission);GO:0007274(neuromuscular synaptic transmission);GO:0008017(microtubule binding);GO:0008089(anterograde axon cargo transport);GO:0008152(metabolic process);GO:0008574(ATP-dependent microtubule motor activity, plus-end-directed);GO:0016192(vesicle-mediated transport);GO:0016887(ATPase activity);GO:0019894(kinesin binding);GO:0030659(cytoplasmic vesicle membrane);GO:0030705(cytoskeleton-dependent intracellular transport);GO:0031410(cytoplasmic vesicle);GO:0043005(neuron projection);GO:0047497(mitochondrion transport along microtubule) | NA | NA | NA | kinesin family member 1B [Source:HGNC Symbol;Acc:HGNC:16636] | 13.93 | 2.02 | 30.46 | 4.27 | 12.06 | 2.03 | 3.84 | 0.56 | 4.15 | 0.78 | 3.96 | 0.73 | 1456.43 | 10.51 | 0.02 | 0.06 | up | yes |
| 1396 | "=" | chr1 | + | 10399080 | 10420144 | ENST00000270776 | 13 | 1885 | MSTRG.201 | PGD | GO:0004616(phosphogluconate dehydrogenase (decarboxylating) activity);GO:0005634(nucleus);GO:0005829(cytosol);GO:0005975(carbohydrate metabolic process);GO:0006098(pentose-phosphate shunt);GO:0009051(pentose-phosphate shunt, oxidative branch);GO:0019322(pentose biosynthetic process);GO:0019521(D-gluconate metabolic process);GO:0044281(small molecule metabolic process);GO:0050661(NADP binding);GO:0055114(oxidation-reduction process);GO:0070062(extracellular exosome) | 00030(Pentose phosphate pathway);00480(Glutathione metabolism);01100(Metabolic pathways) | NA | NA | phosphogluconate dehydrogenase [Source:HGNC Symbol;Acc:HGNC:8891] | 163.49 | 23.75 | 194.32 | 27.25 | 141.83 | 23.91 | 87.34 | 12.84 | 68.35 | 12.87 | 69.13 | 12.83 | 9.10 | 3.19 | 0.00 | 0.02 | up | yes |
| 1419 | "=" | chr1 | - | 10462468 | 10472488 | ENST00000377036 | 5 | 1403 | MSTRG.205 | DFFA | GO:0000790(nuclear chromatin);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005829(cytosol);GO:0006309(apoptotic DNA fragmentation);GO:0006915(apoptotic process);GO:0006921(cellular component disassembly involved in execution phase of apoptosis);GO:0007165(signal transduction);GO:0012501(programmed cell death);GO:0043065(positive regulation of apoptotic process);GO:0070242(thymocyte apoptotic process);GO:1900118(negative regulation of execution phase of apoptosis);GO:1902511(negative regulation of apoptotic DNA fragmentation) | NA | NA | NA | DNA fragmentation factor, 45kDa, alpha polypeptide [Source:HGNC Symbol;Acc:HGNC:2772] | 29.33 | 4.26 | 22.07 | 3.09 | 25.21 | 4.25 | 21.23 | 3.12 | 10.22 | 1.92 | 10.11 | 1.88 | 0.16 | -2.64 | 0.56 | 0.69 | down | no |
| 1445 | "=" | chr1 | + | 11012400 | 11026420 | ENST00000240185 | 6 | 5367 | MSTRG.212 | TARDBP | GO:0000166(nucleotide binding);GO:0001205(RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription);GO:0001933(negative regulation of protein phosphorylation);GO:0003676(nucleic acid binding);GO:0003690(double-stranded DNA binding);GO:0003700(sequence-specific DNA binding transcription factor activity);GO:0003723(RNA binding);GO:0003730(mRNA 3'-UTR binding);GO:0005515(protein binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005726(perichromatin fibrils);GO:0005737(cytoplasm);GO:0006366(transcription from RNA polymerase II promoter);GO:0006397(mRNA processing);GO:0008380(RNA splicing);GO:0010629(negative regulation of gene expression);GO:0016607(nuclear speck);GO:0030264(nuclear fragmentation involved in apoptotic nuclear change);GO:0032024(positive regulation of insulin secretion);GO:0034976(response to endoplasmic reticulum stress);GO:0035061(interchromatin granule);GO:0042802(identical protein binding);GO:0043922(negative regulation by host of viral transcription);GO:0044822(poly(A) RNA binding);GO:0045944(positive regulation of transcription from RNA polymerase II promoter);GO:0051726(regulation of cell cycle);GO:0070935(3'-UTR-mediated mRNA stabilization);GO:0071765(nuclear inner membrane organization) | NA | NA | NA | TAR DNA binding protein [Source:HGNC Symbol;Acc:HGNC:11571] | 2.03 | 0.29 | 2.99 | 0.42 | 2.85 | 0.48 | 38.76 | 5.70 | 30.73 | 5.79 | 30.80 | 5.72 | 0.28 | -1.85 | 0.23 | 0.36 | down | no |
| 1479 | "=" | chr1 | - | 11026523 | 11047223 | ENST00000400897 | 11 | 2439 | MSTRG.213 | MASP2 | GO:0001855(complement component C4b binding);GO:0001867(complement activation, lectin pathway);GO:0004252(serine-type endopeptidase activity);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0006508(proteolysis);GO:0006956(complement activation);GO:0006958(complement activation, classical pathway);GO:0008233(peptidase activity);GO:0045087(innate immune response);GO:0048306(calcium-dependent protein binding);GO:0070062(extracellular exosome) | 04610(Complement and coagulation cascades);05150(Staphylococcus aureus infection) | NA | NA | mannan-binding lectin serine peptidase 2 [Source:HGNC Symbol;Acc:HGNC:6902] | 0 | 0 | 2.64 | 0.37 | 0 | 0 | 96.64 | 14.21 | 73.45 | 13.83 | 73.64 | 13.67 | 3.82 | 1.93 | 0.01 | 0.04 | up | yes |
| 1485 | "=" | chr1 | - | 11044798 | 11047233 | ENST00000400898 | 5 | 726 | MSTRG.213 | MASP2 | GO:0001855(complement component C4b binding);GO:0001867(complement activation, lectin pathway);GO:0004252(serine-type endopeptidase activity);GO:0005509(calcium ion binding);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0006508(proteolysis);GO:0006956(complement activation);GO:0006958(complement activation, classical pathway);GO:0008233(peptidase activity);GO:0045087(innate immune response);GO:0048306(calcium-dependent protein binding);GO:0070062(extracellular exosome) | 04610(Complement and coagulation cascades);05150(Staphylococcus aureus infection) | NA | NA | mannan-binding lectin serine peptidase 2 [Source:HGNC Symbol;Acc:HGNC:6902] | 0 | 0 | 63.25 | 8.87 | 0 | 0 | 152.36 | 22.40 | 147.85 | 27.84 | 149.22 | 27.69 | 77764525931.23 | 36.18 | 0.01 | 0.04 | up | yes |
| 1487 | "=" | chr1 | - | 11054589 | 11060024 | ENST00000376957 | 8 | 1266 | MSTRG.211 | SRM | GO:0003824(catalytic activity);GO:0004766(spermidine synthase activity);GO:0005829(cytosol);GO:0006595(polyamine metabolic process);GO:0008152(metabolic process);GO:0008295(spermidine biosynthetic process);GO:0016740(transferase activity);GO:0034641(cellular nitrogen compound metabolic process);GO:0042803(protein homodimerization activity);GO:0044281(small molecule metabolic process) | 00270(Cysteine and methionine metabolism);00330(Arginine and proline metabolism);00410(beta-Alanine metabolism);00480(Glutathione metabolism);01100(Metabolic pathways) | K00797 | 2.5.1.16 | spermidine synthase [Source:HGNC Symbol;Acc:HGNC:11296] | 78.38 | 11.39 | 76.54 | 10.73 | 67.52 | 11.38 | 27.50 | 4.04 | 25.72 | 4.84 | 25.72 | 4.77 | 0.80 | -0.31 | 0.83 | 0.88 | down | no |
| 1493 | "=" | chr1 | - | 11066618 | 11099881 | ENST00000376936 | 25 | 2808 | MSTRG.214 | EXOSC10 | GO:0000166(nucleotide binding);GO:0000176(nuclear exosome (RNase complex));GO:0000178(exosome (RNase complex));GO:0000184(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay);GO:0000460(maturation of 5.8S rRNA);GO:0000956(nuclear-transcribed mRNA catabolic process);GO:0003676(nucleic acid binding);GO:0003824(catalytic activity);GO:0004532(exoribonuclease activity);GO:0005515(protein binding);GO:0005622(intracellular);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005730(nucleolus);GO:0005737(cytoplasm);GO:0006139(nucleobase-containing compound metabolic process);GO:0006396(RNA processing);GO:0008408(3'-5' exonuclease activity);GO:0009048(dosage compensation by inactivation of X chromosome);GO:0016020(membrane);GO:0035327(transcriptionally active chromatin);GO:0044237(cellular metabolic process);GO:0044822(poly(A) RNA binding);GO:0071028(nuclear mRNA surveillance);GO:0071034(CUT catabolic process);GO:0071035(nuclear polyadenylation-dependent rRNA catabolic process);GO:0071044(histone mRNA catabolic process);GO:0071048(nuclear retention of unspliced pre-mRNA at the site of transcription);GO:0090503(RNA phosphodiester bond hydrolysis, exonucleolytic) | 03018(RNA degradation) | NA | NA | exosome component 10 [Source:HGNC Symbol;Acc:HGNC:9138] | 74.48 | 10.82 | 90.55 | 12.70 | 66.32 | 11.18 | 58.51 | 8.60 | 46.41 | 8.74 | 47.05 | 8.73 | 6.38 | 2.67 | 0.01 | 0.04 | up | yes |
| 1508 | "=" | chr1 | - | 11106535 | 11262507 | ENST00000361445 | 58 | 8677 | MSTRG.220 | MTOR | GO:0000139(Golgi membrane);GO:0000724(double-strand break repair via homologous recombination);GO:0001030(RNA polymerase III type 1 promoter DNA binding);GO:0001031(RNA polymerase III type 2 promoter DNA binding);GO:0001032(RNA polymerase III type 3 promoter DNA binding);GO:0001156(TFIIIC-class transcription factor binding);GO:0001934(positive regulation of protein phosphorylation);GO:0001938(positive regulation of endothelial cell proliferation);GO:0004674(protein serine/threonine kinase activity);GO:0005488(binding);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005634(nucleus);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005741(mitochondrial outer membrane);GO:0005764(lysosome);GO:0005765(lysosomal membrane);GO:0005789(endoplasmic reticulum membrane);GO:0005829(cytosol);GO:0005942(phosphatidylinositol 3-kinase complex);GO:0005979(regulation of glycogen biosynthetic process);GO:0006109(regulation of carbohydrate metabolic process);GO:0006207('de novo' pyrimidine nucleobase biosynthetic process);GO:0006367(transcription initiation from RNA polymerase II promoter);GO:0006468(protein phosphorylation);GO:0006950(response to stress);GO:0007050(cell cycle arrest);GO:0007165(signal transduction);GO:0007173(epidermal growth factor receptor signaling pathway);GO:0007281(germ cell development);GO:0007584(response to nutrient);GO:0008144(drug binding);GO:0008286(insulin receptor signaling pathway);GO:0008543(fibroblast growth factor receptor signaling pathway);GO:0010467(gene expression);GO:0010507(negative regulation of autophagy);GO:0010592(positive regulation of lamellipodium assembly);GO:0010628(positive regulation of gene expression);GO:0010831(positive regulation of myotube differentiation);GO:0012505(endomembrane system);GO:0016020(membrane);GO:0016049(cell growth);GO:0016242(negative regulation of macroautophagy);GO:0016301(kinase activity);GO:0016310(phosphorylation);GO:0016605(PML body);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0016773(phosphotransferase activity, alcohol group as acceptor);GO:0018105(peptidyl-serine phosphorylation);GO:0018107(peptidyl-threonine phosphorylation);GO:0019904(protein domain specific binding);GO:0030030(cell projection organization);GO:0030163(protein catabolic process);GO:0030425(dendrite);GO:0030838(positive regulation of actin filament polymerization);GO:0031295(T cell costimulation);GO:0031529(ruffle organization);GO:0031641(regulation of myelination);GO:0031669(cellular response to nutrient levels);GO:0031929(TOR signaling);GO:0031931(TORC1 complex);GO:0031932(TORC2 complex);GO:0031998(regulation of fatty acid beta-oxidation);GO:0032095(regulation of response to food);GO:0032868(response to insulin);GO:0032956(regulation of actin cytoskeleton organization);GO:0032991(macromolecular complex);GO:0034605(cellular response to heat);GO:0038095(Fc-epsilon receptor signaling pathway);GO:0040007(growth);GO:0043022(ribosome binding);GO:0043025(neuronal cell body);GO:0043087(regulation of GTPase activity);GO:0043200(response to amino acid);GO:0043610(regulation of carbohydrate utilization);GO:0045087(innate immune response);GO:0045670(regulation of osteoclast differentiation);GO:0045727(positive regulation of translation);GO:0045792(negative regulation of cell size);GO:0045859(regulation of protein kinase activity);GO:0045945(positive regulation of transcription from RNA polymerase III promoter);GO:0046777(protein autophosphorylation);GO:0046889(positive regulation of lipid biosynthetic process);GO:0046983(protein dimerization activity);GO:0048010(vascular endothelial growth factor receptor signaling pathway);GO:0048011(neurotrophin TRK receptor signaling pathway);GO:0048015(phosphatidylinositol-mediated signaling);GO:0050731(positive regulation of peptidyl-tyrosine phosphorylation);GO:0051219(phosphoprotein binding);GO:0051496(positive regulation of stress fiber assembly);GO:0051534(negative regulation of NFAT protein import into nucleus);GO:0051897(positive regulation of protein kinase B signaling);GO:0055006(cardiac cell development);GO:0071456(cellular response to hypoxia);GO:1900034(regulation of cellular response to heat);GO:1903147(negative regulation of mitochondrion degradation) | 04012(ErbB signaling pathway);04150(mTOR signaling pathway);04910(Insulin signaling pathway);04920(Adipocytokine signaling pathway);04930(Type II diabetes mellitus);05200(Pathways in cancer);05214(Glioma);05215(Prostate cancer);05221(Acute myeloid leukemia) | NA | NA | mechanistic target of rapamycin (serine/threonine kinase) [Source:HGNC Symbol;Acc:HGNC:3942] | 95.24 | 13.83 | 108.24 | 15.18 | 82.51 | 13.91 | 62.49 | 9.19 | 54.67 | 10.30 | 55.31 | 10.26 | 3.08 | 1.62 | 0.27 | 0.42 | up | no |
| 1531 | "=" | chr1 | - | 11648367 | 11654682 | ENST00000354287 | 6 | 1560 | MSTRG.227 | FBXO2 | GO:0001540(beta-amyloid binding);GO:0001948(glycoprotein binding);GO:0004842(ubiquitin-protein transferase activity);GO:0005515(protein binding);GO:0005783(endoplasmic reticulum);GO:0005829(cytosol);GO:0006464(cellular protein modification process);GO:0006508(proteolysis);GO:0006511(ubiquitin-dependent protein catabolic process);GO:0006516(glycoprotein catabolic process);GO:0008285(negative regulation of cell proliferation);GO:0016567(protein ubiquitination);GO:0019005(SCF ubiquitin ligase complex);GO:0030246(carbohydrate binding);GO:0030433(ER-associated ubiquitin-dependent protein catabolic process);GO:0031090(organelle membrane);GO:0031146(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process);GO:0031396(regulation of protein ubiquitination);GO:0043197(dendritic spine);GO:0070062(extracellular exosome) | 04120(Ubiquitin mediated proteolysis);04141(Protein processing in endoplasmic reticulum) | NA | NA | F-box protein 2 [Source:HGNC Symbol;Acc:HGNC:13581] | 2.76 | 0.40 | 2.84 | 0.40 | 2.76 | 0.47 | 23.32 | 3.43 | 16.79 | 3.16 | 16.83 | 3.12 | 0.29 | -1.78 | 0.13 | 0.23 | down | no |
| 1546 | "=" | chr1 | + | 11664124 | 11674354 | ENST00000376753 | 6 | 1520 | MSTRG.228 | FBXO6 | GO:0000077(DNA damage checkpoint);GO:0001948(glycoprotein binding);GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0006281(DNA repair);GO:0006508(proteolysis);GO:0006516(glycoprotein catabolic process);GO:0006986(response to unfolded protein);GO:0016567(protein ubiquitination);GO:0019005(SCF ubiquitin ligase complex);GO:0030246(carbohydrate binding);GO:0030433(ER-associated ubiquitin-dependent protein catabolic process);GO:0031146(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process);GO:0061630(ubiquitin protein ligase activity) | 04141(Protein processing in endoplasmic reticulum) | NA | NA | F-box protein 6 [Source:HGNC Symbol;Acc:HGNC:13585] | 33.63 | 4.89 | 43.98 | 6.17 | 30.66 | 5.17 | 12.40 | 1.82 | 9.74 | 1.83 | 10.70 | 1.99 | 17.60 | 4.14 | 0.02 | 0.06 | up | yes |
| 1567 | "=" | chr1 | + | 11736155 | 11750765 | ENST00000314340 | 5 | 1107 | MSTRG.230 | AGTRAP | GO:0000139(Golgi membrane);GO:0001666(response to hypoxia);GO:0004945(angiotensin type II receptor activity);GO:0005515(protein binding);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0005789(endoplasmic reticulum membrane);GO:0005886(plasma membrane);GO:0005938(cell cortex);GO:0008217(regulation of blood pressure);GO:0016021(integral component of membrane);GO:0030659(cytoplasmic vesicle membrane);GO:0038166(angiotensin-activated signaling pathway);GO:0043231(intracellular membrane-bounded organelle) | NA | NA | NA | angiotensin II receptor-associated protein [Source:HGNC Symbol;Acc:HGNC:13539] | 58.51 | 8.50 | 36.47 | 5.11 | 29.43 | 4.96 | 9.72 | 1.43 | 6.98 | 1.31 | 6.98 | 1.30 | 0.25 | -1.98 | 0.68 | 0.77 | down | no |
| 1612 | "=" | chr1 | - | 11919591 | 11926423 | ENST00000376572 | 3 | 2815 | MSTRG.231 | KIAA2013 | GO:0016020(membrane);GO:0016021(integral component of membrane) | NA | NA | NA | KIAA2013 [Source:HGNC Symbol;Acc:HGNC:28513] | 113.15 | 16.44 | 139.32 | 19.54 | 98.22 | 16.56 | 174.88 | 25.71 | 151.27 | 28.48 | 153.51 | 28.49 | 3.65 | 1.87 | 0.26 | 0.40 | up | no |
| 1619 | "=" | chr1 | + | 11934753 | 11975537 | ENST00000196061 | 19 | 2940 | MSTRG.238 | PLOD1 | GO:0001666(response to hypoxia);GO:0005506(iron ion binding);GO:0005783(endoplasmic reticulum);GO:0005789(endoplasmic reticulum membrane);GO:0006464(cellular protein modification process);GO:0008198(ferrous iron binding);GO:0008475(procollagen-lysine 5-dioxygenase activity);GO:0008544(epidermis development);GO:0016491(oxidoreductase activity);GO:0016705(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen);GO:0016706(oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors);GO:0017185(peptidyl-lysine hydroxylation);GO:0030198(extracellular matrix organization);GO:0030867(rough endoplasmic reticulum membrane);GO:0031418(L-ascorbic acid binding);GO:0032870(cellular response to hormone stimulus);GO:0042277(peptide binding);GO:0042803(protein homodimerization activity);GO:0046947(hydroxylysine biosynthetic process);GO:0055114(oxidation-reduction process);GO:0070062(extracellular exosome) | 00310(Lysine degradation) | NA | NA | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 [Source:HGNC Symbol;Acc:HGNC:9081] | 236.91 | 34.41 | 258.15 | 36.20 | 204.07 | 34.41 | 174.80 | 25.70 | 138.36 | 26.05 | 140.11 | 26.00 | 2.38 | 1.25 | 0.01 | 0.04 | up | yes |
| 1624 | "=" | chr1 | + | 11980181 | 12013514 | ENST00000444836 | 18 | 4531 | MSTRG.239 | MFN2 | GO:0001825(blastocyst formation);GO:0003924(GTPase activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0005739(mitochondrion);GO:0005741(mitochondrial outer membrane);GO:0005829(cytosol);GO:0006626(protein targeting to mitochondrion);GO:0006914(autophagy);GO:0006915(apoptotic process);GO:0006986(response to unfolded protein);GO:0007006(mitochondrial membrane organization);GO:0007596(blood coagulation);GO:0008053(mitochondrial fusion);GO:0008152(metabolic process);GO:0015630(microtubule cytoskeleton);GO:0016021(integral component of membrane);GO:0031306(intrinsic component of mitochondrial outer membrane);GO:0031625(ubiquitin protein ligase binding);GO:0034497(protein localization to pre-autophagosomal structure);GO:0046580(negative regulation of Ras protein signal transduction);GO:0048593(camera-type eye morphogenesis);GO:0048662(negative regulation of smooth muscle cell proliferation);GO:0051646(mitochondrion localization) | NA | NA | NA | mitofusin 2 [Source:HGNC Symbol;Acc:HGNC:16877] | 15.72 | 2.28 | 28.70 | 4.02 | 14.65 | 2.47 | 6.05 | 0.89 | 5.87 | 1.10 | 5.82 | 1.08 | 197.40 | 7.62 | 0.03 | 0.08 | up | yes |
| 1626 | "=" | chr1 | + | 11980312 | 12013508 | ENST00000235329 | 19 | 4539 | MSTRG.239 | MFN2 | GO:0001825(blastocyst formation);GO:0003924(GTPase activity);GO:0005515(protein binding);GO:0005525(GTP binding);GO:0005739(mitochondrion);GO:0005741(mitochondrial outer membrane);GO:0005829(cytosol);GO:0006626(protein targeting to mitochondrion);GO:0006914(autophagy);GO:0006915(apoptotic process);GO:0006986(response to unfolded protein);GO:0007006(mitochondrial membrane organization);GO:0007596(blood coagulation);GO:0008053(mitochondrial fusion);GO:0008152(metabolic process);GO:0015630(microtubule cytoskeleton);GO:0016021(integral component of membrane);GO:0031306(intrinsic component of mitochondrial outer membrane);GO:0031625(ubiquitin protein ligase binding);GO:0034497(protein localization to pre-autophagosomal structure);GO:0046580(negative regulation of Ras protein signal transduction);GO:0048593(camera-type eye morphogenesis);GO:0048662(negative regulation of smooth muscle cell proliferation);GO:0051646(mitochondrion localization) | NA | NA | NA | mitofusin 2 [Source:HGNC Symbol;Acc:HGNC:16877] | 86.29 | 12.53 | 101.62 | 14.25 | 75.68 | 12.76 | 125.06 | 18.39 | 96.39 | 18.15 | 97.44 | 18.08 | 2.98 | 1.58 | 0.00 | 0.02 | up | yes |
| 1633 | "=" | chr1 | + | 12019466 | 12032045 | ENST00000235332 | 10 | 1573 | MSTRG.240 | MIIP | GO:0005515(protein binding) | NA | NA | NA | migration and invasion inhibitory protein [Source:HGNC Symbol;Acc:HGNC:25715] | 39.65 | 5.76 | 39.39 | 5.52 | 34.59 | 5.83 | 20.90 | 3.07 | 19.84 | 3.74 | 20.14 | 3.74 | 0.63 | -0.67 | 0.68 | 0.78 | down | no |
| 1652 | "=" | chr1 | + | 12167003 | 12209228 | ENST00000376259 | 10 | 3683 | MSTRG.243 | TNFRSF1B | GO:0005031(tumor necrosis factor-activated receptor activity);GO:0005515(protein binding);GO:0005576(extracellular region);GO:0005634(nucleus);GO:0005886(plasma membrane);GO:0006954(inflammatory response);GO:0006955(immune response);GO:0007166(cell surface receptor signaling pathway);GO:0007568(aging);GO:0008630(intrinsic apoptotic signaling pathway in response to DNA damage);GO:0016020(membrane);GO:0016021(integral component of membrane);GO:0030424(axon);GO:0031625(ubiquitin protein ligase binding);GO:0032496(response to lipopolysaccharide);GO:0033209(tumor necrosis factor-mediated signaling pathway);GO:0043025(neuronal cell body);GO:0043196(varicosity);GO:0045121(membrane raft);GO:0048471(perinuclear region of cytoplasm);GO:0050728(negative regulation of inflammatory response);GO:0050779(RNA destabilization);GO:0051044(positive regulation of membrane protein ectodomain proteolysis);GO:0071222(cellular response to lipopolysaccharide);GO:0071363(cellular response to growth factor stimulus);GO:0097191(extrinsic apoptotic signaling pathway) | 04060(Cytokine-cytokine receptor interaction);04920(Adipocytokine signaling pathway);05014(Amyotrophic lateral sclerosis (ALS)) | NA | NA | tumor necrosis factor receptor superfamily, member 1B [Source:HGNC Symbol;Acc:HGNC:11917] | 38.59 | 5.61 | 27.52 | 3.86 | 30.39 | 5.12 | 81.07 | 11.92 | 65.71 | 12.37 | 66.77 | 12.39 | 0.01 | -6.08 | 0.00 | 0.02 | down | yes |
| 1659 | "=" | chr1 | + | 12230067 | 12512047 | ENST00000613099 | 69 | 16245 | MSTRG.246 | VPS13D | GO:0005515(protein binding);GO:0005622(intracellular);GO:0005623(cell);GO:0006623(protein targeting to vacuole);GO:0019898(extrinsic component of membrane);GO:0045053(protein retention in Golgi apparatus);GO:0070062(extracellular exosome) | NA | NA | NA | vacuolar protein sorting 13 homolog D (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:23595] | 30.86 | 4.48 | 24.07 | 3.37 | 32.62 | 5.50 | 5.47 | 0.80 | 4.29 | 0.81 | 5.41 | 1.00 | 0.06 | -4.11 | 0.11 | 0.21 | down | no |
| 1677 | "=" | chr1 | - | 12567910 | 12617731 | ENST00000616661 | 6 | 1722 | MSTRG.249 | DHRS3 | GO:0000166(nucleotide binding);GO:0001523(retinoid metabolic process);GO:0003151(outflow tract morphogenesis);GO:0004745(retinol dehydrogenase activity);GO:0005789(endoplasmic reticulum membrane);GO:0007601(visual perception);GO:0007603(phototransduction, visible light);GO:0008152(metabolic process);GO:0009055(electron carrier activity);GO:0016021(integral component of membrane);GO:0016491(oxidoreductase activity);GO:0030278(regulation of ossification);GO:0042572(retinol metabolic process);GO:0042622(photoreceptor outer segment membrane);GO:0048387(negative regulation of retinoic acid receptor signaling pathway);GO:0052650(NADP-retinol dehydrogenase activity);GO:0055114(oxidation-reduction process);GO:0060021(palate development);GO:0060349(bone morphogenesis);GO:0060411(cardiac septum morphogenesis) | 00830(Retinol metabolism);01100(Metabolic pathways) | NA | NA | dehydrogenase/reductase (SDR family) member 3 [Source:HGNC Symbol;Acc:HGNC:17693] | 216.49 | 31.45 | 333.67 | 46.79 | 190.03 | 32.04 | 504.01 | 74.10 | 398.87 | 75.11 | 403.41 | 74.86 | 49.49 | 5.63 | 0.01 | 0.03 | up | yes |
| 1870 | "=" | chr1 | - | 15572353 | 15585110 | ENST00000375826 | 7 | 2500 | MSTRG.271 | AGMAT | GO:0005739(mitochondrion);GO:0006595(polyamine metabolic process);GO:0008295(spermidine biosynthetic process);GO:0008783(agmatinase activity);GO:0016813(hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines);GO:0033388(putrescine biosynthetic process from arginine);GO:0034641(cellular nitrogen compound metabolic process);GO:0044281(small molecule metabolic process);GO:0046872(metal ion binding);GO:0070062(extracellular exosome);GO:0097055(agmatine biosynthetic process) | NA | K01480 | 3.5.3.11 | agmatine ureohydrolase (agmatinase) [Source:HGNC Symbol;Acc:HGNC:18407] | 100.89 | 14.66 | 136.66 | 19.16 | 86.09 | 14.52 | 214.93 | 31.60 | 167.88 | 31.61 | 169.81 | 31.51 | 12.31 | 3.62 | 0.01 | 0.03 | up | yes |
| 1876 | "=" | chr1 | + | 15617500 | 15669044 | ENST00000480945 | 10 | 10625 | MSTRG.274 | DDI2 | GO:0004190(aspartic-type endopeptidase activity);GO:0005515(protein binding);GO:0005654(nucleoplasm);GO:0005737(cytoplasm);GO:0006508(proteolysis) | NA | NA | NA | DNA-damage inducible 1 homolog 2 (S. cerevisiae) [Source:HGNC Symbol;Acc:HGNC:24578] | 63.61 | 9.24 | 66.28 | 9.29 | 54.42 | 9.18 | 91.72 | 13.48 | 70.56 | 13.29 | 71.69 | 13.30 | 0.82 | -0.29 | 0.11 | 0.21 | down | no |
| 1884 | "=" | chr1 | + | 15684332 | 15734769 | ENST00000375799 | 20 | 4122 | MSTRG.275 | PLEKHM2 | GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0007030(Golgi organization);GO:0019894(kinesin binding);GO:0032880(regulation of protein localization) | NA | NA | NA | pleckstrin homology domain containing, family M (with RUN domain) member 2 [Source:HGNC Symbol;Acc:HGNC:29131] | 19.02 | 2.76 | 28.97 | 4.06 | 17.17 | 2.90 | 39.13 | 5.75 | 31.18 | 5.87 | 31.75 | 5.89 | 18.17 | 4.18 | 0.01 | 0.05 | up | yes |
| 1885 | "=" | chr1 | + | 15684390 | 15734769 | ENST00000375793 | 19 | 4004 | MSTRG.275 | PLEKHM2 | GO:0005515(protein binding);GO:0005737(cytoplasm);GO:0007030(Golgi organization);GO:0019894(kinesin binding);GO:0032880(regulation of protein localization) | NA | NA | NA | pleckstrin homology domain containing, family M (with RUN domain) member 2 [Source:HGNC Symbol;Acc:HGNC:29131] | 24.77 | 3.60 | 17.13 | 2.40 | 21.03 | 3.55 | 4.30 | 0.63 | 2.23 | 0.42 | 2.17 | 0.40 | 0.10 | -3.25 | 0.22 | 0.35 | down | no |
| 1970 | "=" | chr1 | - | 16124337 | 16156087 | ENST00000358432 | 17 | 3964 | MSTRG.287 | EPHA2 | GO:0001501(skeletal system development);GO:0001525(angiogenesis);GO:0001568(blood vessel development);GO:0001570(vasculogenesis);GO:0001649(osteoblast differentiation);GO:0004672(protein kinase activity);GO:0004713(protein tyrosine kinase activity);GO:0004714(transmembrane receptor protein tyrosine kinase activity);GO:0005003(ephrin receptor activity);GO:0005515(protein binding);GO:0005524(ATP binding);GO:0005622(intracellular);GO:0005886(plasma membrane);GO:0005887(integral component of plasma membrane);GO:0005925(focal adhesion);GO:0006468(protein phosphorylation);GO:0007155(cell adhesion);GO:0007169(transmembrane receptor protein tyrosine kinase signaling pathway);GO:0007275(multicellular organismal development);GO:0007411(axon guidance);GO:0008630(intrinsic apoptotic signaling pathway in response to DNA damage);GO:0009986(cell surface);GO:0010591(regulation of lamellipodium assembly);GO:0014028(notochord formation);GO:0016021(integral component of membrane);GO:0016032(viral process);GO:0016477(cell migration);GO:0016772(transferase activity, transferring phosphorus-containing groups);GO:0018108(peptidyl-tyrosine phosphorylation);GO:0021915(neural tube development);GO:0030182(neuron differentiation);GO:0030216(keratinocyte differentiation);GO:0030316(osteoclast differentiation);GO:0031256(leading edge membrane);GO:0031258(lamellipodium membrane);GO:0032587(ruffle membrane);GO:0033598(mammary gland epithelial cell proliferation);GO:0033628(regulation of cell adhesion mediated by integrin);GO:0036342(post-anal tail morphogenesis);GO:0043491(protein kinase B signaling);GO:0043535(regulation of blood vessel endothelial cell migration);GO:0045765(regulation of angiogenesis);GO:0046849(bone remodeling);GO:0048013(ephrin receptor signaling pathway);GO:0048320(axial mesoderm formation);GO:0048570(notochord morphogenesis);GO:0051898(negative regulation of protein kinase B signaling);GO:0060035(notochord cell development);GO:0060326(cell chemotaxis);GO:0060444(branching involved in mammary gland duct morphogenesis);GO:0070309(lens fiber cell morphogenesis);GO:0070372(regulation of ERK1 and ERK2 cascade);GO:0070848(response to growth factor);GO:0090004(positive regulation of establishment of protein localization to plasma membrane);GO:0090630(activation of GTPase activity) | 04360(Axon guidance) | NA | NA | EPH receptor A2 [Source:HGNC Symbol;Acc:HGNC:3386] | 14.23 | 2.07 | 14.73 | 2.07 | 12.34 | 2.08 | 98.34 | 14.46 | 98.86 | 18.62 | 100.35 | 18.62 | 0.09 | -3.43 | 0.25 | 0.39 | down | no |
| 2002 | "=" | chr1 | + | 16367265 | 16398142 | ENST00000492354 | 3 | 3401 | MSTRG.293 | SZRD1 | NA | NA | NA | NA | SUZ RNA binding domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30232] | 16.53 | 2.40 | 2.86 | 0.40 | 15.61 | 2.63 | 3.69 | 0.54 | 2.88 | 0.54 | 2.99 | 0.55 | 0.00 | -15.55 | 0.00 | 0.02 | down | yes |
| 2014 | "=" | chr1 | + | 16440672 | 16460078 | ENST00000337132 | 8 | 2070 | MSTRG.298 | NECAP2 | GO:0005622(intracellular);GO:0005886(plasma membrane);GO:0005905(coated pit);GO:0006897(endocytosis);GO:0015031(protein transport);GO:0016020(membrane);GO:0030125(clathrin vesicle coat) | NA | NA | NA | NECAP endocytosis associated 2 [Source:HGNC Symbol;Acc:HGNC:25528] | 20.68 | 3.00 | 33.55 | 4.71 | 18.54 | 3.13 | 90.48 | 13.30 | 70.87 | 13.35 | 71.88 | 13.34 | 20.31 | 4.34 | 0.01 | 0.04 | up | yes |
| 2021 | "=" | chr1 | + | 16440743 | 16460077 | ENST00000492095 | 9 | 1787 | MSTRG.298 | NECAP2 | GO:0005622(intracellular);GO:0005886(plasma membrane);GO:0005905(coated pit);GO:0006897(endocytosis);GO:0015031(protein transport);GO:0016020(membrane);GO:0030125(clathrin vesicle coat) | NA | NA | NA | NECAP endocytosis associated 2 [Source:HGNC Symbol;Acc:HGNC:25528] | 20.10 | 2.92 | 21.08 | 2.96 | 18.22 | 3.07 | 0.86 | 0.13 | 0.90 | 0.17 | 0.89 | 0.17 | 2.82 | 1.49 | 0.05 | 0.12 | up | no |
| 2076 | "=" | chr1 | - | 16666785 | 16666948 | ENST00000384782 | 1 | 164 | MSTRG.303 | RNU1-3 | NA | NA | NA | NA | NA | 224.53 | 32.62 | 257.49 | 36.11 | 194.06 | 32.72 | 0 | 0 | 0 | 0 | 0 | 0 | 114.74 | 6.84 | 0.00 | 0.01 | up | yes |
| 2089 | "=" | chr1 | + | 16740516 | 16740679 | ENST00000384659 | 1 | 164 | MSTRG.309 | RNU1-4 | NA | NA | NA | NA | NA | 224.22 | 32.57 | 255.21 | 35.79 | 193.58 | 32.64 | 0 | 0 | 0 | 0 | 0 | 0 | 105.15 | 6.72 | 0.00 | 0.01 | up | yes |
document location:
summary/3_2_transcript_differential_expression/*VS*/Gene_differential_expression.xlsx
summary/3_2_transcript_differential_expression/*VS*/Transcript_differential_expression.xlsx
document location:
summary/3_2_transcript_differential_expression/*VS*/*_Genes_volcano.png
summary/3_2_transcript_differential_expression/*VS*/*_Transcript_volcano.png
document location:
summary/3_2_transcript_differential_expression/*VS*/*_genes_heatmap.png
summary/3_2_transcript_differential_expression/*VS*/*_transcripts_heatmap.png
Gene ontology (GO) (http://www.geneontology.org) is a major bioinformatics initiative to unify the representation of gene and gene product attributes across all species. More specifically, the project aims to: 1) maintain and develop its controlled vocabulary of gene and gene product attributes; 2) annotate genes and gene products, and assimilate and disseminate annotation data; and 3) provide tools for easy access to all aspects of the data provided by the project, and to enable functional interpretation of experimental data using the GO, for example via enrichment analysis.
GO is part of a larger classification effort, the Open Biomedical Ontologies (OBO).
Although gene nomenclature itself aims to maintain and develop controlled vocabulary of gene and gene products, the Gene Ontology extends the effort by using markup language to make the data (not only of the genes and their products but also of all their attributes) machine readable, and to do so in a way that is unified across all species (whereas gene nomenclature conventions vary by biologic taxon).
Significant GO terms::
| GO_ID | GO_Term | GO_function | GO_class | Genes | S gene number | TS gene number | B gene number | TB gene number | pvalue |
| GO:0006415 | translational termination | biological_process | 8 | ETF1;GSPT2;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;UBA52 | 61 | 2120 | 84 | 7087 | 0.00 |
| GO:0006414 | translational elongation | biological_process | 8 | EEF1A1;EEF1B2;EEF1D;EEF1G;ELOF1;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;TCEA2;UBA52 | 65 | 2120 | 94 | 7087 | 0.00 |
| GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | biological_process | 9 | DDOST;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPN2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;SEC11A;SRP54;SRP9;SSR1;SSR2;TRAM1;UBA52 | 67 | 2120 | 102 | 7087 | 0.00 |
| GO:0006413 | translational initiation | biological_process | 8 | ABCF1;DDX3Y;EIF2B2;EIF2D;EIF2S2;EIF3A;EIF3D;EIF3E;EIF3F;EIF3H;EIF3I;EIF3J;EIF3L;EIF4A2;EIF4E2;EIF4H;EIF5B;PABPC1;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;UBA52 | 77 | 2120 | 128 | 7087 | 0.00 |
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | biological_process | 11 | CASC3;EIF3E;ETF1;GSPT2;PABPC1;PARN;PPP2CA;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;UBA52;UPF2;WIBG | 68 | 2120 | 109 | 7087 | 0.00 |
| GO:0070062 | extracellular exosome | cellular_component | 7 | ABCB1;ABCB4;ACACA;ACAT2;ACLY;ACMSD;ACOT13;ACP1;ACP5;ACSL4;ACSM1;ACTA2;ACTN4;ADAM9;ADGRE5;ADH6;AEBP1;AFM;AGA;AHSG;AK2;AK4;AKR1B10;AKR7A2;ALCAM;ALDH1A3;ALDH1L1;ALDH2;ALDH6A1;ALDH7A1;ALDOB;ANGPTL1;ANGPTL2;ANGPTL6;ANXA2;ANXA7;AP1S1;AP2M1;APMAP;APOA2;APOC3;APOM;ARF6;ARG1;ARHGEF12;ARPC2;ARPC5L;ARSD;ASL;ASPA;ATAD2;ATP5J2;ATP6V1B2;ATP6V1C1;AXL;AZGP1;B2M;B3GNT2;BAIAP2;BASP1;BAX;BCAM;BDH2;BHMT2;BOLA2B;BPNT1;BST1;BST2;BTN2A1;C1QA;C1QB;C1QC;C1RL;C1S;C3;C6;C7;C8A;C8B;CA2;CADM1;CAD;CALM1;CANX;CAP1;CAPG;CAPZA2;CASC5;CAT;CCT2;CCT3;CCT4;CCT6A;CCT7;CD2AP;CD55;CD63;CD74;CD81;CDK1;CETP;CFD;CFI;CH507-152C13.3;CHMP2B;CIB1;CLDN2;CLDN3;CMPK1;CMTM6;COL18A1;COL1A2;COL6A1;COL6A2;COTL1;COX4I1;COX5A;CPB2;CPN2;CP;CREG1;CRISPLD2;CRYAA;CSE1L;CSNK2B;CSRP1;CST3;CSTA;CTSA;CTSC;CTSD;CTSF;CTSH;CTSL;CTSZ;CTTN;CXCR4;CYB5R1;CYB5R3;CYFIP2;CYSTM1;DAB2;DAD1;DBI;DCXR;DDC;DEFB1;DLST;DNAJB1;DNAJC7;DPP7;DPT;DPYSL2;DSG1;DUSP3;ECHDC1;ECHS1;EEF1A1;EEF1G;EFEMP1;EFNA1;EFR3A;EIF3E;EIF3H;EIF3I;ELFN1;ENO3;ENOPH1;ENPEP;F11;F12;FABP1;FAM129B;FAM151A;FAM171A1;FAM20A;FAM20C;FAM3C;FBLN2;FBN1;FBP1;FCGR3A;FCN2;FETUB;FGB;FGG;FIBP;FKBP1A;FKBP4;FLNA;FN1;FNBP1L;FOLH1;FRK;FSCN1;FTL;FUCA1;FUCA2;FZD4;G6PD;GALNT2;GANAB;GARS;GAS6;GDF15;GDI2;GFPT1;GGH;GIPC2;GLO1;GLRX3;GLYAT;GNA11;GNA13;GNAI1;GNAI2;GNAS;GNAZ;GNB1;GNG5;GOT2;GPC1;GPC3;GPT;GPX1;GRB2;GSR;GSS;GSTO1;H2AFX;H2AFY;H3F3A;H3F3B;HAGH;HBA1;HBA2;HBB;HDDC2;HEBP1;HINT3;HIST1H2AC;HIST1H2AI;HIST1H2AK;HIST1H2BC;HIST1H2BG;HIST1H3C;HIST1H4B;HIST1H4J;HIST2H2AC;HIST2H3A;HIST2H3C;HIST2H4B;HIST4H4;HLA-B;HLA-DRB1;HLA-DRB5;HNRNPA1;HNRNPD;HNRNPK;HNRNPM;HPD;HPX;HRSP12;HSP90AA1;HSP90B1;HSPA8;HSPE1;HSPG2;IARS;ICAM1;IDH1;IDH2;IFT20;IGF2R;IGFALS;IGFBP2;IGFBP3;IGFBP7;IGHA1;IGSF8;IMPDH2;IRF6;ISOC1;IST1;ITGAV;ITGB5;ITM2C;JUP;KDELR2;KRT7;LAD1;LAMA2;LAMB2;LAMC1;LAMP1;LAMP2;LAMTOR1;LASP1;LBP;LCP1;LGALS3BP;LGALS8;LGMN;LIN7A;LIN7C;LIPA;LSP1;LTBP3;LTBP4;LUM;LYPLA1;LYPLA2;LYVE1;MAL2;MAN1A2;MAN1C1;MAN2B1;MAOB;MAPK1;MARC2;MARCKS;MAT2B;MDH2;MEP1A;METTL7A;MGAT4A;MGRN1;MGST3;MITD1;MME;MMRN2;MOGS;MON2;MPDU1;MRGPRF;MSRA;MTHFD1;MUC13;MXRA8;MYH11;MYH9;MYO5C;NAMPT;NAPG;NCL;NDRG2;NDUFA13;NDUFA4;NDUFB9;NEDD4;NPNT;NRAS;NSF;NUDT1;NUDT5;OAF;OLA1;ORM1;PA2G4;PABPC1L;PABPC1;PAH;PARD6B;PARK7;PBLD;PCK1;PCK2;PCMT1;PCNA;PCOLCE2;PCOLCE;PCYOX1;PDCD2;PDCD6IP;PDDC1;PDHB;PDIA3;PDIA6;PDZK1;PEF1;PFDN2;PFKL;PGD;PGLS;PGM1;PGRMC1;PIGR;PITPNB;PLAUR;PLAU;PLCB1;PLP2;PLS1;PLSCR4;PLVAP;PM20D2;PPA1;PPAP2B;PPIB;PPL;PPP1CA;PPP2CA;PPP2CB;PPP2R1B;PRDX1;PRDX3;PRDX6;PRELP;PRKCZ;PROZ;PRSS23;PRSS8;PSMA2;PSMA3;PSMA7;PSMB1;PSMB5;PSMB8;PSMD13;PTBP1;PTER;PTH1R;PTPN6;PTPRD;PVRL2;PVR;PXDN;PYGB;PZP;QDPR;QSOX1;RAB11A;RAB11B;RAB13;RAB14;RAB7A;RAB8A;RACGAP1;RARS;RBKS;RBL2;RDX;RHEB;RHOBTB3;RHOB;RHOC;RHOF;RHOG;RNASE1;RNASET2;RPE;RPL10A;RPL11;RPL12;RPL14;RPL23A;RPL23;RPL24;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL37A;RPL3;RPL4;RPL7A;RPL7;RPLP0;RPLP1;RPLP2;RPS10;RPS11;RPS13;RPS16;RPS17;RPS18;RPS19;RPS25;RPS26;RPS27A;RPS29;RPS3A;RPS3;RPS4X;RPS5;RPS7;RPS8;RPS9;RPSA;RRM1;RSU1;S100A11;S100A16;S100A8;SAA1;SAA2;SAMM50;SARS;SCAMP3;SCP2;SEC11A;SEC13;SELENBP1;SEMA5A;SERPINA1;SERPINB6;SERPINF1;SERPING1;SERPINH1;SERPINI1;SH3BP4;SHISA5;SHMT1;SLC1A4;SLC25A25;SLC25A5;SLC44A2;SLC46A3;SMPDL3A;SNRPB;SNRPE;SNX12;SNX18;SOD1;SOD2;SPINK1;SPON2;SPP1;SPPL2A;SPR;SPTAN1;SRP9;SSBP1;ST14;STEAP4;STK26;STMN1;STOM;STX12;STX3;TBC1D4;TBCA;TCP1;TGM2;THBS4;THY1;TINAGL1;TKT;TM7SF3;TMBIM1;TMC6;TMPRSS2;TNFAIP3;TOM1L2;TOM1;TOMM40;TOR3A;TPM3;TPRG1L;TRMT112;TSPAN3;TSPAN8;TSPO;TSTA3;TTYH3;TUBA1B;TUBB2A;TUBB6;UBA52;UBAC1;UBE2D2;UBE2G1;UBE2K;UBE2M;UBE2N;UBL3;UEVLD;UGDH;UGT2B7;UQCR10;UXS1;VASN;VCL;VDAC1;VIL1;VMO1;VPS4A;VSIG4;WARS;WWP1;XPC;XPNPEP2;YBX1;YWHAZ;ZNF445 | 597 | 2120 | 1628 | 7087 | 0.00 |
| GO:0019083 | viral transcription | biological_process | 9 | NUP205;NUP50;NUPL1;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;SEH1L;UBA52 | 63 | 2120 | 102 | 7087 | 0.00 |
| GO:0006412 | translation | biological_process | 7 | ABCF1;DDOST;EEF1A1;EEF1B2;EEF1D;EEF1G;EIF2B2;EIF2S2;EIF3A;EIF3D;EIF3E;EIF3F;EIF3H;EIF3I;EIF3J;EIF4A2;EIF4H;EIF5B;EPRS;ETF1;FARSB;GSPT2;HARS;IGF2BP3;MRPL13;MRPL14;MRPL16;MRPL18;MRPL20;MRPL24;MRPL34;MRPL36;MRPL51;MRPS12;PABPC1;PABPC4;QARS;RBM3;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL22L1;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL36AL;RPL37A;RPL37;RPL39L;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPN2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS6KB2;RPS7;RPS8;RPS9;RPSA;RRBP1;RSL24D1;SARS;SEC11A;SRP54;SRP9;SSR1;SSR2;TRAM1;UBA52;WARS | 112 | 2120 | 222 | 7087 | 0.00 |
| GO:0022627 | cytosolic small ribosomal subunit | cellular_component | 12 | EIF2D;HBA1;HBA2;MCTS1;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA | 29 | 2120 | 36 | 7087 | 0.00 |
| GO:0022625 | cytosolic large ribosomal subunit | cellular_component | 11 | RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL36AL;RPL37A;RPL37;RPL39L;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;UBA52 | 36 | 2120 | 50 | 7087 | 0.00 |
| GO:0044267 | cellular protein metabolic process | biological_process | 6 | ADAMTSL4;ALG8;ARFGAP1;ARSD;B3GNT2;BLM;BRCA1;CANX;CBX4;CCT2;CCT3;CCT4;CCT6A;CCT7;CDKN2A;CFP;CTDSP2;CTSA;CTSZ;DAD1;DDOST;DNAJB11;DOLK;DOLPP1;DPH2;EDEM1;EEF1A1;EEF1B2;EEF1D;EEF1G;EIF2B2;EIF2S2;EIF3A;EIF3D;EIF3E;EIF3F;EIF3H;EIF3I;EIF3J;EIF4A2;EIF4H;EIF5B;ENPEP;ETF1;EXOC4;EXOC6;EXOC8;EXTL3;GALNT2;GANAB;GAS6;GFPT1;GNPNAT1;GRPEL2;GSPT2;HDGF;HERPUD1;HSP90B1;IGF1;IGFALS;IGFBP2;IGFBP3;IGFBP4;KDELR3;LMNA;MAN1A2;MAN1C1;MBTPS2;MCFD2;MGAT4A;MLEC;MME;MMP2;MOGS;MUC13;NPL;NUP205;NUP50;NUPL1;PABPC1;PDIA3;PDIA6;PFDN2;PFDN6;PIAS1;PIGC;PIGK;PIGM;PLA2G7;PLAUR;PMPCA;PMPCB;PPP2R5B;PROZ;RAD21;REN;RFT1;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPN2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;SAMM50;SEC11A;SEC13;SEC23A;SEC24D;SEH1L;SLC17A5;SLC25A6;SMC3;SMC5;SMC6;SRP54;SRP9;SSR1;SSR2;STAG1;SUMO1;TBCA;TBCB;TCP1;TIMM13;TOMM40;TRAM1;TUBA1B;TUBA1C;TUBB2A;TUBB2B;TUBB6;TUSC3;UBA52;VKORC1;XPC | 188 | 2120 | 444 | 7087 | 0.00 |
| GO:0019058 | viral life cycle | biological_process | 6 | CHMP2B;NUP205;NUP50;NUPL1;PDCD6IP;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;SEH1L;SLC25A6;UBA52;VPS37A;VPS4A | 68 | 2120 | 126 | 7087 | 0.00 |
| GO:0005840 | ribosome | cellular_component | 9 | ABCF1;CANX;MRPL13;MRPL14;MRPL16;MRPL18;MRPL20;MRPL24;MRPL34;MRPL36;MRPL44;MRPL54;MRPS12;MRPS27;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL22L1;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL36AL;RPL37A;RPL37;RPL39L;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS7;RPS8;RPS9;RPSA;RRBP1;RSL24D1;UBA52 | 75 | 2120 | 145 | 7087 | 0.00 |
| GO:0003735 | structural constituent of ribosome | molecular_function | 4 | MRPL13;MRPL14;MRPL16;MRPL18;MRPL20;MRPL24;MRPL34;MRPL36;MRPL51;MRPS12;MRPS35;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL22L1;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL36AL;RPL37A;RPL37;RPL39L;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;RSL24D1;UBA52 | 72 | 2120 | 139 | 7087 | 0.00 |
| GO:0005576 | extracellular region | cellular_component | 3 | ACTN4;ADAM9;ADAMTS2;ADAMTSL2;AFM;AHSG;AOAH;APOA2;APOA5;APOC3;APOL1;APOL2;APOL6;APOM;ATG4C;AZGP1;B2M;BMPER;BOLA3;C19orf80;C1QA;C1QB;C1QC;C1QTNF1;C1S;C3;C4BPA;C6;C7;C8A;C8B;CALM1;CALU;CAPZA2;CCL21;CCL4;CCL5;CD163;CD55;CETP;CFD;CFI;CFP;CHST9;CLEC4M;COL18A1;COL1A1;COL1A2;COL3A1;COL6A1;COL6A2;COLEC10;COLEC11;CPN2;CP;CRISPLD2;CST3;CTGF;CTSD;CTSL;CXCL14;CYR61;DBH;DCN;DEFB1;DKK1;EFEMP1;EFNA1;EGFL7;EMC10;EPHA3;EREG;ESM1;F11;F12;F2R;FAM180A;FAM3C;FBLN2;FBN1;FCN2;FCN3;FGB;FGFR3;FGG;FLNA;FMOD;FN1;FOLR2;GAS6;GDF15;GNAS;H3F3A;H3F3B;HAMP;HBA1;HBA2;HBB;HEBP1;HGF;HIST1H3C;HIST1H4B;HIST1H4J;HIST2H3A;HIST2H3C;HIST2H4B;HIST4H4;HPX;HSP90AA1;HSP90B1;HSPG2;ICOS;IGF1;IGFALS;IGFBP2;IGFBP3;IGFBP4;IGFBP7;IGHA1;IGSF1;KIAA0100;LAMA2;LAMB2;LAMC1;LAMC3;LBP;LIPG;LTBP3;LTBP4;LUM;MASP1;MET;MFAP1;MMP2;MMRN1;NGFR;NOTCH1;NOTCH4;NPIPB15;NPNT;NPW;NTS;ORM1;PCCA;PCOLCE2;PKDCC;PLA2G7;PLAU;PLEK;PLGLB1;PLGLB2;PLTP;PLXNB1;PON2;PRELP;PROZ;PRSS8;PZP;REN;RNASET2;S100A8;SAA1;SAA2;SERPINA1;SERPINF1;SERPING1;SIGLEC1;SOD1;SPINT2;SPP1;ST14;SVEP1;TFPI;THBS2;THBS4;THEM6;TINAGL1;TNFRSF1B;TUFT1;UTS2;VCL;VWA8 | 182 | 2120 | 451 | 7087 | 0.00 |
| GO:0031012 | extracellular matrix | cellular_component | 3 | ADAMTS16;ADAMTS2;ADAMTSL2;ADAMTSL4;AEBP1;ANXA2;ASPN;CFP;COL18A1;COL1A1;COL1A2;COL3A1;COL6A1;COL6A2;CPXM2;CTSD;CYR61;DCN;DPT;EFEMP1;EGFL7;FBLN2;FBN1;FKBP1A;FMOD;FN1;HNRNPM;HSP90B1;HSPG2;IGFBP7;LAMA2;LAMB2;LAMC1;LGALS3BP;LTBP3;LTBP4;LUM;MATN2;MMP14;MMP15;MMP2;NPNT;PCOLCE;PRELP;PXDN;RPSA;SERPINF1;SOD1;THBS2;THBS4;TINAGL1 | 51 | 2120 | 97 | 7087 | 0.00 |
| GO:0005615 | extracellular space | cellular_component | 5 | ACTA2;ACTN4;ADAM9;ADGRE5;AEBP1;AFM;AFP;AHSG;ANGPTL1;ANGPTL2;ANXA2;APOA2;APOA5;APOC3;APOL1;APOM;ARG1;AXL;AZGP1;B2M;BMPER;C1QC;C1QTNF1;C1RL;C3;C4BPA;C8A;C8B;CA2;CAT;CCL21;CCL4;CCL5;CD36;CECR1;CETP;CFD;CFI;CFP;CMTM4;CMTM6;COL18A1;COL1A1;COL1A2;COL3A1;COL6A2;CPB2;CPXM2;CP;CRHBP;CST3;CSTA;CTGF;CTSC;CTSD;CTSF;CTSH;CTSL;CTSZ;CXCL14;DCN;DEFB1;DKK1;DLK1;DPT;DPYSL3;EEF1A1;EFEMP1;EGFL7;ENG;ENO3;EREG;F11;F12;FAM20C;FBN1;FETUB;FGB;FGG;FMOD;FN1;FUCA2;GAS6;GDF15;GGH;GNL3;GPC1;GPC3;HAMP;HDGF;HGF;HIST1H2BC;HIST1H2BG;HMGB2;HPX;HSPA8;HSPG2;ICAM1;IGF1;IGFALS;IGFBP2;IGFBP3;IGFBP4;IGFBP7;IGHA1;IK;IL27;IL33;IRF2BPL;KDSR;LAMC1;LBP;LCP1;LGALS3BP;LGALS8;LIME1;LIPG;LTBP4;LTB;LUM;MANF;MASP1;MEP1A;METRN;MMP2;MMRN2;MRPL18;MTUS1;MUC13;NAMPT;NENF;ORM1;PCOLCE;PIGR;PLA2G7;PLAU;PLTP;PMPCA;PPP1R1A;PRDX1;PRDX6;PRKAG2;PRSS8;PTGIS;PVR;PXDN;PZP;QSOX1;RAB11FIP4;RAMP1;RDX;REN;RNASET2;RPL39;S100A11;S100A8;SAA1;SAA2;SELENBP1;SELP;SERPINA1;SERPINB6;SERPINF1;SERPING1;SERPINI1;SMPDL3A;SOD1;SPINK1;SPON2;SPP1;SRPX2;ST14;STOM;TFPI;THBS4;THNSL2;TINAGL1;UTS2;VASN;VNN3;YWHAZ;ZSWIM5 | 182 | 2120 | 471 | 7087 | 0.00 |
| GO:0019843 | rRNA binding | molecular_function | 7 | DDX21;MRPL16;MRPL20;RPF2;RPL11;RPL23A;RPL37;RPL8;RPL9;RPS11;RPS18;RPS4X;RPS4Y1;RPS9 | 14 | 2120 | 18 | 7087 | 0.00 |
| GO:0015935 | small ribosomal subunit | cellular_component | 11 | DAP3;MRPS12;RPS16;RPS18;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS29;RPS3;RPS4X;RPS5;RPS9;RPSA | 16 | 2120 | 22 | 7087 | 0.00 |
| GO:0007095 | mitotic G2 DNA damage checkpoint | biological_process | 13 | BLM;CCNA2;CDK1;CDK5RAP3;FOXN3;NBN;SYF2;TAOK3 | 8 | 2120 | 8 | 7087 | 0.00 |
| GO:0005925 | focal adhesion | cellular_component | 6 | ACTN4;ADAM9;ADGRE5;ALCAM;ARF6;ARPC2;ARPC5L;B2M;CAP1;CAT;CD81;CD99;CSRP1;CTTN;DAB2;ENG;FGFR3;FLNA;GDI2;GNA13;HACD3;HNRNPK;HSP90B1;HSPA8;HSPG2;ICAM1;IGF2R;ILK;ITGA6;ITGAV;ITGB5;JUP;LASP1;LCP1;LIMA1;LIMS2;LRP1;MAPK1;MARCKS;MME;MMP14;MPZL1;MRC2;MYH9;NPM1;PABPC1;PDCD6IP;PDIA3;PLAUR;PLAU;PPFIA1;PPIB;PTK7;PVRL2;PVR;RDX;REXO2;RHOB;RHOG;RPL10A;RPL12;RPL13A;RPL18;RPL19;RPL23;RPL27;RPL30;RPL31;RPL37A;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS10;RPS11;RPS13;RPS16;RPS17;RPS18;RPS19;RPS29;RPS3A;RPS3;RPS4X;RPS5;RPS7;RPS8;RPS9;RSU1;SLC4A2;SNTB1;SYNPO2;TADA1;TES;TGM2;THY1;TNS1;TRPV4;TSPAN4;VCL;YWHAZ | 107 | 2120 | 262 | 7087 | 0.00 |
| GO:0005581 | collagen trimer | cellular_component | 3 | C1QA;C1QB;C1QC;C1QTNF1;COL18A1;COL1A1;COL1A2;COL3A1;COL6A2;COLEC10;COLEC11;FCN2;FCN3;MARCO;MSR1;RPS18 | 16 | 2120 | 24 | 7087 | 0.00 |
| GO:0005604 | basement membrane | cellular_component | 6 | ANXA2;COL18A1;CST3;FBN1;FN1;GSTO1;HSPG2;ITGA6;LAD1;LAMA2;LAMB2;LAMC1;LAMC3;MATN2;MMRN2;NPNT;P3H2;RPSA;SERPINF1;SMC3;THBS2;THBS4;USH2A | 23 | 2120 | 40 | 7087 | 0.00 |
| GO:0010467 | gene expression | biological_process | 6 | AIMP2;ANP32A;CARS2;CASC3;CCNC;CDC5L;CLNS1A;CNOT11;COX4I1;COX5A;COX6B1;COX6C;COX7A2L;COX7C;CREBBP;CSTF3;CTGF;CWC15;DDOST;DHX9;EEF1A1;EEF1B2;EEF1D;EEF1G;EIF2B2;EIF2S2;EIF3A;EIF3D;EIF3E;EIF3F;EIF3H;EIF3I;EIF3J;EIF4A2;EIF4H;EIF5B;EPRS;ETF1;EXOSC1;EXOSC5;EZH2;FARSB;G6PD;GARS;GLS2;GLS;GSPT2;GSR;GTF2E2;GTF2H1;H3F3A;H3F3B;HARS;HIST1H3C;HIST1H4B;HIST1H4J;HIST2H3A;HIST2H3C;HIST2H4B;HIST4H4;HNF4G;HNRNPA1;HNRNPD;HNRNPH1;HNRNPH2;HNRNPK;HNRNPM;HNRNPUL1;HNRNPU;HSPA8;IARS2;IARS;IGF2BP3;IPO8;LARS;LSM4;LSM7;LTB;MED16;MED20;MED30;NELFCD;NELFE;NOTCH1;NOTCH4;NR1H4;NR1I3;NR2F1;NR2F6;NR3C1;NR5A2;NRBP1;NUP205;NUP50;NUPL1;P2RX7;PABPC1;PAPOLA;PARN;POLR2G;POLR2I;POLR3C;PPA1;PPARD;PPP2CA;PRDX1;PRKAA2;PRKAG2;PSMA2;PSMA3;PSMA7;PSMB10;PSMB1;PSMB5;PSMB8;PSMC3;PSMC4;PSMD13;PTBP1;QARS;RARS;RHEB;RNMT;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPN2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;RQCD1;SARS;SEC11A;SEH1L;SET;SF3B1;SIN3A;SLBP;SNRNP40;SNRPA1;SNRPA;SNRPB2;SNRPB;SNRPE;SNRPF;SNRPG;SRP54;SRP9;SRSF3;SRSF4;SSR1;SSR2;TAF1D;TAF2;TAF4;TRAM1;U2AF2;UBA52;UBE2D1;UPF2;WARS;XPO5;YBX1;YWHAZ;ZNF143;ZNRD1 | 218 | 2120 | 603 | 7087 | 0.00 |
| GO:0005887 | integral component of plasma membrane | cellular_component | 7 | ABCA1;ABCB4;ADGRE5;ADRA1A;APOM;AQP3;AXL;BCAM;BST2;BTN2A1;C1QTNF1;C3AR1;C5AR1;CD163;CD1D;CD36;CD55;CD63;CD81;CD83;CD99;CLCN5;CLDN3;CLEC1B;CLEC4M;DCBLD2;DEGS1;EBP;EFNA1;ENPEP;EPHA3;EREG;F2RL1;F2R;FADS2;FAM26F;FAM47E-STBD1;FCER1G;FGFR3;FLVCR1;FOLH1;FZD4;GCGR;GPC1;GPC3;HLA-B;HLA-DPA1;HNRNPM;ICAM1;ICOS;IGF2R;IL17RC;ITGAV;KTN1;LAMP1;LAPTM5;LDLR;LGR4;LINC00116;LRP1;LY6E;LYVE1;MARCO;MEP1A;MET;MFSD2A;MME;MMP14;MMP15;MPP1;MPZL1;MRC1;MRGPRF;MSR1;NGFR;NOTCH4;NPY1R;P2RX7;P2RY13;PALM;PERP;PIGR;PLAUR;PLXNB1;PODXL2;PTAFR;PTH1R;PTK7;PTPRB;PTPRC;PTPRD;RAMP1;RAMP3;SELP;SEMA6A;SGCE;SLC10A1;SLC16A2;SLC16A3;SLC17A2;SLC17A3;SLC17A4;SLC17A5;SLC19A1;SLC1A4;SLC22A1;SLC22A3;SLC25A13;SLC25A5;SLC26A6;SLC28A1;SLC2A10;SLC4A2;ST14;STAB1;STAB2;STEAP4;STOM;TENM2;THY1;TM2D1;TM4SF5;TMPRSS2;TNFRSF21;TSPAN13;TUSC3;TYROBP;VIPR1 | 128 | 2120 | 332 | 7087 | 0.00 |
| GO:0005578 | proteinaceous extracellular matrix | cellular_component | 5 | ADAMTS16;ADAMTS2;ADAMTSL2;ADAMTSL3;ADAMTSL4;ASPN;COL1A1;COL3A1;COL6A1;COL6A2;CRISPLD2;CTGF;CYR61;DCN;DPT;EFEMP1;FBLN2;FBN1;FMOD;FN1;GPC1;GPC3;HSPG2;LAMC1;LAMC3;LGALS3BP;LTBP4;LUM;MATN2;MMP2;NPNT;PRELP;PXDN;SERPINA1;SPOCK2;SPON2;TFIP11;THBS2 | 38 | 2120 | 80 | 7087 | 0.00 |
| GO:0007155 | cell adhesion | biological_process | 4 | ACKR3;ADAM9;ADGRE5;ALCAM;ARF6;AZGP1;BCAM;CADM1;CCL4;CD24;CD36;CD4;CD99;CDH5;CHST10;CIB1;COL18A1;COL6A1;COL6A2;CTGF;CYR61;DPT;DSG1;EGFL7;EMP2;ENG;EPHA3;FEZ1;FN1;GAS6;HES1;ICAM1;IGFALS;IGFBP7;ITGA6;ITGA9;ITGAV;ITGB5;JUP;LAMA2;LAMB2;LAMC1;LAMC3;LGALS3BP;LYVE1;MMRN1;MPDZ;MYH9;PKN2;PPAP2B;PTK7;PVR;RHOB;RPSA;SDC3;SELP;SEMA5A;SIGLEC11;SPON2;SPP1;SRPX;SSX2IP;STAB1;STAB2;SVEP1;THBS2;THBS4;THEMIS2;TINAGL1;TNFRSF12A;TPM3;TROAP;VCL | 73 | 2120 | 177 | 7087 | 0.00 |
| GO:0006898 | receptor-mediated endocytosis | biological_process | 8 | AP1S1;APOL1;CAP1;CD163;CD36;CETP;CFI;COL1A1;COL1A2;COL3A1;COLEC11;CTTN;FTL;HBA1;HBA2;HBB;HPX;HSP90AA1;HSP90B1;IGF2R;IGHA1;LDLR;LGALS3BP;LRP1;LRP3;MARCO;MASP1;MRC1;MSR1;PI4KB;RABEPK;SAA1;STAB1;STAB2;TINAGL1;TMPRSS2 | 36 | 2120 | 77 | 7087 | 0.00 |
| GO:0003723 | RNA binding | molecular_function | 6 | ASCC1;BRCA1;CASC3;CDKN2AIP;CRNKL1;CSTF3;CWC15;DDX10;DDX21;DDX3Y;DDX60;DKC1;EIF2D;EIF2S2;EIF4E2;EIF4H;ETF1;EXOSC1;EXOSC5;EZH2;FAM103A1;FARSB;HBP1;HNRNPA1;HNRNPD;HNRNPH1;HNRNPH2;HNRNPK;HNRNPM;HNRNPUL1;HNRNPU;HSP90B1;IGF2BP3;ILF2;IMP3;IMPDH2;LSM7;MCTS1;MPHOSPH6;MRPL44;NCL;NELFE;NIFK;NOP56;NOP9;NPM1;PABPC1L;PABPC1;PABPC4;PAPOLA;PARN;PDCD4;PNPT1;PPARGC1A;PPP1R8;PPP5C;PTBP1;PURB;PUS3;QKI;RAD51AP1;RBM39;RBM3;RBMS1;RNASET2;RNMT;RPL10A;RPL11;RPL14;RPL18;RPL19;RPL21;RPL24;RPL27A;RPL28;RPL30;RPL31;RPL34;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS16;RPS18;RPS25;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS9;RPUSD1;RPUSD3;SARS;SLBP;SNRPA;SNRPE;SNRPF;SNRPG;SON;SRP9;SRSF3;TARBP1;U2AF2;UHMK1;UPF2;WDHD1;XPO5;YBX1 | 118 | 2120 | 312 | 7087 | 0.00 |
| GO:0090307 | mitotic spindle assembly | biological_process | 9 | BIRC5;CHEK2;FLNA;KIF11;MYBL2;NEK2;RAB11A;RACGAP1 | 8 | 2120 | 10 | 7087 | 0.00 |
| GO:0004888 | transmembrane signaling receptor activity | molecular_function | 5 | ADGRE5;ADGRG7;BCAM;CD4;CLDN3;CLEC1B;EBP;ENG;FCER1G;FZD4;GCGR;ICAM1;LGR4;LILRB5;LYVE1;MARCO;MRC1;NGFR;PLXNB1;PTH1R;SEMA6A;VIPR1 | 22 | 2120 | 42 | 7087 | 0.00 |
| GO:0042542 | response to hydrogen peroxide | biological_process | 7 | ADAM9;BAD;CASP3;COL1A1;DUSP1;GNAO1;GPX1;HBA1;HBA2;HBB;JUN;PARK7;PPP1R15B;PPP2CB;PRDX3;SOD1;SOD2;STK26;TXNIP | 19 | 2120 | 35 | 7087 | 0.00 |
| GO:0048678 | response to axon injury | biological_process | 6 | AIF1;ARG1;BAX;CST3;DPYSL3;FGFR3;MATN2;NTS;SOD1;SOD2;TSPO | 11 | 2120 | 17 | 7087 | 0.00 |
| GO:0007186 | G-protein coupled receptor signaling pathway | biological_process | 8 | ABCA1;ACKR3;ADGRE5;ADGRG7;ADRA1A;APOC3;ARHGEF12;C3AR1;C3;C5AR1;CALM1;CCL21;CCL5;CXCR4;DEFB1;F2RL1;F2R;FPR3;FZD4;GCGR;GNA11;GNA13;GNAI1;GNAI2;GNAO1;GNAS;GNAZ;GNB1;GNG5;GPSM2;LGR4;MRGPRF;NPW;NPY1R;P2RY13;PREX1;PTAFR;PTH1R;PTPN6;RAMP1;RAMP3;RASD1;SORT1;TM2D1;VAV1;VIPR1;ZNF219 | 47 | 2120 | 111 | 7087 | 0.00 |
| GO:0006956 | complement activation | biological_process | 5 | C1QA;C1QB;C1QC;C1S;C3;C6;C7;C8A;C8B;CFD;CFP;FCN2;FCN3;MASP1 | 14 | 2120 | 24 | 7087 | 0.00 |
| GO:0033630 | positive regulation of cell adhesion mediated by integrin | biological_process | 6 | ADAM9;CCL21;CD24;CIB1;PTPN6;SYK | 6 | 2120 | 7 | 7087 | 0.00 |
| GO:0050853 | B cell receptor signaling pathway | biological_process | 8 | LIME1;MAPK1;PIK3CD;PTPN6;PTPRC;SYK | 6 | 2120 | 7 | 7087 | 0.00 |
| GO:0015701 | bicarbonate transport | biological_process | 8 | CA2;HBA1;HBA2;HBB;SLC26A6;SLC4A2 | 6 | 2120 | 7 | 7087 | 0.00 |
| GO:0032776 | DNA methylation on cytosine | biological_process | 12 | H3F3A;H3F3B;HIST1H3C;HIST1H4B;HIST1H4J;HIST2H3A;HIST2H3C;HIST2H4B;HIST4H4 | 9 | 2120 | 13 | 7087 | 0.00 |
| GO:0005520 | insulin-like growth factor binding | molecular_function | 6 | CTGF;CYR61;ESM1;IGF2R;IGFALS;IGFBP2;IGFBP3;IGFBP4;IGFBP7 | 9 | 2120 | 13 | 7087 | 0.00 |
| GO:0008283 | cell proliferation | biological_process | 4 | ANXA7;ASCC3;BAD;BAX;BIN1;BOP1;BST2;BUB1B;BUB1;CD74;CD81;CDC25C;CDC27;CDK5RAP3;CENPF;CITED2;CKS1B;CKS2;CNOT11;CREBBP;CREG1;CSE1L;CYR61;DAB2;DKC1;DLGAP5;ECD;ENPEP;EPS15;FSCN1;GAS6;GNAI2;GNB1;GNL3;GPX1;HDGF;HHEX;IGF1;IGFBP4;IGSF8;ILK;KIF15;LIPA;LIPG;LRP1;MAPRE2;MCM7;MET;MORF4L1;NAA60;NBN;PA2G4;PAK1IP1;PCNA;PDZK1;PELO;PES1;PIM1;PPARD;PPP1R8;PRDX1;PTPN6;PURB;RPL23A;RPS27;SERPINF1;SYK;TSPO;XRCC5;ZMYND11 | 70 | 2120 | 178 | 7087 | 0.00 |
| GO:0005687 | U4 snRNP | cellular_component | 9 | DDX39B;PRPF31;SNRPB;SNRPE;SNRPF;SNRPG;SNRPN | 7 | 2120 | 9 | 7087 | 0.00 |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | biological_process | 12 | ADRA1A;C1QTNF1;C3AR1;C5AR1;CD55;CXCR4;F2RL1;F2R;GNA13;GNB1;PTH1R;SAA1;SWAP70;TRPV4;UTS2 | 15 | 2120 | 27 | 7087 | 0.00 |
| GO:0006958 | complement activation, classical pathway | biological_process | 10 | C1QA;C1QB;C1QC;C1RL;C1S;C3;C4BPA;C6;C7;C8A;C8B;CD55;CFI;SERPING1 | 14 | 2120 | 25 | 7087 | 0.01 |
| GO:0005178 | integrin binding | molecular_function | 6 | ACTN4;ADAM9;ANXA7;COL3A1;CTGF;CYR61;EMP2;ESM1;FBN1;FN1;ICAM1;IGF1;ILK;ITGA6;ITGB5;LAMB2;LTBP4;MMP14;NPNT;PPAP2B;SYK;THBS4;THY1;TSPAN4;TSPAN8 | 25 | 2120 | 53 | 7087 | 0.01 |
| GO:0000786 | nucleosome | cellular_component | 12 | H1FX;H2AFX;H2AFY;H3F3A;H3F3B;HIST1H2AC;HIST1H2AI;HIST1H2AK;HIST1H2BC;HIST1H2BG;HIST1H3C;HIST1H4B;HIST1H4J;HIST2H2AC;HIST2H3A;HIST2H3C;HIST2H4B;HIST4H4 | 18 | 2120 | 35 | 7087 | 0.01 |
| GO:0000775 | chromosome, centromeric region | cellular_component | 12 | BIRC5;BUB1;CDCA8;CENPB;CENPF;CENPN;CENPQ;CENPW;HELLS;HJURP;MAD2L1;NDC80;NUF2;OIP5;PPP2CA;PPP2CB;RAD21;SMC3;STAG1;TNKS;WDHD1 | 21 | 2120 | 43 | 7087 | 0.01 |
| GO:0005044 | scavenger receptor activity | molecular_function | 5 | ACKR3;CD163;CFI;LGALS3BP;MARCO;MSR1;STAB1;STAB2;TINAGL1;TMPRSS2 | 10 | 2120 | 16 | 7087 | 0.01 |
| GO:0050776 | regulation of immune response | biological_process | 5 | B2M;C3;CD81;FCER1G;FCGR2B;FCGR3A;FKBP1A;HLA-B;ICAM1;IFITM1;PTPRD;PVRL2;PVR;SPPL2A;TYROBP | 15 | 2120 | 28 | 7087 | 0.01 |
| GO:0032432 | actin filament bundle | cellular_component | 11 | FLNA;LCP1;MICALL2;VIL1 | 4 | 2120 | 4 | 7087 | 0.01 |
| GO:0032133 | chromosome passenger complex | cellular_component | 12 | AURKA;AURKB;BIRC5;CDCA8 | 4 | 2120 | 4 | 7087 | 0.01 |
| GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation | biological_process | 10 | PRKCZ;PTPN6;PTPRC;SPINK1 | 4 | 2120 | 4 | 7087 | 0.01 |
| GO:2001046 | positive regulation of integrin-mediated signaling pathway | biological_process | 10 | CD63;EMP2;FLNA;LIMS2 | 4 | 2120 | 4 | 7087 | 0.01 |
| GO:0005833 | hemoglobin complex | cellular_component | 11 | CYB5R3;HBA1;HBA2;HBB | 4 | 2120 | 4 | 7087 | 0.01 |
| GO:0097208 | alveolar lamellar body | cellular_component | 13 | CTSH;LAMP1;RAB14;RAB7A | 4 | 2120 | 4 | 7087 | 0.01 |
| GO:0005834 | heterotrimeric G-protein complex | cellular_component | 7 | GNA11;GNA13;GNAI1;GNAI2;GNAO1;GNAS;GNAZ;GNB1;GNG5 | 9 | 2120 | 14 | 7087 | 0.01 |
| GO:0042744 | hydrogen peroxide catabolic process | biological_process | 6 | CAT;GPX1;HBA1;HBA2;HBB;PRDX1;PRDX3;PRDX6;PXDN | 9 | 2120 | 14 | 7087 | 0.01 |
| GO:0016020 | membrane | cellular_component | 3 | ABCB1;ABCB4;ABCF1;ACLY;ACSL4;ADGRE5;ADGRG7;ADRA1A;AGPAT1;AGPAT6;AIMP2;AMFR;ANKLE2;ANXA2;ANXA7;AP1S1;AP3B1;AP3D1;APMAP;APOL2;AQP3;ARF6;ARHGEF12;ASCC3;ASPH;AVEN;B2M;B3GALT6;B3GNT2;B9D1;BAX;BCL2L10;BET1L;BIN1;BST2;BTN3A3;BUB1;BZW1;BZW2;C8A;C8B;CAD;CALU;CANX;CAPZA2;CAST;CAT;CCNB1;CCNB2;CD163;CD302;CD36;CD68;CD74;CD81;CDC5L;CDH5;CDK1;CDK5RAP3;CEP55;CFI;CHST10;CIB1;CISD2;CLCN5;CLEC4M;CLPTM1L;CMTM4;CMTM6;CNNM3;COL6A1;COPZ1;COX4I1;CSE1L;CSNK1G2;CTAGE5;CTSA;CTSC;CYB5R1;CYB5R3;CYC1;CYFIP2;CYP20A1;CYP51A1;DAD1;DBH;DCXR;DDOST;DDX1;DDX21;DDX24;DDX3Y;DEGS1;DHCR7;DHRS7;DHX9;DISP1;DLST;DNAJB11;DNAJB6;DNAJC7;DOLPP1;DPYSL2;DRG2;DSG1;DYNLL2;EDEM1;EEF1A1;EEF1G;EFNA1;EIF3A;EIF3D;EIF3E;EIF3F;EIF3H;EIF3L;EIF4ENIF1;EIF4H;ELOVL5;EML4;ENO3;ENPP7;ENTPD8;EPRS;EPS15;ERGIC3;ERH;EXOC4;EXOC8;F11;FADS1;FADS2;FAM120A;FAM151A;FAM47E-STBD1;FARSB;FCER1G;FIBP;FKBP1A;FKBP8;FLNA;FOLH1;FOLR2;FTL;FZD4;G6PC;G6PD;GALNT2;GANAB;GAS2;GCGR;GCNT2;GDI2;GNA13;GNAI1;GNAI2;GNAO1;GNAS;GNB1;GNG5;GNL3;GNPAT;GOLGB1;GOLT1B;GOPC;GPC1;GPC3;GRB2;GTF2I;GTPBP4;HBA1;HBA2;HEATR1;HERPUD1;HGF;HIST1H3C;HIST1H4B;HIST1H4J;HIST2H4B;HIST4H4;HLA-B;HLA-DPA1;HLA-DRB1;HLA-DRB5;HMHA1;HMMR;HNRNPA1;HNRNPH1;HNRNPH2;HNRNPK;HNRNPM;HNRNPU;HOMER1;HSD11B1;HSP90AA1;HSP90B1;HSPA8;HSPE1;IARS;ICAM1;IFITM1;IGF2R;IGSF1;IGSF8;ILF2;ILK;IMPDH2;ITGA9;ITGAV;JUP;KCNAB2;KCND3;KDSR;KIAA2018;KIF11;KIF14;KIF15;KIF4A;KPNA2;KTN1;LAMC3;LAMP1;LAMP2;LARP4B;LDLR;LGALS3BP;LGALS8;LIN7A;LMBRD1;LMNB1;LONP2;LPCAT3;LPPR2;LRRC1;LRRC8A;LSP1;LTB;LYVE1;MAL2;MAMDC4;MAN1A2;MAN1C1;MAP3K13;MARCH6;MARCKS;MARCO;MBTPS2;MCM4;MCM5;MCM7;MDH2;MED16;MEP1A;METTL7A;MET;MFSD5;MGAT4A;MGRN1;MGST3;MLEC;MME;MOGS;MOSPD2;MPDU1;MPP1;MRC2;MSH2;MSR1;MSRA;MTHFD1;MTMR7;MYH9;NCAPD2;NCAPG2;NCAPG;NCAPH2;NCL;NDC1;NDC80;NEDD4;NELFCD;NENF;NIPSNAP1;NOP56;NOP58;NOTCH1;NOTCH4;NPM1;NPNT;NR3C1;NRAS;NRBP1;NSMF;NUF2;NUP205;NUS1;OCIAD1;OGFR;OLA1;ORAI3;ORC6;OSBP;P2RX7;P4HA1;PA2G4;PABPC1;PAF1;PALM;PARP14;PDCD6IP;PEF1;PES1;PEX2;PFKL;PGRMC1;PHLPP1;PI4KB;PIGK;PLAU;PLEK;PLP2;PLXNB1;PNPT1;PPAP2B;PPAPDC2;PPIB;PPP2CA;PPP5C;PRDX6;PRKCZ;PSMC3;PSMC4;PSMD13;PTAFR;PTBP1;PTDSS1;PTDSS2;PTH1R;PTK7;PTPN6;PYGB;RAB11A;RAB11B;RAB12;RAB13;RAB14;RAB32;RAB7A;RAB8A;RAD21;RARS;RASD1;RHEB;RHOB;RHOC;RHOF;RHOG;RIPK4;RNF5;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL18;RPL19;RPL21;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL35A;RPL35;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP2;RPN2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS23;RPS24;RPS26;RPS27A;RPS3;RPS4X;RPS4Y1;RPS5;RPS6KC1;RPS7;RPS8;RPS9;RPSA;RQCD1;RRBP1;SCD;SCN9A;SCP2;SDC2;SDC3;SEC11A;SELENBP1;SELP;SEMA5A;SEMA6A;SERINC3;SFXN3;SGCE;SIRT3;SLC10A1;SLC15A3;SLC16A2;SLC16A3;SLC17A2;SLC17A4;SLC17A5;SLC19A1;SLC1A4;SLC22A1;SLC22A3;SLC25A5;SLC26A6;SLC27A3;SLC27A4;SLC28A1;SLC35B2;SLC35C1;SLC39A1;SLC39A7;SLC39A8;SLC4A2;SLCO2B1;SNX15;SNX1;SPG7;SPPL2A;SPRED2;SPTAN1;SRD5A2;SREBF2;SRPX;ST14;STARD10;STMN1;STOM;STX12;STX18;STX3;SVEP1;TMEM14A;TMPO;TMPRSS2;TNFRSF1B;TOM1;TOMM34;TRPM7;TRPM8;TRPV4;TSPAN13;TTK;UBR4;UGT2B7;ULK3;VDAC1;VIPR1;WDR11;XAB2;XPNPEP2;XRCC5;XRCC6 | 483 | 2120 | 1487 | 7087 | 0.01 |
| GO:0043588 | skin development | biological_process | 8 | ADAMTS2;ARRDC3;COL1A1;COL3A1;DBI;GNAS;IRF6;ITGA6;JUP;LTB;NGFR;SLC27A4 | 12 | 2120 | 21 | 7087 | 0.01 |
| GO:0002244 | hematopoietic progenitor cell differentiation | biological_process | 7 | ANLN;CITED2;DHTKD1;ESCO2;GPATCH4;KCNAB2;PAPD4;PLEK;PTPN6;SIN3A;SRSF4;TOP2A;WDR7;ZFAT | 14 | 2120 | 26 | 7087 | 0.01 |
| GO:0071276 | cellular response to cadmium ion | biological_process | 8 | CYP1A2;MT1F;MT1G;MT1H;MT1X;OGG1;PPP5C;SOD1 | 8 | 2120 | 12 | 7087 | 0.01 |
| GO:0030532 | small nuclear ribonucleoprotein complex | cellular_component | 8 | LSM4;SF3B1;SNRPA1;SNRPB;SNRPE;SNRPF;SNRPG;SNRPN | 8 | 2120 | 12 | 7087 | 0.01 |
| GO:0016032 | viral process | biological_process | 5 | ACKR3;AP1S1;AP2M1;AP2S1;APOA2;B2M;BAX;BIN1;BUB1;CCNA2;CD1D;CD4;CDC25C;CHMP2B;CREBBP;CXCR4;EIF4A2;EIF4H;FBXW7;FCGR2B;FDPS;FKBP8;GRB2;GTF2E2;GTF2H1;H2AFX;HLA-B;HNRNPA1;HNRNPK;HPX;HSPA8;KPNA2;KRT7;LAMP1;LDLR;LMBRD1;MAPK1;MPDZ;NELFCD;NELFE;NFKBIA;NPM1;NUP205;NUP50;NUPL1;PDCD6IP;PDCL3;POLR2G;POLR2I;PRMT6;PSMA2;PSMA3;PSMA7;PSMB10;PSMB1;PSMB5;PSMB8;PSMC3;PSMC4;PSMD13;PVR;RAB11FIP4;RAD23A;RBX1;RNMT;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL23A;RPL23;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL37A;RPL37;RPL39;RPL3;RPL4;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPLP2;RPS10;RPS11;RPS12;RPS13;RPS16;RPS17;RPS18;RPS19;RPS21;RPS23;RPS24;RPS25;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS4X;RPS4Y1;RPS5;RPS7;RPS8;RPS9;RPSA;RSAD2;SEH1L;SEPT6;SET;SLC25A5;SLC25A6;SRPK1;STAT2;SYK;TAF2;TAF4;TRAM1;TRIM22;TRIM25;UBA52;UBR4;VDAC1;VPRBP;VPS37A;VPS4A;XRCC5;XRCC6;ZMYND11 | 146 | 2120 | 415 | 7087 | 0.01 |
| GO:0009897 | external side of plasma membrane | cellular_component | 6 | ABCA1;ALCAM;B2M;BCAM;CD24;CD36;CD4;CD74;CD83;DLK1;ENG;ENPEP;FCER1G;FCGR3A;FGB;FGG;GSR;HLA-DRB1;ICAM1;ICOS;ITGA6;ITGAV;LAMP1;LDLR;NGFR;P2RX7;PTPRC;SELP;STAB2;THY1;TMEM123;TRPM8 | 32 | 2120 | 74 | 7087 | 0.01 |
| GO:0031683 | G-protein beta/gamma-subunit complex binding | molecular_function | 6 | GNA11;GNA13;GNAI1;GNAI2;GNAO1;GNAS;GNAZ | 7 | 2120 | 10 | 7087 | 0.01 |
| GO:0019001 | guanyl nucleotide binding | molecular_function | 7 | GNA11;GNA13;GNAI1;GNAI2;GNAO1;GNAS;GNAZ | 7 | 2120 | 10 | 7087 | 0.01 |
| GO:0043277 | apoptotic cell clearance | biological_process | 6 | AXL;CD36;GAS6;ITGAV;LRP1;MARCO;TGM2 | 7 | 2120 | 10 | 7087 | 0.01 |
| GO:0010719 | negative regulation of epithelial to mesenchymal transition | biological_process | 12 | EFNA1;FOXA1;LDLRAD4;PBLD;PPP2CA;SDHAF2;VASN | 7 | 2120 | 10 | 7087 | 0.01 |
| GO:0071294 | cellular response to zinc ion | biological_process | 8 | MT1F;MT1G;MT1H;MT1M;MT1X;MT2A;TSPO | 7 | 2120 | 10 | 7087 | 0.01 |
| GO:0007339 | binding of sperm to zona pellucida | biological_process | 8 | CCT2;CCT3;CCT4;CCT7;CLGN;FETUB;TCP1 | 7 | 2120 | 10 | 7087 | 0.01 |
| GO:0006334 | nucleosome assembly | biological_process | 12 | ASF1A;CASC5;CENPH;CENPN;CENPQ;CENPW;H1FX;H2AFX;H2AFY;H3F3A;H3F3B;HIST1H2BC;HIST1H2BG;HIST1H3C;HIST1H4B;HIST1H4J;HIST2H3A;HIST2H3C;HIST2H4B;HIST4H4;HJURP;HMGB2;MCM2;NAA60;NPM1;OIP5;SET;SMYD3;TSPYL1 | 29 | 2120 | 66 | 7087 | 0.01 |
| GO:0006475 | internal protein amino acid acetylation | biological_process | 10 | ASL;EHHADH;HAT1;MDH2;PCK1 | 5 | 2120 | 6 | 7087 | 0.01 |
| GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity | biological_process | 7 | CADM1;LAMP1;PVRL2;PVR;VAV1 | 5 | 2120 | 6 | 7087 | 0.01 |
| GO:0034101 | erythrocyte homeostasis | biological_process | 5 | AXL;KLF2;PRDX1;RPS17;RPS24 | 5 | 2120 | 6 | 7087 | 0.01 |
| GO:0042119 | neutrophil activation | biological_process | 7 | CCL5;CXCR4;F2RL1;KMT2E;PREX1 | 5 | 2120 | 6 | 7087 | 0.01 |
| GO:0002009 | morphogenesis of an epithelium | biological_process | 6 | CA2;FGFR3;HHEX;RIPK4;TIMELESS;VCL | 6 | 2120 | 8 | 7087 | 0.01 |
| GO:0005686 | U2 snRNP | cellular_component | 9 | CCDC97;SNRPA1;SNRPB2;SNRPB;SNRPE;SNRPN | 6 | 2120 | 8 | 7087 | 0.01 |
| GO:0006268 | DNA unwinding involved in DNA replication | biological_process | 11 | MCM2;MCM4;MCM6;MCM7;TOP2A;TOP2B | 6 | 2120 | 8 | 7087 | 0.01 |
| GO:0007188 | adenylate cyclase-modulating G-protein coupled receptor signaling pathway | biological_process | 10 | GCGR;GNA11;GNAI1;GNAO1;GNAZ;PTH1R | 6 | 2120 | 8 | 7087 | 0.01 |
| GO:0004601 | peroxidase activity | molecular_function | 6 | HBA1;HBA2;HBB;MGST3;PRDX1;PXDN | 6 | 2120 | 8 | 7087 | 0.01 |
| GO:0010466 | negative regulation of peptidase activity | biological_process | 10 | CAST;CST3;CSTA;GPC3;SPINK1;TFPI | 6 | 2120 | 8 | 7087 | 0.01 |
| GO:0031616 | spindle pole centrosome | cellular_component | 10 | AURKA;AURKB;BNIP2;DLGAP5;NPM1;TBCCD1 | 6 | 2120 | 8 | 7087 | 0.01 |
| GO:0005832 | chaperonin-containing T-complex | cellular_component | 11 | CCT2;CCT3;CCT4;CCT6A;CCT7;TCP1 | 6 | 2120 | 8 | 7087 | 0.01 |
| GO:0000228 | nuclear chromosome | cellular_component | 11 | BIRC5;BLM;H2AFY;H3F3A;H3F3B;HIST1H3C;HIST1H4B;HIST1H4J;HIST2H4B;HIST4H4;JUN;MSH2;NCAPD2;RAD21;TOP2A | 15 | 2120 | 29 | 7087 | 0.01 |
| GO:0051084 | 'de novo' posttranslational protein folding | biological_process | 9 | CCT2;CCT3;CCT4;CCT6A;CCT7;PFDN2;PFDN6;TBCA;TBCB;TCP1;TUBA1B;TUBA1C;TUBB2A;TUBB2B;TUBB6 | 15 | 2120 | 29 | 7087 | 0.01 |
| GO:0009612 | response to mechanical stimulus | biological_process | 5 | CCNB1;CITED2;COL1A1;COL3A1;DCN;ETS1;FOSB;IGFBP2;JUN;MMP14;P2RX7;PIEZO2;RCAN1;TRPV4;TXNIP | 15 | 2120 | 29 | 7087 | 0.01 |
| GO:0004930 | G-protein coupled receptor activity | molecular_function | 6 | ACKR3;ADGRE5;ADGRG7;ADRA1A;C3AR1;C5AR1;CXCR4;F2RL1;F2R;FPR3;FZD4;GCGR;LGR4;MRGPRF;NPY1R;P2RY13;PTAFR;PTH1R;TM2D1;VIPR1 | 20 | 2120 | 42 | 7087 | 0.01 |
| GO:0030529 | ribonucleoprotein complex | cellular_component | 7 | ACTN4;BOP1;BRCA1;CASC3;DDX1;DHX9;EPRS;HNRNPA1;HNRNPD;HNRNPH2;HNRNPUL1;HNRNPU;HSPA8;ILF2;NCL;NPM1;PA2G4;PABPC1;PABPC4;RPL13A;RPL27;RPL4;RPL7A;RPL7;RPLP0;RPS3A;RPS3;RPS4X;RPS5;RPS7;RPS8;RPS9;SLBP;SLIRP;SNRPA1;YBX1 | 36 | 2120 | 86 | 7087 | 0.01 |
| GO:0001731 | formation of translation preinitiation complex | biological_process | 9 | EIF2D;EIF3A;EIF3D;EIF3E;EIF3F;EIF3H;EIF3I;EIF3J;EIF3L;MCTS1 | 10 | 2120 | 17 | 7087 | 0.01 |
| GO:0034446 | substrate adhesion-dependent cell spreading | biological_process | 9 | AKIP1;AXL;EFNA1;FN1;FZD4;ILK;ITGAV;KIF14;LAMC1;MICALL2 | 10 | 2120 | 17 | 7087 | 0.01 |
| GO:0007267 | cell-cell signaling | biological_process | 6 | ADGRE5;ADRA1A;BST2;C1QA;CCL21;CCL4;CCL5;CTGF;CXCL14;CYR61;EFNA1;ENPEP;EREG;FADS1;GDF15;GRAP;GRB2;IK;LTB;MPZL1;NAMPT;SEMA5A;SRD5A2;STAB1 | 24 | 2120 | 53 | 7087 | 0.01 |
| GO:0030666 | endocytic vesicle membrane | cellular_component | 12 | AP2M1;AP2S1;CD163;CD36;CD74;HLA-DPA1;HLA-DRB1;HLA-DRB5;LRP1;MARCO;MSR1;NOSTRIN;RPS27A;STAB1;STAB2;UBA52 | 16 | 2120 | 32 | 7087 | 0.01 |
| GO:0048146 | positive regulation of fibroblast proliferation | biological_process | 6 | ANXA2;CCNA2;CCNB1;CD74;CDK4;CDKN1A;E2F1;EREG;FN1;FOSL2;GAS6;IGF1;JUN;NGFR;NRAS;UTS2 | 16 | 2120 | 32 | 7087 | 0.01 |
| GO:0045335 | phagocytic vesicle | cellular_component | 12 | ABCA1;CD36;ITGAV;ITGB5;LAMP1;RAB11A;RAB11B;RAB14;RAB32;RAB7A;RAB8A;STX12 | 12 | 2120 | 22 | 7087 | 0.01 |
| GO:0070527 | platelet aggregation | biological_process | 7 | BLOC1S4;CSRP1;FGB;FGG;FIBP;FLNA;GAS6;GNAS;HBB;ILK;MYH9;PLEK;PTPN6;VCL | 14 | 2120 | 27 | 7087 | 0.01 |
| GO:0044255 | cellular lipid metabolic process | biological_process | 5 | ABCA1;ABCB4;ACACA;ACACB;ACADL;ACADS;ACLY;ACOX2;ACSL4;AGPAT1;AGPAT6;ALAS1;AMACR;APOA2;APOA5;C19orf80;CD36;CRAT;CREBBP;CTGF;ECHS1;ELOVL2;ELOVL5;ELOVL6;FABP1;FADS1;G0S2;GNPAT;GPD2;HADHA;HADH;HMGCR;HMGCS1;IDH1;PCCA;PRKAA2;PRKAG2;SCP2;SIN3A;SLC25A20;TNFRSF21;TRIB3 | 42 | 2120 | 104 | 7087 | 0.01 |
| GO:0030658 | transport vesicle membrane | cellular_component | 12 | CD74;DBH;HLA-DPA1;HLA-DRB1;HLA-DRB5;ICA1;RAB11FIP5;RAB13;SPRED2 | 9 | 2120 | 15 | 7087 | 0.01 |
| GO:0036464 | cytoplasmic ribonucleoprotein granule | cellular_component | 9 | DDX3Y;DHX9;HNRNPU;NCL;PABPC1;RPL28;RPL6;RPLP0;RPS4X | 9 | 2120 | 15 | 7087 | 0.01 |
| GO:0008289 | lipid binding | molecular_function | 4 | AP2M1;APOA2;APOA5;APOC3;APOL1;APOL2;APOL6;ATP5G3;BAD;BAX;C3;CD36;CD55;CETP;DBI;EPN2;FABP1;FAM21A;FNBP1L;LBP;OSBPL11;PITPNB;PLTP;PPARD;PPP5C;RUFY1;STARD10;STARD13;STARD5;STARD7;UNC119B | 31 | 2120 | 73 | 7087 | 0.01 |
document location: summary/3_2_transcript_differential_expression/*VS*/1_GO_Enrichment/*VS*_GO_enrichment_Gene.xlsx
Barplot of enriched GO terms:
document location: summary/3_2_transcript_differential_expression/*VS*/1_GO_Enrichment/*VS*_GO_enrichment.png
Scatterplot of GO enrichment:
document location: summary/3_2_transcript_differential_expression/*VS*/1_GO_Enrichment/*VS*_GO_enrichment_scatterplot.png
KEGG (Kyoto Encyclopedia of Genes and Genomes) (http://www.kegg.jp/) is a collection of databases dealing with genomes, biological pathways, diseases, drugs, and chemical substances. KEGG is utilized for bioinformatics research and education, including data analysis in genomics, metagenomics, metabolomics and other omics studies, modeling and simulation in systems biology, and translational research in drug development.
Significant KEGG pathways::
| pathway_id | pathway_name | Genes | S gene number | TS gene number | B gene number | TB gene number | pvalue |
| ko03010 | Ribosome | MRPL13;RPL10A;RPL11;RPL12;RPL13A;RPL14;RPL17;RPL18;RPL19;RPL21;RPL22L1;RPL24;RPL27A;RPL27;RPL28;RPL30;RPL31;RPL34;RPL35A;RPL35;RPL39;RPL3;RPL6;RPL7A;RPL7;RPL8;RPL9;RPLP0;RPLP1;RPS10;RPS11;RPS13;RPS16;RPS17;RPS18;RPS21;RPS23;RPS24;RPS26;RPS27A;RPS27;RPS29;RPS3A;RPS3;RPS5;RPS7;RPS8;RPS9;RPSA;UBA52 | 50 | 847 | 67 | 2533 | 0.00 |
| ko05150 | Staphylococcus aureus infection | C1QA;C1QB;C1QC;C1S;C3AR1;C3;C5AR1;CFI;DSG1;FCGR2B;FCGR3A;FGG;FPR3;HLA-DPA1;HLA-DRB1;HLA-DRB5;ICAM1;MASP1;PTAFR;SELP | 20 | 847 | 32 | 2533 | 0.00 |
| ko05322 | Systemic lupus erythematosus | C1QA;C1QB;C1QC;C1S;C3;C6;C7;C8A;C8B;FCGR2B;FCGR3A;H2AFX;H2AFY;H3F3A;H3F3B;HIST1H2AC;HIST1H2AI;HIST1H4J;HIST2H2AC;HLA-DPA1;HLA-DRB1;HLA-DRB5;SNRPB | 23 | 847 | 40 | 2533 | 0.00 |
| ko05020 | Prion diseases | BAX;C1QA;C1QB;C1QC;C6;C7;C8A;C8B;LAMC1;MAPK1;NOTCH1;SOD1;STIP1 | 13 | 847 | 19 | 2533 | 0.00 |
| ko05144 | Malaria | CD36;CD81;HBA1;HBA2;HBB;HGF;LRP1;MET;MYD88;SDC2;SELP;THBS2;THBS4 | 13 | 847 | 20 | 2533 | 0.00 |
| ko00380 | Tryptophan metabolism | AADAT;ACMSD;ALDH1B1;ALDH2;ALDH7A1;CYP1A2;DDC;ECHS1;EHHADH;GCDH;HADHA;HADH;INMT;MAOB;OGDHL;WARS | 16 | 847 | 28 | 2533 | 0.01 |
| ko04610 | Complement and coagulation cascades | C1QA;C1QB;C1QC;C1S;C3AR1;C3;C4BPA;C5AR1;C6;C7;C8A;C8B;CD55;CFD;CFI;CPB2;F11;F12;F2R;FGG;MASP1;PLAUR;PLAU;SERPINA1;SERPING1;TFPI | 26 | 847 | 52 | 2533 | 0.01 |
| ko04080 | Neuroactive ligand-receptor interaction | ADRA1A;C3AR1;C5AR1;F2RL1;F2R;FPR3;GCGR;NPY1R;NR3C1;P2RY13;PTAFR;PTH1R;TSPO;VIPR1 | 14 | 847 | 24 | 2533 | 0.01 |
| ko04512 | ECM-receptor interaction | CD36;COL1A1;COL1A2;COL3A1;COL6A1;COL6A2;FN1;HMMR;HSPG2;ITGA6;ITGAV;LAMA2;LAMB2;LAMC1;LAMC3;SDC2;SPP1;THBS2;THBS4 | 19 | 847 | 36 | 2533 | 0.01 |
| ko04514 | Cell adhesion molecules (CAMs) | ALCAM;CADM1;CD4;CD99;CDH5;CLDN2;CLDN3;HLA-B;HLA-DPA1;HLA-DRB1;HLA-DRB5;HLA-E;ICAM1;ICOS;ITGA6;ITGAV;MPZL1;PTPRC;PVRL2;PVR;SDC2;SELP;SIGLEC1 | 23 | 847 | 47 | 2533 | 0.02 |
| ko00360 | Phenylalanine metabolism | ALDH1A3;DDC;GOT2;HPD;MAOB;PAH;PRDX6 | 7 | 847 | 10 | 2533 | 0.02 |
| ko00040 | Pentose and glucuronate interconversions | ALDH1B1;ALDH2;DCXR;RPE;UGDH;UGT2A3;UGT2B11;UGT2B4;UGT2B7 | 9 | 847 | 15 | 2533 | 0.03 |
| ko00053 | Ascorbate and aldarate metabolism | ALDH1B1;ALDH2;ALDH7A1;UGDH;UGT2A3;UGT2B11;UGT2B4;UGT2B7 | 8 | 847 | 13 | 2533 | 0.03 |
| ko00471 | D-Glutamine and D-glutamate metabolism | GLS2;GLS;GLUD1 | 3 | 847 | 3 | 2533 | 0.04 |
| ko03320 | PPAR signaling pathway | ACADL;ACOX2;ACSL4;APOA2;APOA5;APOC3;CD36;DBI;EHHADH;FABP1;FADS2;ILK;PCK1;PCK2;PLTP;PPARD;SCD;SCP2;SLC27A4;SLC27A5 | 20 | 847 | 42 | 2533 | 0.04 |
| ko04320 | Dorso-ventral axis formation | ETS1;ETS2;GRB2;MAPK1;NOTCH1;NOTCH4 | 6 | 847 | 10 | 2533 | 0.08 |
| ko04672 | Intestinal immune network for IgA production | CXCR4;HLA-DPA1;HLA-DRB1;HLA-DRB5;ICOS;PIGR | 6 | 847 | 10 | 2533 | 0.08 |
| ko00350 | Tyrosine metabolism | ADH1C;ADH4;ADH6;ALDH1A3;DBH;DDC;GOT2;GSTZ1;HPD;MAOB;WBSCR22 | 11 | 847 | 22 | 2533 | 0.08 |
| ko04110 | Cell cycle | ANAPC11;ANAPC1;BUB1B;BUB1;CCNA2;CCNB1;CCNB2;CDC20;CDC23;CDC25C;CDC27;CDK1;CDK4;CDKN1A;CDKN2A;CHEK2;CREBBP;DBF4;E2F1;GADD45A;GADD45B;MAD2L1;MCM2;MCM4;MCM5;MCM6;MCM7;ORC6;PCNA;PTTG1;RAD21;RBL2;SMC3;STAG1;TTK;YWHAZ | 36 | 847 | 88 | 2533 | 0.08 |
| ko05142 | Chagas disease (American trypanosomiasis) | AKT3;C1QA;C1QB;C1QC;C3;GNAI1;GNAI2;GNAO1;GNAS;JUN;MAPK1;MAPK8;MYD88;NFKBIA;PIK3CD;PLCB1;PPP2CB;PPP2R1B | 18 | 847 | 40 | 2533 | 0.08 |
| ko05143 | African trypanosomiasis | APOL1;F2RL1;HBA1;HBA2;HBB;ICAM1;MYD88;PLCB1 | 8 | 847 | 15 | 2533 | 0.09 |
| ko00071 | Fatty acid metabolism | ACADL;ACADS;ACSL4;ADH1C;ADH4;ADH6;ALDH1B1;ALDH2;ALDH7A1;ECHS1;EHHADH;GCDH;HADHA;HADH | 14 | 847 | 30 | 2533 | 0.09 |
| ko04914 | Progesterone-mediated oocyte maturation | AKT3;ANAPC11;ANAPC1;BUB1;CCNA2;CCNB1;CCNB2;CDC23;CDC25C;CDC27;CDK1;GNAI1;GNAI2;HSP90AA1;IGF1;MAD2L1;MAPK1;MAPK8;PIK3CD | 19 | 847 | 43 | 2533 | 0.09 |
| ko03440 | Homologous recombination | BLM;EME1;MUS81;NBN;RAD54B;RPA2;SSBP1 | 7 | 847 | 13 | 2533 | 0.10 |
| ko00010 | Glycolysis / Gluconeogenesis | ADH1C;ADH4;ADH6;ALDH1A3;ALDH1B1;ALDH2;ALDH7A1;ALDOB;DLAT;ENO3;FBP1;PCK1;PCK2;PDHB;PFKL;PGM1 | 16 | 847 | 36 | 2533 | 0.11 |
| ko00300 | Lysine biosynthesis | AADAT;ALDH7A1 | 2 | 847 | 2 | 2533 | 0.11 |
| ko00620 | Pyruvate metabolism | ACACB;ACYP2;ALDH1B1;ALDH2;ALDH7A1;DLAT;GLO1;HAGH;LDHD;PCK1;PCK2;PDHB | 12 | 847 | 26 | 2533 | 0.12 |
| ko00020 | Citrate cycle (TCA cycle) | ACLY;ACO2;DLAT;DLST;IDH1;OGDHL;PCK1;PCK2;PDHB;SDHA | 10 | 847 | 21 | 2533 | 0.13 |
| ko04145 | Phagosome | ATP6V0B;ATP6V1B2;ATP6V1C1;C3;CANX;CD36;CLEC4M;COLEC11;CTSL;FCGR2B;FCGR3A;HLA-B;HLA-DPA1;HLA-DRB1;HLA-DRB5;HLA-E;ITGAV;LAMP1;LAMP2;MARCO;MRC2;MSR1;RAB7A;STX12;STX18;THBS2;THBS4;TUBA1B;TUBA1C;TUBB2A;TUBB2B;TUBB6 | 32 | 847 | 80 | 2533 | 0.13 |
| ko01040 | Biosynthesis of unsaturated fatty acids | ELOVL2;ELOVL5;ELOVL6;FADS1;FADS2;HADHA;PECR;SCD | 8 | 847 | 16 | 2533 | 0.13 |
| ko05146 | Amoebiasis | ARG1;C8A;C8B;CASP3;COL1A1;COL1A2;COL3A1;FN1;GNAS;LAMA2;LAMB2;LAMC1;LAMC3;PIK3CD;PLCB1;RAB7A;SERPINB6;VCL | 18 | 847 | 42 | 2533 | 0.13 |
| ko04114 | Oocyte meiosis | ANAPC11;ANAPC1;AURKA;BUB1;CALM1;CCNB1;CCNB2;CDC20;CDC23;CDC25C;CDC27;CDK1;FBXW11;IGF1;MAD2L1;MAPK1;PPP1CA;PPP2CB;PPP2R1B;PPP2R5B;PTTG1;SMC3;YWHAZ | 23 | 847 | 56 | 2533 | 0.14 |
| ko03030 | DNA replication | MCM2;MCM4;MCM5;MCM6;MCM7;PCNA;POLE3;RFC2;RFC4;RPA2;SSBP1 | 11 | 847 | 24 | 2533 | 0.14 |
| ko00030 | Pentose phosphate pathway | ALDOB;FBP1;G6PD;PFKL;PGD;PGLS;PGM1;RPE;TKT | 9 | 847 | 19 | 2533 | 0.15 |
| ko05145 | Toxoplasmosis | AKT3;BAD;BIRC2;CASP3;GNAI1;GNAI2;GNAO1;HLA-DPA1;HLA-DRB1;HLA-DRB5;HSPA8;ITGA6;LAMA2;LAMB2;LAMC1;LAMC3;LDLR;MAPK1;MAPK8;NFKBIA;PIK3CD | 21 | 847 | 51 | 2533 | 0.15 |
| ko05218 | Melanoma | AKT3;BAD;CDK4;CDKN1A;CDKN2A;E2F1;HGF;IGF1;MAPK1;MET;NRAS;PIK3CD | 12 | 847 | 27 | 2533 | 0.16 |
| ko00982 | Drug metabolism - cytochrome P450 | ADH1C;ADH4;ADH6;ALDH1A3;CYP1A2;FMO4;GSTA4;GSTM1;GSTO1;GSTZ1;MAOB;UGT2A3;UGT2B11;UGT2B4;UGT2B7 | 15 | 847 | 35 | 2533 | 0.16 |
| ko05152 | Tuberculosis | AKT3;ARHGEF12;ATP6V0B;BAD;BAX;C3;CALM1;CASP3;CD74;CLEC4M;CREBBP;CTSD;FCER1G;FCGR2B;FCGR3A;HLA-DPA1;HLA-DRB1;HLA-DRB5;IRAK2;LAMP1;LAMP2;LBP;LSP1;MAPK1;MAPK8;MRC2;MYD88;PLK3;RAB7A;RFX5;SYK | 31 | 847 | 79 | 2533 | 0.16 |
| ko05310 | Asthma | FCER1G;HLA-DPA1;HLA-DRB1;HLA-DRB5 | 4 | 847 | 7 | 2533 | 0.17 |
| ko04940 | Type I diabetes mellitus | HLA-B;HLA-DPA1;HLA-DRB1;HLA-DRB5;HLA-E;ICA1 | 6 | 847 | 12 | 2533 | 0.18 |
| ko04730 | Long-term depression | GNAI1;GNAI2;GNAO1;GNAS;GNAZ;IGF1;MAPK1;NRAS;PLCB1;PPP2CB;PPP2R1B | 11 | 847 | 25 | 2533 | 0.18 |
| ko00650 | Butanoate metabolism | ACADS;ACSM1;ACSM2A;AKR1B10;ECHS1;EHHADH;HADHA;HADH;PDHB | 9 | 847 | 20 | 2533 | 0.19 |
| ko00330 | Arginine and proline metabolism | ALDH18A1;ALDH1B1;ALDH2;ALDH7A1;ARG1;ASL;DAO;GLS2;GLS;GLUD1;GOT2;MAOB;P4HA1;PRODH;PYCRL;SAT1 | 16 | 847 | 39 | 2533 | 0.20 |
| ko00980 | Metabolism of xenobiotics by cytochrome P450 | ADH1C;ADH4;ADH6;ALDH1A3;CYP1A2;GSTA4;GSTM1;GSTO1;GSTZ1;UGT2A3;UGT2B11;UGT2B4;UGT2B7 | 13 | 847 | 31 | 2533 | 0.20 |
| ko05320 | Autoimmune thyroid disease | HLA-B;HLA-DPA1;HLA-DRB1;HLA-DRB5;HLA-E | 5 | 847 | 10 | 2533 | 0.21 |
| ko05330 | Allograft rejection | HLA-B;HLA-DPA1;HLA-DRB1;HLA-DRB5;HLA-E | 5 | 847 | 10 | 2533 | 0.21 |
| ko05332 | Graft-versus-host disease | HLA-B;HLA-DPA1;HLA-DRB1;HLA-DRB5;HLA-E | 5 | 847 | 10 | 2533 | 0.21 |
| ko04612 | Antigen processing and presentation | CANX;CD4;CD74;CTSL;HLA-B;HLA-DPA1;HLA-DRB1;HLA-DRB5;HLA-E;HSP90AA1;HSPA8;LGMN;PDIA3;RFX5 | 14 | 847 | 34 | 2533 | 0.22 |
| ko00510 | N-Glycan biosynthesis | ALG8;DAD1;DDOST;DOLK;DOLPP1;GANAB;MGAT4A;MOGS;RFT1;RPN2;TUSC3 | 11 | 847 | 26 | 2533 | 0.22 |
| ko00340 | Histidine metabolism | ALDH1A3;ALDH1B1;ALDH2;ALDH7A1;DDC;MAOB;UROC1;WBSCR22 | 8 | 847 | 18 | 2533 | 0.23 |
| ko04964 | Proximal tubule bicarbonate reclamation | CA2;GLS2;GLS;GLUD1;PCK1;PCK2 | 6 | 847 | 13 | 2533 | 0.24 |
| ko04115 | p53 signaling pathway | BAX;CASP3;CCNB1;CCNB2;CDK1;CDK4;CDKN1A;CDKN2A;CHEK2;GADD45A;GADD45B;IGF1;IGFBP3;SHISA5 | 14 | 847 | 35 | 2533 | 0.26 |
| ko00400 | Phenylalanine, tyrosine and tryptophan biosynthesis | GOT2;PAH | 2 | 847 | 3 | 2533 | 0.26 |
| ko04742 | Taste transduction | GNAS;GNB1 | 2 | 847 | 3 | 2533 | 0.26 |
| ko05222 | Small cell lung cancer | AKT3;BIRC2;CDK4;CKS1B;E2F1;FN1;ITGA6;ITGAV;LAMA2;LAMB2;LAMC1;LAMC3;NFKBIA;PIAS1;PIK3CD | 15 | 847 | 38 | 2533 | 0.26 |
| ko04540 | Gap junction | CDK1;GNAI1;GNAI2;GNAS;GRB2;MAPK1;NRAS;PLCB1;TUBA1B;TUBA1C;TUBB2A;TUBB2B;TUBB6 | 13 | 847 | 33 | 2533 | 0.29 |
| ko04662 | B cell receptor signaling pathway | AKT3;CD81;FCGR2B;GRB2;IFITM1;JUN;MAPK1;NFKBIA;NRAS;PIK3CD;PTPN6;SYK;VAV1 | 13 | 847 | 33 | 2533 | 0.29 |
| ko00640 | Propanoate metabolism | ACACB;ALDH1B1;ALDH2;ALDH6A1;ALDH7A1;ECHS1;EHHADH;HADHA;PCCA | 9 | 847 | 22 | 2533 | 0.30 |
| ko05223 | Non-small cell lung cancer | AKT3;BAD;CDK4;CDKN2A;E2F1;GRB2;MAPK1;NRAS;PIK3CD;STK4 | 10 | 847 | 25 | 2533 | 0.31 |
| ko00062 | Fatty acid elongation in mitochondria | ECHS1;HADHA;HADH | 3 | 847 | 6 | 2533 | 0.32 |
| ko00410 | beta-Alanine metabolism | ALDH1A3;ALDH1B1;ALDH2;ALDH7A1;ECHS1;EHHADH;HADHA | 7 | 847 | 17 | 2533 | 0.33 |
| ko00472 | D-Arginine and D-ornithine metabolism | DAO | 1 | 847 | 1 | 2533 | 0.33 |
| ko04510 | Focal adhesion | AKT3;ARHGAP35;BAD;BIRC2;COL1A1;COL1A2;COL3A1;COL6A1;COL6A2;DIAPH1;FLNA;FN1;GRB2;HGF;IGF1;ILK;ITGA6;ITGAV;JUN;LAMA2;LAMB2;LAMC1;LAMC3;MAPK1;MAPK8;MET;PIK3CD;PPP1CA;SHC2;SPP1;THBS2;THBS4;VAV1;VCL | 34 | 847 | 95 | 2533 | 0.35 |
| ko03015 | mRNA surveillance pathway | CASC3;CSTF3;DDX39B;ETF1;GSPT2;NXT1;PABPC1L;PABPC1;PABPC4;PAPOLA;PPP2CB;PPP2R1B;PPP2R5B;RNMT;UPF2;WIBG | 16 | 847 | 43 | 2533 | 0.35 |
| ko00910 | Nitrogen metabolism | CA2;GLS2;GLS;GLUD1 | 4 | 847 | 9 | 2533 | 0.35 |
| ko00290 | Valine, leucine and isoleucine biosynthesis | IARS2;IARS;LARS;PDHB | 4 | 847 | 9 | 2533 | 0.35 |
| ko05014 | Amyotrophic lateral sclerosis (ALS) | BAD;BAX;CASP3;CAT;GPX1;SOD1;TNFRSF1B;TOMM40L;TOMM40 | 9 | 847 | 23 | 2533 | 0.35 |
| ko00260 | Glycine, serine and threonine metabolism | ALAS1;ALDH7A1;CBS;DAO;DMGDH;GCAT;GNMT;MAOB;SARDH;SHMT1 | 10 | 847 | 26 | 2533 | 0.36 |
| ko04974 | Protein digestion and absorption | COL18A1;COL1A1;COL1A2;COL3A1;COL6A1;COL6A2;CPB2;MEP1A;MME;SLC36A1;XPNPEP2 | 11 | 847 | 29 | 2533 | 0.37 |
| ko00310 | Lysine degradation | AADAT;ALDH1B1;ALDH2;ALDH7A1;DLST;ECHS1;EHHADH;GCDH;HADHA;HADH;KMT2E;OGDHL | 12 | 847 | 32 | 2533 | 0.37 |
| ko00970 | Aminoacyl-tRNA biosynthesis | CARS2;EPRS;FARSB;GARS;HARS;IARS2;IARS;LARS;QARS;RARS;SARS;WARS | 12 | 847 | 32 | 2533 | 0.37 |
| ko05214 | Glioma | AKT3;CALM1;CDK4;CDKN1A;CDKN2A;E2F1;GRB2;IGF1;MAPK1;NRAS;PIK3CD;SHC2 | 12 | 847 | 32 | 2533 | 0.37 |
| ko00250 | Alanine, aspartate and glutamate metabolism | ASL;CAD;GFPT1;GLS2;GLS;GLUD1;GOT2;GPT | 8 | 847 | 21 | 2533 | 0.40 |
| ko04530 | Tight junction | AKT3;CDK4;CLDN2;CLDN3;CSNK2A2;CSNK2B;CTTN;EXOC4;GNAI1;GNAI2;MPDZ;MYH11;MYH9;NRAS;PARD6B;PPP2CB;PPP2R1B;PRKCZ;RAB13;SPTAN1 | 20 | 847 | 56 | 2533 | 0.41 |
| ko04744 | Phototransduction | CALM1;GNB1 | 2 | 847 | 4 | 2533 | 0.41 |
| ko00232 | Caffeine metabolism | CYP1A2;NAT2 | 2 | 847 | 4 | 2533 | 0.41 |
| ko04260 | Cardiac muscle contraction | COX4I1;COX6A2;COX6B1;COX6C;COX7A2L;COX7A2;CYC1;TPM3;UQCR10 | 9 | 847 | 24 | 2533 | 0.41 |
| ko00520 | Amino sugar and nucleotide sugar metabolism | AMDHD2;CYB5R1;CYB5R3;GALK2;GFPT1;GNPNAT1;NPL;PGM1;TSTA3;UGDH;UXS1 | 11 | 847 | 30 | 2533 | 0.42 |
| ko04920 | Adipocytokine signaling pathway | ACACB;ACSL4;AKT3;CD36;MAPK8;NFKBIA;PCK1;PCK2;PPARGC1A;PRKAA2;PRKAG2;TNFRSF1B | 12 | 847 | 33 | 2533 | 0.42 |
| ko00100 | Steroid biosynthesis | CYP51A1;DHCR7;LIPA;MSMO1;SQLE | 5 | 847 | 13 | 2533 | 0.45 |
| ko03430 | Mismatch repair | MSH2;PCNA;RFC2;RFC4;RPA2;SSBP1 | 6 | 847 | 16 | 2533 | 0.46 |
| ko00860 | Porphyrin and chlorophyll metabolism | ALAS1;CP;EPRS;FTL;UGT2A3;UGT2B11;UGT2B4;UGT2B7 | 8 | 847 | 22 | 2533 | 0.46 |
| ko00983 | Drug metabolism - other enzymes | CES1;GMPS;IMPDH2;NAT2;TYMP;UGT2A3;UGT2B11;UGT2B4;UGT2B7 | 9 | 847 | 25 | 2533 | 0.47 |
| ko04916 | Melanogenesis | CALM1;CREBBP;FZD4;GNAI1;GNAI2;GNAO1;GNAS;MAPK1;NRAS;PLCB1 | 10 | 847 | 28 | 2533 | 0.47 |
| ko05140 | Leishmaniasis | C3;FCGR3A;HLA-DPA1;HLA-DRB1;HLA-DRB5;JUN;MAPK1;MYD88;NFKBIA;PTPN6 | 10 | 847 | 28 | 2533 | 0.47 |
| ko05416 | Viral myocarditis | CASP3;CD55;HLA-B;HLA-DPA1;HLA-DRB1;HLA-DRB5;HLA-E;ICAM1;LAMA2;MYH11;MYH9 | 11 | 847 | 31 | 2533 | 0.47 |
| ko04976 | Bile secretion | ABCB1;ABCB4;CA2;GNAS;HMGCR;KCNN2;LDLR;NR1H4;SLC22A1;SLC27A5;SLC4A2;UGT2B4 | 12 | 847 | 34 | 2533 | 0.47 |
| ko04141 | Protein processing in endoplasmic reticulum | AMFR;ATF6B;BAG2;BAX;CANX;CRYAA;DAD1;DDOST;DNAJB11;DNAJB1;DNAJB2;EDEM1;EIF2AK1;GANAB;HERPUD1;HSP90AA1;HSP90B1;HSPA8;HSPBP1;MAPK8;MBTPS2;MOGS;NFE2L2;PDIA3;PDIA4;PDIA6;RAD23A;RNF5;RPN2;RRBP1;SEC13;SEC23A;SEC24D;SSR1;SSR2;TRAM1;TUSC3;UBE2D2;UBE2G1 | 39 | 847 | 115 | 2533 | 0.49 |
| ko05164 | Influenza A | AKT3;CREBBP;DDX39B;DNAJB1;EIF2AK1;FDPS;HLA-DPA1;HLA-DRB1;HLA-DRB5;HNRNPUL1;HSPA8;ICAM1;IL33;JUN;KPNA2;MAPK1;MAPK8;MYD88;NFKBIA;NXT1;PIK3CD;RSAD2;TMPRSS2;TRIM25;VDAC1 | 25 | 847 | 74 | 2533 | 0.52 |
| ko00280 | Valine, leucine and isoleucine degradation | ACADS;ALDH1B1;ALDH2;ALDH6A1;ALDH7A1;BCKDHB;ECHS1;EHHADH;HADHA;HADH;PCCA | 11 | 847 | 32 | 2533 | 0.52 |
| ko04350 | TGF-beta signaling pathway | CREBBP;DCN;ID1;MAPK1;PPP2CB;PPP2R1B;RBL2;RPS6KB2;SMAD6;THBS2;THBS4 | 11 | 847 | 32 | 2533 | 0.52 |
| ko04664 | Fc epsilon RI signaling pathway | AKT3;FCER1G;GRB2;MAPK1;MAPK8;NRAS;PIK3CD;SYK;VAV1 | 9 | 847 | 26 | 2533 | 0.52 |
| ko05219 | Bladder cancer | CDK4;CDKN1A;CDKN2A;E2F1;FGFR3;MAPK1;MMP2;NRAS;TYMP | 9 | 847 | 26 | 2533 | 0.52 |
| ko00500 | Starch and sucrose metabolism | PGM1;PYGB;UGDH;UGT2A3;UGT2B11;UGT2B4;UGT2B7;UXS1 | 8 | 847 | 23 | 2533 | 0.52 |
| ko04971 | Gastric acid secretion | CA2;CALM1;GNAI1;GNAI2;GNAS;PLCB1;SLC4A2 | 7 | 847 | 20 | 2533 | 0.52 |
| ko04975 | Fat digestion and absorption | ABCA1;AGPAT1;CD36;FABP1;GOT2;PPAP2B;SLC27A4 | 7 | 847 | 20 | 2533 | 0.52 |
| ko05340 | Primary immunodeficiency | CD4;ICOS;PTPRC;RFX5 | 4 | 847 | 11 | 2533 | 0.53 |
| ko04140 | Regulation of autophagy | ATG4A;ATG4C;PRKAA2;ULK3 | 4 | 847 | 11 | 2533 | 0.53 |
| ko00740 | Riboflavin metabolism | ACP1;ACP5;FLAD1 | 3 | 847 | 8 | 2533 | 0.53 |
document location: summary/3_2_transcript_differential_expression/*VS*/2_KEGG_Enrichment/*VS*_KEGG_enrichment_Gene.xlsx
Scatterplot of KEGG enrichment:
document location:
summary/3_2_transcript_differential_expression/*VS*/2_KEGG_Enrichment/*VS*_KEGG_enrichment_scatterplot.png
summary/3_2_transcript_differential_expression/*VS*/3_KEGG_Pictures/*.png
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