Researchers at Heidelberg University used a combination of expression profiling of miRNAs and subsequent functional inhibitory screening in primary hippocampal neurons to identify miRNAs in the synaptodendritic compartment that function during synaptic development.  MicroRNA microarrays identified ten mature miRNAs that were enriched and four mature miRNAs that were strongly depleted in synaptosomes compared with whole forebrain. Northern […]
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Why synthesize thousands of oligonucleotides individually? Why perform thousands of individual reactions while handling thousands of tubes? When you can Synthesize one OligoMix®. Perform thousands of parallel (multiplex) reactions in a single tube. Save time and money. Be kind to our environment. For instance; for a small genome of 5Mbp, 250,000 oligos of 40mers are […]
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LC Sciences provides a unique new tool, OligoMix® enabling low cost, multiplex custom oligonucleotides for various applications serving diverse needs in genomics, proteomics, protein/antibody engineering, synthetic biology, drug discovery, and emerging new fields of science such as next-generation sequencing. OligoMix® is a MIXTURE of a large number of DESIGNED synthetic DNA oligonucleotide sequences delivered in […]
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Cell Development and Biology 1. Li Y, Piatigorsky J. 2009) Targeted deletion of Dicer disrupts lens morphogenesis, corneal epithelium stratification, and whole eye development. Dev Dyn 38(9), 2388-400. [abstract] 2. Lin Q, Gao Z, Alarcon RM, Ye J, Yun Z. (2009) A role of miR-27 in the regulation of adipogenesis. FEBS J 276(8):2348-58. [abstract] 3. […]
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Heart disease and cancer represent the number one and number two killer diseases in developed countries. Identifying biomarkers to detect these and other diseases at early stages remains an important research goal and researchers are scrambling for ways to identify contributing factors to the pathogenesis of diseased cells in the body.  In recent years, research […]
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Steatohepatitis is a type of liver disease, characterized by inflammation and fat accumulation in the liver, which can lead to cirrhosis. Steatohepatitis is frequently seen in alcoholics and people with diabetes and/or obesity and alcoholic and nonalcoholic steatohepatitis are leading causes of liver diseases worldwide. Researchers at UMASS Medical School used LC Sciences microarray service […]
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Web Links PMRD:  plant miRNA Database http://bioinformatics.cau.edu.cn/PMRD/ This site offers a complete list of all publicly known plant miRNA sequences.  The database is composed of a total of 8,433 sequences including all known sequences in the miRBase database. PlantGDB http://www.plantgdb.org/ This website is dedicated entirely to plant miRNA and provides many useful tools such as […]
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The most current probe content available delivering the most complete microRNA expression profile of your samples miRBase Sequence Database Content – Release 14.0 – September 2009 The miRBase database provides a searchable online repository for published microRNA sequences and associated annotation.  miRBase 14 Probe content is available now at LC Sciences! 10883 entries representing hairpin […]
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Press Release
October 15, 2009 – Houston, TX – Taking full advantage of its flexible µParaflo® Biochip Technology, Houston based LC Sciences today announced immediate availability of probe content from the newly created Plant MicroRNA Database (PMRD) for their microRNA (miRNA) microarray customers. This announcement comes immediately following a publication in Nucleic Acids Research introducing the public […]
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