The current probe content comes from version 14.0 of the miRBase sequence database which was updated on September 15th, 2009.  (See the 14.0 release summary) (See a comparison to previous versions) Version 14.0 of the miRBase 14.0 release summary Comparison to previous versions We can synthesize microRNA arrays for all species that are listed in […]
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Yale researchers put LC Sciences’ microRNA Microarray Service to work to study microRNA involvement in obesity.  Their results strongly suggest that miR-27 represents a new class of adipogenic inhibitors and may play a role in the pathological development of obesity.  [abstract]
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The rapid improvements in DNA synthesis technology hold the potential to revolutionize biosciences in the near future. Traditional genetic engineering methods are template dependent and make extensive but laborious use of site-directed mutagenesis to explore the impact of small variations on an existing sequence “theme.” De novo gene and genome synthesis frees the investigator from the […]
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In 1992, Ronald Frank published the first seminal paper on simultaneous parallel synthesis of multiple peptides on filter paper. He defined the approach as SPOT synthesis, an easy technique for positionally addressable, parallel chemical synthesis on a membrane support. Here, a basic overview of this technology is presented and a recently published applications are highlighted. […]
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September 15th, 2009 – With the addition of 1580 new mature miR and miR* sequences, the Sanger microRNA Sequence Database (miRBase) announced a significant update to the miRBase sequence database which has now topped 10,000 entries.  This latest release is miRBase version 14.0 and features a total of 10,581 mature miRNA sequences. The number of […]
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The miRBase database has moved to a new location at http://www.mirbase.org/, hosted in the Faculty of Life Sciences, University of Manchester. miRBase in Manchester is now funded by the BBSRC. The miRBase Targets site and pipeline have devolved into the Enright research group at EBI under the name MicroCosm (http://www.ebi.ac.uk/enright-srv/microcosm/htdocs/targets/). All pre-existing Sanger site URLs […]
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Press Release
Houston, TX – September 4, 2009 – LC Sciences announced today the publication of the 100th peer-reviewed study by one of its customers using the company’s microarray service for analyzing microRNA (miRNA) expression profiles and for discovery of novel small RNAs. These studies, by leading researchers in the field, contribute to a fast growing body […]
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MicroRNAs (miRNAs) have proven to be extremely important part of the gene expression regulation mechanism. LC Sciences microRNA profiling services have helped many researchers to explore and examine miRNA cellular networks. Expression profiling and functional studies indicate that miRNAs participate in the regulation of almost every cellular process investigated and that changes in their expression […]
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