millet_custom-2eaf52b1cfd8315bebbd3dab5ae2ab259e6cce58-s900-c85
Sigma factors are necessary for the initiation of transcription by RNA polymerase in bacteria and plastids of plants. In plants, a small family of nuclear genes is responsible for encoding the sigma factor proteins. In a recent study, researchers performed a genome-wide identification and expression analysis of leaf gradient in millet (Setaria italica) to characterize sigma factor genes and their proteins. By applying several bioinformatics tools, they identified chromosome locations of seven sigma factor genes in millet and their protein 3D structures...
Read More
adipogenic-diff
Muscle cells are able to trans-differentiate into adipocytes with adipogenesis induction. MicroRNAs (miRNAs), a class of small non-coding RNAs, widely participate in the regulation of growth and development of cells. However, the expression and regulatory role of miRNAs in the trans-differentiation of muscle cell are largely unknown...
Read More
princ_rm_photo_of_prostate_cancer_cells
MicroRNAs (miRNAs), a group of small non-coding RNAs, can regulate gene expression by triggering translation repressing and/or RNA degradation. Recent studies proved that they were deeply involved in tumorigenesis. In a recent study, a team led by researchers from the Medical College of Georgia show that, compared with the two normal prostate cell lines, eighteen miRNAs detected by LC Sciences miRNA microarray were over-expressed and 18 showed lower levels of expression in at least 2 of 3 cancer cell lines...
Read More
deat 1
Glomerular mesangial cells (MCs) hypertrophy is one of the earliest pathological abnormalities in diabetic nephropathy (DN), which correlates with eventual glomerulosclerosis. A recent study led by researchers from Shanghai Jiao Tong University School of Medicine aimed to investigate the therapeutic role of miRNA in diabetic glomerular MCs hypertrophy and synthesis of extracellular matrix (ECM)...
Read More
Female REPRODUCTIVE system x-ray view
The occurrence of drug resistance limits the efficacy of platinum compounds in the cure of ovarian carcinoma. Since microRNAs (miRNAs) may contribute to this phenomenon by regulating different aspects of tumor cell response, the aim of a recent study by researchers from Istituto Nazionale dei Tumori sought to exploit the analysis of expression of miRNAs in platinum sensitive/resistant cells in an attempt to identify potential regulators of drug response...
Read More
ovary
For successful embryo implantation, endometrial stromal cells must undergo functional and morphological changes, referred to as decidualization. However, the molecular mechanisms that regulate implantation and decidualization are not well defined. Recent work by researchers from the University of Texas Southwestern used LC Sciences miRNA microarray service to demonstrate that the estradiol- and progesterone-regulated miR-200 family...
Read More
Snapshot 1 (8-9-2016 4-07 PM)
The 16S rRNA gene is a highly conserved component of the transcriptional machinery of all DNA-based life forms and thus is highly suited as a target gene for sequencing DNA in samples containing up to thousands of different species. 16S rRNA gene sequencing is commonly used for identification, classification and quantitation of microbes in complex biological mixtures such as environmental samples like water, soil or air, and microbiome samples such as milk or feces...
Read More
srep30640-f2
Vasoactive liabilities are typically assayed using wire myography, which is limited by its high cost and low throughput. To meet the demand for higher throughput in vitro alternatives, researchers from Nano3D Biosciences, LC Sciences, and AstraZeneca introduced a magnetic 3D bioprinting-based vasoactivity assay. The principle...
Read More
HepatitisHCV
MicroRNAs (miRNAs) play a pivotal role in the development of liver fibrosis. However, the functions of miRNAs in hepatitis C virus (HCV)-related liver fibrosis remain unclear. In this study, researchers from Hebei Medical University and the Bethune International Peace Hospital systematically analyzed the microarray data of the serum miRNAs in patients with HCV-induced hepatic fibrosis...
Read More
maxresdefault
Thyroid cancer is one of the most common carcinomas of the endocrine system with an increasing incidence. A growing number of studies have focused on the diagnostic and prognostic values of dysregulated microRNAs (miRNAs) in thyroid carcinoma. However, differences in the measurement platforms, variations in lab protocols, and small sample sizes can make gene profiling data incomparable...
Read More