LC Sciences
Leukoencephalopathies are a group of white matter disorders related to abnormal formation, maintenance, and turnover of myelin in the central nervous system. These disorders of the brain are categorized according to neuroradiological and pathophysiological criteria...
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Hepatitis E virus- (HEV-) mediated hepatitis has become a global public health problem. An important regulatory protein of HEV, ORF3, influences multiple signal pathways in host cells. In a recent study led by researchers from Hainan University, the function of ORF3 from the swine form of HEV (SHEV) was investigated using high-throughput RNA-Seq-based screening in an effort to identify the differentially expressed genes in ORF3-expressing HepG2 cells...
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LC Sciences
Bone marrow-derived mesenchymal stem cells (MSCs) have been recently used in clinical treatment of inflammatory diseases. Practical strategies improving the immunosuppressive property of MSCs are urgently needed for MSC immunotherapy. In a recent study, a team led by researchers from Fourth Military Medical University aimed to develop a microRNA-based strategy to improve MSC immunotherapy...
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Along with the well-studied microRNA (miRNA) and small interfering RNA (siRNA) is a new class of transfer RNA-derived small RNA (tsRNA), which has recently been detected in multiple organisms and is implicated in gene regulation. However, while miRNAs and siRNAs are known to repress gene expression through sequence-specific RNA cleavage or translational repression, how tsRNAs regulate gene expression remains unclear...
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Male muskrats have one pair of scented glands that grow and involute annually. To investigate the annual changes in the scented gland, researchers from Beijing Forestry University measured the expressions of aromatase cytochrome P450 (P450arom) and estrogen receptors (ERs) in the scented glands...
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Drosophila melanogaster is widely used as a model system to study innate immunity and signaling pathways related to innate immunity, including the Toll signaling pathway. Although this pathway is well-studied, the precise mechanisms of post-transcriptional regulation of key components of the Toll signaling pathway by microRNAs (miRNAs) remain obscure...
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Alcohol consumption is a risk factor for breast cancer. Little is known regarding the mechanism, although it is assumed that acetaldehyde or estrogen mediated pathways play a role. A team of rsearchers from UCLA previously showed that long-term exposure to 2.5 mM ethanol (blood alcohol ~0.012%) of MCF-12A, a human normal epithelial breast cell line, induced epithelial mesenchymal transition (EMT) and oncogenic transformation. In their most recent study...
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Ischemia reperfusion (I/R) injury is an inevitable event arising during the cardiovascular diseases development and the process of potent surgical treatments. microRNAs (miRNAs) are critical regulators of multiple cell processes including I/R injury. A recent study published by researchers from The Second Affiliated Hospital of Anhui Medical University aimed to quantify miRNA alterations and regulated genes upon hypoxia-reoxygenation (H/R) injury in a rat heart failure model comparing with normal cardiomyocytes...
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Beet Webworm
The beet webworm, Loxostege sticticalis (L.) (Lepidoptera: Crambidae), is an important insect pest that infests crops such as sugar beet, maize, and potato in Asia, Europe, and North America. The ovary grade is a reliable factor that can be used to forecast L. sticticalis outbreaks. However, forecasting outbreaks by dissecting female ovaries is tedious and generally impractical. Better methods for outbreak forecasting need to be developed. Molecular information on ovary transcriptomes potentially provides criteria for ovary grade.
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Our understanding of the highly specialized functions for small non-coding single-stranded RNA (ssRNA) in the transcriptome of the human central nervous system (CNS) continues to evolve. Circular RNAs (circRNAs), a recently discovered class of ssRNA enriched in the brain and retina, are extremely stable and intrinsically resilient to degradation by exonuclease...
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