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3d render of dna structure, abstract  background
Alcohol consumption is a risk factor for breast cancer. Little is known regarding the mechanism, although it is assumed that acetaldehyde or estrogen mediated pathways play a role. A team of rsearchers from UCLA previously showed that long-term exposure to 2.5 mM ethanol (blood alcohol ~0.012%) of MCF-12A, a human normal epithelial breast cell line, induced epithelial mesenchymal transition (EMT) and oncogenic transformation. In their most recent study...
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Male anatomy of human organs in x-ray view
Ischemia reperfusion (I/R) injury is an inevitable event arising during the cardiovascular diseases development and the process of potent surgical treatments. microRNAs (miRNAs) are critical regulators of multiple cell processes including I/R injury. A recent study published by researchers from The Second Affiliated Hospital of Anhui Medical University aimed to quantify miRNA alterations and regulated genes upon hypoxia-reoxygenation (H/R) injury in a rat heart failure model comparing with normal cardiomyocytes...
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Beet Webworm
The beet webworm, Loxostege sticticalis (L.) (Lepidoptera: Crambidae), is an important insect pest that infests crops such as sugar beet, maize, and potato in Asia, Europe, and North America. The ovary grade is a reliable factor that can be used to forecast L. sticticalis outbreaks. However, forecasting outbreaks by dissecting female ovaries is tedious and generally impractical. Better methods for outbreak forecasting need to be developed. Molecular information on ovary transcriptomes potentially provides criteria for ovary grade.
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Alzheimers-Jerry-Nelson
Our understanding of the highly specialized functions for small non-coding single-stranded RNA (ssRNA) in the transcriptome of the human central nervous system (CNS) continues to evolve. Circular RNAs (circRNAs), a recently discovered class of ssRNA enriched in the brain and retina, are extremely stable and intrinsically resilient to degradation by exonuclease...
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apoptosis
Keloids are fibrous overgrowths induced by cutaneous injury. MicroRNAs (miRNAs) have recently emerged as post-transcriptional gene repressors and participants in a diverse array of pathophysiological processes leading to skin disease. The purpose of a recent study by researchers from...
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fatcells
Conjugated linoleic acids (CLAs) are known to induce apoptosis in adipocytes; however, the cellular mechanisms involved remained illdefined. Researchers from the Chongqing Academy of Animal Science recently explored the different apoptotic induction effects of two CLA isomers on adipocytes and then investigated the expression and function of microRNAs (miRNAs) related to the apoptosis...
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featured
F-box proteins are critical components of the SKP1-CUL1-F-box (SCF) E3 ubiquitin ligases and involved in the ubiquitin-dependent proteolytic pathway. Dysregulation of F-box protein-mediated proteolysis often leads to human malignancies. F-box only protein 8 (FBX8), a novel component of F-box proteins, is down-regulated in several tumors and closely correlates with tumor progression...
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thymus_gland
Decline of transcription factor FoxN1, which predominantly regulates thymic epithelial cell (TEC) differentiation and homeostasis lifelong, is demonstrated to be casually related to age-related thymic involution. Whereas, a global role of microRNAs (miRNAs) has also been demonstrated to control and maintain TEC-constituting thymic microenvironment and to be changed in expression profile in the aged thymus...
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retinoic acid
Researchers from Dalian Medical University previously reported that excess retinoic acid (RA) resulted in hypoplastic and derangement of myofilaments in embryonic tongue by inhibiting myogenic proliferation and differentiation through CamKIID pathway. Their further studies revealed that the expression of a series of miRNAs was altered by RA administration in embryonic tongue as well as in C2C12 cells...
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maxresdefault
miRNAs are small non-coding regulatory RNAs that play key roles in diverse biological processes. A recent study led by researchers from Northwest A&F University used miRNA sequencing service to profile miRNAs in breeder cock testes to illustrate their functions...
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