Yersinia-pestis-rod-shaped-bacteria-in-the-bubonic-form
Yersinia pestis, the causative agent of plague, poses a serious health threat to rodents and human beings. TyrR is a transcriptional regulator (TyrR) that controls the metabolism of aromatic amino acids in Escherichia coli. In a recent paper, published by a team led by researchers from the University of South China, TyrR was shown to […]
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alzheimers-disease
Alzheimer’s disease (AD) is a uniquely human, age-related central nervous system (CNS) disorder for which there is no adequate experimental model. While well over 100 transgenic murine models of AD (TgAD) have been developed that recapitulate many of the neuropathological features of AD, key pathological features of AD such as progressive neuronal atrophy, neuron cell […]
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Atrial-fibrillation
The molecular mechanisms underlying the early development of atrial fibrillation (AF) remain poorly understood. Emerging evidence suggests that abnormal epigenetic modulation via microRNAs (miRNAs) might be involved in the pathogenesis of paroxysmal AF (pAF). To identify key molecular changes associated with pAF, a team of scientists led by researchers from the Baylor College of Medicine […]
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KEGG
A successful approach for decreasing breast cancer fatalities depends upon reliable diagnostic screening and optimal treatment modalities. Ionizing radiation is widely used for both screening and therapeutic procedures. The main aim of recent work put forth by a researcher from Precarpathian National University was to analyze the effect of low (diagnostic) and high (treatment) doses […]
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placenta feat
MicroRNAs (miRNAs) are single-stranded RNA (20-23 bp) molecules which regulate expression of protein-coding gene by promoting mRNA degradation and translational inhibition in mammalians. miRNAs are involved in several mechanisms such as cardiovascular, central nervous system processes and cancer. It is also known that miRNAs can be produced by human placenta and are significant for placental […]
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TRAMP Comlpex
The RNA exosome is one of the main 3′ to 5′ exoribonucleases in eukaryotic cells. Although it is responsible for degradation or processing of a wide variety of substrate RNAs, it is very specific and distinguishes between substrate and non-substrate RNAs as well as between substrates that need to be 3′ processed and those that […]
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Orange_Tube_Sponge_Aplysina_fistularis
The origin of neurons and neural systems is a research area that has begun to experience increased progress with the growing availability of genomic data from a range of basal metazoans and closely related outgroups. This has allowed a reevaluation of previous models of neural evolution. Consequently, the aim of a recent thesis published by […]
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microRNA Discovery & Analysis MicroRNAs are a class of small non-coding RNAs that are negative regulators of gene expression in eukaryotic organisms. Some common characteristics of microRNAs include: short length (17-25nt), predictable stem and loop structure of precursors, highly conserved nature, existence in high copy numbers, and their expression is tissue (and developmental stage) specific. […]
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dicer
Recently, it was reported that knockdown of DICER reduced the ATM-dependent DNA damage response and homologous recombination repair (HRR) via decreasing DICER-generated small RNAs at the damage sites. In a recent paper, however, a team led by researchers from The First Hospital of Jilin University found that knockdown of DICER dramatically increased cell resistance to […]
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ovaries
In recent work published by a team led by researchers from Shandong University, investigators sought to determine whether plasma microRNAs (miRNAs) were differentially expressed between women with and without premature ovarian failure (POF), and to uncover the association of miRNAs with risk of POF. In their study, fifty-one differentially expressed miRNAs were identified by LC […]
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