Litchi has a high commercial value due to its bright color and rich nutrients. However, it deteriorates with the pericarp turning brown within 1–2 days after harvest. The factors that mediate litchi fruit senescence are complicated. Because microRNAs are known to act as negative regulators in almost every physiological process, researchers from the Chinese Academy of […]
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Oligonucleotide aptamers can specifically bind biomarkers on cancer cells and can be readily chemically modified with different functional molecules for personalized medicine. To target acute myeloid leukemia (AML) cells, researchers from Houston Methodist Hospital developed a single-strand DNA aptamer specific for the biomarker CD117, which is highly expressed on AML cells. Through the help of […]
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The molecular mechanism of kidney aging is not well understood, but the abnormal expression of miRNAs with aging is considered to be an important contributor. In a recent paper, researchers from Chinese PLA General Hospital and Medical College screened miR-184 and miR-150 using LC Sciences’ miRNA microarray service and found they were significantly upregulated in […]
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Recent studies have found that extracellular vesicles (EVs) play an important role in normal and disease processes. In their recent study, a team of scientists led by researchers from the University of Nebraska Medical Center isolated and characterized EVs from the brains of rhesus macaques, both with and without simian immunodeficiency virus (SIV) induced central nervous system (CNS) disease.
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The anterior pituitary is the most important endocrine organ modulating animal postnatal growth, mainly by controlling growth hormone (GH) gene transcription, synthesis, and secretion. As an ideal model for animal postnatal growth studies, the Bama minipig is characterized as having a lower growth performance and fewer individual differences compared with larger pig breeds. In a […]
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LC Sciences offers a customized solution to high-throughput genome wide variant analysis. The VariantPro™ system is comprised of three distinct innovations, all developed by scientists right here at LC Sciences: Relay-PCR™, Omega Primers™ and OligoMix®...
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Texas Medical Center
Event: S3 Vendor Show – Texas Medical Center – Houston Date: July 15, 2015 Show Hours: 8:00-10:00AM Location: TMC Commons Building Address: 6550 Bertner St, Houston, TX; (map) Texas Medical Center is the world’s largest life sciences destination. With 106,000 employees, 50,000 life science students, and thousands of volunteers and patient visits, over 160,000 people […]
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Pathologic conditions in the central nervous system, regardless of the underlying injury mechanism, show a certain level of blood–brain barrier (BBB) impairment. Endothelial dysfunction is the earliest event in the initiation of vascular damage caused by inflammation due to stroke, atherosclerosis, trauma, or brain infections. Recently, microRNAs (miRNAs) have emerged as a class of gene […]
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MicroRNAs (miRNAs) are small non-coding RNAs that are known to control mRNA translation. Most miRNAs are transcribed from specific genes with well-defined promoters located throughout the genome. The mechanisms that control miRNA expression under normal and pathological conditions are not yet understood clearly. Peroxisome proliferator activated receptor (PPAR) γ is a ligand-activated transcription factor that […]
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cell signaling
from Science Magazine by Caitlin Smith New proteomics tools enable researchers to dive deeply into signaling networks, allowing them to tease out interactions among key molecules. But this comes with a new challenge of increased complexity. Can cell signaling scientists balance the bewildering complexity that comes with the discovery power of proteomics technology? Proteomics seems […]
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