streptococcus-mutans6500
MicroRNAs in eukaryotic cells are thought to control highly complex signal transduction and other biological processes by regulating coding transcripts, accounting for their important role in cellular events in eukaryotes. Recently, a novel class of bacterial RNAs similar in size [18–22 nucleotides (nt)] to microRNAs has been reported. In a recent study, researchers from Kyungpook National University describe microRNAs, small RNAs from the oral pathogen Streptococcus sanguinis. The bacteria are normally present in the oral cavities and cause endocarditis by contaminating bloodstreams...
Read More
prostate-cancer-s20-photo-of-prostate-cancer-cells
A recent study by researchers from Beijing Anzhen Hospital sought to identify prostate cancer stem cells and determine the effects of modulating specific miRNAs on prostate CSC proliferation and apoptosis. Investigators applied flow cytometry sorting of side population cells to cultures of prostate cancer cell lines (TSU, DU145, PC-3 and LNCaP). The proportion of SP cells in the TSU line was...
Read More
130730_neuro
Autism spectrum disorders (ASD) are heritable neurodevelopmental conditions characterized by impairment in social interaction and communication and restricted, repetitive, stereotyped patterns of behavior. ASD likely involve deregulation of multiple genes related to brain function and development. MicroRNAs (miRNAs) are post-transcriptional regulators that play key roles in brain development, synapse formation and fine-tuning of genes underlying synaptic plasticity and memory formation. In a recent study, researchers from the Necker-Enfants Malades Hospital employed miRNA micorarray profiling services to review recent studies providing genetic and molecular links between miRNA deregulation and ASD pathophysiology. Their findings highlight the potential of miRNAs as both biomarkers and therapeutic tools in ASD...
Read More
7968
Angiogenesis is a crucial process for brain tissue repair and remodeling after brain injury. It has been demonstrated that microRNA (miRNA or miR) expression profiles are altered in tissues under hypoxic-ischemic conditions. However, its role in angiogenesis subsequent to cerebral ischemia is not fully understood. A recent study led by researchers from the Affiliated Hospital of Hebei University of Engineering aimed to investigate the role of miR-519 in angiogenesis and the molecular mechanisms mediated by HIF-1α in an in vitro model for cerebral ischemia. ..
Read More
aaeaaqaaaaaaaaciaaaajdy4ndezzte3ltmwnmetngq2mi04yjbkltgxmzu3mgzhogy1mg
Many factors have been reported to affect rainbow trout egg quality, among which, postovulatory aging is one of the most significant causes as reared rainbow trout do not usually volitionally oviposit the ovulated eggs. In order to uncover the genetic regulation underlying egg deterioration caused by postovulatory aging in rainbow trout, a team led by researchers from the National Center for Cool and Cold Water Aquaculture analyzed mitochondrial genome-encoded small RNA (mitosRNAs) from unfertilized eggs on...
Read More
LC Sciences
The development of multidrug resistance (MDR) in cancer cells to chemotherapy drugs continues to be a major clinical problem. MicroRNAs (miRNA, miR) play an important role in regulating tumour cell growth and survival; however, the role of miRs in the development of drug resistance in osteosarcoma cells is largely uncharacterized...
Read More
img_8476
Hybrid vigor contributes in a large way to the yield and quality of cotton (Gossypium hirsutum) fiber. Although microRNAs play essential regulatory roles in flower induction and development, it is still unclear if microRNAs are involved in male sterility, as the regulatory molecular mechanisms of male sterility in cotton need to be better defined...
Read More
amongolicus-1
MicroRNAs (miRNAs) regulate target gene expression to modulate plant growth, development, and biotic and abiotic stress response at the post-transcriptional level. Ammopiptanthus mongolicus, an ecologically important desert plant, is increasingly used as a model for studying stress tolerance in plants. The miRNA-mediated gene regulatory network might remarkably contribute to the high stress tolerance of A. mongolicus...
Read More
LC Sciences
MicroRNAs (miRNAs or miRs) act as key regulators in neuronal development, synaptic morphogenesis and plasticity. However, their role in the neuronal differentiation of inner ear neural stem cells (NSCs) remains unclear. In a recent study by researchers from Sun Yat-sen University, 6 miRNAs were selected and their expression patterns during the neuronal differentiation of inner ear NSCs were examined by RT-qPCR...
Read More
07
Light is a major environmental factor that affects metabolic pathways and stimulates the production of secondary metabolites in potato. However, adaptive changes in potato metabolic pathways and physiological functions triggered by light are partly explained by gene expression changes. Regulation of secondary metabolic pathways in potato has been extensively studied at transcriptional level, but little is known about the mechanisms of post-transcriptional regulation by miRNAs...
Read More