MicroRNAs (miRNAs) are small, non-coding single stranded RNAs that play crucial roles in numerous biological processes. Vertebrate herpesviruses encode multiple viral miRNAs that modulate host and viral genes. However, the roles of viral miRNAs in lower vertebrates have not been fully determined. In a recent study, high-throughput sequencing was used to analyse the miRNA and mRNA expression profiles of Carassius auratus gibelio in response to infection by cyprinid herpesvirus 2 (CyHV-2)...
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Plant microRNAs (miRNAs) are a class of non-coding RNAs that play important roles in plant development, defense, and symptom development. In a recent study, 547 known miRNAs representing 129 miRNA families, and 282 potential novel miRNAs were identified in Beta macrocarpa using small RNA deep sequencing...
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Hypertrophic scar (HS) formation is associated with the fibrosis of fibrocytes which is caused by excessive extracellular matrix (ECM) synthesis and deposition. A recent high throughput screen of miRNA expression profiles using miRNA microarray technology identified hsa-miR31-5p was most differentially expressed in normal skin fibroblasts (NS) and HS...
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LC Sciences
Chronic idiopathic urticaria (CIU) is a complicated skin disease with unknown pathophysiology. MicroRNAs (miRNA) have been shown to be active in cellular regulation. The goal of this pilot study was to examine whether miRNAs may be involved in the regulation of CIU or as biomarkers for CIU....
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MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post transcriptionally through silencing or degrading its targets, playing important roles in immune response. However, the role of miRNAs in host response against infectious bursal disease virus (IBDV) infection is not clear. In a recent study, researchers use miRNA sequencing to show that the expression of a series of miRNAs was significantly altered in DF-1 cells after infectious bursal disease virus (IBDV) infection...
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The plastid-encoded RNA polymerase (PEP) plays an important role in the transcription machinery of mature chloroplasts, yet details of its function remain elusive in rice. In a recent study, we identified a novel PEP-associated protein (PAP), WLP2, based on its two allelic white leaf and panicle mutants, wlp2s and wlp2w...
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Tumor-stromal communications impact tumorigenesis in ways that are incompletely understood. In a recent report, researchers from the University of Texas MD Anderson Cancer Center showed that Glioma Associated-human Mesenchymal Stem Cells (GA-hMSCs), a newly identified stromal component of glioblastoma, release exosomes that increase the proliferation and clonogenicity of tumor-initiating Glioma Stem-like Cells (GSCs). This event leads to a significantly greater tumor burden and decreased host survival compared with untreated GSCs in orthotopic xenografts...
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Albinism, a phenomenon characterized by pigmentation deficiency on the ocular side of Japanese flounder (Paralichthys olivaceus), has caused significant damage and limited mRNA and microRNA (miRNA) information is available on fish pigmentation deficiency. In a recent study, a team led by scientists from the Qingdao National Laboratory for Marine Science and Technology employed RNA sequencing to identify the mRNA and miRNAs involved in P. olivaceusalbinism...
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AACR
Presentations at the Annual Meeting will cover the latest basic, translational, clinical, and prevention-focused research in the field, including important areas such as early detection, cancer interception, and survivorship in all populations. We will feature new sessions on cancer health disparities that have been inspired by one of the important AACR presidential initiatives. We will also be reprising a popular new feature from Annual Meeting 2017, “Unsolved Mysteries,” featuring provocative questions and their in-depth discussion by speakers and members of the audience...
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MicroRNAs (miRNAs) are small non-coding RNAs that promote the progression of cancer by negatively regulating gene expression. Down-regulation of miR-483-5p was reported in a number of cancers. However, the biological functions of miR-483-5p in esophageal squamous cell carcinomas are not fully understood. In a recent study by researchers from Henan University of Science and Technology, the expression levels of miRNAs in the immortalized human esophageal epithelial cell line SHEE and the malignantly transformed esophageal carcinoma cell line SHEEC were examined by miRNA microarray...
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