VariantPro
VariantPro™ is an innovative multiplex PCR-based targeted sequencing method that accomplishes target selection, library preparation and molecular tagging in a simple one-step workflow. The method incorporates novel Relay-PCR™ and Omega Primer™ technologies to produce amplicons of high uniformity & specificity (Figure 1). Designed for 100% amplicon coverage (16,569 bp) of the mitochondrion genome, the VariantPro™ […]
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Traumatic brain injury (TBI) is an important health concern for which effective treatment strategies remain elusive. Understanding the complex multi-cellular response to TBI may provide new avenues for intervention. In the context of TBI, cell–cell communication is critical. One relatively unexplored form of cell–cell communication in TBI is extracellular vesicles (EVs). These membrane-bound vesicles can carry many different types of cargo between cells. Recently, microRNAs (miRNAs) in EVs have been shown to mediate neuroinflammation and neuronal injury....
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MicroRNAs (miRs) regulate gene expression to support important physiological functions. Significant evidence suggests that miRs play a crucial role in many pathological events and in the cell response to various stresses. With the aim to identify new miRs induced by perturbation of intracellular calcium homeostasis, researchers from the The University of Salerno used LC Sciences miRNA microarray service to analyze miR expression profiles of thapsigargin (TG)-treated cells.
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lc Sciences
Hepatocellular carcinoma (HCC) is the third leading cause of death due to cancer worldwide with over 500,000 people affected annually. Although chemotherapy has been widely used to treat patients with HCC, alternate modalities to specifically deliver therapeutic cargos to cancer cells have been sought in recent years due to the severe side effects of chemotherapy...
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Several phytohormones have been demonstrated to be involved in iron (Fe) homeostasis. A team led by researchers from Hangzhou Normal University recently took advantage of a salicylic acid (SA) biosynthesis defective mutant phytoalexin deficient 4 (pad4: T-DNA Salk_089936) to explore the possible effects of endogenous SA on the morphological and physiological responses to Fe deprivation...
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The European Human Genetics Conference (now in its 49th year) is a forum for all workers in human and medical genetics to review advances and develop research collaborations. The conference has become one of the premier events in the field of human genetics with over 3.000 delegates, more than 215 oral presentations, 18 workshops, 8 […]
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Hepatitis E Virus (HEV)-mediated hepatitis has become a global public health problem. An important regulatory protein of HEV, ORF3, influences multiple signal pathways in host cells. In a recent study led by researchers from Hainan University, to investigate the function of ORF3 from the swine form of HEV (SHEV), poly(A) RNA-seq services were employed...
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microrna microarray
Drug resistance is one of the major obstacles for improving the prognosis of breast cancer patients. Increasing evidence has linked the association of aberrantly expressed microRNAs (miRNAs) with tumour development and progression, as well as chemoresistance. Despite recent advances, there is still little known about the potential role and mechanism of miRNAs in breast cancer chemoresistance...
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The inability to digest lactose, due to lactase nonpersistence, is a common trait in adult mammals, except in certain human populations that exhibit lactase persistence. Because it is not known how the lactase gene is dramatically downregulated...
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Ionizing radiation causes depletion of hematopoietic cells and enhances the risk of developing secondary hematopoietic malignancies. Vitamin E analog gamma-tocotrienol (GT3), which has anticancer properties, promotes postirradiation hematopoietic cell recovery by enhancing spleen colony-forming capacity, and provides protection against radiation-induced lethality in mice. However, the underlying molecular mechanism involved in GT3-mediated postirradiation survival is not clearly understood...
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