The aggregation of Aβ42-peptides and the formation of drusen in age-related macular degeneration (AMD) are due in part to the inability of homeostatic phagocytic mechanisms to clear self-aggregating Aβ42-peptides from the extracellular space. The triggering receptor expressed in myeloid/microglial cells-2 (TREM2), a trans-membrane-spanning, sensor-receptor of the immune-globulin/lectin-like gene superfamily is a critical component of Aβ42-peptide […]
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Schizophrenia is a severe disabling brain disease affecting about 1% of the world’s population. Due to the dynamic nature of the peripheral blood transcriptome, understanding miRNAs gene expression signature in schizophrenia is a promising tool for discovery of disease-related biomarkers and biological pathways involved. A recent study by researchers from the University of Plovdiv “Paisii […]
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SUMOylation and ubiquitination are two essential post translational modifications (PTMs) involved in the regulation of important biological processes in eukaryotic cells. Identification of ubiquitin (Ub) and small ubiquitin-related modifier (SUMO)-conjugated lysine residues in proteins is critical for understanding the role of ubiquitination and SUMOylation, but remains experimentally challenging. A team of researchers from the University […]
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MicroRNAs (miRNAs) are small non-coding RNAs that play a mostly post-transcriptional regulatory role in gene expression. Using RAW264.7 pre-osteoclast cells and genome-wide expression analysis, a team led by researchers from Purdue University identified a set of miRNAs that are involved in osteoclastogenesis. Based on in silico analysis, they specifically focused on miR-222-3p and evaluated its […]
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Researchers from the Second Affiliated Hospital of Harbin Medical University recently used comprehensive miRNA microarray analysis to determine miRNA expression in differentiated cardiac stem cells (CSCs). They selected miR218 for functional follow-up studies to examine its significance in CSCs. They observed that the expression of miR218 was altered in CSCs during differentiation into cardiomyocytes, and […]
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The double strand breaks elicited by sapacitabine, a clinically active nucleoside analog prodrug are repaired by Rad51 and the homologous recombination repair (HR) pathway which could potentially limit its toxicity. A team led by reseachers from Ohio State University recently  investigated the mechanism by which HDAC inhibitors targeted Rad51 and HR to sensitize AML cells […]
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Arsenic is a naturally-occurring toxicant that exists in bedrock and can be leached into ground water. Humans can be exposed to arsenic via contaminated drinking water, fruit, rice or crops. Epidemiological studies have shown that arsenic is a developmental toxicant, and in utero exposure reduces IQ scores, verbal learning ability, decreases long term memory, and […]
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The hyperaccumulating ecotype of Sedum alfredii Hance is a cadmium (Cd)/zinc/lead co-hyperaccumulating species of Crassulaceae. It is a promising phytoremediation candidate accumulating substantial heavy metal ions without obvious signs of poisoning. However, few studies have focused on the regulatory roles of miRNAs and their targets in the hyperaccumulating ecotype of S. alfredii. In a recent […]
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Endothelial progenitor cells (EPCs) contribute to recanalization of deep vein thrombosis (DVT). A recent study by researchers from The Second Affiliated Hospital of Soochow University aimed to detect miRNA expression profiles in EPCs from patients with DVT and characterize the role of miRNA in EPCs dysfunction. In their study, EPCs were isolated from DVT patients […]
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