newt feat
The molecular events underlying epimorphic regeneration of the adult urodele amphibian tail and caudal spinal cord are undetermined. Given the dynamic nature of gene expression control by retinoic acid (RA) signaling and the pleiotropic effects of microRNAs (miRNAs) on multiple mRNA targets in this complex system, researchers from Brock University examined whether RA signaling through […]
Read More
904e1f1a-7e4a-40a1-b142-e68b3e52c389
N6-methyladenosine (m6A) is the most abundant internal modification of messenger RNA. While the presence of m6A on transcripts can impact nuclear RNA fates, a reader of this mark that mediates processing of nuclear transcripts has not been identified. In recent  work by researchers from Rockefeller University, they have found that the RNA-binding protein HNRNPA2B1 binds […]
Read More
bladder cancer
Exosomes are small membrane vesicles secreted by most cell types. They are first found in reticulocytes and play important roles in cell-to-cell communication. Recent studies suggest that exosomes secreted by tumor cells containing tumor specific proteins and miRNAs and that exosomes purified from high grade bladder cancer can promote cancer progression. A recent study by […]
Read More
endofeat
It is known that there is an increased risk of developing ovarian cancer (OC) in patients with endometriosis. Hence, development of new biomarkers may provide a positive clinical outcome for early detection. MicroRNAs (miRNAs) are small non-coding RNAs that play an important role in biological and pathological process and are currently used as diagnostic and […]
Read More
folding
Acute lung injury (ALI) is characterized by severe lung edema and an increase in the inflammatory reaction. Considerable evidence has indicated that microRNAs (miRNAs or miRs) are involved in various human diseases; however, the expression profile and function of miRNAs in ALI have been rarely reported. A recent study by researchers from Zhejiang Hospital used […]
Read More
Figure 3
from GenomeWeb by Justin Petrone NEW YORK (GenomeWeb) – Crop researchers are increasingly turning to next-generation sequencing, citing the declining cost of the technology, the higher complexity of plant genomes compared to animal genomes, and a host of other reasons. At the same time, vendors like Affymetrix and Illumina, who sell both sequencing and microarray […]
Read More
QPCR Data
The transcription factor hepatocyte nuclear factor-1β (HNF-1β) regulates tissue-specific gene expression in the kidney and other epithelial organs. Mutations of HNF-1β produce kidney cysts, and previous studies have shown that HNF-1β regulates the transcription of cystic disease genes, including Pkd2 and Pkhd1. In a recent collaborative study led by researchers from the University Texas Southwestern, […]
Read More
hearing-loss
Circulating microRNAs (miRNAs) have attracted interests as non-invasive biomarkers of physiological and pathological conditions, which may be applied in noise-induced hearing loss (NIHL). However, no epidemiology studies have yet examined the potential effects of NIHL or noise exposure on miRNA expression profiles until now. A team of scientists led by researchers from Nanjing Medical University […]
Read More