MicroRNAs (miRNAs) are a class of non-coding small RNAs that play important roles in the regulation of gene expression. Although animal miRNAs have been extensively studied in model systems, less is known in other animal with limited genome sequence data, including Chinese giant salamander (Andrias davidianus). To increase our understanding of physiological function in this endangered urodele amphibian, researchers from Henan University of Science and Technology sought to identify the full repertoire of miRNAs expressed in the liver, spleen and muscle of A. davidianus...
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LC Sciences
It is well accepted that molecular profiling of cellular proteins or nucleic acids can offer answers to courses of diseases and underlined connections of pathogenic molecules, and thus, pointing out therapeutic targets. However, protein profiling, especially at the cellular level of protein profiling has been challenging. There is only limited choices to allow systematic investigation of cellular protein activities, such as their responses, i.e., sensitive, responsive or nonresponsive or resistant, to therapeutic treatment. This presentation reports peptide microarray chip (PepArray) technology developed as a powerful molecular tool for proteomic profiling of Cellular Signaling Proteins (CSPs) to interrogate CSP variations in pancreatic cancer induced by treatment of a new generation of anti-cancer therapies, i.e., tyrosine kinase therapeutics (TKls). PepArray chips encodes
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MicroRNAs (miRNAs) have a great influence on various physiological functions. A lot of high-throughput sequencing (HTS) research on miRNAs has been executed in the caprine mammary gland at different lactation periods (common milk lactation and dry period), but little is known about differentially expressed miRNAs in the caprine mammary gland of colostrum and peak lactation periods...
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MicroRNAs are short, single-stranded non-coding RNA molecules that function as regulators of tumor progression in various cancers, including glioma. A recent study by a team from Inner Mongolia Medical University sought to investigate the biological functions of miR-9-3p in glioma progression...
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Calcineurin inhibitors are powerful immunosuppressants that revolutionized organ transplantation; however, non-immune effects of the calcineurin inhibitor, such as cyclosporine A (CsA), have significantly hindered their use. Specifically, nephrotoxicity, which is associated with tubulointerstitial fibrosis, inflammation, and podocyte damage, affects up to half of all transplant patients. Calcineurin is involved in many aspects of kidney development and function; therefore, mechanisms of CsA-induced nephrotoxicity are complex and not yet fully understood...
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Chinese fir (Cunninghamia lanceolata) is an excellent fast-growing timber species which has significant value to the forestry industry. In order to increase nitrogen and phosphorus absorption and utilization in Chinese fir, shared differentially expressed genes under low nitrogen and phosphorus stress were screened in a recent study by researchers from Zhejiang A & F University...
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Hepatocellular carcinoma (HCC) is the fifth most widespread type of malignancy and has a 5-year postoperative survival rate of only 18%. However, the prognostic value of microRNAs (miRNAs) for HCC has not been fully studied until recently. In a recent review, researchers from Guangxi Medical University aimed to identify the potential candidates of dysregulated miRNAs for HCC prognosis in the profiling studies based on high-throughput miRNA microarray...
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The origin of vertebrate-specific characters and functional systems is one of the most important questions in the evolutionary biology. Amphioxus, the most basal chordate, is considered as the sister of vertebrates based on the recent molecular phylogenetic evidences, and it is used as an ideal model organism to study the origin and evolution of vertebrate organ systems including immune system. Three digestive organs, gill slits, hepatic caecum and intestine in amphioxus were also considered as primitive immune organs of amphioxus...
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Production of high-quality meat is important to satisfy the consumer and allow the pork industry to be competitive. It is evident that different muscle fiber types in different breeds greatly influence the pork quality, but the underlying molecular mechanism remains unclear. A team led by researchers from South China Agricultural University recently utilized Total RNA-Seq and miRNA-Seq services to examine global expressions of protein-coding transcripts and non-coding RNAs including miRNA, lncRNA, and circRNA in the longissimus dorsi of Landrace and Lantang pigs...
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A large number of antimicrobial peptides (AMPs) act with high selectivity and specificity through interactions with membrane lipid components. These peptides undergo complex conformational changes in solution; upon binding to an interface, one major conformation is stabilized. A recent publication by researchers from Federal University de Janeiro describe the interaction between tritrpticin (TRP3), a cathelicidin AMP, and micelles of different chemical composition...
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