netochord
Recently, amphioxus has served as a model for studying the origin and evolution of vertebrate immunity. However, little is known about how microRNAs (miRNAs) are involved in the immune defense in amphioxus. In a recent article, researchers from Nanjing University identified the amphioxus miRNAs in the acute-phase response to lipopolysaccharide (LPS)...
Read More
Cancer-of-Nasopharyngeal-ca
Oleuropein (OL) is a well-known anti-oxidative agent and is shown to reduce the hypoxia-inducible factor 1 α (HIF1α) protein expression after radiation. A recent study by researchers from The Second People’s Hospital of Wuxi investigated the effects of OL on radiation response in nasopharyngeal carcinoma (NPC)...
Read More
LC Sciences
Leukoencephalopathies are a group of white matter disorders related to abnormal formation, maintenance, and turnover of myelin in the central nervous system. These disorders of the brain are categorized according to neuroradiological and pathophysiological criteria...
Read More
_76530628_c0172635-virus_particles_in_bloodstream
Hepatitis E virus- (HEV-) mediated hepatitis has become a global public health problem. An important regulatory protein of HEV, ORF3, influences multiple signal pathways in host cells. In a recent study led by researchers from Hainan University, the function of ORF3 from the swine form of HEV (SHEV) was investigated using high-throughput RNA-Seq-based screening in an effort to identify the differentially expressed genes in ORF3-expressing HepG2 cells...
Read More
LC Sciences
Bone marrow-derived mesenchymal stem cells (MSCs) have been recently used in clinical treatment of inflammatory diseases. Practical strategies improving the immunosuppressive property of MSCs are urgently needed for MSC immunotherapy. In a recent study, a team led by researchers from Fourth Military Medical University aimed to develop a microRNA-based strategy to improve MSC immunotherapy...
Read More
fpls-07-01938-g003
Along with the well-studied microRNA (miRNA) and small interfering RNA (siRNA) is a new class of transfer RNA-derived small RNA (tsRNA), which has recently been detected in multiple organisms and is implicated in gene regulation. However, while miRNAs and siRNAs are known to repress gene expression through sequence-specific RNA cleavage or translational repression, how tsRNAs regulate gene expression remains unclear...
Read More
thinkstockphotos-484323904
Male muskrats have one pair of scented glands that grow and involute annually. To investigate the annual changes in the scented gland, researchers from Beijing Forestry University measured the expressions of aromatase cytochrome P450 (P450arom) and estrogen receptors (ERs) in the scented glands...
Read More
Drosophila
Drosophila melanogaster is widely used as a model system to study innate immunity and signaling pathways related to innate immunity, including the Toll signaling pathway. Although this pathway is well-studied, the precise mechanisms of post-transcriptional regulation of key components of the Toll signaling pathway by microRNAs (miRNAs) remain obscure...
Read More
(DigitalGenetics - Fotolia/stock.adobe.com)
3d render of dna structure, abstract  background
Alcohol consumption is a risk factor for breast cancer. Little is known regarding the mechanism, although it is assumed that acetaldehyde or estrogen mediated pathways play a role. A team of rsearchers from UCLA previously showed that long-term exposure to 2.5 mM ethanol (blood alcohol ~0.012%) of MCF-12A, a human normal epithelial breast cell line, induced epithelial mesenchymal transition (EMT) and oncogenic transformation. In their most recent study...
Read More
Male anatomy of human organs in x-ray view
Ischemia reperfusion (I/R) injury is an inevitable event arising during the cardiovascular diseases development and the process of potent surgical treatments. microRNAs (miRNAs) are critical regulators of multiple cell processes including I/R injury. A recent study published by researchers from The Second Affiliated Hospital of Anhui Medical University aimed to quantify miRNA alterations and regulated genes upon hypoxia-reoxygenation (H/R) injury in a rat heart failure model comparing with normal cardiomyocytes...
Read More