microRNAs are small non-coding RNAs that are important regulators of gene expression in a range of animals, including nematodes. Scientists from the University of Glasgow have analysed a cluster of four miRNAs from the pathogenic nematode species Haemonchus contortus that are closely linked in the genome...
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LC Sciences
Ground-state pluripotency is a cell state in which pluripotency is established and maintained through efficient repression of endogenous differentiation pathways. Self-renewal and pluripotency of embryonic stem cells (ESCs) are influenced by ESC-associated microRNAs...
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The aim of a recent study sought to evaluate tadalafil-mediated effects at the molecular level on bone marrow-derived mesenchymal stem cells (MSCs) survival and their homing into infarcted hearts to promote cardiac repair and improve function...
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To determine the miRNA expression profiles of neuroblastomas with different clinical and histological characteristics, a recent study utilized 24 samples from 17 patients. Their microRNA profiles were compared using miRNA microarray technology...
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Triclosan (TCS) exposure has widely adverse biological effects such as influencing biological reproduction and endocrine disorders. While some studies have addressed TCS-induced expression changes of miRNAs and their related down-stream target genes, no data are available concerning how TCS impairs miRNA expression...
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Cold and salt are common stresses in salinized land, which significantly limit plant growth and development. Harnessing and prevention of land salinization is crucial to agricultural production and economic welfare. Although cold or salt stress response has been widely investigated, the information on combined cold and salt stress is few...
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1,4-Dioxane (dioxane) is a groundwater contaminant of emerging concern for which bioremediation may be a promising strategy. Several bacterial strains can metabolize dioxane or degrade it cometabolically. However, the molecular basis of dioxane biodegradation is only partially understood, and the gene coding for dioxane/tetrahydrofuran (THF) monooxygenase in Pseudonocardia dioxanivorans CB1190 is the only well-characterized catabolic gene...
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Plants in the genus Ammopiptanthus are relic trees of the Tertiary period that have survived dramatic climate change in the Central Asia dryland. Currently, the only two remaining Ammopiptanthus species, A. nanus and A. mongolicus, are distributed in distinct arid regions. Comparative analysis between the two species recently facilitated our understanding of speciation and their different adaptation mechanisms. However, lack of nucleotide sequence data hindered the functional genomics research on A. nanus and comparative transcriptome analysis between the two Ammopiptanthus species...
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Cartilage dyshomeostasis contributes to osteoarthritis (OA) pathogenesis, and tumor necrosis factor (TNF)-α has critical role in this process by driving inflammatory cascades and cartilage degradation. However, the negative regulation of TNF-α-mediated signaling remains undefined. In a recent study, scientists demonstrate the crucial role of miR-145 in the modulation of TNF-α-mediated signaling and cartilage matrix degradation...
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OligoMix
MicroRNAs (miRNAs) are small, non-coding single stranded RNAs that play crucial roles in numerous biological processes. Vertebrate herpesviruses encode multiple viral miRNAs that modulate host and viral genes. However, the roles of viral miRNAs in lower vertebrates have not been fully determined. In a recent study, high-throughput sequencing was used to analyse the miRNA and mRNA expression profiles of Carassius auratus gibelio in response to infection by cyprinid herpesvirus 2 (CyHV-2)...
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