b271ebd0-ad4b-4e79-a979-37667e2075b8_shutterstock_2637017_virus_cellen_LR_32a2e47e_490x330
Hepatitis E Virus (HEV)-mediated hepatitis has become a global public health problem. An important regulatory protein of HEV, ORF3, influences multiple signal pathways in host cells. In a recent study led by researchers from Hainan University, to investigate the function of ORF3 from the swine form of HEV (SHEV), poly(A) RNA-seq services were employed...
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microrna microarray
Drug resistance is one of the major obstacles for improving the prognosis of breast cancer patients. Increasing evidence has linked the association of aberrantly expressed microRNAs (miRNAs) with tumour development and progression, as well as chemoresistance. Despite recent advances, there is still little known about the potential role and mechanism of miRNAs in breast cancer chemoresistance...
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bisulfate lock
The inability to digest lactose, due to lactase nonpersistence, is a common trait in adult mammals, except in certain human populations that exhibit lactase persistence. Because it is not known how the lactase gene is dramatically downregulated...
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An anterior view of the spleen (red) relative to the pancreas and the duodenum.
Ionizing radiation causes depletion of hematopoietic cells and enhances the risk of developing secondary hematopoietic malignancies. Vitamin E analog gamma-tocotrienol (GT3), which has anticancer properties, promotes postirradiation hematopoietic cell recovery by enhancing spleen colony-forming capacity, and provides protection against radiation-induced lethality in mice. However, the underlying molecular mechanism involved in GT3-mediated postirradiation survival is not clearly understood...
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Turbot3
MicroRNAs (miRNAs) are highly conserved short non-coding RNAs which play a key role in a wide array of processes. They are usually at the center of regulatory networks modulating the expression of a large number of mRNAs. miRNAs have been found to regulate processes related to relevant aquaculture traits like growth or immune response. For this reason, a team led by researchers from Universidade de Santiago de Compostela...
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leezard
Lizards are evolutionarily the most closely related vertebrates to humans that can lose and regrow an entire appendage. Regeneration in lizards involves differential expression of hundreds of genes that regulate wound healing, musculoskeletal development, hormonal response, and embryonic morphogenesis. While microRNAs are able to regulate large groups of genes, their role in lizard regeneration has […]
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350px-Human_Aortic_SMC
There is growing evidence that microRNAs are implicated in pulmonary arterial hypertension (PAH), but underlying mechanisms remain elusive. In a recent study led by researchers from Shenzhen University, scientists used miRNA microarray services to identify that miR-223 was significantly downregulated in chronically hypoxic mouse and rat lungs, as well as in pulmonary artery and pulmonary […]
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single-fruit-fly-drosophila-melanogaster-on-white-background-cropped
Drosophila Dscam1 (Down Syndrome Cell Adhesion Molecules) and vertebrate clustered protocadherins (Pcdhs) are two classic examples of the extraordinary isoform diversity from a single genomic locus. Dscam1 encodes 38,016 distinct isoforms via mutually exclusive splicing in D. melanogaster, while the vertebrate clustered Pcdhs utilize alternative promoters to generate isoform diversity...
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473262501_d1
MicroRNAs (miRNAs) play key roles in plant reproduction. However, knowledge on microRNAome analysis in autotetraploid rice is rather limited. In a recent studyby researchers from South China Agricultural University, miRNA/small RNA sequencing was employed to analyze miRNAomes during pollen development in diploid and polyploid rice...
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soil-microbes
Recently, inhalable particulate matter has been reported to carry microorganisms responsible for human allergy and respiratory disease. The unique geographical environment and adverse weather conditions of Urumqi cause double pollution of dust and smog, but research on the microbial content of the atmosphere has not been commenced.
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