Pacific_Sea_Nettle,_Baltimore,_MD_Aquarium
Jellyfish venoms are rich sources of toxins designed to capture prey or deter predators, but they can also elicit harmful effects in humans. In a recent study led by researchers from the University of Melbourne, an integrated transcriptomic and proteomic approach was used to identify putative toxins and their potential role in the venom of the scyphozoan jellyfish Chrysaora fuscescens...
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shortnosesturgeon8980_robertmichelson
MicroRNAs (miRNAs) are involved in post-transcriptional gene regulation and have crucial roles in regulating the expression of gametogenesis-related genes in animals. However, the mechanism of sex determination and differentiation in the sturgeon has remained unclear. Identifying miRNAs and characterizing sex-biased miRNA expression is therefore critical for understanding the role of miRNAs during sexual differentiation in sturgeon...
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LC Sciences
If you would like to discuss how microRNAs function in cancer or learn about our new multiplex PCR approach for target enrichment in next-gen sequencing, stop by booth#457 at the AACR meeting and have a chat with us.
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oligomix
Post-transcriptional gene regulation controls the amount of protein produced from an individual mRNA by altering rates of decay and translation. Although differences in cis-regulatory DNA are known to underlie human variation and disease, predicting the effects of cis-regulatory variants on gene expression remains challenging. Many sequence elements that direct post-transcriptional regulation have been found; in […]
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catfeash
Pelteobagrus vachelli is a well-known commercial species in Asia. However, a sudden lack of oxygen will result in mortality and eventually to pond turnover. Studying the molecular mechanisms of hypoxia adaptation in fishes will not only help us to understand fish speciation and the evolution of the hypoxia-signaling pathway, but will also guide us in the breeding of hypoxia-tolerant fish strains. Despite this, the genetic regulatory network for miRNA-mRNA and the signaling pathways involved in hypoxia responses in fish have remained unexamined...
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Breast-cancer-revelation-other-hormone-receptors-could-be-targeted-for-novel-therapies
Alcoholism is associated with breast cancer incidence and progression, and moderate chronic consumption of ethanol is a risk factor. The mechanisms involved in alcohol’s oncogenic effects are unknown, but it has been speculated that they may be mediated by acetaldehyde. Researchers from Charles Drew University recently used the immortalized normal human epithelial breast cell line MCF-12A […]
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grow-cucumbers.jpg.653x0_q80_crop-smart
Root-shoot communication plays a vital role in plant growth, development and adaptation to environmental stimuli. Grafting-induced stress tolerance is associated with the induction of plentiful stress-related genes and proteins, the mechanism involved, however, remains obscure. In a recent publication, researchers from Zhejiang University show that the enhanced tolerance against heat stress in cucumber plants with […]
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crispr
With <2% of the human genome coding for proteins, a major challenge is to interpret the function of the noncoding DNA. Millions of regulatory sequences have been predicted in the human genome through analysis of DNA methylation, chromatin modification, hypersensitivity to nucleases, and transcription factor binding, but few have been shown to regulate transcription in […]
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featimhg
The successful treatment of cancer, including breast cancer, depends largely on radiation therapy and proper diagnostics. The effect of ionizing radiation on cells and tissues depends on the radiation dose and energy level, but there is insufficient evidence concerning how tumor cells respond to the low and high doses of radiation that are often used in medical diagnostic and treatment modalities. The purpose of a recent study by researchers from the University of Lethbridge was to investigate radiation-induced gene expression changes in the MCF-7 breast adenocarcinoma cell line...
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cajl
Because the mechanisms underlying nuclear body (NB) formation and their contribution to genome function are unknown, researchers from the Rosalind Franklin University of Medicine and Science recently examined the non-random positioning of Cajal bodies (CBs), major NBs involved in spliceosomal snRNP assembly and their role in genome organization. CBs are predominantly located at the periphery […]
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