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Researchers in the field of mitochondrial biology are increasingly unveiling of the complex mechanisms between mitochondrial dysfunction and noncoding RNAs (ncRNAs). However, roles of ncRNAs underlying mitochondrial myopathy remain unexplored. The aim of a recent study led by researchers from Shandong University sought to elucidate the regulating networks of dysregulated ncRNAs in Mitochondrial myopathy, Encephalopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) with mitochondrial DNA (mtDNA) A3243G mutation...
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MicroRNAs (miRNAs) are a class of endogenous, evolutionarily conserved small non-coding RNA molecules that mediate the posttranscriptional processing of target genes, leading to translational repression or degradation of target mRNAs. A series of studies have indicated that miRNAs play an important role in tumor initiation, development and progression. In a recent study led by researchers from Shanghai Jiao Tong University School of Medicine, they found that down regulation of miR-598 was a frequent event in CRC tissues compared to the paracarcinoma tissues. Their study also demonstrated that miR-598 was implicated in CRC metastasis...
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plantleaf
miR1444s are functionally significant miRNAs targeting polyphenol oxidase (PPO) genes for cleavage and MIR1444 genes have only been reported in Populus trichocarpa. Through computational analysis of RNA-seq data, four whole genome sequences of Salicaceae species and small RNA deep sequencing of six P. trichocarpa libraries, researchers from Peking Union Medical College investigated the origin and evolution history of these MIR1444 genes...
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Leukoencephalopathies are a group of white matter disorders related to abnormal formation, maintenance, and turnover of myelin in the central nervous system. These disorders of the brain are categorized according to neuroradiological and pathophysiological criteria. In a recent study, a team led by researchers from Galilee Medical Center identified a unique form of leukoencephalopathy in seven patients presenting at ages 2 to 4 months with progressive microcephaly, spastic quadriparesis, and global developmental delay...
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spleen
Extensive epidemiological data have demonstrated an exponential rise in the incidence of non-Hodgkin lymphoma (NHL) that is associated with increasing age. The molecular etiology of this remains largely unknown, which impacts the effectiveness of treatment for patients. A team led by researchers from University of Massachusetts Medical School proposed that age-dependent circulating microRNA (miRNA) signatures in the host influence diffuse large B cell lymphoma (DLBCL) development. The objective of their recent study was to examine tumor development in an age-based DLBCL system using an inventive systems biology approach...
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Evidence suggests miRNA-1 may participate in regulating ischemia–reperfusion injury (IRI) by affecting the expression and distribution of connexin 43 (Cx43). To investigate this phenomenon, a recent study by researchers from Tianjin Medical University examined miR-1 expression and its potential role in regulating Cx43 during ischemic postconditioning (IPOST) in a rat model...
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Electroacupuncture has been shown to improve cerebral blood flow in animal models of stroke. However, it is unclear whether electroacupuncture alters miRNA expression in the cortex. A recent study by researchers from Tianjin University examined changes in the cerebral cortical miRNA profile, cerebral blood flow and neurological function induced by electroacupuncture in a rat model of stroke...
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Astragalus Polysaccharide (APS) is an important feed additive due to its immunomodulatory functions. Previous studies have proven that miRNAs play important roles in posttranscriptional gene regulation. Researchers from Northwest A&F University recently sought to identify differentially expressed miRNAs in testes in responses to APS dietary supplements and to find the effects of APS on breeder cock testes...
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Peanut-Farm
Aflatoxin contamination is a major constraint in food production worldwide. In peanut (Arachis hypogaea L.), these toxic and carcinogenic aflatoxins are mainly produced by Aspergillus flavus Link and A. parasiticus Speare. The use of RNA interference (RNAi) is a promising method to reduce or prevent the accumulation of aflatoxin in peanut seed...
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picoarray
The chemical synthesis of DNA oligonucleotides and their assembly into synthons, genes, circuits, and even entire genomes by gene synthesis methods has become an enabling technology for modern molecular biology and enables the design, build, test, learn, and repeat cycle underpinning innovations in synthetic biology. In their latest perspective, researchers from the University of Texas at Austin briefly review the techniques and technologies that enable the synthesis of DNA oligonucleotides and their assembly into larger DNA constructs...
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