Pyropia yezoensis is commonly known as a valuable marine red alga. As a cold-temperate species, high temperature is a critical abiotic stress factor that can affect the growth and development of this seaweed. Exploring the regulatory mechanisms of P. yezoensis resistance to high temperatures has significance in breeding high temperature-resistant strains...
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Spiroplasma eriocheiris is a novel pathogen similar to the Spiroplasma mirum and also had an ability to infect the newborn mice and caused cataract. A study by scientists from Nanjing Normal University was designed to study how S. eriocheiris infects mouse 3T6-Swiss albino cells and to elucidate the cellular molecular pathogenesis of Spiroplasma...
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Under natural conditions, some embryos cannot implant successfully because of the dysfunction of receptive endometrium (RE). Thus, it is imperative to study the molecular mechanisms involved in the formation of RE from pre-receptive endometrium (PE). In a recent study, researchers from Northwest A&F University collected endometrium from gestational day 5 (D5, PE) and gestational day 15 (D15, RE) dairy goats to analyze the transcriptome using strand-specific total RNA-Seq...
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Consuming ergot alkaloids found in endophyte-infected tall fescue seed causes intrauterine growth restriction due to uteroplacental insufficiency. The objective of a recent study by scientists from Clemson University was to assess the impact on gene expression levels in placental tissue from feeding ergot alkaloids during gestation...
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To understand the role of miRNAs in regulating genes involved in the host response to Salmonella enteritidis (SE) infection, next generation sequencing was applied to explore the altered splenic expression of microRNAs (miRNAs) and deregulated genes in specific-pathogen-free chickens. In the study by researchers from the Chinese Academy of Agricultural Sciences, birds were either infected or not (controls, C) and those challenged with SE were evaluated 24 h later and separated into two groups on the basis of the severity of clinical symptoms and blood load of SE...
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Rapid and efficient methods for the determination of cured pulmonary tuberculosis (TB) are lacking. Researchers from Zhejiang University screened serum miRNAs using miRNA sequencing methods among untreated TB patients, two-month treated TB patients, cured TB patients, and healthy controls...
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Cardiogenesis processes in human and animals have differential dynamics, suggesting the existence of species-specific regulators during heart development. However, it remains a challenge to discover the human-specific cardiac regulatory genes, given that most coding genes are conserved. Here, we report the identification of a human-specific long noncoding RNA, Heart Brake LncRNA 1 (HBL1), which regulates cardiomyocyte development from human induced pluripotent stem cells (hiPSCs)...
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Calcific aortic valve disease (CAVD) is the most common heart valve disorder, yet its mechanism remains poorly understood. Valve interstitial cells (VICs) are the prevalent cells in aortic valve and their osteogenic differentiation may be responsible for calcific nodule formation in CAVD pathogenesis. Emerging evidence shows microRNA (miRNA, or miR) can function as important regulators of many pathological processes, including osteogenic differentiation. In a recent study, a team led by researchers from Third Military Medical University aimed to explore the function of miR-449c-5p in CAVD pathogenesis...
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Genetically improved farmed tilapia (GIFT, Oreochromis niloticus) are commercially important fish that are cultured in China. GIFT are highly susceptible to diseases when exposed to high temperatures in summer. Better understanding the GIFT regulatory response to heat stress will not only help in determining the relationship between heat stress signaling pathways and adaption mechanisms, but will also contribute to breeding new high-temperature tolerant strains of GIFT...
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