journal.pone.0175242.g001
Calcineurin inhibitors are powerful immunosuppressants that revolutionized organ transplantation; however, non-immune effects of the calcineurin inhibitor, such as cyclosporine A (CsA), have significantly hindered their use. Specifically, nephrotoxicity, which is associated with tubulointerstitial fibrosis, inflammation, and podocyte damage, affects up to half of all transplant patients. Calcineurin is involved in many aspects of kidney development and function; therefore, mechanisms of CsA-induced nephrotoxicity are complex and not yet fully understood...
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Chinese fir (Cunninghamia lanceolata) is an excellent fast-growing timber species which has significant value to the forestry industry. In order to increase nitrogen and phosphorus absorption and utilization in Chinese fir, shared differentially expressed genes under low nitrogen and phosphorus stress were screened in a recent study by researchers from Zhejiang A & F University...
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Cirrhotic_Liver_Focal_Tumor
Hepatocellular carcinoma (HCC) is the fifth most widespread type of malignancy and has a 5-year postoperative survival rate of only 18%. However, the prognostic value of microRNAs (miRNAs) for HCC has not been fully studied until recently. In a recent review, researchers from Guangxi Medical University aimed to identify the potential candidates of dysregulated miRNAs for HCC prognosis in the profiling studies based on high-throughput miRNA microarray...
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The origin of vertebrate-specific characters and functional systems is one of the most important questions in the evolutionary biology. Amphioxus, the most basal chordate, is considered as the sister of vertebrates based on the recent molecular phylogenetic evidences, and it is used as an ideal model organism to study the origin and evolution of vertebrate organ systems including immune system. Three digestive organs, gill slits, hepatic caecum and intestine in amphioxus were also considered as primitive immune organs of amphioxus...
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497730-pig
Production of high-quality meat is important to satisfy the consumer and allow the pork industry to be competitive. It is evident that different muscle fiber types in different breeds greatly influence the pork quality, but the underlying molecular mechanism remains unclear. A team led by researchers from South China Agricultural University recently utilized Total RNA-Seq and miRNA-Seq services to examine global expressions of protein-coding transcripts and non-coding RNAs including miRNA, lncRNA, and circRNA in the longissimus dorsi of Landrace and Lantang pigs...
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toroid feat
A large number of antimicrobial peptides (AMPs) act with high selectivity and specificity through interactions with membrane lipid components. These peptides undergo complex conformational changes in solution; upon binding to an interface, one major conformation is stabilized. A recent publication by researchers from Federal University de Janeiro describe the interaction between tritrpticin (TRP3), a cathelicidin AMP, and micelles of different chemical composition...
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WSSV-624x468
Autophagy is known to be involved in viral infection. However, the relationship between autophagy and viral infection has not been characterized. MicroRNAs (miRNAs), important regulators of gene transcription, play central roles in many biologic processes, including autophagy and viral infection. It was therefore of interest to investigate the miRNAs regulating viral infection and host autophagy...
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A transposable element (TE) is a DNA fragment that can change its position within a genome. Transposable elements play important roles in maintaining the stability and diversity of organisms by transposition. Recent studies have shown that approximately half of the genes in Bombyx mori are TEs...
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black locust under tree
Indole-3-butyric acid (IBA) is applied to the cuttings of various plant species to induce formation of adventitious roots (ARs) in commercial settings. Tetraploid black locust is an attractive ornamental tree that is drought resistant, sand tolerant, can prevent sand erosion and has various commercial uses. To further elucidate the mechanisms of AR formation, researchers from Northwest A&F University used RNA sequencing to analyze transcriptome dynamics and differential gene expression at four developmental stages in control (CK) and IBA-treated groups...
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The AACR Annual Meeting 2017 will be held at the Walter E. Washington Convention Center in Washington, D.C., from April 1-5, with exhibit dates April 2-5. The AACR Annual Meeting highlights the best cancer science and medicine from institutions all over the world. Attendees are invited to stretch their boundaries, form collaborations, attend sessions outside […]
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